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Träfflista för sökning "WFRF:(Varghese L) srt2:(2010-2014)"

Sökning: WFRF:(Varghese L) > (2010-2014)

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  • Ferrins, Lori, et al. (författare)
  • Pyridyl Benzamides as a Novel Class of Potent Inhibitors for the Kinetoplastid Trypanosoma brucei
  • 2014
  • Ingår i: Journal of Medicinal Chemistry. - : American Chemical Society (ACS). - 0022-2623 .- 1520-4804. ; 57:15, s. 6393-6402
  • Tidskriftsartikel (refereegranskat)abstract
    • A whole-organism screen of approximately 87000 compounds against Trypanosoma brucei brucei identified a number of promising compounds for medicinal chemistry optimization. One of these classes of compounds we termed the pyridyl benzamides. While the initial hit had an IC50 of 12 mu M, it was small enough to be attractive for further optimization, and we utilized three parallel approaches to develop the structure-activity relationships. We determined that the physicochemical properties for this class are generally favorable with particular positions identified that appear to block metabolism when substituted and others that modulate solubility. Our most active compound is 79, which has an IC50 of 0.045 mu M against the human pathogenic strain Trypanosoma brucei rhodesiense and is more than 4000 times less active against the mammalian L6 cell line.
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  • Liu, Y., et al. (författare)
  • Bandwidth scaling of phase-modulated CW comb through four-wave mixing on silicon nano-waveguide
  • 2013
  • Ingår i: 2013 Conference on Lasers and Electro-Optics, CLEO 2013; San Jose, CA; United States; 9 June 2013 through 14 June 2013. - 9781557529725 ; , s. Art. no. 6833039-
  • Konferensbidrag (refereegranskat)abstract
    • We demonstrate a scheme to scale the bandwidth of a frequency comb generated by phase modulation of CW lasers using four-wave mixing in a silicon nano-waveguides, resulting in >100 comb lines spaced by 10-GHz within 5-dB bandwidth.
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  • Karthik, K. R. G., et al. (författare)
  • Physical and Electrical Properties of Single Zn2SnO4 Nanowires
  • 2011
  • Ingår i: Electrochemical and solid-state letters. - Pennington, NJ : Electrochemical Society. - 1099-0062 .- 1944-8775. ; 14:1, s. K5-K7
  • Tidskriftsartikel (refereegranskat)abstract
    • Electrical characterizations of single Zn2SnO4 (ZTO) nanowire devices are presented. These include resistivity, mobility, and photosensing measurements. The resistivity and the mobility of the Zn2SnO4 nanowire were measured to be 5.6 cm and 0.2 cm2/Vs, respectively. These values were found to be strongly dependent on the amount of electron-donating defects and less dependent on the thickness of the nanowires. An increase in the resistivity when changing the ambient atmosphere is observed. This change is caused by defect states lying in the bandgap, as shown by photoluminescence. The results imply the potential of ZTO nanowires as phototransistors and other photosensitive devices. © 2010 The Electrochemical Society.
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