| 1. |
- Ahrné, Karin, et al.
(författare)
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Rödlista över fjärilar Lepidoptera
- 2015
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Ingår i: Rödlistade arter i Sverige 2015. - Uppsala : ArtDatabanken SLU. - 9789187853104 ; , s. 98-112
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 2. |
- Jakobson Mo, Susanna, et al.
(författare)
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Dopamine transporter imaging with [18F]FE-PE2I PET and [123I]FP-CIT SPECT – a clinical comparison
- 2018
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Ingår i: EJNMMI Research. - : Springer. - 2191-219X. ; 8
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Tidskriftsartikel (refereegranskat)abstract
- Background: Dopamine transporter (DAT) imaging may be of diagnostic value in patients with clinically suspected parkinsonian disease. The purpose of this study was to compare the diagnostic performance of DAT imaging with positron emission computed tomography (PET), using the recently developed, highly DAT-selective radiopharmaceutical [18F]FE-PE2I (FE-PE2I), to the commercially available and frequently used method with [123I]FP-CIT (FP-CIT) single-photon emission computed tomography (SPECT) in early-stage idiopathic parkinsonian syndrome (PS).Methods: Twenty-two patients with a clinical de novo diagnosis of PS and 28 healthy controls (HC) participating in an on-going clinical trial of FE-PE2I were analyzed in this study. Within the trial protocol, participants are clinically reassessed 2 years after inclusion. A commercially available software was used for automatic calculation of FP-CIT-specific uptake ratio (SUR). MRI-based volumes of interest combined with threshold PET segmentation were used for FE-PE2I binding potential relative to non-displaceable binding (BPND) quantification and specific uptake value ratios (SUVR).Results: PET with FE-PE2I revealed significant differences between patients with a clinical de novo diagnosis of PS and healthy controls in striatal DAT availability (p < 0.001), with excellent accuracy of predicting dopaminergic deficit in early-stage PS. The effect sizes were calculated for FE-PE2I BPND (Glass’s Δ = 2.95), FE-PE2I SUVR (Glass’s Δ = 2.57), and FP-CIT SUR (Glass’s Δ = 2.29). The intraclass correlation (ICC) between FE-PE2I BPND FP-CIT SUR was high in the caudate (ICC = 0.923), putamen (ICC = 0.922), and striatum (ICC = 0.946), p < 0.001. Five of the 22 patients displayed preserved striatal DAT availability in the striatum with both methods. At follow-up, a non-PS clinical diagnosis was confirmed in three of these, while one was clinically diagnosed with corticobasal syndrome. In these patients, FE-PE2I binding was also normal in the substantia nigra (SN), while significantly reduced in the remaining patients. FE-PE2I measurement of the mean DAT availability in the putamen was strongly correlated with BPND in the SN (R = 0.816, p < 0.001). Olfaction and mean putamen DAT availability was correlated using both FE-PE2I BPND and FP-CIT SUR (R ≥ 0.616, p < 0.001).Conclusion: DAT imaging with FE-PE2I PET yields excellent basic diagnostic differentiation in early-stage PS, at least as good as FP-CIT SPECT.
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| 3. |
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| 4. |
- Al-Gburi, Majid, et al.
(författare)
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Prediction of Restraint in Second Cast Sections of Concrete Culverts using Artificial Neural Networks
- 2018
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Ingår i: European Journal of Environmental and Civil Engineering. - : Taylor & Francis. - 1964-8189 .- 2116-7214. ; 22:2, s. 226-245
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Tidskriftsartikel (refereegranskat)abstract
- Estimation of restraint is very important for accurately predicting the risk of early thermal and shrinkage cracking in concrete structures. The stress in young concrete is affected by changes in its dimensions during hydration and the restraint imposed by adjoining structures. In concrete culverts, the restraints from existing structures acting upon the first and second casting sections to be cast are different, causing them to exhibit different early cracking behaviour. This work presents a new method for predicting restraint in complex concrete structures using artificial neural networks (ANNs). Finite element calculations were performed to predict restraint in 108 slabs, 324 walls and 972 roofs from second sections of concrete culverts, and the results obtained were used to train and validate ANN models. The ANN models were then used to study the effects of varying selected parameters (the thickness and width of the roof and slab, the thickness and height of the walls, and the length of the culvert section) on the predicted restraint. Mathematical expressions for predicting restraint values in slabs, walls and roofs were derived based on the ANN models’ output and implemented in an Excel spreadsheet that provides a simple way of predicting restraint in practical applications. Restraint values predicted in this way agree well with the results of finite-element calculations
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| 5. |
- Al-Gburi, Majid, et al.
