| 1. |
- Eriksdotter-Jönhagen, Maria, et al.
(författare)
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Encapsulated cell biodelivery of nerve growth factor to the Basal forebrain in patients with Alzheimer's disease.
- 2012
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Ingår i: Dementia and geriatric cognitive disorders. - : S. Karger AG. - 1421-9824 .- 1420-8008. ; 33:1, s. 18-28
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Tidskriftsartikel (refereegranskat)abstract
- Degeneration of cholinergic neurons in the basal forebrain correlates with cognitive decline in patients with Alzheimer's disease (AD). Targeted delivery of exogenous nerve growth factor (NGF) has emerged as a potential AD therapy due to its regenerative effects on the basal forebrain cholinergic neurons in AD animal models. Here we report the results of a first-in-man study of encapsulated cell (EC) biodelivery of NGF to the basal forebrain of AD patients with the primary objective to explore safety and tolerability.
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| 2. |
- Howner, Katarina, et al.
(författare)
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Brain processing of fearful facial expression in mentally disordered offenders
- 2011
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Ingår i: Journal of Behavioral and Brain Science. - Irvine, CA : Scientific Research Publishing. - 2160-5866 .- 2160-5874. ; 1:3, s. 115-123
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Tidskriftsartikel (refereegranskat)abstract
- Emotional facial expressions are important cues for interaction between people. The aim of the present study was to investigate brain function when processing fearful facial expressions in offenders with two psychiatric disorders which include impaired emotional facial perception; autism spectrum disorder (ASD) and psychopathy (PSY). Fourteen offenders undergoing forensic psychiatric assessment (7 with ASD, and 7 psychopathic offenders) and 12 healthy controls (HC) viewed fearful and neutral faces while undergoing functional magnetic resonance imaging (fMRI). Brain activity (fearful versus neutral faces) was compared both between HC and offenders and between the two offender groups (PSY and ASD). Functional co-activation was also investigated. The offenders had increased activity bilaterally in amygdala and medial cingulate cortex as well as the left hippocampus during processing fearful facial expressions compared to HC. The two subgroups of offenders differed in five regions compared with each other. Results from functional co-activation analysis suggested a strong correlation between the amygdala and anterior cingulate cortex (ACC) in the left hemisphere only in the PSY group. These findings suggest enhanced neural processing of fearful faces in the amygdala as well as in other facial processing brain areas in offenders compared to HC. Moreover, the co-activation between amygdala and ACC in the PSY but not the ASD group suggested qualitative differences in amygdala activity in the two groups. Since the sample size is small the study should be regarded as a pilot study.
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| 3. |
- Wiberg, Britt, et al.
(författare)
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A qualitative and quantitative study of seven persons with balanced time perspective (BTP) according to S-ZTPI
- 2012
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Ingår i: 1st international conference on time perspective and research. - : ESPACOBRANCO. ; , s. 120-120
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Konferensbidrag (refereegranskat)abstract
- The theoretical notion of balanced time perspective (BTP) has been suggested by a number of authors and some attempts to operationalize BTP (Boniwell, 2005; Drake, Duncan, Sutherland, Abernethy & Henry, 2008; Sircova & Mitina, 2008; Boniwell, Osin, Linley & Ivanchenko, 2010) has been done. The aim of the present study was to get a deeper understanding of the BTP-concept by studying seven BTP-persons with both interviews and self-rating scales (e.g. SCL-90, Life Events scale, Scales of Psychological Well-Being (C. Ryff) and Satisfaction with Life Scale (E.Diener) at two occasions. Swedish Zimbardo Time Perspective Inventory (S-ZTPI) (Carelli, Wiberg & Wiberg, 2011) was administered in order to study the stability and change in BTP-level. The results showed a great stability in the BTP-level (Wiberg, Sircova, Wiberg& Carelli, in press), although a small change was observed. The 14 interviews were analyzed according to Interpretative Phenomenological Analysis (IPA). The result shows a consciousness about the "now" among the participants and a synchronicity between the present and the past and also between the present and the future. The results give strength to a holistic present scale (Zimbardo & Boyd, 2008) and an "extended now".
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| 4. |
- Wiberg, Marie, 1976-, et al.
