| 1. |
- Birney, Ewan, et al.
(författare)
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Prepublication data sharing
- 2009
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 461:7261, s. 168-170
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Tidskriftsartikel (refereegranskat)abstract
- Rapid release of prepublication data has served the field of genomics well. Attendees at a workshop in Toronto recommend extending the practice to other biological data sets.
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| 2. |
- Hudson, Brian, 1951-, et al.
(författare)
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Orchestrating interdependence in an international online learning community
- 2006
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Ingår i: British Journal of Educational Technology. - Oxford : Blackwell Publishing. - 0007-1013 .- 1467-8535. ; 37:5, s. 733-748
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Tidskriftsartikel (refereegranskat)abstract
- This paper focuses on research into the student experience as participants in the development of an international online community. The background context for this is an international master's programme and the specific context for the research is a module on Digital Media Applications (DMA), which are outlined. The programme design emphasises peer and formative assessment practices and the pedagogical approach aims to foster group collaboration in international teams. Following an overview of the research methods adopted, a number of emergent themes from the data analysis of student diaries are discussed, including issues of language, culture and identity. In conclusion, we offer some reflections on these issues and discuss the underpinning assumptions (in relation to assessment practices in particular) that have given direction to our subsequent ongoing research and development.
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| 3. |
- Bäckström, Ann, 1976-
(författare)
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Rock damage caused by underground excavation and meteorite impacts
- 2008
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The intent of this thesis is to contribute to the understanding of the origin of fractures in rock. The man-made fracturing from engineering activities in crystalline rock as well as the fracturing induced by the natural process of meteorite impacts is studied by means of various characterization methods. In contrast to engineering induced rock fracturing, where the goal usually is to minimize rock damage, meteorite impacts cause abundant fracturing in the surrounding bedrock. In a rock mass the interactions of fractures on the microscopic scale (mm-cm scale) influence fractures on the mesoscopic scale (dm-m scale) as well as the interaction of the mesocopic fractures influencing fractures on the macroscopic scale (m-km scale). Thus, among several methods used on different scales, two characterization tools have been developed further. This investigation ranges from the investigation of micro-fracturing in ultra-brittle rock on laboratory scale to the remote sensing of fractures in large scale structures, such as meteorite impacts. On the microscopic scale, the role of fractures pre-existing to the laboratory testing is observed to affect the development of new fractures. On the mesoscopic scale, the evaluation of the geometric information from 3D-laser scanning has been further developed for the characterisation of fractures from tunnelling and to evaluate the efficiency of the tunnel blasting technique in crystalline rock. By combining information on: i) the overbreak and underbreak; ii) the orientation and visibility of blasting drillholes and; iii) the natural and blasting fractures in three dimensions; a analysis of the rock mass can be made. This analysis of the rock mass is much deeper than usually obtained in rock engineering for site characterization in relation to the blasting technique can be obtained based on the new data acquisition. Finally, the estimation of fracturing in and around two meteorite impact structures has been used to reach a deeper understanding of the relation between fracture, their water content and the electric properties of the rock mass. A correlation between electric resistivity and fracture frequency in highly fractured crystalline rock has been developed and applied to potential impact crater structures. The results presented in this thesis enables more accurate modelling of rock fractures, both supporting rock engineering design and interpretation of meteorite impact phenomena.
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| 4. |
- Cloarec, Olivier, et al.
(författare)
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Statistical Total Correlation Spectroscopy: An Exploratory Approach for Latent Biomarker Identification from Metabolic 1H NMR Data Sets
- 2005
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Ingår i: Analytical Chemistry. - : American Chemical Society (ACS). - 0003-2700 .- 1520-6882. ; 77:5, s. 1282-89
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Tidskriftsartikel (refereegranskat)abstract
- We describe here the implementation of the statistical total correlation spectroscopy (STOCSY) analysis method for aiding the identification of potential biomarker molecules in metabonomic studies based on NMR spectroscopic data. STOCSY takes advantage of the multicollinearity of the intensity variables in a set of spectra (in this case 1H NMR spectra) to generate a pseudo-two-dimensional NMR spectrum that displays the correlation among the intensities of the various peaks across the whole sample. This method is not limited to the usual connectivities that are deducible from more standard two-dimensional NMR spectroscopic methods, such as TOCSY. Moreover, two or more molecules involved in the same pathway can also present high intermolecular correlations because of biological covariance or can even be anticorrelated. This combination of STOCSY with supervised pattern recognition and particularly orthogonal projection on latent structure-discriminant analysis (O-PLS-DA) offers a new powerful framework for analysis of metabonomic data. In a first step O-PLS-DA extracts the part of NMR spectra related to discrimination. This information is then cross-combined with the STOCSY results to help identify the molecules responsible for the metabolic variation. To illustrate the applicability of the method, it has been applied to 1H NMR spectra of urine from a metabonomic study of a model of insulin resistance based on the administration of a carbohydrate diet to three different mice strains (C57BL/6Oxjr, BALB/cOxjr, and 129S6/SvEvOxjr) in which a series of metabolites of biological importance can be conclusively assigned and identified by use of the STOCSY approach.
