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- Andersson, Åsa, Professor, 1960-, et al.
(författare)
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Serum Protein Response To A Single High-Intensity Interval Training Bout – Comparison Between Individuals With Spondyloarthritis And Healthy Controls
- 2022
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Ingår i: Annals of the Rheumatic Diseases. - London : BMJ Publishing Group Ltd. - 0003-4967 .- 1468-2060. ; 81:Suppl 1, s. 780-781
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Tidskriftsartikel (refereegranskat)abstract
- Axial spondyloarthritis (axSpA) is a chronic inflammatory disease affecting mainly the axial skeleton. To decrease the risk of cardiovascular comorbidity, aerobic training is recommended as a part of disease management in patients with axSpA. High-intensity interval training (HIIT) interventions are, in addition to other recommended treatments, believed to positively affect the disease activity (1). However, the knowledge about the acute effects of HIIT on the inflammatory process at the molecular level is less studied. Understanding the acute HIIT effects on cytokines and additional serum proteins in axSpA is important for further long-term HIIT interventions and recording of the effect of HIIT on the axSpA disease profile.ObjectivesTo study the acute effects on serum proteins, such as cytokines, myokines, and inflammatory- and bone-related proteins, in response to a single bout of HIIT, and to compare the levels between baseline and post-HIIT in patients with axSpA and healthy controls (HC).MethodsThe pilot study included twenty-one participants (10 female, 11 male), mean (SD) age 40 (7) years, ten with axSpA, and eleven age and sex matched HC, who performed a single HIIT on a cycle ergometer consisting of 4x4 minutes interval (90% heart rate, HR-max) with three minutes active rest in between (70% of HR-max). Disease activity (BASDAI, 0-10) in patients with axSpA was 1.6 (0.8). Health status EuroQol (EQ5D, 0-1) were 0.87 (0.11) for axSpA, and 0.93 (0.10) for HC. The groups were well matched with no difference in baseline data for weight, BMI, EQ5D, blood pressure or aerobic capacity.Blood samples were taken before (baseline) and one hour after the single HIIT. The following serum proteins were analyzed on a Luminex MAGPIX System (Luminex corporation, Austin, TX USA): Interleukin (IL)-6, IL-17, IL-18, TNFαAGPIX System (Luminex corporatiosteoprotegerin, osteocalcin, osteopontin, and FGF-23. A three-way analysis of variance (ANOVA) was used to detect differences between groups, between sexes, and before and after a HIIT bout in a 2(group)*2(sex)*2(time) design. For main effects or interactions significant at p≤0.05, simple effect t-tests were used to determine the specific effects.ResultsA group main effect (p=0.048) showed that the serum level of IL-6 was increased one hour after the HIIT session primarily in the HC, 0.4 pg/ml (SD±0.4) at baseline vs. post-HIIT 1.8 (2.0). The concentration of the cytokines/chemokine IL-17, IL-18, TNFα group main effect (p=0.048) showed that the serum level of IL-6 was increased one hour after the HIIT session primarily in30) in VEGF-A showed that the axSpA group had significantly lower VEGF-A at baseline, 159 pg/ml (138) vs 326 (184) in the control group (which might be due to anti-inflammatory medication). A sex main effect (p=0.029) was observed from baseline to post-HIIT for the bone hormone osteocalcin, with a more pronounced decrease of serum osteocalcin in women with axSpA, 14.0 ng/ml (8.3) vs. post HIIT 13.2 (6.9). Moreover, the level of the multifunctional protein osteopontin was significantly lower (sex main effect, p=0.021) in women, 10.7 ng/ml (7.0) vs. men 20.4 (10.1), post-HIIT.ConclusionThis pilot study shows that one bout of HIIT influences the expression of proteins involved in inflammation and metabolism, and that sex is an important factor in the response to HIIT. The results should be followed up in longer intervention studies including higher numbers of participants.References[1]Sveaas, S. H. et al. (2019). High intensity exercise for 3 months reduces disease activity in axial spondyloarthritis (axSpA): a multicentre randomised trial of 100 patients. British journal of sports medicine, 54(5), 292-297.Disclosure of InterestsÅsa Andersson: None declared, Emma Haglund Consultant of: Novartis, Emma Berthold: None declared, Elisabeth Mogard Consultant of: Novartis, Anna Torell: None declared, M Charlotte Olsson: None declared
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| 2. |
- Larsson, Jonas, 1968-, et al.
