| 1. |
- Abbafati, Cristiana, et al.
(författare)
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- 2020
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Tidskriftsartikel (refereegranskat)
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| 2. |
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| 3. |
- Feigin, Valery L., et al.
(författare)
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Global, regional, and national burden of stroke and its risk factors, 1990-2019 : a systematic analysis for the Global Burden of Disease Study 2019
- 2021
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Ingår i: Lancet Neurology. - : Elsevier. - 1474-4422 .- 1474-4465. ; 20:10, s. 795-820
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Tidskriftsartikel (refereegranskat)abstract
- Background Regularly updated data on stroke and its pathological types, including data on their incidence, prevalence, mortality, disability, risk factors, and epidemiological trends, are important for evidence-based stroke care planning and resource allocation. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) aims to provide a standardised and comprehensive measurement of these metrics at global, regional, and national levels. Methods We applied GBD 2019 analytical tools to calculate stroke incidence, prevalence, mortality, disability-adjusted life-years (DALYs), and the population attributable fraction (PAF) of DALYs (with corresponding 95% uncertainty intervals [UIs]) associated with 19 risk factors, for 204 countries and territories from 1990 to 2019. These estimates were provided for ischaemic stroke, intracerebral haemorrhage, subarachnoid haemorrhage, and all strokes combined, and stratified by sex, age group, and World Bank country income level. Findings In 2019, there were 12.2 million (95% UI 11.0-13.6) incident cases of stroke, 101 million (93.2-111) prevalent cases of stroke, 143 million (133-153) DALYs due to stroke, and 6.55 million (6.00-7.02) deaths from stroke. Globally, stroke remained the second-leading cause of death (11.6% [10.8-12.2] of total deaths) and the third-leading cause of death and disability combined (5.7% [5.1-6.2] of total DALYs) in 2019. From 1990 to 2019, the absolute number of incident strokes increased by 70.0% (67.0-73.0), prevalent strokes increased by 85.0% (83.0-88.0), deaths from stroke increased by 43.0% (31.0-55.0), and DALYs due to stroke increased by 32.0% (22.0-42.0). During the same period, age-standardised rates of stroke incidence decreased by 17.0% (15.0-18.0), mortality decreased by 36.0% (31.0-42.0), prevalence decreased by 6.0% (5.0-7.0), and DALYs decreased by 36.0% (31.0-42.0). However, among people younger than 70 years, prevalence rates increased by 22.0% (21.0-24.0) and incidence rates increased by 15.0% (12.0-18.0). In 2019, the age-standardised stroke-related mortality rate was 3.6 (3.5-3.8) times higher in the World Bank low-income group than in the World Bank high-income group, and the age-standardised stroke-related DALY rate was 3.7 (3.5-3.9) times higher in the low-income group than the high-income group. Ischaemic stroke constituted 62.4% of all incident strokes in 2019 (7.63 million [6.57-8.96]), while intracerebral haemorrhage constituted 27.9% (3.41 million [2.97-3.91]) and subarachnoid haemorrhage constituted 9.7% (1.18 million [1.01-1.39]). In 2019, the five leading risk factors for stroke were high systolic blood pressure (contributing to 79.6 million [67.7-90.8] DALYs or 55.5% [48.2-62.0] of total stroke DALYs), high body-mass index (34.9 million [22.3-48.6] DALYs or 24.3% [15.7-33.2]), high fasting plasma glucose (28.9 million [19.8-41.5] DALYs or 20.2% [13.8-29.1]), ambient particulate matter pollution (28.7 million [23.4-33.4] DALYs or 20.1% [16.6-23.0]), and smoking (25.3 million [22.6-28.2] DALYs or 17.6% [16.4-19.0]). Interpretation The annual number of strokes and deaths due to stroke increased substantially from 1990 to 2019, despite substantial reductions in age-standardised rates, particularly among people older than 70 years. The highest age-standardised stroke-related mortality and DALY rates were in the World Bank low-income group. The fastest-growing risk factor for stroke between 1990 and 2019 was high body-mass index. Without urgent implementation of effective primary prevention strategies, the stroke burden will probably continue to grow across the world, particularly in low-income countries.