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| 5. |
- Harrington, Robert A., et al.
(författare)
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The Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRA.CER) trial : study design and rationale
- 2009
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Ingår i: American Heart Journal. - : Elsevier BV. - 0002-8703 .- 1097-6744. ; 158:3, s. 327-334
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Tidskriftsartikel (refereegranskat)abstract
- Background The protease-activated receptor 1 (PAR-1), the main platelet receptor for thrombin, represents a novel target for treatment of arterial thrombosis, and SCH 530348 is an orally active, selective, competitive PAR-1 antagonist. We designed TRA.CER to evaluate the efficacy and safety of SCH 530348 compared with placebo in addition to standard of care in patients with non-ST-segment elevation (NSTE) acute coronary syndromes (ACS) and high-risk features. Trial design TRA.CER is a prospective, randomized, double-blind, multicenter, phase III trial with an original estimated sample size of 10,000 subjects. Our primary objective is to demonstrate that SCH 530348 in addition to standard of care will reduce the incidence of the composite of cardiovascular death, myocardial infarction (MI), stroke, recurrent ischemia with rehospitalization, and urgent coronary revascularization compared with standard of care alone. Our key secondary objective is to determine whether SCH 530348 will reduce the composite of cardiovascular death, MI, or stroke compared with standard of care alone. Secondary objectives related to safety are the composite of moderate and severe GUSTO bleeding and clinically significant TIMI bleeding. The trial will continue until a predetermined minimum number of centrally adjudicated primary and key secondary end point events have occurred and all subjects have participated in the study for at least I year. The TRA.CER trial is part of the large phase III SCH 530348 development program that includes a concomitant evaluation in secondary prevention. Conclusion TRA.CER will define efficacy and safety of the novel platelet PAR-1 inhibitor SCH 530348 in the treatment of high-risk patients with NSTE ACS in the setting of current treatment strategies.
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| 6. |
- Horvath, Rita, et al.
(författare)
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Molecular basis of infantile reversible cytochrome c oxidase deficiency myopathy.
- 2009
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Ingår i: Brain : a journal of neurology. - : Oxford University Press (OUP). - 1460-2156. ; 132:Pt 11, s. 3165-74
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Tidskriftsartikel (refereegranskat)abstract
- Childhood-onset mitochondrial encephalomyopathies are usually severe, relentlessly progressive conditions that have a fatal outcome. However, a puzzling infantile disorder, long known as 'benign cytochrome c oxidase deficiency myopathy' is an exception because it shows spontaneous recovery if infants survive the first months of life. Current investigations cannot distinguish those with a good prognosis from those with terminal disease, making it very difficult to decide when to continue intensive supportive care. Here we define the principal molecular basis of the disorder by identifying a maternally inherited, homoplasmic m.14674T>C mt-tRNA(Glu) mutation in 17 patients from 12 families. Our results provide functional evidence for the pathogenicity of the mutation and show that tissue-specific mechanisms downstream of tRNA(Glu) may explain the spontaneous recovery. This study provides the rationale for a simple genetic test to identify infants with mitochondrial myopathy and good prognosis.
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| 7. |
- Hudson, John A., et al.
(författare)
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Characterising and modelling the excavation damaged zone in crystalline rock in the context of radioactive waste disposal
- 2009
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Ingår i: Environmental Geology. - : Springer Science and Business Media LLC. - 0943-0105 .- 1432-0495. ; 57:6, s. 1275-1297
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Tidskriftsartikel (refereegranskat)abstract
- This paper describes current knowledge about the nature of and potential for thermo-hydro-mechanical-chemical modelling of the excavation damaged zone (EDZ) around the excavations for an underground radioactive waste repository. In the first part of the paper, the disturbances associated with excavation are explained, together with reviews of Workshops that have been held on the subject. In the second part of the paper, the results of a DECOVALEX [DEmonstration of COupled models and their VALidation against EXperiment: research funded by an international consortium of radioactive waste regulators and implementers (http://www.decovalex.com)] research programme on modelling the EDZ are presented. Four research teams used four different models to simulate the complete stress-strain curve for Avro granite from the Swedish A"spo Hard Rock Laboratory. Subsequent research extended the work to computer simulation of the evolution of the repository using a 'wall-block model' and a 'near-field model'. This included assessing the evolution of stress, failure and permeability and time-dependent effects during repository evolution. As discussed, all the computer models are well suited to sensitivity studies for evaluating the influence of their respective supporting parameters on the complete stress-strain curve for rock and for modelling the EDZ.
