| 1. |
- Hedrén, Mikael, et al.
(författare)
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Patterns of polyploid evolution in Greek marsh orchids (Dactylorhiza; Orchidaceae) as revealed by allozymes, AFLPs, and plastid DNA data
- 2007
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Ingår i: American Journal of Botany. - 0002-9122. ; 94:7, s. 1205-1218
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Tidskriftsartikel (refereegranskat)abstract
- Polyploidy is common in higher plants, and speciation in polyploid complexes is usually the result of reticulate evolution. We examined variation in nuclear AFLP fingerprints, nuclear isozymes, and hypervariable plastid DNA loci to describe speciation patterns and species relationships in the Dactylorhiza incarnatalmaculata polyploid complex (marsh orchids; Orchidaceae) in Greece. Several endemic taxa with restricted distribution have been described from this area, and to propose meaningful conservation priorities, detailed relationships need to be known. We identified four independently derived allopolyploid lineages, which is a pattern poorly correlated with prevailing taxonomy. Three lineages were composed of populations restricted to small areas and may be of recent origins from extant parental lineages. One lineage with wide distribution in northern Greece was characterized by several unique plastid haplotypes that were phylogenetically related and evidently older. The D. incarnatal maculata polyploid complex in Greece has high levels of genetic diversity at the polyploid level. This diversity has accumulated over a long time and may include genetic variants originating from now extinct parental populations. Our data also indicate that the Balkans may have constituted an important refuge from which northern European Dactylorhiza were recruited after the Weichselian ice age.
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| 2. |
- Helgadottir, Anna, et al.
(författare)
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The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm
- 2008
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 40:2, s. 217-224
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Tidskriftsartikel (refereegranskat)abstract
- Recently, two common sequence variants on 9p21, tagged by rs10757278-G and rs10811661-T, were reported to be associated with coronary artery disease (CAD)(1-4) and type 2 diabetes (T2D)(5-7), respectively. We proceeded to further investigate the contributions of these variants to arterial diseases and T2D. Here we report that rs10757278-G is associated with, in addition to CAD, abdominal aortic aneurysm (AAA; odds ratio (OR) 1.31, P = 1.2 x 10(-12)) and intracranial aneurysm (OR = 1.29, P = 2.5 x 10(-6)), but not with T2D. This variant is the first to be described that affects the risk of AAA and intracranial aneurysm in many populations. The association of rs10811661-T to T2D replicates in our samples, but the variant does not associate with any of the five arterial diseases examined. These findings extend our insight into the role of the sequence variant tagged by rs10757278-G and show that it is not confined to atherosclerotic diseases.
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| 3. |
- Nielsen, Flemming S., et al.
(författare)
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Characterization of prototype self-nanoemulsifying formulations of lipophilic compounds
- 2007
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Ingår i: Journal of Pharmaceutical Sciences. - : Elsevier BV. - 0022-3549. ; 96:4, s. 876-892
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Tidskriftsartikel (refereegranskat)abstract
- This study describes the evaluation and characterization of a self-nanoemulsifying drug delivery system (SNEDDS) consisting of a nonionic surfactant (Cremophor RH40), a mixture of long chain mono-, di-, and triacylglycerides (Maisine 35-1 and Sesame oil) and ethanol. Compositions containing 10% (w/w) ethanol, 40%-60% (w/w) lipid content, and 30%-50% (w/w) Cremophor RH40 were identified as pharmaceutically relevant, robust, and self-nanoemulsifying when dispersed in aqueous media. The influence of adding three different lipophilic model drug compounds (danazol, halofantrine, and probucol) to the SNEDDS was evaluated. While danazol precipitated from the SNEDDS after dispersion in aqueous media, halofantrine and procubol remained solubilized. Halofantrine- and procubol-loaded SNEDDS were evaluated in both saline and in media simulating fasted and fed-state intestinal fluid (FaSSIF and FeSSIF) using dynamic light scattering and small-angle X-ray scattering (SAXS) techniques. Stable nanoemulsions with droplet sizes in the range of 20-50 nm were formed in all media and with and without drugs. The mean size of the droplets was neither affected significantly by being dispersed into the media simulating gastro intestinal fluid, nor by addition of the drug.
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| 4. |
- Pedersen, Helena, 1968-
(författare)
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Animals in Schools : Processes and strategies in human-animal education
- 2009
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- Animals in Schools explores important questions in the field of critical animal studies and education by close examination of a wide range of educational situations and classroom activities. How are human- animal relations expressed and discussed in school? How do teachers and students develop strategies to handle ethical conflicts arising from the ascribed position of animals as accessible to human control, use, and killing? How do schools deal with topics such as zoos, hunting, and meat consumption? These are questions that have profound implications for education and society. They are graphically described, discussed, and rendered problematic based on detailed ethnographic research and are analyzed by means of a synthesis of perspectives from critical theory, gender, and postcolonial thought.
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| 5. |
- Pedersen, Helena
(författare)
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Art, Artistic Research, and the Animal Question
- 2009
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Ingår i: Conference Proceedings: Kultur~Natur: Konferens för kulturstudier i Sverige. - : Linköping University Electronic Press. ; , s. 25-31
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Recent developments in cultural studies and other areas of the humanities and social sciences point to an ‘animal turn’, an increasing interest in posthumanist, non-anthropocentric approaches toward exploring the multiple roles and meanings of animals in human lifeworlds. This paper focuses on areas of contemporary art that place ‘the question of the animal’ centrally and engage in the practice of human-animal boundary work, identity production, and meaning. By addressing a number of animal art projects employing a diversity of visual and material approaches and techniques, from Joseph Beuys’s Coyote (1974) to Eduardo Kac’s GFP Bunny (2000), the paper discusses what it means to reclaim the presence, visibility, and agency of animals in art and artistic research. By the concept of zooësis, artistic space is carved out for human-animal relationalities to be critically interrogated and re-conceptualized, and the ontological security of 'the human' to become disturbed. This paper draws on an article with the same title by Helena Pedersen & Bryndís Snæbjörnsdóttir, published in ArtMonitor, No. 3, 2008.
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| 6. |
- Pedersen, Helena, 1968-, et al.
(författare)
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Art, artistic research and the animal question
- 2008
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Ingår i: ArtMonitor: A Journal of Artistic Research. - Göteborg : Göteborgs universitet. - 1653-9958. ; :3, s. 109-123
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 7. |
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| 8. |
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| 9. |
- Pedersen, Helena
(författare)
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Djuren hjälper oss att förstå oss själva
- 2008
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Ingår i: Svenska Dagbladet. - Stockholm : Hb Svenska dagbladets AB & Co. - 1101-2412. ; :28/1
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Tidskriftsartikel (populärvet., debatt m.m.)
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| 10. |
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