| 1. |
- Moberg, Christina, et al.
(författare)
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De unga gör helt rätt när de stämmer staten
- 2022
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Ingår i: Aftonbladet. - 1103-9000.
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- 1 620 forskare och lärare i forskarvärlden: Vi ställer oss bakom Auroras klimatkrav
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| 2. |
- Alström, Per, Professor, et al.
(författare)
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Multiple species delimitation approaches applied to the avian lark genus Alaudala
- 2021
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Ingår i: Molecular Phylogenetics and Evolution. - : Elsevier BV. - 1055-7903 .- 1095-9513. ; 154
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Tidskriftsartikel (refereegranskat)abstract
- Species delimitation has advanced from a purely phenotypic exercise to a branch of science that integrates multiple sources of data to identify independently evolving lineages that can be treated as species. We here test species limits in the avian Lesser Short-toed Lark Alaudala rufesens-Sand Lark A. raytal complex, which has an intricate taxonomic history, ranging from a single to three recognised species, with different inclusiveness in different treatments. Our integrative taxonomic approach is based on a combination of DNA sequences, plumage, biometrics, songs, song-flights, geographical distributions, habitat, and bioclimatic data, and using various methods including a species delimitation program (STACEY) based on the multispecies coalescent model. We propose that four species should be recognised: Lesser Short-toed Lark A. rufescens (sensu stricto), Heine's Short-toed Lark A. heinei, Asian Short-toed Lark A. cheleensis and Sand Lark A. raytal. There is also some evidence suggesting lineage separation within A. cheleensis and A. raytal, but additional data are required to evaluate this. The species delimitation based on STACEY agrees well with the non-genetic data. Although computer-based species delimitation programs can be useful in identifying independently evolving lineages, we stress that whenever possible, species hypotheses proposed by these programs should be tested by independent, non-genetic data. Our results highlight the difficulty and subjectivity of delimiting lineages and species, especially at early stages in the speciation process.
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| 3. |
- Arnqvist, Goran, et al.
(författare)
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Falsk marknadsföring om hållbart skogsbruk
- 2022
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Ingår i: Svenska Dagbladet Debatt. - 1101-2412.
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Dagens svenska skogsbruk är inte ekologiskt hållbart. Att saluföra det som hållbart är därför – för att tala klarspråk – falsk marknadsföring, skriver forskare.
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| 4. |
- Brandtberg, Per-Olov, et al.
(författare)
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Effects of wood ash, green residues and N-free fertiliser on naturally regenerated birch and field vegetation in a young Norway spruce stand in SW Sweden
- 2021
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Ingår i: Scandinavian Journal of Forest Research. - : Informa UK Limited. - 0282-7581 .- 1651-1891. ; 36, s. 364-373
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Tidskriftsartikel (refereegranskat)abstract
- Treatments added to young conifer stands aiming to compensate for the loss of nutrients and alkalinity associated with whole-tree harvesting for bioenergy purposes have the potential to affect the growth of competitors to the conifers. Three different nutrient compensation treatments were applied to a young Picea abies (L.) Karst. stand in south-west Sweden, 2 or 3 years following final felling. The treatments were; fine fraction of harvest residues (15 Mg dw ha(-1)); granulated wood ash (4.1 Mg dw ha(-1)); nitrogen-free vitality fertiliser (twice 1.5 Mg ha(-1)); untreated control. Root biomass and total biomass of graminoids (mainly Deschampsia flexuosa (L.) Trin) were significantly greater in the wood ash and vitality fertiliser treatments than in the residues and control treatments. The aboveground and coarse root biomass of naturally regenerated birch (Betula spp.) and the aboveground biomass of dwarf shrubs (mainly Calluna vulgaris (L.) Hull.) and bottom layer were not affected by the treatments. Calcium and magnesium concentrations in the aboveground biomass of graminoids and phosphorus concentration in the biomass of bottom layer were significantly the highest in the vitality fertiliser treatment. Thus, nutrient compensation with vitality fertiliser or granulated wood ash may increase competition from graminoids in the establishment phase.
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| 5. |
- Bzhalava, Levan, et al.
(författare)
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Mapping the Wave of Industry Digitalization by Co-Word Analysis : An Exploration of Four Disruptive Industries
- 2022
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Ingår i: International Journal of Innovation and Technology Management (IJITM). - : World Scientific. - 0219-8770 .- 1793-6950. ; 19:2
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Tidskriftsartikel (refereegranskat)abstract
- This paper aims to identify global digital trends across industries and to map emerging business areas by co-word analysis. As the industrial landscape has become complex and dynamic due to the rapid pace of technological changes and digital transformation, identifying industrial trends can be critical for strategic planning and investment policy at the ¯rm and regional level. For this purpose, the paper examines industry and technology pro¯les of top startups across four industries (i.e. education, ¯nance, healthcare, manufacturing) using CrunchBase metadata for the period 2016–2018 and studies in which subsector early-stage ¯rms bring digital technologies on a global level. In particular, we apply word co-occurrence analysis to reveal which subindustry and digital technology keywords/keyphrases appear together in startup company classification. We also use network analysis to visualize industry structure and to identify digitalization trends across sectors. The results obtained from the analysis show that gamification and personalization are emerging trends in the education sector. In the finance industry, digital technologies penetrate in a wide set of services such as financial transactions, payments, insurance, venture capital, stock exchange, asset and risk management. Moreover, the data analyses indicate that health diagnostics and elderly care areas are at the forefront of the healthcare industry digitalization. In the manufacturing sector, startup companies focus on automating industrial processes and creating smart interconnected manufacturing. Finally, we discuss the implications of the study for strategic planning and management.
