| 11. |
- Zhang, Wei, et al.
(författare)
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Activation of nuclear factor-kappa B pathway is responsible for tumor necrosis factor-a-induced up-regulation of endothelin B2 receptor expression in vascular smooth muscle cells in vitro
- 2012
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Ingår i: Toxicology Letters. - : Elsevier BV. - 1879-3169 .- 0378-4274. ; 209:2, s. 107-112
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Tidskriftsartikel (refereegranskat)abstract
- The endothelin B2 (ETB2) receptors are induced in vascular smooth muscle cells (VSMCs) in cardiovascular diseases. We tested if in vitro short-term exposure to the pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) could up-regulate ETB2 receptors in rat mesenteric arteries, and if this effect is through activation of intracellular nuclear factor-kappa B (NF-kappa B) pathway. The mesenteric arteries were dissected from male Sprague-Dawley rats and the endothelium was removed. The arteries were co-incubated with TNF-alpha in serum-free Dulbecco's modified Eagle's medium. Real-time reverse transcription-PCR, Western blot and immunohistochemical staining were employed to assess the mRNA/protein expression of ETB2 receptors and activation of NF-kappa B pathway. The results showed that, during organ culture. TNF-alpha concentration-dependently enhanced ET52 receptors expression at both mRNA and protein levels, paralleled with activation of NF-kappa B pathway in VSMC. The up-regulated ETB2 receptor expression and NF-kappa B activation could be effectively suppressed by general transcriptional inhibitor actinomycin D, or either of the selective I kappa B kinase inhibitors wedelolactone and IMD-0354. Conclusively, the activation of intracellular NF-kappa B pathway is responsible for the up-regulation of ETB2 receptors induced by short-term exposure to TNF-alpha. This could partly explain the toxic effects of TNF-alpha on VSMCs that account for cardiovascular diseases. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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| 12. |
- Zhang, Xu, et al.
(författare)
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Dynamic Group PCI Assignment Scheme
- 2011
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Ingår i: The Seventh International Conference on Wireless and Mobile Communications (ICWMC 2011). ; , s. 101-106
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Konferensbidrag (refereegranskat)abstract
- The Physical Cell Identity (PCI) is used to identify femtocell in LTE femtocell as the physical layer identity. Due to the fact that a) the PCIs are normally allocated without planning; and b) the limitation of the number of PCI, the cross-tier PCI confusion problem has arisen. The current solution in 3GPP Release 9 is to use Cell Global Identity (CGI) associated with PCI to solve this problem of confusion. However, using CGI has many serious drawbacks. Especially CGI might cause the inbound-handover is failure. In order to mitigate the CGI problem, this research proposes a dynamic PCI assignment scheme of DG-PCI in the macrocell and femtocell environment. The proposed scheme is tested by using system-level simulation. The simulations showed that the approach offers an optimal PCI distribution between macrocell and femtocell. The test showed that the CGI problem can be solved, and hence increase the successful rate of inbound-handover.
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| 13. |
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| 14. |
- Ai, Yue-Jie, et al.
(författare)
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Ultrafast deactivation processes in the 2-aminopyridine dimer and the adenine-thymine base pair : Similarities and differences
- 2010
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Ingår i: Journal of Chemical Physics. - : AIP Publishing. - 0021-9606 .- 1089-7690. ; 133:6, s. 064302-
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Tidskriftsartikel (refereegranskat)abstract
- 2-aminopyridine dimer has frequently been used as a model system for studying photochemistry of DNA base pairs. We examine here the relevance of 2-aminopyridine dimer for a Watson-Crick adenine-thymine base pair by studying UV-light induced photodynamics along two main hydrogen bridges after the excitation to the localized (1)pi pi(*) excited-state. The respective two-dimensional potential-energy surfaces have been determined by time-dependent density functional theory with Coulomb-attenuated hybrid exchange-correlation functional (CAM-B3LYP). Different mechanistic aspects of the deactivation pathway have been analyzed and compared in detail for both systems, while the related reaction rates have also be obtained from Monte Carlo kinetic simulations. The limitations of the 2-aminopyridine dimer as a model system for the adenine-thymine base pair are discussed. (C) 2010 American Institute of Physics. [doi:10.1063/1.3464485]
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| 15. |
- Alayon Glazunov, Andres, et al.
(författare)
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Clustering impact on the statistics of the multipole expansion coefficients of a wireless channel
- 2011
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Ingår i: Progress in Electromagnetics Research Symposium. ; , s. 603-607
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Konferensbidrag (refereegranskat)abstract
- It has been widely known that experimental results show that multipath components seem to arrive at the receiver in concentrated groups. These groups of multipath components, or clusters, are usually a result of scattering from large physical structures. Their impact on the capacity of Multiple-Input Multiple-Output (MIMO) systems has been widely studied. However, their impact on the spherical vector waves (svw) expansion of the propagation channel has not yet been addressed in the literature. As we have recently shown, a svw expansion provides a compact and straightforward representation of both antennas and channels. This can potentially facilitate designing antennas tailored to take advantage of the spatial and polarimetric characteristics of the propagation environment, which is essential to the deployment of efficient wireless networks. In this paper, we therefore study the impact of clustering on the first and second order statistics of the multimode expansion coefficients. We adopt the simulation approach to exemplify our results and provide numerical examples.
