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Träfflista för sökning "WFRF:(Katayama N.) srt2:(2010-2014)"

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1.	Forrest, ARR, et al. (author) A promoter-level mammalian expression atlas 2014 In: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 507:7493, s. 462- Journal article (peer-reviewed)
2.	Ravasi, T, et al. (author) An Atlas of Combinatorial Transcriptional Regulation in Mouse and Man (vol 140, pg 744, 2010) 2010 In: CELL. - : Elsevier BV. - 0092-8674. ; 141:2, s. 369-369 Journal article (other academic/artistic)
3.	Jiang, LQ, et al. (author) Autocrine role of interleukin-13 on skeletal muscle glucose metabolism in type 2 diabetic patients involves microRNA let-7 2013 In: American journal of physiology. Endocrinology and metabolism. - : American Physiological Society. - 1522-1555 .- 0193-1849. ; 305:11, s. E1359-E1366 Journal article (peer-reviewed)abstract Low-grade inflammation associated with type 2 diabetes (T2DM) is postulated to exacerbate insulin resistance. We report that serum levels, as well as IL-13 secreted from cultured skeletal muscle, are reduced in T2DM vs. normal glucose-tolerant (NGT) subjects. IL-13 exposure increases skeletal muscle glucose uptake, oxidation, and glycogen synthesis via an Akt-dependent mechanism. Expression of microRNA let-7a and let-7d, which are direct translational repressors of the IL-13 gene, was increased in skeletal muscle from T2DM patients. Overexpression of let-7a and let-7d in cultured myotubes reduced IL-13 secretion. Furthermore, basal glycogen synthesis was reduced in cultured myotubes exposed to an IL-13-neutralizing antibody. Thus, IL-13 is synthesized and released by skeletal muscle through a mechanism involving let-7, and this effect is attenuated in skeletal muscle from insulin-resistant T2DM patients. In conclusion, IL-13 plays an autocrine role in skeletal muscle to increase glucose uptake and metabolism, suggesting a role in glucose homeostasis in metabolic disease.

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Type of publication: journal article (3)

Type of content: peer-reviewed (2); other academic/artistic (1)

Author/Editor: Katayama, S (2); Suzuki, H. (2); Arner, P (2); Carninci, P (2); Chen, Y. (1); Hasegawa, Y. (1); show more...; Nakamura, T. (1); Yamaguchi, Y. (1); Schaefer, U. (1); Kitamura, T. (1); Zucchelli, S. (1); Kaur, M. (1); Yoshida, S. (1); Joshi, A (1); Sugiyama, T. (1); Suzuki, M. (1); Sato, H. (1); Watanabe, S. (1); Krook, A (1); Zierath, JR (1); Nakamura, Y. (1); Roy, S (1); Lennartsson, A (1); Ekwall, K (1); Kere, J (1); Fujita, R. (1); Tanaka, H. (1); Li, K. (1); Kato, S. (1); Thompson, M (1); Tegner, J (1); Hasegawa, A (1); Kasukawa, T (1); Vitezic, M (1); Persson, H (1); Itoh, M. (1); Vijayan, D (1); Sakai, M (1); Andersson, R. (1); Suzuki, N (1); Nozaki, T (1); Kondo, N (1); Severin, J (1); Makeev, VJ (1); Okazaki, Y (1); Ramilowski, JA (1); Kulakovskiy, IV (1); Shin, JW (1); de Hoon, MJL (1); Rashid, M. (1); show less...

University: Karolinska Institutet (3)

Language: English (3)

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