| 1. |
- Adua, Eric, et al.
(author)
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Effect of Neutrophils on Nitric Oxide Production from Stimulated Macrophages
- 2015
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In: Iranian Journal of Immunology. - : SHIRAZ INST CANCER RES. - 1735-1383 .- 1735-367X. ; 12:2, s. 94-103
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Journal article (peer-reviewed)abstract
- Background: During the initial phase of an infection, there is an upregulation of inducible nitric oxide synthase in the macrophages for the production of nitric oxide. This is followed by the recruitment of polymorphonuclear leukocytes (neutrophils) which release arginase. Arginase competes with inducible nitric oxide synthase for a common substrate L-arginine. Objective: To investigate whether the entry of neutrophils and release of arginase can interfere with nitric oxide production from stimulated mouse macrophages. Methods: Neutrophils were isolated from human blood and stimulated with cytodex-3 beads. Cultured macrophages were stimulated with lipopolysaccharide and interferon gamma with or without N (G)-nitro-L-arginine methyl ester or N (omega)-hydroxy-nor-L-arginine. Measurement of NO2-/NO3- and urea were done using the spectrophotometer. Results: A significantly higher level of nitric oxide production from stimulated macrophages was observed compared to control. There was a decrease in nitric oxide production when stimulated macrophages were treated with the supernatant from activated neutrophils (pless than0.05). Conclusion: Arginase from neutrophils can modulate nitric oxide production from activated macrophages which may affect the course of infection by intracellular bacteria.
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| 3. |
- Granbom, Marianne, et al.
(author)
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Community Relocation in Very Old Age: Changes in Housing Accessibility.
- 2016
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In: American Journal of Occupational Therapy. - : AOTA Press. - 0272-9490 .- 1943-7676. ; 70:2, s. 1-7002270020
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Journal article (peer-reviewed)abstract
- The objective of this study was to compare environmental barriers, housing accessibility, and usability before and after relocation of very old, single-living people in the community. It also examined whether accessibility improved after relocation compared with a simulated scenario in which participants would have remained in their former dwellings.
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| 4. |
- Haak, Maria, et al.
(author)
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Cross-National User Priorities for Housing Provision and Accessibility - Findings from the European innovAge Project.
- 2015
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In: International Journal of Environmental Research and Public Health. - : MDPI AG. - 1660-4601. ; 12:3, s. 2670-2686
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Journal article (peer-reviewed)abstract
- To develop an innovative information and communication technology (ICT) tool intended to help older people in their search for optimal housing solutions, a first step in the development process is to gain knowledge from the intended users. Thus the aim of this study was to deepen the knowledge about needs and expectations about housing options as expressed and prioritized by older people, people ageing with disabilities and professionals. A participatory design focus was adopted; 26 people with a range of functional limitations representing the user perspective and 15 professionals with a variety of backgrounds, participated in research circles that were conducted in four European countries. An additional 20 experts were invited as guests to the different research circle meetings. Three themes illustrating cross-national user priorities for housing provision and accessibility were identified: "Information barrier: accessible housing", "Information barrier: housing adaptation benefits", and "Cost barrier: housing adaptations". In conclusion, early user involvement and identification of cross-national differences in priorities and housing options will strengthen the development of a user-friendly ICT tool that can empower older people and people with disabilities to be more active consumers regarding housing provision.
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| 5. |
- Iwarsson, Susanne, et al.
(author)
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Synthesizing ENABLE-AGE Research Findings to Suggest Evidence-Based Home and Health Interventions
- 2016
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In: Journal of Housing for the Elderly. - : Informa UK Limited. - 0276-3893 .- 1540-353X. ; 30:3, s. 330-343
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Journal article (peer-reviewed)abstract
- As the quest for knowledge translation from research to practice and policy contexts is growing stronger, researchers need to develop strategies for synthesizing research findings. Since home environments constitute an important context for the delivery of health care and social services to older adults and people aging with disabilities, research in this field can serve as an example for such endeavors. Using 35 original publications and one unpublished doctoral dissertation based on the European ENABLE-AGE Project, we aimed to demonstrate a systematic approach to synthesize research findings generated by large research projects as the basis for evidence-based interventions. The synthesized findings highlighted the complex interactions between objective and perceived aspects of housing and aspects of health in very old age, impacting on, for example, residential decision making. Independence in daily activity is influenced by the sociocultural care and service context. A familiar and safe neighborhood, a social network, and a good supply of services are important to perceptions of participation. Going further, we suggest housing-related interventions that address problems and challenges related to ongoing demographic changes. This article contributes to the development of strategies for knowledge translation, connecting research and practice and policy contexts struggling to meet the societal challenges that accompany population aging.
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| 6. |
- Jonsson, Oskar, et al.
(author)
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The "Free from housing accessibility problems" app
- 2016
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In: Universal Design 2016: Learning from the Past, Designing for the Future - Proceedings of the 3rd International Conference on Universal Design, UD 2016. - 0926-9630 .- 1879-8365. - 9781614996835 ; 229, s. 567-570
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Conference paper (peer-reviewed)abstract
- The present study concerns the development of a computerized tool targeting housing accessibility issues. A user-centered approach involving professionals from the housing sector and senior citizens from four European countries resulted in a fully functional prototype of a mobile application (app) including an apartment database. The app raises awareness on housing accessibility and has the potential to support decision making and strengthen all citizens regardless of functional capacity to be more active in their endeavors for a satisfying housing solution. Further refinements and additional features are needed to enhance the potential benefits; they include addressing potential challenges facing senior citizens, developing interactive features that allow users to provide input and adapting to different national contexts to make the app applicable for the European market.
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