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| 16. |
- Alayon Glazunov, Andres, 1969-, et al.
(författare)
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On Some Optimal MIMO Antenna Coefficients in Multipath Channels
- 2011
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Ingår i: Progress in Electromagnetics Research B. - 1937-6472. ; 35, s. 87-109
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Tidskriftsartikel (refereegranskat)abstract
- This paper derives some optimum transmit and receive antenna coefficients in wireless multipath channels based on the spherical vector wave multimode expansion of the multiple-input multiple-output (MIMO) channel matrix. The derived antenna coefficients satisfy the following specific optimization criteria: (i) maximum MIMO mean effective link gain (link MEG) based on the multimode channel realizations or (ii) maximum MIMO link MEG based on the multimode correlation matrix or (iii) correlation minimization by diagonalization of the MIMO full-correlation matrix. It is shown that the proposed approach leads to matrix equations belonging to the nearest Kronecker product (NKP) problem family, which in general have no trivial solution. However, we show that exact solutions are provided to the posed NKP problems under the assumption of the Kronecker model for the MIMO full-correlation matrix. The results are illustrated by numerical examples. The proposed approach is a complement to existing antenna pattern analysis methods.
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| 17. |
- Alayon Glazunov, Andres, et al.
(författare)
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Outdoor-Indoor Channel
- 2012
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Ingår i: LTE-Advanced and Next Generation Wireless Networks. - Chichester, U.K. : John Wiley & Sons. - 9781119976707 ; , s. 123-151
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Bokkapitel (refereegranskat)
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| 18. |
- Alayon Glazunov, Andres, et al.
(författare)
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Some Examples of Uncorrelated Antenna Radiation Patterns for MIMO Applications
- 2011
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Ingår i: Progress in Electromagnetics Research Symposium. ; , s. 598-602
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Konferensbidrag (refereegranskat)abstract
- In this paper, we provide some examples of an approach resulting in uncorrelatedantenna radiation patterns at both ends of a MIMO (Multiple-Input Multiple-Output) wireless link in a given propagation channel. The patterns of antennas exciting dipole or dipole and quadrupole TE and TM modes are analyzed for two generic MIMO channel models based on the Kronecker correlation model with Laplacian angle-of-arrival (AoA) and angle-of-departure (AoD) distributions. The presented results are of a fundamental nature and essential to achieve the promise of MIMO systems.
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| 19. |
- Aplenc, Richard, et al.
(författare)
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Effect of body mass in children with hematologic malignancies undergoing allogeneic bone marrow transplantation.
- 2014
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Ingår i: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 123:22, s. 3504-11
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Tidskriftsartikel (refereegranskat)abstract
- The rising incidence of pediatric obesity may significantly affect bone marrow transplantation (BMT) outcomes. We analyzed outcomes in 3687 children worldwide who received cyclophosphamide-based BMT regimens for leukemias between 1990 and 2007. Recipients were classified according to age-adjusted body mass index (BMI) percentiles as underweight (UW), at risk of UW (RUW), normal, overweight (OW), or obese (OB). Median age and race were similar in all groups. Sixty-one percent of OB children were from the United States/Canada. Three-year relapse-free and overall survival ranged from 48% to 52% (P = .54) and 55% to 58% (P = .81) across BMI groups. Three-year leukemia relapses were 33%, 33%, 29%, 25%, and 21% in the UW, RUW, normal, OW, and OB groups, respectively (P < .001). Corresponding cumulative incidences for transplant-related mortality (TRM) were 18%, 19%, 21%, 22%, and 28% (P < .01). Multivariate analysis demonstrated a decreased risk of relapse compared with normal BMI (relative risk [RR] = 0.73; P < .01) and a trend toward higher TRM (RR = 1.28; P = .014). BMI in children is not significantly associated with different survival after BMT for hematologic malignancies. Obese children experience less relapse posttransplant compared with children with normal BMI; however, this benefit is offset by excess in TRM.
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| 20. |
- Canelas, A.B., et al.
(författare)
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Integrated multilaboratory systems biology reveals differences in protein metabolism between two reference yeast strains
- 2010
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723 .- 2041-1723. ; 1:9
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Tidskriftsartikel (refereegranskat)abstract
- The field of systems biology is often held back by difficulties in obtaining comprehensive, high-quality, quantitative data sets. In this paper, we undertook an interlaboratory effort to generate such a data set for a very large number of cellular components in the yeast Saccharomyces cerevisiae, a widely used model organism that is also used in the production of fuels, chemicals, food ingredients and pharmaceuticals. With the current focus on biofuels and sustainability, there is much interest in harnessing this species as a general cell factory. In this study, we characterized two yeast strains, under two standard growth conditions. We ensured the high quality of the experimental data by evaluating a wide range of sampling and analytical techniques. Here we show significant differences in the maximum specific growth rate and biomass yield between the two strains. On the basis of the integrated analysis of the high-throughput data, we hypothesize that differences in phenotype are due to differences in protein metabolism.
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