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Sökning: WFRF:(Sjöblom M.) > (2010-2014)

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  • Vihma, T, et al. (författare)
  • Characteristics of temperature and humidity inversions and low-level jets over Svalbard fjords in spring
  • 2011
  • Ingår i: Advances in Meteorology. - : Hindawi Limited. - 1687-9309 .- 1687-9317.
  • Tidskriftsartikel (refereegranskat)abstract
    • Air temperature and specific humidity inversions and low-level jets were studied over two Svalbard fjords, Isfjorden and Kongsfjorden, applying three tethersonde systems. Tethersonde operation practices notably affected observations on inversion and jet properties. The inversion strength and depth were strongly affected by weather conditions at the 850 hPa level. Strong inversions were deep with a highly elevated base, and the strongest ones occurred in warm air mass. Unexpectedly, downward longwave radiation measured at the sounding site did not correlate with the inversion properties. Temperature inversions had lower base and top heights than humidity inversions, the former due to surface cooling and the latter due to adiabatic cooling with height. Most low-level jets were related to katabatic winds. Over the ice-covered Kongsfjorden, jets were lifted above a cold-air pool on the fjord; the jet core was located highest when the snow surface was coldest. At the ice-free Isfjorden, jets were located lower.
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  • Pena, Cristina, et al. (författare)
  • STC1 Expression By Cancer-Associated Fibroblasts Drives Metastasis of Colorectal Cancer
  • 2013
  • Ingår i: Cancer Research. - : American Association for Cancer Research. - 0008-5472 .- 1538-7445. ; 74:4, s. 1287-1297
  • Tidskriftsartikel (refereegranskat)abstract
    • Platelet-derived growth factor (PDGF) receptor signaling is a major functional determinant of cancer-associated fibroblasts (CAF). Elevated expression of PDGF receptors on stromal CAFs is associated with metastasis and poor prognosis, but mechanism(s) that underlie these connections are not understood. Here, we report the identification of the secreted glycoprotein stanniocalcin-1 (STC1) as a mediator of metastasis by PDGF receptor function in the setting of colorectal cancer. PDGF-stimulated fibroblasts increased migration and invasion of cocultured colorectal cancer cells in an STC1-dependent manner. Analyses of human colorectal cancers revealed significant associations between stromal PDGF receptor and STC1 expression. In an orthotopic mouse model of colorectal cancer, tumors formed in the presence of STC1-deficient fibroblasts displayed reduced intravasation of tumor cells along with fewer and smaller distant metastases formed. Our results reveal a mechanistic basis for understanding the contribution of PDGF-activated CAFs to cancer metastasis. Cancer Res; 73(4); 1287-97.
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  • Resultat 1-6 av 6

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