| 1. |
- Moberg, Christina, et al.
(författare)
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De unga gör helt rätt när de stämmer staten
- 2022
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Ingår i: Aftonbladet. - 1103-9000.
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- 1 620 forskare och lärare i forskarvärlden: Vi ställer oss bakom Auroras klimatkrav
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| 2. |
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| 3. |
- Ahearn, Thomas U., et al.
(författare)
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Common variants in breast cancer risk loci predispose to distinct tumor subtypes
- 2022
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Ingår i: Breast Cancer Research. - : Springer Nature. - 1465-5411 .- 1465-542X. ; 24:1
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundGenome-wide association studies (GWAS) have identified multiple common breast cancer susceptibility variants. Many of these variants have differential associations by estrogen receptor (ER) status, but how these variants relate with other tumor features and intrinsic molecular subtypes is unclear.MethodsAmong 106,571 invasive breast cancer cases and 95,762 controls of European ancestry with data on 173 breast cancer variants identified in previous GWAS, we used novel two-stage polytomous logistic regression models to evaluate variants in relation to multiple tumor features (ER, progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and grade) adjusting for each other, and to intrinsic-like subtypes.ResultsEighty-five of 173 variants were associated with at least one tumor feature (false discovery rate < 5%), most commonly ER and grade, followed by PR and HER2. Models for intrinsic-like subtypes found nearly all of these variants (83 of 85) associated at p < 0.05 with risk for at least one luminal-like subtype, and approximately half (41 of 85) of the variants were associated with risk of at least one non-luminal subtype, including 32 variants associated with triple-negative (TN) disease. Ten variants were associated with risk of all subtypes in different magnitude. Five variants were associated with risk of luminal A-like and TN subtypes in opposite directions.ConclusionThis report demonstrates a high level of complexity in the etiology heterogeneity of breast cancer susceptibility variants and can inform investigations of subtype-specific risk prediction.
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| 4. |
- Alkharaan, Hassan, et al.
(författare)
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Persisting Salivary IgG Against SARS-CoV-2 at 9 Months After Mild COVID-19 : A Complementary Approach to Population Surveys
- 2021
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Ingår i: Journal of Infectious Diseases. - : Oxford University Press (OUP). - 0022-1899 .- 1537-6613. ; 224:3, s. 407-414
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Tidskriftsartikel (refereegranskat)abstract
- Background. Declining humoral immunity in coronavirus disease 2019 (COVID-19) patients and possible reinfection have raised concern. Mucosal immunity, particularly salivary antibodies, may be short lived although long-term studies are lacking. Methods. Using a multiplex bead-based array platform, we investigated antibodies specific to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) proteins in 256 saliva samples from convalescent patients 1-9 months after symptomatic COVID-19 (n = 74, cohort 1), undiagnosed individuals with self-reported questionnaires (n = 147, cohort 2), and individuals sampled prepandemic (n = 35, cohort 3). Results. Salivary IgG antibody responses in cohort 1 (mainly mild COVID-19) were detectable up to 9 months postrecovery, with high correlations between spike and nucleocapsid specificity. At 9 months, IgG remained in blood and saliva in most patients. Salivary IgA was rarely detected at this time point. In cohort 2, salivary IgG and IgA responses were significantly associated with recent history of COVID-19-like symptoms. Salivary IgG tolerated temperature and detergent pretreatments. Conclusions. Unlike SARS-CoV-2 salivary IgA that appeared short lived, specific saliva IgG appeared stable even after mild COVID-19, as for blood serology. This noninvasive saliva-based SARS-CoV-2 antibody test with home self-collection may be a complementary alternative to conventional blood serology.
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| 5. |
- Andersén, Mikael, 1985-, et al.
