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- Aurumskjöld, Marie-Louise, et al.
(författare)
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Model based iterative reconstruction IMR gives possibility to evaluate thinner slice thicknesses than conventional iterative reconstruction iDose(4) - a phantom study
- 2015
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Ingår i: Medical Imaging 2015: Physics of Medical Imaging. - : SPIE. - 1996-756X .- 0277-786X. ; 9412, s. 94124-94124
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Konferensbidrag (refereegranskat)abstract
- Computed tomography (CT) is one of the most important modalities in a radiological department, which produces images with high diagnostic confidence, but in some cases contributes to a high radiation dose to the patient. The radiation dose can be reduced by the use of advanced image reconstruction algorithms. This study was done on a Philips Brilliance iCT with iterative reconstruction iDose(4) and model-based iterative reconstruction IMR. The purpose was to investigate the effect on the image quality with thin slice images reconstructed with IMR, compared to standard slice thickness reconstructed with iDose(4). Objective measurements of noise and contrast-to-noise ratio were performed using an image quality phantom, an anthropomorphic phantom and clinical cases. Subjective evaluations of low-contrast resolution were performed by observers using an image quality phantom. IMR gives strong noise reduction and enhanced low-contrast and thereby enable selection of thinner slice thickness. Objective evaluation of image noise shows that thin slices reconstructed with IMR provides lower noise than thicker slice images reconstructed with iDose(4). With IMR the slice thickness is of less importance for the noise. With thinner slices the partial volume artefacts becomes less pronounced. In conclusion, we have shown that IMR enables reduction of the slice thickness and at the same time maintain or even reduce the noise level compared to iDose(4) reconstruction with standard slice thickness. This will subsequently result in an improvement of image quality for images reconstructed with IMR.
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| 2. |
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| 3. |
- Lindman, J., et al.
(författare)
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Diabetes and pre-diabetes among police officers in Guinea-Bissau
- 2017
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Ingår i: African Journal of Diabetes Medicine. - 2042-8545. ; 25:2, s. 19-20
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Tidskriftsartikel (refereegranskat)abstract
- This study has investigated the prevalence of type 2 diabetes among 1119 police officers in Guinea-Bissau. Those with a random blood glucose (RBG) > 8.0 mol/l had HbA1c (glycated haemoglobin) testing. Diabetes (HbA1c > 6.5%) was present in 4.1%, and pre-diabetes (HbA1c 5.7-6.5%) was present in a further 4.2%. Factors associated with diabetes were age, weight and ethnicity.
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| 4. |
- Waldenström, Jesper, 1985, et al.
(författare)
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Randomized Trial Evaluating the Impact of Ribavirin Mono-Therapy and Double Dosing on Viral Kinetics, Ribavirin Pharmacokinetics and Anemia in Hepatitis C Virus Genotype 1 Infection
- 2016
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Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 11:5
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Tidskriftsartikel (refereegranskat)abstract
- In this pilot study (RibaC), 58 hepatitis C virus (HCV) genotype 1 infected treatment-naive patients were randomized to (i) 2 weeks ribavirin double dosing concomitant with pegylated interferon-alpha (pegIFN-alpha), (ii) 4 weeks ribavirin mono-therapy prior to adding pegIFN-alpha, or (iii) standard-of-care (SOC) ribavirin dosing concurrent with pegIFN-alpha. Four weeks of ribavirin mono-therapy resulted in a mean 0.46 log(10) IU/mL HCV RNA reduction differentially regulated across IL28B genotypes (0.89 vs. 0.21 log(10) IU/mL for CC and CT/TT respectively; P = 0.006), increased likelihood of undetectable HCV RNA week 4 after initiating pegIFN-alpha and thus shortened treatment duration (P < 0.05), and decreased median IP-10 concentration from 550 to 345 pg/mL (P < 0.001). Both experimental strategies impacted on ribavirin concentrations, and high levels were achieved after one week of double dosing. However, by day 14, double dosing entailed a greater hemoglobin decline as compared to SOC (2.2 vs. 1.4 g/dL; P = 0.03). Conclusion: Ribavirin down-regulates IP-10, and may have an antiviral effect differently regulated across IL28B genotypes.
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