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- Aschan, Gunnar, et al.
(författare)
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Xylene exposure. Electronystagmografic and gaschromatografic studies in rabbit
- 1977
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Ingår i: Acta Oto-Laryngologica. - : Informa Healthcare. - 0001-6489 .- 1651-2251. ; 84:1-6, s. 370-376
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Tidskriftsartikel (refereegranskat)abstract
- Complaints of vertigo from people who are exposed to industrial solvents have focused interest on their toxic effect on the nervous system. In order to evaluate the influence of an organic solvent, xylene, on the mammalian vestibular system, a series of rabbit experiments were performed. To achieve a constant concentration, the xylene was infused as a lipid emulsion. Blood concentrations were estimated by gas chromatography. Elec-tronystagmography in darkness revealed that at blood xylene concentrations of 30 ppm all rabbits had a positional nystagmus. The beat direction was the opposite of positional alcohol nystagmus. Another difference between the alcohol and the xylene reaction was that rotatory nystagmus responses were exaggerated. The relations between the present findings and the reactions and blood concentrations in people exposed to industrial solvents are discussed.
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- Gejrot, Tomas, et al.
(författare)
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Apropå otologins profiler
- 2002
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Ingår i: Svensk ÖNH tidskrift. - 1400-0121. ; 9, s. 17-17
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Tidskriftsartikel (populärvet., debatt m.m.)
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- Hydén, Dag, et al.
(författare)
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Broad frequency rotatory testing
- 1988
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Ingår i: Acta oto-laryngologica. Supplementum. - : Informa Healthcare. - 0365-5237 .- 1651-2464 .- 0001-6489 .- 1651-2251. ; 105:s455, s. 48-52
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Tidskriftsartikel (refereegranskat)abstract
- The method of broad-frequency-band rotatory testing with results from normal subjects and patients with peripheral uni- and bilateral loss as well as central vestibular disorders are reviewed. The following conclusions are drawn: adequate testing of the vestibulo-ocular reflex including side detection of unilateral loss in light or in darkness can only be done with either random or high-frequency (2.5–3 Hz) sinusoidal stimulation. Measurements of compensatory eye movements at lower frequencies where vestibular and non-vestibular signals interact are of interest for central vestibular diagnosis. A decreased ability to suppress vestibular nystagmus is not an uncommon finding in patients with large acoustic neuromas or pathology in the brainstem or cerebellum.
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