(författare)
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“It’s about how you take in things with your brain” - young people’s perspectives on mental health and help seeking : an interview study
- 2024
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Ingår i: BMC Public Health. - : BioMed Central (BMC). - 1471-2458. ; 24:1
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: Poor mental health in young people has become a growing problem globally over the past decades. However, young people have also been shown to underutilize available healthcare resources. The World Health Organisation (WHO) has formulated guidelines for youth-friendly health services (YFHSs) to increase youth participation in healthcare. Still, little is known about how young people using these services perceive mental health, indicating a knowledge gap concerning the subjective evaluation of their mental health.Aim: To investigate how young people visiting youth health clinics (YHC) perceive the concept of mental health and factors they view as central to maintaining mental health.Methods: In total 21 interviews were carried out, 16 in 2018, and 5 in 2023 to assure no changes in findings after the COVID-19 pandemic. Subjects were recruited during visits to youth health clinics (YHCs) in mid-Sweden and were aged 15–23 years. Recruitment strived to achieve heterogeneity in the sample concerning gender, sexual orientation, gender identity and age. Interviews were transcribed and analysed using qualitative content analysis.Findings: Findings of the analysis revealed two themes, “Mental health is helped and hindered by the surroundings” and “Mental health is difficult to understand and difficult to achieve”. The participants described their health as highly dependent on their social surroundings, and that these are important to maintaining health but may also affect health negatively. They described mixed experiences of the health care services and mentioned prerequisites for seeking care for mental health problems such as accessibility and respect for their integrity, including the right to turn down offered treatment. The informants also viewed mental health as an ongoing undertaking that one must work for, and that it is sometimes difficult to know what constitutes mental health. They also expressed a need from healthcare services to enquire about their health, and to show an active interest in how they are doing.Conclusions: Findings underline the need of young people’s individual needs to be met in the healthcare system and their vulnerability to their social surroundings. Health status assessments in young people should consider social and individual factors to fully capture mental health.
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| 6. |
- Blenckner, Thorsten, et al.
(författare)
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The Baltic Health Index (BHI): Assessing the social-ecological status of the Baltic Sea
- 2021
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Ingår i: People and Nature. - : Wiley. - 2575-8314. ; 3:2, s. 359-375
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Tidskriftsartikel (refereegranskat)abstract
- Improving the health of coastal and open sea marine ecosystems represents a substantial challenge for sustainable marine resource management, since it requires balancing human benefits and impacts on the ocean. This challenge is often exacerbated by incomplete knowledge and lack of tools that measure ocean and coastal ecosystem health in a way that allows consistent monitoring of progress towards predefined management targets. The lack of such tools often limits capabilities to enact and enforce effective governance. We introduce the Baltic Health Index (BHI) as a transparent, collaborative and repeatable assessment tool. The Index complements existing, more ecological-oriented, approaches by including a human dimension on the status of the Baltic Sea, an ecosystem impacted by multiple anthropogenic pressures and governed by a multitude of comprehensive national and international policies. Using a large amount of social-ecological data available, we assessed the health of the Baltic Sea for nine goals that represent the status towards set targets, for example, clean waters, biodiversity, food provision, natural products extraction and tourism. Our results indicate that the overall health of the Baltic Sea is suboptimal (a score of 76 out of 100), and a substantial effort is required to reach the management objectives and associated targets. Subregionally, the lowest BHI scores were measured for carbon storage, contaminants and lasting special places (i.e. marine protected areas), albeit with large spatial variation. Overall, the likely future status of all goals in the BHI averaged for the entire Baltic Sea is better than the present status, indicating a positive trend towards a healthier Baltic Sea. However, in some Baltic Sea basins, the trend for specific goals was decreasing, highlighting locations and issues that should be the focus of management priorities. The BHI outcomes can be used to identify both pan-Baltic and subregional scale management priorities and to illustrate the interconnectedness between goals linked by cumulative pressures. Hence, the information provided by the BHI tool and its further development will contribute towards the fulfilment of the UN Agenda 2030 and its Sustainability Development Goals. A free Plain Language Summary can be found within the Supporting Information of this article. A free Plain Language Summary can be found within the Supporting Information of this article.
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| 7. |
- Boss, Annika, et al.
