| 1. |
- Borge, M. J. G., et al.
(author)
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Beta-Decay to the Proton Halo State in F-17
- 1993
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In: Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 317:1-2, s. 25-30
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Journal article (peer-reviewed)abstract
- In the first experiment at the newly constructed ISOLDE Facility the first-forbidden beta-decay of Ne-17 into the first excited state of F-17 has been measured. It is a factor two faster than the corresponding mirror decay and thus gives one of the largest recorded asymmetries for beta decays feeding bound final states. Shell-model calculations can only reproduce the asymmetry if the halo structure of the F-17 state is taken into account.
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| 2. |
- Burnet, N G, et al.
(author)
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Prediction of normal-tissue tolerance to radiotherapy from in-vitro cellular radiation sensitivity.
- 1992
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In: Lancet. - 0140-6736. ; 339:8809, s. 1570-1
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Journal article (peer-reviewed)abstract
- The success of radiotherapy depends on the total radiation dose, which is limited by the tolerance of surrounding normal tissues. Since there is substantial variation among patients in normal-tissue radiosensitivity, we have tested the hypothesis that in-vitro cellular radiosensitivity is correlated with in-vitro normal-tissue responses. We exposed skin fibroblast cell lines from six radiation-treated patients to various doses of radiation and measured the proportions surviving. There was a strong relation between fibroblast sensitivity in vitro and normal-tissue reactions, especially acute effects. Assessment of radiosensitivity could lead to improved tumour cure rates by enabling radiation doses to be tailored to the individual.
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| 3. |
- Burnet, N G, et al.
(author)
-
The relationship between cellular radiation sensitivity and tissue response may provide the basis for individualising radiotherapy schedules.
- 1994
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In: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. - 0167-8140. ; 33:3, s. 228-38
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Journal article (peer-reviewed)abstract
- There is a wide variation in normal tissue reactions to radiotherapy and in many situations the severity of these reactions limits radiotherapy dose. Clinical fractionation studies carried out in Gothenburg have demonstrated that a large part of the spectrum of normal tissue reactions is due to differences in individual normal tissue sensitivity. If this variation in normal tissue reactions is due to differences in intrinsic cellular radiosensitivity, it should be possible to predict tissue response based on measurement of cellular sensitivity. Here we report the initial results of a study aimed at establishing whether a direct relationship exists between cellular radiosensitivity and tissue response. Ten fibroblasts strains, including four duplicates, were established from a group of patients in the Gothenburg fractionation trials who had received radiotherapy following mastectomy. Skin doses were measured and both acute and late skin changes were observed following radiotherapy. Right and left parasternal areas were treated with different dose fractionation schedules. Clonogenic assays were used to assess intrinsic cellular radiosensitivity, and all experiments were carried out without prior knowledge of the clinical response, or which strains were duplicates. Irradiation was carried out using 60Co gamma-rays at high dose-rate (HDR) of 1-2 Gy/min and low dose-rate (LDR) of 1 cGy/min. A spectrum of sensitivity was seen, with SF2 values of 0.17-0.28 at HDR and 0.25-0.34 at LDR, and values of D0.01 of 5.07-6.38 Gy at HDR and 6.43-8.12 Gy at LDR. Comparison of the in vitro results with the clinical normal tissue effects shows a correlation between cellular sensitivity and late tissue reactions, which is highly significant with p = 0.02. A correlation between cellular sensitivity and acute effects was noted in the left-sided parasternal fields, but not the right. This is thought to be coincidental, and without biological significance. Our results suggest that cellular sensitivity might form the basis for the development of an assay system capable of predicting late normal tissue effects to curative radiotherapy, which might allow dose escalation in some patients. Increased local control and cure, with unchanged or improved normal tissue complications, could result from such individualised radiotherapy prescriptions.
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| 4. |
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| 5. |
- Keller, H., et al.
