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Träfflista för sökning "WFRF:(Winblad B) srt2:(2005-2009)"

Search: WFRF:(Winblad B) > (2005-2009)

  • Result 1-10 of 195
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1.
  • Visser, P. J., et al. (author)
  • Development of screening guidelines and clinical criteria for predementia Alzheimer's disease
  • 2008
  • In: Neuroepidemiology. - : S. Karger AG. - 1423-0208 .- 0251-5350. ; 30:4, s. 254-265
  • Journal article (peer-reviewed)abstract
    • Background: There is an urgent need to identify subjects with Alzheimer's disease (AD) in the predementia phase, but validated diagnostic approaches are currently lacking. In this paper, we present the background, design and methods of a study, which aims to develop clinical criteria for predementia AD. We also present baseline characteristics of the subjects included. The study was part of the multicentre DESCRIPA project, which is being conducted within the network of the European Alzheimer's Disease Consortium. Methods: Clinical criteria will be based on a prospective cohort study of non-demented subjects older than 55 years and referred to a memory clinic. At baseline, a number of markers and risk factors for AD were collected, including demographic variables, measures of performance in activities of daily living, cognitive, neuroimaging and genetic markers, and serum and cerebrospinal fluid markers. Subjects will be reassessed annually for 2 - 3 years, and we will evaluate which combination of variables best predicts AD-type dementia at follow-up. Results: Between 2003 and 2005, 881 subjects were included from 20 memory clinics. Subjects were on average 70.3 years old, and had 10.4 years of education. The average score on the Mini-Mental State Examination was 27.4.
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  • Burns, A, et al. (author)
  • The clinical use of memantine.
  • 2005
  • In: Research and Practice in Alzheimer's Disease. ; 10, s. 205-20
  • Journal article (peer-reviewed)
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  • Gauthier, S, et al. (author)
  • Mild cognitive impairment
  • 2006
  • In: Lancet (London, England). - 1474-547X. ; 367:9518, s. 1262-1270
  • Journal article (peer-reviewed)
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8.
  • Olomon, A. S., et al. (author)
  • Serum total cholesterol, statins and cognition in non-demented elderly
  • 2009
  • In: Neurobiology of Aging. - : Elsevier BV. - 0197-4580 .- 1558-1497. ; 30:6, s. 1006-1009
  • Journal article (peer-reviewed)abstract
    • Background: The association between serum total cholesterol (TC), lipid-lowering drugs and cognition in the elderly is currently controversial. Objective: To investigate the relationship between TC, lipid-lowering drugs and cognitive functions in non-demented elderly. Design and Setting: Participants of the Cardiovascular risk factors, aging and dementia (CAIDE) study were derived from random, population-based samples previously studied in 1972, 1977, 1982 or 1987. Analyses are based on 1382 non-demented participants re-examined in 1998 after an average follow-up of 21 years. Results: High midlife TC was associated with poorer late-life episodic memory and category fluency. TC decreased in most individuals over time. A more pronounced decrease was related to poorer late-life episodic memory and psychomotor speed, but not if subjects used statins. Conclusions: The TC-cognition relationship seems bidirectional. High midlife TC is associated with poorer late-life cognition, but decreasing TC after midlife may reflect poorer cognitive status. Statins may be beneficial for cognition in non-demented elderly.
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  • Result 1-10 of 195

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