| 1. |
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| 2. |
- Hedmer, Maria, et al.
(author)
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Validation of urinary excretion of cyclophosphamide as a biomarker of exposure by studying its renal clearance at high and low plasma concentrations in cancer patients
- 2008
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In: International Archives of Occupational and Environmental Health. - : Springer Science and Business Media LLC. - 1432-1246 .- 0340-0131. ; 81:3, s. 285-293
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Journal article (peer-reviewed)abstract
- OBJECTIVES: Cyclophosphamide (CP) is an alkylating agent classified as a human carcinogen. Health care workers handling this drug may be exposed during, e.g., preparation or administration. Cyclophosphamide is readily absorbed by inhalation and by dermal uptake. A biomarker, CP in urine, has frequently been used to assess the occupational exposure to CP, but has not been fully validated. The aim of this study was to investigate if the proportion of the CP dose that is excreted in urine (renal clearance) is constant over different plasma drug concentrations and other pharmacokinetic parameters, e.g., urine flow. METHODS: Pharmacokinetics of CP were studied in 16 breast cancer patients that were treated with postoperative adjuvant chemotherapy including CP. Plasma and urine from the patients were collected at different occasions up to 12 days after the dose. Urine was collected during 4-h periods and blood was sampled at the end of each period. Analysis of CP was performed by liquid chromatography tandem mass spectrometry. The limit of detection for CP in urine and plasma was 0.01 and 0.02 ng/ml, respectively. The precisions of the developed methods were determined to
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| 3. |
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| 4. |
- Albin, Maria, et al.
(author)
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Arbets- och miljömedicin
- 2009
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In: Folkhälsa som tvärvetenskap. - 9789144040097 ; , s. 293-316
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Book chapter (other academic/artistic)
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| 5. |
- Albin, Maria, et al.
(author)
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Att säkra arbetslivsforskning av hög relevans och kvalitet
- 2009
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In: Arbetsmarknad & Arbetsliv. - Karlstad : Karlstads universitet. - 1400-9692 .- 2002-343X. ; 15:2, s. 55-68
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Journal article (peer-reviewed)abstract
- Arbetslivsforskningen studerar frågor som är högst relevanta för samhället. Det är mycket viktigt att forskningen håller god kvalitet. Svensk arbetslivsforskning håller en god eller mycket god vetenskaplig standard och har så gjort i åtminstone ett par decennier till följd av de stora satsningar som gjorts genom åren. Sådan forskning har överförts till förändringar i arbetslivet. Medlen till denna typ av forskning har minskat de senaste åren; först med omläggningen av forskningsfinansieringen och sedan i samband med nedläggningen av Arbetslivsinstitutet. Vi har för FAS (Forskningsrådet för arbetsliv och socialvetenskap) genomfört en kartläggning och analys av utvecklingen av arbetslivsforskningen i Sverige. Denna artikel sammanfattar vår rapport till FAS.
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| 6. |
- Albin, Maria, et al.
(author)
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Delegation med viktigt uppdrag
- 2009
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In: Bulletin från Arbets- och miljömedicin Syd och Yrkes- och miljödermatologi, Malmö. - 2000-3633.
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Journal article (pop. science, debate, etc.)
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| 7. |
- Albin, Maria, et al.
(author)
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Doser från bostad och föda--små men farliga.
- 2007
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In: Läkartidningen. - 0023-7205. ; 104:48, s. 3659-3663
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Journal article (peer-reviewed)abstract
- he health gains from risk reduction with regard to chemical health hazards have so far been most evident in the occupational setting. Development with regard to analytical and epidemiological methods, and possibilities to measure discrete effects, do however indicate health effects also at low levels of exposure, relevant for the general environment. Efficient risk reduction in the general, and even domestic, environment is possible as illustrated by the reduced exposure to tobacco smoke. Current exposures in Sweden to radon, mercury, cadmium, lead, PCBs, dioxins, and other persistent organic pollutants, affect diseases of major concern for public health like cancer, reproductive effects, cardiovascular disease, and osteoporosis. Lung cancer from domestic radon exposure remains a major concern, and should be targeted with higher ambition.
