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- Aghaei, Mohammadreza, et al.
(författare)
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Collective Intelligence for Energy Flexibility - Collectief : An EU H2020 Project for Enhancing Energy Efficiency and Flexibility in Existing Buildings
- 2023
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Ingår i: 2023 International Conference on Future Energy Solutions, FES 2023. - 9798350332308
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Konferensbidrag (refereegranskat)abstract
- COLLECTiEF (Collective Intelligence for Energy Flexibility) is an EU-funded H2020 project running from June 2021 to May 2025. COLLECTiEF aims to enhance, implement, test, and evaluate an interoperable and saleable energy management system based on collective intelligence that allows easy and seamless integration of legacy equipment into a collaborative network within and between existing buildings and urban energy systems with reduced installation cost, data transfer, and computational power while increasing user comfort, energy flexibility, climate resilience, and data security. To achieve this goal, the COLLECTiEF solution requires the development of software and hardware packages to smart up buildings and their legacy equipment on a large scale while maintaining simple and robust communication with the energy grid. Here, we present the project concept, structure, objectives, and working packages. Furthermore, the main progress and achievements obtained during the first two years of the project are presented.
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| 2. |
- Phokaewvarangkul, Onanong, et al.
(författare)
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Homocysteine, vitamin B metabolites, dopamine-substituting compounds, and symptomatology in Parkinson’s disease : clinical and therapeutic considerations
- 2023
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Ingår i: Journal of Neural Transmission. - 0300-9564. ; 130:11, s. 1451-1462
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Forskningsöversikt (refereegranskat)abstract
- Emerging studies suggest a correlation between elevated plasma homocysteine (hcy) levels and the risk of atherosclerosis, vascular disorders, and neurodegenerative diseases, including Parkinson's disease (PD). This narrative review delves into the intricate relationships between Hcy, vitamin B metabolites, dopamine-substituting compounds, and various symptoms of PD. Patients undergoing a long-term L-dopa/dopa-decarboxylase inhibitor (DDI) regimen, especially without a concurrent catechol-O-methyl transferase (COMT) inhibitor or methyl group-donating vitamin supplementation, such as vitamins B6 and B12, exhibit an elevation in Hcy and a decline in vitamin B metabolites. These altered concentrations appear to be associated with heightened risks of developing non-motor symptoms, including peripheral neuropathy and cognitive disturbances. The review underscores the impact of levodopa metabolism via COMT on homocysteine levels. In light of these findings, we advocate for the supplementation of methyl group-donating vitamins, notably B6 and B12, in patients undergoing a high-dose L-dopa/DDI regimen, particularly those treated with L-dopa/carbidopa intestinal gel (LCIG) infusion.
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