(författare)
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Cardiorespiratory responses of load carriage in female and male soldiers
- 2022
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Ingår i: Applied Ergonomics. - Oxford : Elsevier. - 0003-6870 .- 1872-9126. ; 101
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Tidskriftsartikel (refereegranskat)abstract
- PurposeTo investigate the effect of sex and load carriage on cardiorespiratory responses to high intensity exercise in male and female soldiers.MethodsSoldiers (9 women, 9 men) performed a graded treadmill test until exhaustion with no load (NL) and combat-gear with body armor (CG). Cohen's d effect sizes, paired t-tests and ANOVA were used to study differences between conditions. A mixed linear regression model analyzed the relationship between heart rate (HR) and oxygen uptake (V̇O2) with load and between sexes.ResultsWearing CG resulted in, for both sexes, a decreased time to exhaustion (−11 min), lower V̇O2peak (L/min) ES = 0.56; VO2peak (mL//kg/min) ES = 2.44, both p < 0.001, a net decrease in minute ventilation (ES = 3.53) and no change in HRmax. No sex-difference were present except for absolute V̇O2peak. The VO2 and HR relationship showed a cardiorespiratory reduction wearing CG vs. NL. Added load was equal between sexes, although female soldiers' CG relative to body mass was higher (25%) than male soldiers’ (20%), p < 0.01.ConclusionWearing CG reduces soldiers’ cardiorespiratory capacity and exercise performance level, although the reduction cannot be explained solely based on the added load of CG, instead CG seems to restrict the capacity to fully ventilate. No sex differences were found in relative cardiorespiratory responses to wearing CG compared to NL.
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| 3. |
- Malmborg, Julia S., 1988-, et al.
(författare)
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Musculoskeletal pain and its association with health status, maturity, and sports performance in adolescent sport school students: a 2-year follow-up
- 2022
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Ingår i: Bmc Sports Science Medicine and Rehabilitation. - London : Springer Science and Business Media LLC. - 2052-1847. ; 14:1
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Tidskriftsartikel (refereegranskat)abstract
- Background Musculoskeletal pain and its risk factors are rarely assessed in studies on adolescent athletes. The aim was to identify risk factors at baseline that were associated with the persistence or development of musculoskeletal pain at a two-year follow-up in adolescent sport school students, and to study cross-sectional associations at follow-up between musculoskeletal pain and sports performance. Methods Sport school students (79 boys and 52 girls, aged 14 years at baseline) were divided into infrequent (never-monthly) or frequent (weekly-almost daily) pain groups, based on frequency of pain using a pain mannequin. Logistic regression analyses were performed to study longitudinal associations between frequent pain at follow-up and baseline variables: pain group, number of regions with frequent pain, health status by EQ-5D, maturity offset (pre, average, or post peak height velocity), and sports (contact or non-contact). Linear regression analyses were used to study cross-sectional associations between pain groups and 20-m sprint, agility T-test, counter-movement jump, and grip strength at follow-up. Results were stratified by sex. Results A higher percentage of girls than boys reported frequent pain at follow-up (62% vs. 37%; p = 0.005). In boys, frequent pain at follow-up was associated with being pre peak height velocity at baseline (OR 3.884, CI 1.146-13.171; p = 0.029) and participating in non-contact sports (OR 3.429, CI 1.001-11.748; p = 0.050). In girls, frequent pain at follow-up was associated with having frequent pain in two or more body regions at baseline (OR 3.600, CI 1.033-12.542; p = 0.044), having a worse health status at baseline (OR 3.571, CI 1.026-12.434; p = 0.045), and participating in non-contact sports (OR 8.282, CI 2.011-34.116; p = 0.003). In boys, frequent pain was associated with worse performances in 20-m sprint and counter-movement jump, but not in agility T-test and grip strength. Conclusions Baseline risk factors for having frequent pain at follow-up were late maturation in boys, frequent pain and worse health status in girls, and participation in non-contact sports in both sexes. Boys with pain performed worse in sports tests. Coaches and school health-care services should pay attention to the risk factors and work towards preventing pain from becoming persistent.
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| 4. |
- Parker, James, 1980-, et al.
(författare)
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Differences in kinematics and driver performance in elite female and male golfers
- 2022
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Ingår i: Sports Biomechanics. - Abingdon : Routledge. - 1476-3141 .- 1752-6116. ; 21:6, s. 731-747
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to compare swing kinematic differences between women and men and investigate which variables predict clubhead speed (CHS) and carry distance (CD) whilst accounting for individual variation. Methods: Swing kinematics and driver performance data were collected on 20 (10 women) elite golfers (HCP 0.7 ± 1.4). We used Bayesian T-test for between sex comparison of swing kinematics and Bayesian Analysis of covariance (ANCOVA) to produce general linear models for CHS and carry distance for elite female and male golfers separately. Results: There was strong evidence that the driver performance variables CHS and CD were decreased in women compared to men, and two kinematic variables; time to arm peak speed downswing and angular wrist peak speed were slower in women. The ANCOVAs identified very strong to overwhelming evidence that participant as a fixed factor was a determinant of CHS for both women and men but was not a determinant of CD. Conclusion: when looking to enhance driver performance among high-level golfers, coaches should be aware that variables that determine CHS and CD differ among women and men and if the aim is to improve CHS coaches should not forget the importance of individual swing characteristics. © 2019 Parker, Hellström & Olsson. Published by Informa UK Limited, trading as Taylor & Francis Group.
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