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| 8. |
- Albin, Maria, et al.
(author)
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Occupational health epidemiology in the Nordic countries – status and trends
- 2009
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In: Scandinavian Joural of Work, Environment and Health, supplements. - 1795-9918. ; suppl:7, s. 7-41
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Journal article (peer-reviewed)abstract
- This overview aims to give an indication of the current status and trends in occupational health epidemiology in the Nordic countries. As indicated by recent biometric reviews, Nordic countries currently rank among the top five globally in terms of research output on the work environment. However, birth-cohort effects and rapid change in institutions and funding may seriously jeopardize this position. As a result, training a new generation of excellent researchers will be a major task for the next decade and require changes in funding structures. With respect to research topics, the ageing population in the Nordic countries will make preservation of work ability a major issue to explore from a multidisciplinary perspective. Moreover, the growing migration of labor, goods, and capital across borders is likely to increase the number of workers involved in dangerous work and unprotected by minimal occupational safety measures. Consequently, there is a need to research the efficiency of the present occupational safety structures under these new conditions. Research on occupational health services remains remarkably scant. The increase of mental ill-health, especially among young women, and the related interaction between structural societal change and the work environment are important challenges. New suggested disease mechanisms (eg, epigenetic change, oxidative stress, and intrauterine priming of sensitivity to postnatal exposure) are also important applied research areas for occupational epidemiology.
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| 9. |
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| 10. |
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| 11. |
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| 12. |
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| 13. |
- Axmon, Anna, et al.
(author)
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Factors affecting time to pregnancy
- 2006
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In: Human Reproduction. - : Oxford University Press (OUP). - 0268-1161 .- 1460-2350. ; 21:5, s. 1279-1284
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Journal article (peer-reviewed)abstract
- BACKGROUND: Both lifestyle factors and occupational and environmental factors have been suggested to affect the female reproductive system. In the present study, the separate and joint effects of several such factors are investigated. METHODS: Information on time to pregnancy (TTP) was available for 1578 women randomly selected from the general Swedish population. The information was collected retrospectively by using self-administered questionnaires. By means of logistic regression of survival data, fecundability odds ratios were determined for many factors. Multivariate models were used to determine which factors had the most impact on TTP. RESULTS: Several lifestyle factors were found to associate with TTP. However, only use of oral contraceptives prior to attempting to conceive, menstrual cycle length, age at conception and parity remained in the multivariate models. Together, these factors explained 14% of the variance in TTP. Excluding first and second month conceptions, only age at conception and menstrual cycle length remained in the multivariate models, together explaining only 8% of the variance in TTP. CONCLUSIONS: Although information on several factors was available, the multivariate model explained only a small fraction of the variation in the observed time to pregnancies. Furthermore, female biological factors seemed more important predictors of TTP than lifestyle factors.
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| 14. |
- Axmon, Anna, et al.
(author)
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Fertility among female hairdressers.
- 2006
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In: Scandinavian journal of work, environment & health. - 0355-3140. ; 32:1, s. 51-60
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Journal article (peer-reviewed)abstract
- The study investigated whether working as a hairdresser has a negative impact on fertility, measured as time to pregnancy and miscarriage risk.
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| 15. |
- Björk, Jonas, et al.
(author)
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Recreational values of the natural environment in relation to neighbourhood satisfaction, physical activity, obesity and wellbeing.
