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- Hedberg, Bo, et al.
(författare)
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Learning in imaginary organizations
- 2001
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Ingår i: Handbook of organizational learning and knowledge. - Oxford : Oxford University Press. - 0198295839 - 0198295820 ; , s. 733-752
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Bokkapitel (refereegranskat)
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- Hedberg, Linda, et al.
(författare)
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Scattered Hammond plots reveal second level of site-specific information in protein folding: ′ (β‡)
- 2004
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America PNAS. - : Proceedings of the National Academy of Sciences. ; 101:20, s. 7606–11-
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Tidskriftsartikel (refereegranskat)abstract
- Site-specific information about structural heterogeneities of the protein-folding transition-state ensemble is commonly derived from the scatter of the Brønsted plot through the individual values of = Δlogkf/ΔlogKD-N. Here, we provide a second level of site-specific detail in the transition-state analysis by demonstrating that the scatter of the Hammond plot is related to heterogeneities in the -value growth. That is, the extent of transition-state movement (Δβ‡) is proportional to the free-energy gradient of the mutational perturbation across the top of the activation barrier, ′(β‡) ΔlogKD-N. The analysis is applied to the two-state protein L23 where the site-specific free-energy gradients are used to identify the interactions that show the highest degree of consolidation after crossing the barrier top. These interactions are distributed as a shell around the high- initiation point and denote the side-chain contacts that add criticality to the folding nucleus.
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