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- Holst, J., et al.
(författare)
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Antithrombotic effect of recombinant truncated tissue factor pathway inhibitor (TFPI1-161) in experimental venous thrombosis : A comparison with low molecular weight heparin
- 1994
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Ingår i: Thrombosis and Haemostasis. - 0340-6245. ; 71:2, s. 214-219
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Tidskriftsartikel (refereegranskat)abstract
- The aim was to investigate whether a truncated recombinant Tissue Factor Pathway Inhibitor (TFPI1-161) which lacked the third Kunitz-type domain and the basic c-terminal region, had an antithrombotic effect comparable to LMWH in a randomised double-dummy study. The experimental thrombosis was induced in jugular veins, in a total of 40 rabbits by a combination of destruction of the endothelium and restricted blood flow. Group 1: placebo, gr 2- LMWH 60 anti-FXa IU/kg, gr 3-5: 0.1, 1.0 and 10.0 mg/kg TFPI1-161. TFPI1-161 reduced the thrombus weights in all treated groups, significantly in doses of 1.0 and 10.0 mg/kg compared to placebo. The frequency of thrombosis and occlusive thrombosis were also significantly reduced in those doses. The antithrombotic properties of TFPI1-161 (1.0-10.0 mg/ kg) measured as thrombus weight, frequency of thrombosis and frequency of occlusive thrombosis was equivalent to the antithrombotic properties of LMWH. In the anti-FXa, APTT and PT-assays TFPI1-161 displayed a dose dependent increase of activity. Recombinant-TFPI1-161 did not influence the anti-FIIa-assay. No haemorrhagic side effects were noted.
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| 5. |
- Brenning, Nils, et al.
(författare)
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Critical ionization velocity interaction in the CRIT I rocket experiment
- 1990
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Ingår i: Advances in Space Research. - : Elsevier BV. - 0273-1177. ; 10, s. 63-66
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Tidskriftsartikel (refereegranskat)abstract
- In the rocket experiment CRIT I, launched from Wallops Island on 13 May 1986, two identical Barium shaped charges were fired from distances of 1.3 km and 3.6 km towards the main experiment payload, which was separated from a sub-payload by a couple of km along the magnetic field. The relevance of earlier proposed mechanisms for electron heating in ionospheric critical velocity experiments is investigated in the light of the CRIT I results. It is concluded that both the "homogeneous" and the "ionizing front" models can be applied, in different parts of the stream. It is also possible that a third, entirely different, mechanism may contribute to the electron heating. This mechanism involves direct energization of electrons in the magnetic-field-aligned component of the DC electric field. © 1989.
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| 6. |
- Brenning, Nils, et al.
(författare)
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Electrodynamic interaction between the CRIT I ionized barium streams and the ambient ionosphere
- 1990
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Ingår i: Advances in Space Research. - : Elsevier BV. - 0273-1177. ; 10, s. 67-70
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Tidskriftsartikel (refereegranskat)abstract
- In the CRIT I Critical Velocity experiment, launched from Wallops Island on 13 May, 1986, two fast barium streams were ejected by means of shaped charges. Their electrodynamic interaction with the ambient ionosphere is discussed. An outstanding feature of the DC electric field observed within the streams was a large magnetic-field-aligned component, persisting on the time scale of the passage of the streams. One interpretation of the DC electric field data is that the internal electric fields of the streams is not greatly modified by Birkeland currents, i.e. a state is established, where the transverse currents are to a first approximation divergence-free. It is argued that this interpretation can explain why a reversal of the strong explosion-directed electric field was observed in the first explosion but not in the second (more distant one). © 1989.
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| 7. |
- Brenning, Nils, et al.
