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| 2. |
- Blanco, A., et al.
(författare)
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Use of modelling and simulation in the pulp and paper industry
- 2009
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Ingår i: Mathematical and Computer Modelling of Dynamical Systems. - : Informa UK Limited. - 1387-3954 .- 1744-5051. ; 15:5, s. 409-423
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Tidskriftsartikel (refereegranskat)abstract
- In pulp and paper the modelling and simulation of the pulp production processes was the first major application. Since then several other applications have been realised though papermaking has never been on the lead concerning the use of computer-based modelling and simulation. The complex nature of the materials is one of the most demanding challenges and the biggest hurdle for any electronic description of the papermaking process or paper itself. So other industries took the lead and it is now for the paper industry to learn from these industries what can be done with the help of computers to control or optimise processes or to design new grades. The application of results gained with the use of modelling and simulation techniques in pulp and paper manufacturing processes has helped the industry to, for example, reduce emissions and increase the productivity and cost-efficiency of the processes. Still there are many important tasks open. A better understanding of the mechanisms of the processes and their control loops has to be achieved in order to further improve the paper quality, stabilise the wet-end chemistry, and enhance the runnability. Important features to be developed are new process designs, efficient process monitoring and systems that offer decision support during operation. In this paper a review of the state of the art on modelling and simulation in the pulp and paper industry is presented as well as further research needs.
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| 3. |
- Lepäntalo, M., et al.
(författare)
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PTFE bypass or thrupass for superficial femoral artery occlusion? : A randomised controlled trial
- 2009
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Ingår i: European Journal of Vascular and Endovascular Surgery. - : Elsevier BV. - 1078-5884 .- 1532-2165. ; 37:5, s. 578-584
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Tidskriftsartikel (refereegranskat)abstract
- Early results of a thrupass endograft in the treatment of femoral lesions are promising. Less morbidity and better cost-effectiveness are suggested to be achieved in the treatment of chronic lower limb ischaemia with endovascular treatment compared to surgical treatment. PATIENTS AND METHODS: This randomised multicentre trial aimed to enroll a group of 60+60 patients for the treatment of 5-25-cm occlusions of superficial femoral artery (SFA) to be followed up for 3 years. Patients were treated either with endoluminal PTFE thrupass (WL Gore & Ass) or with surgical polytetrafluoroethylene (PTFE) bypass to proximal popliteal artery. Primary patency at 3 years was scheduled to be the primary end-point and secondary patency, functional success, costs and quality of life the secondary end-points. RESULTS: A sample of 100 consecutive SFA occlusions in one of the centres revealed that only 4% of the lesions were amenable for the study. The trial was prematurely terminated due to the results of an interim analysis at the time when 44 patients were recruited: the 1-year primary patency (excluding technical failures) was 48% for thrupass and 95% for bypass (p=0.02). The patency difference in favour of surgical bypass over endovascular thrupass was also sustained after completion of 1-year follow-up, the primary patencies being 46% and 84% at 1 year with grossly equilinear life-table curves thereafter (p=0.18), respectively. The corresponding secondary patencies were 63% and 100% (p=0.05) when excluding technical failures and 58% and 100% (p=0.02) according to intention-to-treat analysis. Secondary outcomes were thus not analysed. CONCLUSION: Treatment of SFA occlusions (TASC IIB and C or Imelda Ia and II) should be done by PTFE bypass rather than by PTFE thrupass, as thrupass is connected with worse early outcome. These results represent only a small category of femoral disease.
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| 4. |
- Hakanen, Jussi, et al.
(författare)
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On Interactive Multiobjective Optimization with NIMBUS in Chemical Process Design
- 2005
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Ingår i: Journal of Multi-Criteria Decision Analysis. - : Wiley. - 1057-9214 .- 1099-1360. ; 13:2-3, s. 125-134
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Tidskriftsartikel (refereegranskat)abstract
- We study multiobjective optimization problems arising from chemical process simulation. The interactive multiobjective optimization method NIMBUS®, developed at the University of Jyväskylä, is combined with the BALAS® process simulator, developed at the VTT Technical Research Center of Finland, in order to provide a new interactive tool for designing chemical processes. Continuous interaction between the method and the designer provides a new efficient approach to explore Pareto optimal solutions and helps the designer to learn about the behaviour of the process. As an example of how the new tool can be used, we report the results of applying it in a heat recovery system design problem related to the process water system of a paper mill.
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| 5. |
- Huyghe, Jeroen R., et al.