- 2008
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In: Journal of Epidemiology and Community Health. - : BMJ. - 1470-2738 .- 0143-005X. ; 62:4, s. 2-2
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Journal article (peer-reviewed)abstract
- OBJECTIVES: The aim of this population-based study was to investigate associations between recreational values of the close natural environment and neighbourhood satisfaction, physical activity, obesity and wellbeing. METHODS: Data from a large public health survey distributed as a mailed questionnaire in suburban and rural areas of southern Sweden were used (N = 24,819; 59% participation rate). Geocoded residential addresses and the geographical information system technique were used to assess objectively five recreational values of the close natural environment: serene, wild, lush, spacious and culture. RESULTS: On average, a citizen of the Scania region, inner city areas excluded, only had access to 0.67 recreational values within 300 metres distance from their residence. The number of recreational values near the residence was strongly associated with neighbourhood satisfaction and physical activity. The effect on satisfaction was especially marked among tenants and the presence of recreational values was associated with low or normal body mass index in this group. A less marked positive association with vitality among women was observed. No evident effect on self-rated health was detectable. CONCLUSIONS: Immediate access to natural environments with high recreational values was rare in the study population and was distributed in an inequitable manner. Moreover, such access was associated with a positive assessment of neighbourhood satisfaction and time spent on physical activity, which can be expected to reduce obesity and increase vitality by having a buffering effect on stress.
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| 16. |
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| 17. |
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| 18. |
- Björk, Jonas, et al.
(author)
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Skydda naturen nära oss
- 2007
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In: Skånska dagbladet. - 1103-9973. ; , s. 5-5
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Journal article (pop. science, debate, etc.)
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| 19. |
- Björk, Jonas, et al.
(author)
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Smoking as a risk factor for myelodysplastic syndromes and acute myeloid leukemia and its relation to cytogenetic findings: A case-control study.
- 2009
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In: Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis. - : Elsevier BV. - 1873-5835. ; Nov 17, s. 788-791
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Journal article (peer-reviewed)abstract
- In this case-control study, interview data on smoking habits were available for 179 de novo cases (116 with cytogenetic data) of acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). Smoking habits were compared with a pooled set of population controls and hospital controls (diagnosed with malignant melanoma). Each pack-year of smoking increased the risk of MDS with 1.3% (95% CI 0.1-2.6%), corresponding to an estimated excess risk of 71% (95% CI 3-180%) for 40 pack-years. Associations between smoking and the specific aberrations -5/5q-, -7/7q-, and +8 in AML and MDS were indicated but the estimates were imprecise.
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| 20. |
- Bodin, Theo, et al.
(author)
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Road traffic noise and hypertension: results from a cross-sectional public health survey in southern Sweden.
- 2009
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In: Environmental Health. - 1476-069X. ; 8:38
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Journal article (peer-reviewed)abstract
- BACKGROUND: Results from studies of road traffic noise and hypertension are heterogeneous with respect to effect size, effects among males and females and with respect to effects across age groups. Our objective was to further explore these associations. METHODS: The study used cross-sectional public health survey data from southern Sweden, including 24,238 adults (18 - 80 years old). We used a geographic information system (GIS) to assess the average road noise (LAeq 24 hr) at the current residential address. Effects on self-reported hypertension were estimated by logistic regression with adjustment for age, sex, BMI, alcohol intake, exercise, education, smoking and socioeconomic status. RESULTS: Modest exposure effects (OR approximately 1.1) were generally noted in intermediate exposure categories (45 -64 dB(A)), and with no obvious trend. The effect was more pronounced at > 64 dB(A) (OR 1.45, 95% CI 1.04 - 2.02). Age modified the relative effect (p = 0.018). An effect was seen among middle-aged (40 - 59 years old) at noise levels 60 - 64 dB(A) (OR = 1.27, 95% CI 1.02 - 1.58)) and at > 64 dB(A) (OR = 1.91, 95% CI 1.19 - 3.06)). An effect was also indicated among younger adults but not among elderly. No apparent effect modification by gender, country of origin, disturbed sleep or strained economy was noted. CONCLUSION: The study supports an association between road traffic noise at high average levels and self-reported hypertension in middle-aged. Future studies should use age group -specific relative effect models to account for differences in prevalence.
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| 21. |
- Bohgard, Mats, et al.
(author)
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Chemical Health Risks
- 2009
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In: Work and Technology on Human Terms. - 9789173650588 ; , s. 307-337
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Book chapter (other academic/artistic)
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| 22. |
- Bohgard, Mats, et al.