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| 6. |
- Cabrita, Rita, et al.
(författare)
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Tertiary lymphoid structures improve immunotherapy and survival in melanoma
- 2020
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 577:7791, s. 561-565
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Tidskriftsartikel (refereegranskat)abstract
- Checkpoint blockade therapies that reactivate tumour-associated T cells can induce durable tumour control and result in the long-term survival of patients with advanced cancers1. Current predictive biomarkers for therapy response include high levels of intratumour immunological activity, a high tumour mutational burden and specific characteristics of the gut microbiota2,3. Although the role of T cells in antitumour responses has thoroughly been studied, other immune cells remain insufficiently explored. Here we use clinical samples of metastatic melanomas to investigate the role of B cells in antitumour responses, and find that the co-occurrence of tumour-associated CD8+ T cells and CD20+ B cells is associated with improved survival, independently of other clinical variables. Immunofluorescence staining of CXCR5 and CXCL13 in combination with CD20 reveals the formation of tertiary lymphoid structures in these CD8+CD20+ tumours. We derived a gene signature associated with tertiary lymphoid structures, which predicted clinical outcomes in cohorts of patients treated with immune checkpoint blockade. Furthermore, B-cell-rich tumours were accompanied by increased levels of TCF7+ naive and/or memory T cells. This was corroborated by digital spatial-profiling data, in which T cells in tumours without tertiary lymphoid structures had a dysfunctional molecular phenotype. Our results indicate that tertiary lymphoid structures have a key role in the immune microenvironment in melanoma, by conferring distinct T cell phenotypes. Therapeutic strategies to induce the formation of tertiary lymphoid structures should be explored to improve responses to cancer immunotherapy.
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| 7. |
- Cabrita, Rita, et al.
(författare)
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Tertiary lymphoid structures improve immunotherapy and survival in melanoma.
- 2020
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Ingår i: Nature. - : Nature Publishing Group. - 1476-4687 .- 0028-0836. ; 577:7791, s. 561-565
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Tidskriftsartikel (refereegranskat)abstract
- Checkpoint blockade therapies that reactivate tumour-associated T cells can induce durable tumour control and result in the long-term survival of patients with advanced cancers1. Current predictive biomarkers for therapy response include high levels of intratumour immunological activity, a high tumour mutational burden and specific characteristics of the gut microbiota2,3. Although the role of T cells in antitumour responses has thoroughly been studied, other immune cells remain insufficiently explored. Here we use clinical samples of metastatic melanomas to investigate the role of B cells in antitumour responses, and find that the co-occurrence of tumour-associated CD8+ T cells and CD20+ B cells is associated with improved survival, independently of other clinical variables. Immunofluorescence staining of CXCR5 and CXCL13 in combination with CD20 reveals the formation of tertiary lymphoid structures in these CD8+CD20+ tumours. We derived a gene signature associated with tertiary lymphoid structures, which predicted clinical outcomes in cohorts of patients treated with immune checkpoint blockade. Furthermore, B-cell-rich tumours were accompanied by increased levels of TCF7+ naive and/or memory T cells. This was corroborated by digital spatial-profiling data, in which T cells in tumours without tertiary lymphoid structures had a dysfunctional molecular phenotype. Our results indicate that tertiary lymphoid structures have a key role in the immune microenvironment in melanoma, by conferring distinct T cell phenotypes. Therapeutic strategies to induce the formation of tertiary lymphoid structures should be explored to improve responses to cancer immunotherapy.
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| 8. |
- Casetou, Sophie, et al.