(författare)
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Reduction of Early Age Crack Risks in Concrete Walls by Using a New Casting Technique
- 2016
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Ingår i: Structural Engineering International. - : International Association for Bridge and Structural Engineering. - 1016-8664 .- 1683-0350. ; 26:3, s. 216-224
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Tidskriftsartikel (refereegranskat)abstract
- Volumetric changes in early age concrete that are restrained might lead to cracks. The degree of restraint is influenced by the casting sequence and the dimensions of the castings. In the current study a new casting technique is proposed to reduce restraint in the newly cast concrete with a new arrangement of the structural joint to the existing old concrete. The proposed technique is valid for the typical structure wall-on-slab using one structural joint. This casting method means that lower part of the wall is cast together with the slab, and that part is called a kicker. Hereby, the behavior of the structure changes from a typical case wall-on-slab to a typical case wall-on-wall. It has been proven by the beam theory and demonstrated by numerical calculations that there is a clear reduction in the restraint from the slab to the wall using kickers. In the paper different kicker heights are studied with the aim of determining the minimum restraint in the upper part of the wall cast in contact with the kicker. The technique using kickers is compared with common measures used in the field to avoid cracking, such as cooling pipes in the new casting and/or heating cables in the adjoining old concrete. The presented method is both cost and time effective, as it opens the possibility to use larger structural length of each casting sequence.
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| 6. |
- Al-Gburi, Majid, et al.
(författare)
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Using Artificial Neural Network to Predict the Restraint in Concrete Culvert at Early Age
- 2015
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Ingår i: Structural Engineering International. - 1016-8664 .- 1683-0350. ; 25:3, s. 258-265
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Tidskriftsartikel (refereegranskat)abstract
- Estimation of restraint is very important for accurate prediction of the risk of concrete cracking at early age. The present study predicts the restraint in 324 walls and 972 roofs for a concrete culvert. A parametric study included the thickness and width of the roofs, thickness and height of the walls, thickness and width of the slab, and length of the structures. Each parameter increased or decreased the restraint in the walls and the roofs. The calculation of the restraint was done elastically by the finite-element method (FE). The results were used by an artificial neural network (ANN) tool, where firstly an influential percentage was investigated as input parameters on the restraint prediction. Equations have been derived by the ANN model to calculate the restraint in the walls and the roofs. It was then used in an Excel sheet to calculate the restraint and compare the result with the result from the finite-element calculations giving high accuracy between the ANN model and the FE calculations
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| 7. |
- Bergström, Ida, et al.
(författare)
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Annexin A1 in blood mononuclear cells from patients with coronary artery disease : Its association with inflammatory status and glucocorticoid sensitivity
- 2017
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Ingår i: PLOS ONE. - : Public Library of Science. - 1932-6203. ; 12:3
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Tidskriftsartikel (refereegranskat)abstract
- Annexin A1 (AnxA1) is a key player in resolution of inflammation and a mediator of glucocorticoid actions. In atherosclerotic tissue, increased expression of AnxA1 has been associated with protective plaque-stabilizing effects. Here, we investigated the expression of AnxA1 in peripheral blood mononuclear cells (PBMCs) from patients with coronary artery disease (CAD). Blood was collected from 57 patients with stable CAD (SCAD) and 41 healthy controls. We also included a minor group (n = 10) with acute coronary syndrome (ACS). AnxA1 mRNA was measured in PBMCs. Expression of AnxA1 protein (total and surface-bound) and glucocorticoid receptors (GR) were detected in PBMC subsets by flow cytometry. Also, salivary cortisol, interleukin(IL)-6 and IL-10 in plasma, and LPS-induced cytokine secretion from PBMCs, with or without dexamethasone, were assessed. AnxA1 mRNA was found to be slightly increased in PBMCs from SCAD patients compared with controls. However, protein expression of AnxA1 or GRs in PBMC subsets did not differ between SCAD patients and controls, despite SCAD patients showing a more proinflammatory cytokine profile ex vivo. Only surface expression of AnxA1 on monocytes correlated with dexamethasone-mediated suppression of cytokines. In ACS patients, a marked activation of AnxA1 was seen involving both gene expression and translocation of protein to cell surface probably reflecting a rapid glucocorticoid action modulating the acute inflammatory response in ACS. To conclude, surface expression of AnxA1 on monocytes may reflect the degree of glucocorticoid sensitivity. Speculatively, "normal" surface expression of AnxA1 indicates that anti-inflammatory capacity is impaired in SCAD patients.