(författare)
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Ämnen som hindrar eller försvårar återvinning av plast i prioriterade produktgrupper inom byggsektorn
- 2023
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- I detta uppdrag undersöker vi kemiska tillsatser i plaster som försvårar eller utgör hinder för återvinning av materialet. I denna rapport avser kemiska tillsatser additiv som medvetet introducerats i produkten eller materialet, och det är dessa kemiska ämnens natur som avgör problematiken ur återvinningssynpunkt. Vi fokuserar på byggsektorn eftersom denna sektor använder stora mängder plast av hög kvalité. Trots detta är återvinningsgraden för plast låg och potentialen att öka återvinningsgraden är därmed stor. Ett materials potential för återvinning bestäms av flera faktorer, varav kemikalieinnehåll är en. Det är viktigt att tänka på vilken eller vilka produkter plasten är lämplig att återvinnas till, och hänsyn måste alltid tas till gällande kemikalielagstiftning för just de produkttyperna. Kemiska ämnen som kan vara skadliga för människan och/eller miljön är särskilt viktiga att utreda, men det finns också andra tillsatser i material och produkter som försvårar återvinningsprocessen eller påverkar kvalitén på den återvunna plasten negativt så att marknaden för det återvunna materialet blir begränsad. Ytterligare en faktor att ta i beaktande är hur exponeringen för kemikalierna ser ut, om de är bundna i plasten eller kan emitteras och utsätta människor och miljön för direkta risker. De stora kategorierna i denna kartläggning har varit golv, rör och rördelar, kablar, profiler och lister, isoleringsmaterial, samt tätningsskikt. För dessa produktgrupper dominerar polymertyperna PVC, PE av olika densitetsgrad och comonomer-innehåll, PP (homo- och copolymer), PS och PUR. Då härdplaster, där även PUR ingår, förekommer i form av lacker, adhesiv och ytbeläggningar i byggprodukter behandlas dessa också övergripande. Många materialströmmar finns tillgängliga för återvinning inom kategorin byggplast generellt sett, men möjligheterna och incitamenten att sortera ut dessa i sina ursprungliga fraktioner är låg. Detta beror antingen på att efterfrågan på mekaniskt återvunnet material i dessa produktkategorier inte är stor nog, som för PEX och vissa typer av rör, eller på att volymerna är för låga för lönsamhet. Ett exempel på det sistnämnda är profiler och lister av PVC där etablerad cirkulär återvinning finns ute i Europa, men produktkategorin är för liten i Sverige för att drivkraften ska uppstå. Eftersom flera av de polymermaterial och produkter vi kartlagt i denna rapport har en historisk användning av idag reglerade, eller till och med förbjudna kemiska ämnen, kompliceras återvinningen av byggplast i att de inkommande avfallsströmmarna är av mycket varierande ålder. För att möjliggöra en högre återvinningsgrad och bättre kvalitet krävs därför utökad och mer noggrann sortering så att problematiska, och i vissa fall hälso- och miljöfarliga, innehållsämnen inte följer med i den mekaniska återvinningen, men inte heller så att kvalitativa fraktioner av en viss produkt- och polymertyp avvisas från återvinning av säkerhetsskäl. Ett axplock av problematiska tillsatser är tungmetallstabilisatorer och mjukgörare i produkter av PVC, flamskyddsmedel i isolering av EPS och XPS, samt silanförnätad PEX som innehåller tennkatalysator. Kontaminering i form av härdplastrester, felsorterad PEX i PE-recyklat, samt tejper och fogar på tätskikt utgör de mer oavsiktliga, fysiska hindren för kvalitetsmässig återvinning tillsammans med faktumet att en stor del av kablar och rör helt enkelt inte utvinns ur marken efter sin användningstid. Sammanfattningsvis skulle fler fraktioner av byggplast kunna återvinnas mekaniskt genom att stärka infrastrukturen kring insamling och sortering, men för detta krävs ökad efterfrågan och långsiktig lönsamhet. Kemiska återvinningsmetoder seglar upp som en möjlig lösning för flera av de hinder som identifieras i denna studie, till exempel tvärbundna material, material med hög andel fyllmedel, eller för avskiljning av oönskade tillsatser likt tungmetaller och ftalater. Kartläggningen av detta område får därför ses som en intressant frågeställning för ytterligare arbete.
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| 8. |
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| 9. |
- Carli Lorenzini, Giana, et al.
(författare)
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Exploring the combined use of solicited diaries and photography by older patients in their process of self-care with medication packaging
- 2021
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Ingår i: Proceedings of the International Conference of Engineering Design (ICED 21). - : Cambridge University Press (CUP). - 2732-527X. ; 1:August 2021, s. 1511-1520
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Konferensbidrag (refereegranskat)abstract
- Design has the potential to include or exclude people, depending on how user needs are translated into products. Design exclusion has been vast in design for health care. Medication packaging design is a common example. It does a good job of protecting the product but can result in creating difficulties when used, especially for those who are older. Research in this area lacks an inclusive and user-centered approach because potential users have been studied outside of their context of living and with methods that limit participation. The aim of this study was to explore the combined use of solicited diaries and photography to engage and include older users in gathering data and reflecting on their day-to-day experiences of using multiple medications and the medication packaging. Our findings show key learnings of using this combined method, as well as related methodological challenges, and provide recommendations to tackle these challenges. The use of solicited diaries with photographs taken by participants is deemed to be relevant in interdisciplinary fields of research and practice, where designers and other professionals aim to better understand the reality of older people and create meaning in their experiences of self-care.
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