(författare)
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Current, steady-state and historical weathering rates of base cations at two forest sites in northern and southern Sweden: a comparison of three methods
- 2020
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Ingår i: Biogeosciences. - : Copernicus GmbH. - 1726-4170 .- 1726-4189. ; 17, s. 281-304
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Tidskriftsartikel (refereegranskat)abstract
- Reliable and accurate methods for estimating soil mineral weathering rates are required tools in evaluating the sustainability of increased harvesting of forest biomass and assessments of critical loads of acidity. A variety of methods that differ in concept, temporal and spatial scale, and data requirements are available for measuring weathering rates. In this study, causes of discrepancies in weathering rates between methods were analysed and were classified as being either conceptual (inevitable) or random. The release rates of base cations (BCs; Ca, Mg, K, Na) by weathering were estimated in podzolised glacial tills at two experimental forest sites, Asa and Flakaliden, in southern and northern Sweden, respectively. Three different methods were used: (i) historical weathering since deglaciation estimated by the depletion method, using Zr as the assumed inert reference; (ii) steady-state weathering rate estimated with the PROFILE model, based on quantitative analysis of soil mineralogy; and (iii) BC budget at stand scale, using measured deposition, leaching and changes in base cation stocks in biomass and soil over a period of 12 years. In the 050 cm soil horizon historical weathering of BCs was 10.6 and 34.1 mmolc m(-2) yr(-1), at Asa and Flakaliden, respectively. Corresponding values of PROFILE weathering rates were 37.1 and 42.7 mmolc m(-2) yr(-1). The PROFILE results indi- cated that steady-state weathering rate increased with soil depth as a function of exposed mineral surface area, reaching a maximum rate at 80 cm (Asa) and 60 cm (Flakaliden). In contrast, the depletion method indicated that the largest postglacial losses were in upper soil horizons, particularly at Flakaliden.With the exception of Mg and Ca in shallow soil horizons, PROFILE produced higher weathering rates than the depletion method, particularly of K and Na in deeper soil horizons. The lower weathering rates of the depletion method were partly explained by natural and anthropogenic variability in Zr gradients. The base cation budget approach produced significantly higher weathering rates of BCs, 134.6 mmolc m(-2) yr(-1) at Asa and 73.2 mmolc m(-2) yr(-1) at Flakaliden, due to high rates estimated for the nutrient elements Ca, Mg and K, whereas weathering rates were lower and similar to those for the depletion method (6.6 and 2.2 mmolc m(-2) yr(-1) at Asa and Flakaliden). The large discrepancy in weathering rates for Ca, Mg and K between the base cation budget approach and the other methods suggests additional sources for tree uptake in the soil not captured by measurements.
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| 9. |
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En båge genom tiden - ritualer kring en göteborgshistoria. Om Flickläroverket i Artisten
- 2024
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Samlingsverk (redaktörskap) (övrigt vetenskapligt/konstnärligt)abstract
- 1929 bildades Göteborgs första Högre allmänna läroverk för Flickor – Flickläroverket som fick en byggnad 1935 i det kulturella centrumet, Götaplatsen. Efter några år som Kjellbergska gymnasiet, sedan Komvux, blev byggnaden del av Artisten, Högskolan för scen och musik, HSM 1992. Byggnaden har burit kvinnors utbildning, konst och kultur över många generationer, en minneskedja som nu är bruten. Boken - En båge genom tiden – ritualer kring en göteborgshistoria – en konst- och forskningsantologi – är resultatet av de offentliga minnesdagar där de deltagande drygt 200 kvinnorna (70– 97 år) som varit elever på Flickläroverket, studenter vid Artisten, konstnärer och forskare – bidrog till och deltog i gestaltande ritualer, minnesrum, dans, utställningar och samtal som gav liv åt en utbildningskultur och konst som berört samhället i generationer. I boken bidrar ett 20-tal Göteborgsbaserade konstnärer och forskare med olika perspektiv på byggnadens poetiska, sociala och konstnärliga dimensioner. Bland annat beskrivs återskapandet av Bågdansen, som dansades varje år vid Lucia mellan 1934-1972. Här beskrivs även den medie-debatt som ledde till räddningen av målningen Dansen av Nils Nilsson från 1935 och hur nedtagningen gick till. Tillsammans med ett rikt foto- och bildmaterial, filmdokumentationer och ett ljudarkiv utgör boken ett tidsdokument där konst fungerar som minnesbärare över tid och rum.
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| 10. |
- Fuchtbauer, Laila, et al.
(författare)
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Increased Number of Retinal Vessels in Acromegaly.
- 2020
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Ingår i: European journal of endocrinology. - 1479-683X. ; 182:3, s. 293-302
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Tidskriftsartikel (refereegranskat)abstract
- Excess of growth hormone (GH) and insulin-like growth factor 1 (IGF-1), as in acromegaly, is associated with an increased risk of diabetes, but whether retinal vessels are altered is unknown. The aim of this study was to evaluate retinal vessel morphology in patients with acromegaly at diagnosis and after treatment and to describe the prevalence of diabetic retinopathy in patients with long-standing acromegaly and diabetes.Two independent observational studies, one being prospective and the other retrospective and cross-sectional.Retinal vessel morphology of 26 patients with acromegaly was examined at diagnosis and 1 year after treatment and compared to 13 healthy controls. Cross-sectional evaluation of 39 patients with long-standing acromegaly and diabetes was performed. Fundus photographs were digitally analyzed for vessel morphology.Patients with acromegaly had a median (interquartile range) of 34.3 (30.0-39.0) vessel branching points compared to 27.0 (24.0-29.0) for healthy controls (P < 0.001). Tortuosity of arterioles and venules remained unchanged. Vessel morphology did not change significantly after treatment. Patients with acromegaly and diabetes for a median of 14 years also had a high number of branching points [34.2 (32.5-35.6)], but the prevalence of diabetic retinopathy was not higher than expected in diabetic patients without acromegaly.Patients with acromegaly have an increased number of vascular branching points in the retina without an alteration of macroscopic vessel morphology. This is consistent with an angiogenic effect of GH/IGF-1 in humans. The prevalence of diabetic retinopathy was not increased in patients with acromegaly and diabetes.
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