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Träfflista för sökning "WFRF:(McMahon Christopher) srt2:(2015-2019)"

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11.	Dent, Jessica R., et al. (author) Sex differences in acute translational repressor 4E-BP1 activity and sprint performance in response to repeated-sprint exercise in team sport athletes 2015 In: Journal of Science and Medicine in Sport. - : Elsevier BV. - 1440-2440 .- 1878-1861. ; 18:6, s. 730-736 Journal article (peer-reviewed)abstract Objectives: The physiological requirements underlying soccer-specific exercise are incomplete and sex-based comparisons are sparse. The aim of this study was to determine the effects of a repeated-sprint protocol on the translational repressor 4E-BP1 and sprint performance in male and female soccer players.Design: Cross-over design involving eight female and seven male university soccer players.Methods: Participants performed four bouts of 6x 30-m maximal sprints spread equally over 40 min. Heart rate, sprint time and sprint decrement were measured for each sprint and during the course of each bout. Venous blood samples and muscle biopsies from the vastus lateralis were taken at rest, at 15 min and 2 h post-exercise. Results: While males maintained a faster mean sprint time for each bout (P < 0.05) females exhibited a greater decrement in sprint performance for each bout (P < 0.05), indicating a superior maintenance of sprint performance in males, with no sex differences for heart rate or lactate. Muscle analyses revealed sex differences in resting total (P< 0.05) and phosphorylated (P< 0.05) 4E-BP1 Thr37/46, and 15 min post-exercise the 4E-BP1 Thr37/46 ratio decreased below resting levels in males only (P < 0.05), indicative of a decreased translation initiation following repeated sprints.Conclusions: We show that females have a larger sprint decrement indicating that males have a superior ability to recover sprint performance. Sex differences in resting 4E-BP1 Thr37/46 suggest diversity in the training-induced phenotype of the muscle of males and females competing in equivalent levels of team-sport competition.
12.	Fitzmaurice, C, et al. (author) Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2016: A Systematic Analysis for the Global Burden of Disease Study 2018 In: JAMA oncology. - : American Medical Association (AMA). - 2374-2445 .- 2374-2437. ; 4:11, s. 1553-1568 Journal article (peer-reviewed)
13.	Kyu, HH, et al. (author) Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017 2018 In: Lancet (London, England). - 1474-547X .- 0140-6736. ; 392:10159, s. 1859-1922 Journal article (peer-reviewed)
14.	Roth, GA, et al. (author) Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980-2017: a systematic analysis for the Global Burden of Disease Study 2017 2018 In: Lancet (London, England). - 1474-547X .- 0140-6736. ; 392:10159, s. 1736-1788 Journal article (peer-reviewed)
15.	Vos, T, et al. (author) Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015 2016 In: Lancet (London, England). - 1474-547X .- 0140-6736. ; 388:10053, s. 1545-1602 Journal article (peer-reviewed)
16.	Weiner, D. J., et al. (author) Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders 2017 In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 49:7 Journal article (peer-reviewed)abstract Autism spectrum disorder (ASD) risk is influenced by common polygenic and de novo variation. We aimed to clarify the influence of polygenic risk for ASD and to identify subgroups of ASD cases, including those with strongly acting de novo variants, in which polygenic risk is relevant. Using a novel approach called the polygenic transmission disequilibrium test and data from 6,454 families with a child with ASD, we show that polygenic risk for ASD, schizophrenia, and greater educational attainment is over-transmitted to children with ASD. These findings hold independent of proband IQ. We find that polygenic variation contributes additively to risk in ASD cases who carry a strongly acting de novo variant. Lastly, we show that elements of polygenic risk are independent and differ in their relationship with phenotype. These results confirm that the genetic influences on ASD are additive and suggest that they create risk through at least partially distinct etiologic pathways.

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Result 11-16 of 16

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Type of publication: journal article (15); conference paper (1)

Type of content: peer-reviewed (16)

Author/Editor: Ahmad Kiadaliri, Ali ... (5); Gupta, R. (4); Weiderpass, E (4); Larsson, Anders (4); Alvis-Guzman, N (4); Bensenor, IM (4); show more...; Castaneda-Orjuela, C ... (4); Catala-Lopez, F (4); Dandona, L (4); Dandona, R (4); Das Neves, J (4); Ebrahimi, H (4); Fischer, F (4); Gopalani, SV (4); Hamadeh, RR (4); Hamidi, S (4); Hay, RJ (4); Hosgood, HD (4); Jonas, JB (4); Khader, YS (4); Khang, YH (4); Kopec, JA (4); Kumar, GA (4); Leigh, J (4); Lunevicius, R (4); Majeed, A (4); Malekzadeh, R (4); Mendoza, W (4); Meretoja, TJ (4); Miller, TR (4); Mohammed, S (4); Mokdad, AH (4); Nangia, V (4); Ogbo, FA (4); Park, EK (4); Pereira, DM (4); Pishgar, F (4); Roshandel, G (4); Sartorius, B (4); Sepanlou, SG (4); Shaikh, MA (4); Sykes, BL (4); Tabares-Seisdedos, R (4); Topor-Madry, R (4); Tran, BX (4); Vollset, SE (4); Yonemoto, N (4); Younis, MZ (4); Murray, CJL (4); Norrving, Bo (4); show less...

University: Karolinska Institutet (13); Uppsala University (9); Lund University (8); University of Gothenburg (6); Högskolan Dalarna (6); Umeå University (4); show more...; Chalmers University of Technology (3); Stockholm University (2); Linköping University (1); Stockholm School of Economics (1); Mid Sweden University (1); Södertörn University (1); Swedish University of Agricultural Sciences (1); show less...

Language: English (16)

Research subject (UKÄ/SCB): Medical and Health Sciences (13); Natural sciences (6); Social Sciences (1)

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