(författare)
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Operationalizing balanced time perspective in a Swedish sample
- 2012
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Ingår i: The International Journal of Educational and Psychological Assessment. - : Time Taylor Academic Journals. - 2094-0734. ; 12:1, s. 95-107
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Tidskriftsartikel (refereegranskat)abstract
- Past research suggests that biases in temporal orientation may have systematic effects ongoal-directed behavior and that physical and mental well-being is associated with balanced time perspective (BTP, Zimbardo and Boyd, 1999). The aim of this study was to examine different operationalizations of the BTP, and to present an alternative proposal in which BTP is measured as a multidimensional, rather than a binary, construct. Two versions of the Zimbardo Time Perspective Inventory (ZTPI) were administered to a sample of 502 individuals. The proposed operationalization shows important advantages in terms of ecological validity of the multidimensional definition, sample independency and possibility to adjust for country differences. Our proposal may also have practical implications both for individuals and groups, e.g. in working teams, psychological counseling, psychotherapy and when recruiting personal forleading positions.
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| 5. |
- Åström, Elisabeth, 1982-, et al.
(författare)
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Insights into features of anxiety through multiple aspects of psychological time
- 2014
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Ingår i: Journal of Integrative Psychology and Therapeutics. - : Herbert Publications Ltd. - 2054-4723. ; 2
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Tidskriftsartikel (refereegranskat)abstract
- Background: It is well-recognized that emotions and emotional disorders may alter the experience of time. Yet relatively little is known about different aspects of psychological time in relation to anxiety. The purpose of the present study was to explore several aspects of temporal processing, including time perspective, prospective and retrospective time estimation, in persons with anxiety symptoms.Methods: A total of 110 individuals with varying degrees of anxiety participated in two studies. They were assigned to two groups (anxiety–control) based on their scores on anxiety measurements. Participants also completed an inventory of time perspective and several time estimation tasks which were analyzed on a group-level. Depressive symptoms were assessed and used as a covariate in the second study.Results: Anxiety was significantly associated with Past Negative and Future Negative time perspectives as measured by the Swedish Zimbardo Time Perspective Inventory (S-ZTPI), even when controlling for the effect of depressive symptoms. No other significant differences were found.Conclusion: Exploring time perspective in persons with anxious symptoms may provide important insights into features of anxiety. These findings may offer new ways of conceptualizing anxiety and provide suggestions for treatment strategies.
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| 6. |
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| 7. |
- Bergman, Åke, et al.
(författare)
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Science and policy on endocrine disrupters must not be mixed : a reply to a "common sense" intervention by toxicology journal editors
- 2013
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Ingår i: Environmental Health. - : BioMed Central (BMC). - 1476-069X. ; 12
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Tidskriftsartikel (refereegranskat)abstract
- The "common sense" intervention by toxicology journal editors regarding proposed European Union endocrine disrupter regulations ignores scientific evidence and well-established principles of chemical risk assessment. In this commentary, endocrine disrupter experts express their concerns about a recently published, and is in our considered opinion inaccurate and factually incorrect, editorial that has appeared in several journals in toxicology. Some of the shortcomings of the editorial are discussed in detail. We call for a better founded scientific debate which may help to overcome a polarisation of views detrimental to reaching a consensus about scientific foundations for endocrine disrupter regulation in the EU.
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| 8. |
- Bolin, Marie, et al.
(författare)
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Prediction of Preeclampsia by Combining Serum Histidine-Rich Glycoprotein and Uterine Artery Doppler
- 2012
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Ingår i: American Journal of Hypertension. - : Oxford University Press (OUP). - 0895-7061 .- 1941-7225. ; 25:12, s. 1305-1310
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundPreeclampsia is associated with both maternal and perinatal morbidity and mortality. Histidine-rich glycoprotein (HRG) is a protein interacting with angiogenesis, coagulation, and inflammatory responses, processes known to be altered in preeclamptic pregnancies. Significantly lower levels of HRG have been demonstrated as early as in the first trimester in women later developing preeclampsia compared with normal pregnancies. The aim of this study was to investigate whether the combination of HRG and uterine artery Doppler ultrasonography can be used as a predictor of preeclampsia.MethodsA total of 175 women were randomly selected from a case-control study; 86 women had an uncomplicated pregnancy and 89 women later developed preeclampsia. Blood samples and pulsatility index (PI) were obtained from both cases and controls in gestational week 14.ResultsHRG levels were significantly lower in women who developed preterm preeclampsia compared with controls, but not for women developing preeclampsia in general. PI was significantly higher in the preeclampsia group compared with controls, especially in preterm preeclampsia. The combination of HRG and PI revealed a sensitivity of 91% and a specificity of 62% for preterm preeclampsia.ConclusionsThe combination of HRG and uterine artery Doppler may predict preterm preeclampsia in early pregnancy.
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| 9. |
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| 10. |
- Brante, Göran, 1951, et al.
(författare)
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Svårt för SD:are att jobba i skolan
- 2014
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Ingår i: Svenska Dagbladet. - 1101-2412. ; :27 september
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Tidskriftsartikel (populärvet., debatt m.m.)
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