(författare)
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Interpretation of the Electric Fields Measured in an Ionospheric Critical Ionization Velocity Experiment
- 1991
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Ingår i: Journal of Geophysical Research. - 0148-0227 .- 2156-2202. ; 96, s. 9719-9733
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Tidskriftsartikel (refereegranskat)abstract
- This paper deals with the quasi-dc electric fields measured in the CRIT I ionospheric release experiment, which was launched from Wallops Island on May 13, 1986. The purpose of the experiment was to study the critical ionization velocity (CIV) mechanism in the ionosphere. Two identical barium shaped charges were fired from distances of 1.99 km and 4.34 km towards a main payload, which made full three-dimensional measurements of the electric field inside the streams. There was also a subpayload separated from the main payload by a couple of kilometers along the magnetic field. The relevance of earlier proposed mechanisms for electron heating in CIV is investigated in the light of the CRIT I results. It is concluded that both the “homogeneous” and the “ionizing front” models probably apply, but in different parts of the stream. It is also possible that electrons are directly accelerated by a magnetic-field-aligned component of the electric field; the quasi-dc electric field observed within the streams had a large magnetic-field-aligned component, persisting on the time scale of the passage of the streams. The coupling between the ambient ionosphere and the ionized barium stream in CRIT I was more complicated than is usually assumed in CIV theories, with strong magnetic-field-aligned electric fields and probably current limitation as important processes. One interpretation of the quasi-dc electric field data is that the internal electric fields of the streams were not greatly modified by magnetic-field-aligned currents, i.e., a state was established where the transverse currents were to a first approximation divergence-free. It is argued that this interpretation can explain both a reversal of the strong explosion-directed electric field in burst 1 and the absence of such a reversal in burst 2.
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| 8. |
- Holbech, J. D., et al.
(författare)
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H2* defect in crystalline silicon
- 1993
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 71:6, s. 875-878
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Tidskriftsartikel (refereegranskat)abstract
- Detailed infrared studies have been carried out on proton- and deuteron-implanted Si. A dominant trigonal defect involving a pair of inequivalent hydrogen atoms has been identified, with local modes at 2061.5, 1838.3, 1599.1, and 817.2 cm-1. The structure, the local modes, and the isotopic shifts of the H2* defect have been calculated using ab initio pseudopotential cluster theory. The structure is consistent with channeling and uniaxial stress experiments. The calculated frequencies and isotopic shifts are in close agreement with those observed.
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| 10. |
- Holst, J., et al.
(författare)
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Protamine neutralization of intravenous and subcutaneous low-molecular-weight heparin (tinzaparin, Logiparin(TM)). An experimental investigation in healthy volunteers
- 1994
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Ingår i: Blood Coagulation and Fibrinolysis. - 0957-5235. ; 5:5, s. 795-803
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Tidskriftsartikel (refereegranskat)abstract
- The aim of the present study was to investigate whether tinzaparin sodium (a low-molecular-weight heparin (LMWH)) was fully and permanently neutralized in vivo in man by protamine sulphate (PS) after intravenous (i.v.) or subcutaneous (s.c.) injection. Fifty healthy adults equally divided in five age- and sex-matched groups were included. The groups received 50 IU unfractionated heparin (UH)/kg body weight (b.w.) i.v., 50 anti-factor Xa (anti-Xa) IU tinzaparin/kg b.w. i.v., 75 anti-Xa IU tinzaparin/kg b.w. s.c., 175 anti-Xa IU tinzaparin/kg b.w. s.c., or 1 ml of saline s.c. PS was given as a 10 min infusion in a dose of 1 mg/100 IU of heparin in the four first groups while 0.5 mg PS/kg b.w. was given in the placebo group. In the i.v. groups PS was administered 45 min after the heparin injection, and in the s.c. groups 180 min post-heparin injection. In the UH group PS fully and permanently neutralized all three activities. In the i.v. tinzaparin group PS reversed 80% of the anti-Xa activity, while the anti-IIa and aPTT activities were fully reversed. A slight, but statistically significant, increase in anti-Xa and anti-Ila activities were seen following i.v. tinzaparin. In the s.c. groups 60-65% of the observed peak anti-Xa activity was neutralized, anti-IIa was almost completely reversed, and aPTT returned nearly to baseline values. A gradual return of the anti-Xa activity (65-75%), anti-IIa activity (55%) and aPTT activity (35-45%) was seen in the s.c. groups 3 h after reversal compared with the observed peak values. A continuous absorption of tinzaparin from the s.c. depot is presumably the cause of the returned activity. PS caused an 8-27% transient drop in the platelet count in all groups. This study confirms that the anti-Xa activity following i.v. and s.c. administration of tinzaparin (a LMWH) is only partially neutralizable by protamine. This is not due to insufficient dosages of the antidote, as an excess of protamine could be demonstrated ex vivo immediately after the protamine infusion. The present results suggest that protamine neutralization of tinzaparin given s.c. should be obtained with intermittent injections or continuous infusion.
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