(author)
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Kemiska hälsorisker
- 2008
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In: Arbete och teknik på människans villkor. - 9789173650373 ; , s. 309-337
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Book chapter (pop. science, debate, etc.)
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| 23. |
- Broberg Palmgren, Karin, et al.
(author)
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Association between polymorphisms in RMI1, TOP3A, and BLM and risk of cancer, a case-control study.
- 2009
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In: BMC Cancer. - : Springer Science and Business Media LLC. - 1471-2407. ; 9:May 11
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Journal article (peer-reviewed)abstract
- BACKGROUND: Mutations altering BLM function are associated with highly elevated cancer susceptibility (Bloom syndrome). Thus, genetic variants of BLM and proteins that form complexes with BLM, such as TOP3A and RMI1, might affect cancer risk as well. METHODS: In this study we have studied 26 tagged single nucleotide polymorphisms (tagSNPs) in RMI1, TOP3A, and BLM and their associations with cancer risk in acute myeloid leukemia/myelodysplatic syndromes (AML/MDS; N = 152), malignant melanoma (N = 170), and bladder cancer (N = 61). Two population-based control groups were used (N = 119 and N = 156). RESULTS: Based on consistency in effect estimates for the three cancer forms and similar allelic frequencies of the variant alleles in the control groups, two SNPs in TOP3A (rs1563634 and rs12945597) and two SNPs in BLM (rs401549 and rs2532105) were selected for analysis in breast cancer cases (N = 200) and a control group recruited from spouses of cancer patients (N = 131). The rs12945597 in TOP3A and rs2532105 in BLM showed increased risk for breast cancer. We then combined all cases (N = 584) and controls (N = 406) respectively and found significantly increased risk for variant carriers of rs1563634 A/G (AG carriers OR = 1.7 [95%CI 1.1-2.6], AA carriers OR = 1.8 [1.2-2.8]), rs12945597 G/A (GA carriers OR = 1.5 [1.1-1.9], AA carriers OR = 1.6 [1.0-2.5]), and rs2532105 C/T (CT+TT carriers OR = 1.8 [1.4-2.5]). Gene-gene interaction analysis suggested an additive effect of carrying more than one risk allele. For the variants of TOP3A, the risk increment was more pronounced for older carriers. CONCLUSION: These results further support a role of low-penetrance genes involved in BLM-associated homologous recombination for cancer risk.
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| 24. |
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| 25. |
- Broberg Palmgren, Karin, et al.
(author)
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Genetic variant of the human homologous recombination-associated gene RMI1 (S455N) impacts the risk of AML/MDS and malignant melanoma.
- 2007
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In: Cancer Letters. - : Elsevier BV. - 1872-7980 .- 0304-3835. ; 258:1, s. 38-44
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Journal article (peer-reviewed)abstract
- The newly identified protein BLAP75/RMI1 associates with the helicase BLM and is critical for the function of the homologous recombination complex. Mutations altering BLM function are associated with highly elevated cancer susceptibility (Bloom's syndrome). We have analyzed the common polymorphism Ser455Asn in RMI1 and its association with cancer risk in acute myeloid leukemia (AML, N=93), myelodysplatic syndromes (MDS, N=74), and malignant melanoma (MM, N=166). Two control groups were used: one population-based (N=119) and one recruited from spouses of cancer patients (N=189). The results showed a consistent pattern, where carriers of the Asn variant had a significantly increased risk of AML/MDS. The risk of AML/MDS for SerAsn+AsnAsn subjects was odds ratio (OR)=1.7, 95% confidence interval (CI) 1.1-2.5 or MM was OR=1.5, 95% CI 1.0-2.2. Age might modify the effect of RMI1 on cancer risk. This was most evident for MM: AsnAsn homozygotes > or =64 years showed OR=2.7, 95% CI 1.1-6.0, whereas individuals <64 years showed OR=0.87, 95% CI 0.31-2.5. These results indicate a role of low-penetrance genes involved in BLM-associated homologous recombination for cancer risk.
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