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| 8. |
- Hudson, John A., et al.
(författare)
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Guidance on numerical modelling of thermo-hydro-mechanical coupled processes for performance assessment of radioactive waste repositories
- 2005
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Ingår i: International Journal of Rock Mechanics And Mining Sciences. - : Elsevier BV. - 1365-1609 .- 1873-4545. ; 42:5-6, s. 850-870
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Tidskriftsartikel (refereegranskat)abstract
- This paper provides advice on how to incorporate thermo-hydro-mechanical (THM) coupled processes into performance and safety assessments and design studies for radioactive waste disposal in geological formations. The advice is based on work conducted for the EU research project BENCHPAR: "Benchmark Tests and Guidance on Coupled Processes for Performance Assessment of Nuclear Waste Repositories". In Section 1, there is an explanation of why numerical analyses incorporating THM mechanisms are required for radioactive waste studies and background material on the subject is provided. Then, the THM processes and their interactions are explained in Section 2. Three case examples of THM numerical analysis are presented in Section 3 to illustrate the type of work that can be conducted to study the near-field, upscaling, and the far-field. The importance and priority of the THM couplings are summarized in Section 4. Recommended soft and hard auditing procedures are presented in Section 5. We place special emphasis on the fact that the most important step in numerical modelling is not executing the calculations per se, but the earlier conceptualization of the problem regarding the dominant processes, the material properties and parameters, the engineering perturbations, and their mathematical presentations. The associated modelling component of addressing the uncertainties and estimating their influence on the results is also important. Thus, the specific models and codes should be studied first to evaluate the harmony between the nature of the problem and the nature of the codes. The tactical use of particular numerical techniques will then be based on a sound strategic foundation. An associated listing of bullet point recommendations and issues for future directions for this THM subject area is given in Section 6.
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| 9. |
- Louglin, John, et al.
(författare)
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The politics of local income tax in Sweden : reform and continuity
- 2005
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Ingår i: Local Government Studies. - : Routledge, Taylor & Francis. - 0300-3930 .- 1743-9388. ; 31:3, s. 351-366
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Tidskriftsartikel (refereegranskat)abstract
- Local authorities have played an important role in the Swedish model of the Welfare State. This state is characterised by high levels of welfare provision paid for through general taxation, the rates of which are very high and the application of uniform standards across the entire country based on the principles of equity and fairness. The main form of income for local authorities is a Local Income Tax which is paid by 85% of the population. In the 1980s and 1990s, Sweden went through an economic crisis which resulted in significant changes to the tax system, although the Local Income Tax was retained. Subsequent changes have followed a pendulum process, with deregulation of local government finances in the 1990s being followed by greater regulation in the following years. Today, Sweden is conducting a major debate about the role and functions of different levels of government in the light of social, economic and political changes in the international scene.
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| 10. |
- Rutqvist, Jonny, et al.
(författare)
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A multiple-code simulation study of the long-term EDZ evolution of geological nuclear waste repositories
- 2009
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Ingår i: Environmental Geology. - : Springer Science and Business Media LLC. - 0943-0105 .- 1432-0495. ; 57:6, s. 1313-1324
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Tidskriftsartikel (refereegranskat)abstract
- This simulation study shows how widely different model approaches can be adapted to model the evolution of the excavation disturbed zone (EDZ) around a heated nuclear waste emplacement drift in fractured rock. The study includes modeling of coupled thermal-hydrological-mechanical (THM) processes, with simplified consideration of chemical coupling in terms of time-dependent strength degradation or subcritical crack growth. The different model approaches applied in this study include boundary element, finite element, finite difference, particle mechanics, and elasto-plastic cellular automata methods. The simulation results indicate that thermally induced differential stresses near the top of the emplacement drift may cause progressive failure and permeability changes during the first 100 years (i.e., after emplacement and drift closure). Moreover, the results indicate that time-dependent mechanical changes may play only a small role during the first 100 years of increasing temperature and thermal stress, whereas such time-dependency is insignificant after peak temperature, because of decreasing thermal stress.
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