(author)
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Search for Forbidden Beta-Decays of the Drip-Line Nucleus Be-12
- 1994
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In: Zeitschrift fur Physik A Hadrons and Nuclei. - 1431-5831 .- 0939-7922. ; 348:1, s. 61-62
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Journal article (peer-reviewed)abstract
- Beta-coincident gamma-rays have been measured from implanted pure samples of Be-12 separated at the LISE3 spectrometer at GANIL. An intensity of 0.040(26)% can be estimated for the branching ratio of the isospin forbidden pure-Fermi transition to the 0+ excited state of B-12 and of 0.008(6) % of the transition to the 1- excited state. Both are taken to represent upper limits. The halflife has been re-measured to be 26.1(2.4) ms.
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| 6. |
- Tengblad, O., et al.
(author)
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Study of Neutron Rich Neon Isotopes
- 1992
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In: Zeitschrift fur Physik A Hadrons and Nuclei. - 1431-5831 .- 0939-7922. ; 342:3, s. 303-307
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Journal article (peer-reviewed)abstract
- The half-lives and P(n)-values of the neutron rich isotopes Ne-26-29 have been determined. The results are compared to shell-model calculations and good agreement is found except for Ne-29, where the half-life exceeds the predictions by more than an order of magnitude. This unexpectedly long half-life can be explained as due to a fp intruder configuration.
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| 7. |
- Borge, M. J. G., et al.
(author)
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Study of Charged-Particles Emitted in the Beta-Decay of He-6,He-8
- 1993
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In: Nuclear Physics A. - 0375-9474. ; 560:2, s. 664-676
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Journal article (peer-reviewed)abstract
- The beta-delayed charged particle spectra from He-6 and He-8 were measured with a telescope consisting of a gas counter and a Si surface barrier detector. Beta-delayed deuterons and tritons are emitted in the two cases with branching ratios of (7.6 +/- 0.6) x 10(-6), E(d) > 350 keV and (8.0 +/- 0.5) x 10(-3), respectively. Both spectra present anomalies that must be due to the special structure of these nuclei (an alpha core surrounded by several neutrons).
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| 8. |
- Borge, M. J. G., et al.
(author)
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Super-Allowed Beta-Decay of Nuclei at the Drip-Line
- 1991
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In: Zeitschrift fur Physik A Hadrons and Nuclei. - 1431-5831 .- 0939-7922. ; 340:3, s. 255-261
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Journal article (peer-reviewed)abstract
- We have investigated the continuous particle spectra following the beta decay of the neutron-rich nuclei that terminate the mass 6, 8, 9 and 11 isobaric chains. Strong beta transitions feeding the very top of the spectrum are found systematically. The favoured states are within a few MeV of the energy of the initial state. This phenomenon seems to be linked to the occurrence of a di-neutron structure or neutron halo in the drip-line nuclei.
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| 9. |
- Borge, M. J. G., et al.
(author)
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The Decay of Ar-31
- 1990
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In: Nuclear Physics A. - 0375-9474. ; 515:1, s. 21-30
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Journal article (peer-reviewed)
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| 10. |
- Nyman, Jan, 1956, et al.
(author)
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Prognostic factors for local control and survival of cancer of the oral tongue. A retrospective analysis of 230 cases in western Sweden.
- 1993
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In: Acta oncologica (Stockholm, Sweden). - 0284-186X. ; 32:6, s. 667-73
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Journal article (peer-reviewed)abstract
- During the 19-year period from 1970 to 1988, 289 cases of squamous cell carcinoma of the oral tongue were diagnosed in Western Sweden. In 230 of these, treatment regimens and results were analysed in an attempt to define prognostic factors for local control and survival. Tumour stages were: T1 26%, T2 32%, T3 30% and T4 13%. Nodal disease was seen in 32% of the patients. Sixty per cent of the patients had surgery, 74% external with or without combination with interstitial irradiation; and 32% received chemotherapy. The local control rate at five years was 59% (T1 66%, T2 67%, T3 44% and T4 0%). Survival at five years was 37% (T1 61%, T2 51%, T3 19% and T4 0%). By a multivariate procedure we demonstrate that the tumour related variables T-category, N-category and extension to the tonsillar region had a significant association with survival. Extension to the tonsillar region, extension to the floor of the mouth and level of neck nodes were significantly associated with local-regional control.
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