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| 8. |
- Bergström, Ida
(författare)
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Pro- and anti-inflammatory actions in coronary artery disease : with focus on CD56+ T cells and Annexin A1
- 2015
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- ¨The atherosclerotic process is considered to be driven by an imbalance between proand anti-inflammatory actions. Still, the inflammatory state in patients with coronary artery disease (CAD) remains to be clarified. Annexin A1 (AnxA1) is a glucocorticoidinduced protein which may have a key role in the anti-inflammatory response as a mediator of glucocorticoid effects.The general aim of this thesis was to deepen the knowledge of pro- and antiinflammatory mechanisms in CAD via phenotypic assessments of immune cell subsets, in particular CD56+ T cells, and exploration of AnxA1. The long-term goal is to reveal basic mechanisms that will lead to the development of biomarkers, which may be used for individualized treatment and monitoring.The AnxA1 protein was constitutively expressed in both neutrophils and peripheral blood mononuclear cells (PBMCs). However, it varied considerably across PBMC subsets, being most abundantly expressed in monocytes. The AnxA1 expression was also higher in CD56+ T cells than in CD56- T cells.The expression of total AnxA1 protein in neutrophils was higher in patients with stable angina (SA) compared with controls. However, this was not accompanied by altered neutrophil activation status. Instead, the neutrophils from patients exhibited an enhanced anti-inflammatory response to exogenous AnxA1, emphasizing the potential of AnxA1 as an inhibitor of neutrophil activity. Only patients with acute coronary syndrome (ACS) showed an increase in cell surface-associated AnxA1.CAD patients, independent of clinical presentation, had increased proportions of CD56+ T cells compared with controls, a phenomenon likely to represent immunological aging. The CD56+ T cells were found to exhibit a distinct proinflammatory phenotype compared with CD56- T cells. In all T cell subsets, the expression of cell surface-associated AnxA1 was significantly increased in ACS patients, while it tended to be increased in post-ACS patients. In addition, dexamethasone clearly inhibited activation of CD56+ T cells in in vitro assays, whereas AnxA1 did not. The findings highlight the need to clarify whether the role of AnxA1 is different in T cells than in innate immune cells.In PBMCs, the mRNA levels of AnxA1 were increased in CAD patients, particularly in ACS patients. Correspondingly, the monocytes in ACS patients exhibited increased AnxA1 protein levels, both totally and on the cell surface. However, only cell surface-associated AnxA1 in monocytes correlated with the glucocorticoid sensitivity of PBMCs ex vivo. We propose the expression of cell surfaceassociated AnxA1 to be a promising candidate marker of glucocorticoid sensitivity, which needs further investigations in larger cohorts and intervention trials. Furthermore, the fact that PBMCs in post-ACS patients exhibited pro-inflammatory activity but no increase in cell surface-associated AnxA1 allow us to speculate that the glucocorticoid action and/or availability might be insufficient in these patients.
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| 9. |
- Castegren, Markus, et al.
(författare)
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Initial levels of organ failure, microbial findings and mortality in intensive care-treated primary, secondary and tertiary sepsis
- 2015
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Ingår i: Critical Care and Resuscitation. - 1441-2772. ; 17:3, s. 174-181
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Tidskriftsartikel (refereegranskat)abstract
- Objective: Analysis of whether patients with primary, secondary and tertiary sepsis, defined by the presence or absence of recent systemic inflammation-inducing events before the onset of sepsis, differ in clinical presentation, microbiological test results, treatment received and outcome. Design, setting and participants: A retrospective observational study in a single, general intensive care unit, of all patients treated for severe sepsis or septic shock from 2006 to 2011. Patients with haematological malignancies, with immunosuppressive diseases or being treated with immunosuppressive drugs were excluded. Interventions: None. Main outcome measures: Sequential Organ Failure Assessment score, incidence of organ failure, microbiological results of blood cultures and mortality. Results: We included 213 patients, who were classified as having primary (n = 121), secondary (n = 65) or tertiary sepsis (n = 27). The groups differed significantly in SOFA score, the incidence of kidney failure and coagulation failure at onset of sepsis in the ICU, as well as in blood culture findings. No differences in 7-day or 28-day mortality were seen, but the time of death occurred earlier among non-survivors in the primary sepsis group. Conclusions: Inflammatory insults before the onset of sepsis affect the clinical picture, blood microbial findings, and in non-survivors, the time of death. These results could, if validated in a prospective study, form a basis for a novel and simple strategy for stratifying patients in clinical studies for immunomodulation therapies in sepsis.
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| 10. |
- Edrees Saeed, Tarek, et al.
(författare)
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Investigation of changes in modal characteristics before and after damage of a railway bridge: a case study
- 2015
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Ingår i: The IES Journal Part A. - : Informa UK Limited. - 1937-3260 .- 1937-3279. ; 8:2, s. 131-144
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Tidskriftsartikel (refereegranskat)abstract
- The linear, time-invariant transfer function Txy has been utilized for the construction of FRF, based on the ambient vibration measurements. The results presented here indicated the possibility to identify and localize damages in steel railway bridges from the variations in the modal characteristics of the structure. The comparison between the modal characteristics for the healthy and collapsed bridge confirmed that damage had been existed. The abnormal percentage of change in modal damping, between the healthy and any other condition for a structure, can be regarded as a serious indicator for early stages of damage, while the high percentage of change in modal damping can clearly indicate the existence of damage in that structure. The average ratio of change in the damping ratio from the healthy to the collapsed bridge was about 206 % and this ration could be regarded as an index for the existence of a serious damage in steel bridges, which needs further evaluation in other test cases.
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