(författare)
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Genome-wide SNP-based linkage scan identifies a locus on 8q24 for an age-related hearing impairment trait
- 2008
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Ingår i: American Journal of Human Genetics. - : Cell Press. - 0002-9297 .- 1537-6605. ; 83:3, s. 401-407
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Tidskriftsartikel (refereegranskat)abstract
- Age-related hearing impairment (ARHI), or presbycusis, is a very common multifactorial disorder. Despite the knowledge that genetics play an important role in the etiology of human ARHI as revealed by heritability studies, to date, its precise genetic determinants remain elusive. Here we report the results of a cross-sectional family-based genetic study employing audiometric data. By using principal component analysis, we were able to reduce the dimensionality of this multivariate phenotype while capturing most of the variation and retaining biologically important features of the audiograms. We conducted a genome-wide association as well as a linkage scan with high-density SNP microarrays. Because of the presence of genetic population substructure, association testing was stratified after which evidence was combined by meta-analysis. No association signals reaching genome-wide significance were detected. Linkage analysis identified a linkage peak on 8q24.13-q24.22 for a trait correlated to audiogram shape. The signal reached genome-wide significance, as assessed by simulations. This finding represents the first locus for an ARHI trait.
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| 6. |
- Koskinen, M., et al.
(författare)
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Spectral properties of rotating electrons in quantum dots and their relation to quantum Hall liquids
- 2007
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Ingår i: Journal of Physics: Condensed Matter. - : IOP Publishing. - 1361-648X .- 0953-8984. ; 19:7
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Tidskriftsartikel (refereegranskat)abstract
- The exact diagonalization technique is used to study many-particle properties of interacting electrons with spin, confined in a two-dimensional harmonic potential. The single-particle basis is limited to the lowest Landau level. The results are analysed as a function of the total angular momentum of the system. Only at angular momenta corresponding to the filling factors 1, 1/3, 1/5, etc is the system fully polarized. The lowest energy states exhibit spin waves, domains, and localization, depending on the angular momentum. Vortices exist only at excited polarized states. The high angular momentum limit shows localization of electrons and separation of the charge and spin excitations.
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| 7. |
- Nikkarila, J-P, et al.
(författare)
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Magnetic phases of one-dimensional lattices with 2-4 fermions per site
- 2008
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Ingår i: New Journal of Physics. - : IOP Publishing. - 1367-2630. ; 10, s. 14-063013
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Tidskriftsartikel (refereegranskat)abstract
- We study the spectral and magnetic properties of one-dimensional lattices filled with 2-4 fermions (with spin-1/2) per lattice site. We use a generalized Hubbard model that takes into account all the interactions on a lattice site, and solve the many-particle problem by exact diagonalization. We find an intriguing magnetic phase diagram which includes ferromagnetism, spin-1 Heisenberg antiferromagnetism and orbital antiferromagnetism.
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| 8. |
- Van Laer, Lut, et al.
(författare)
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The grainyhead like 2 gene (GRHL2), alias TFCP2L3, is associated with age-related hearing impairment
- 2008
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Ingår i: Human Molecular Genetics. - : Oxford University Press. - 0964-6906 .- 1460-2083. ; 17:2, s. 159-169
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Tidskriftsartikel (refereegranskat)abstract
- Age-related hearing impairment (ARHI) is the most prevalent sensory impairment in the elderly. ARHI is a complex disease caused by an interaction between environmental and genetic factors. The contribution of various environmental factors has been relatively extensively studied. In contrast, investigations to identify the genetic risk factors have only recently been initiated. In this paper we describe the results of an association study performed on 2418 ARHI samples derived from nine centers from seven European countries. In 70 candidate genes, a total of 768 tag single nucleotide polymorphisms (SNPs) were selected based on HAPMAP data. These genes were chosen among the monogenic hearing loss genes identified in mice and men in addition to several strong functional candidates. After genotyping and data polishing, statistical analysis of all samples combined resulted in a P-value that survived correction for multiple testing for one SNP in the GRHL2 gene. Other SNPs in this gene were also associated, albeit to a lesser degree. Subsequently, an analysis of the most significant GRHL2 SNP was performed separately for each center. The direction of the association was identical in all nine centers. Two centers showed significant associations and a third center showed a trend towards significance. Subsequent fine mapping of this locus demonstrated that the majority of the associated SNPs reside in intron 1. We hypothesize that the causative variant may change the expression levels of a GRHL2 isoform.
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