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| 4. |
- Micah, Angela E., et al.
(författare)
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Tracking development assistance for health and for COVID-19 : a review of development assistance, government, out-of-pocket, and other private spending on health for 204 countries and territories, 1990-2050
- 2021
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Ingår i: The Lancet. - : Elsevier. - 0140-6736 .- 1474-547X. ; 398:10308, s. 1317-1343
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Forskningsöversikt (refereegranskat)abstract
- Background The rapid spread of COVID-19 renewed the focus on how health systems across the globe are financed, especially during public health emergencies. Development assistance is an important source of health financing in many low-income countries, yet little is known about how much of this funding was disbursed for COVID-19. We aimed to put development assistance for health for COVID-19 in the context of broader trends in global health financing, and to estimate total health spending from 1995 to 2050 and development assistance for COVID-19 in 2020. Methods We estimated domestic health spending and development assistance for health to generate total health-sector spending estimates for 204 countries and territories. We leveraged data from the WHO Global Health Expenditure Database to produce estimates of domestic health spending. To generate estimates for development assistance for health, we relied on project-level disbursement data from the major international development agencies' online databases and annual financial statements and reports for information on income sources. To adjust our estimates for 2020 to include disbursements related to COVID-19, we extracted project data on commitments and disbursements from a broader set of databases (because not all of the data sources used to estimate the historical series extend to 2020), including the UN Office of Humanitarian Assistance Financial Tracking Service and the International Aid Transparency Initiative. We reported all the historic and future spending estimates in inflation-adjusted 2020 US$, 2020 US$ per capita, purchasing-power parity-adjusted US$ per capita, and as a proportion of gross domestic product. We used various models to generate future health spending to 2050. Findings In 2019, health spending globally reached $8. 8 trillion (95% uncertainty interval [UI] 8.7-8.8) or $1132 (1119-1143) per person. Spending on health varied within and across income groups and geographical regions. Of this total, $40.4 billion (0.5%, 95% UI 0.5-0.5) was development assistance for health provided to low-income and middle-income countries, which made up 24.6% (UI 24.0-25.1) of total spending in low-income countries. We estimate that $54.8 billion in development assistance for health was disbursed in 2020. Of this, $13.7 billion was targeted toward the COVID-19 health response. $12.3 billion was newly committed and $1.4 billion was repurposed from existing health projects. $3.1 billion (22.4%) of the funds focused on country-level coordination and $2.4 billion (17.9%) was for supply chain and logistics. Only $714.4 million (7.7%) of COVID-19 development assistance for health went to Latin America, despite this region reporting 34.3% of total recorded COVID-19 deaths in low-income or middle-income countries in 2020. Spending on health is expected to rise to $1519 (1448-1591) per person in 2050, although spending across countries is expected to remain varied. Interpretation Global health spending is expected to continue to grow, but remain unequally distributed between countries. We estimate that development organisations substantially increased the amount of development assistance for health provided in 2020. Continued efforts are needed to raise sufficient resources to mitigate the pandemic for the most vulnerable, and to help curtail the pandemic for all. Copyright (C) 2021 The Author(s). Published by Elsevier Ltd.
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| 5. |
- Sbarra, AN, et al.
(författare)
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Mapping routine measles vaccination in low- and middle-income countries
- 2021
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 589:7842, s. 415-
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Tidskriftsartikel (refereegranskat)abstract
- The safe, highly effective measles vaccine has been recommended globally since 1974, yet in 2017 there were more than 17 million cases of measles and 83,400 deaths in children under 5 years old, and more than 99% of both occurred in low- and middle-income countries (LMICs)1–4. Globally comparable, annual, local estimates of routine first-dose measles-containing vaccine (MCV1) coverage are critical for understanding geographically precise immunity patterns, progress towards the targets of the Global Vaccine Action Plan (GVAP), and high-risk areas amid disruptions to vaccination programmes caused by coronavirus disease 2019 (COVID-19)5–8. Here we generated annual estimates of routine childhood MCV1 coverage at 5 × 5-km2pixel and second administrative levels from 2000 to 2019 in 101 LMICs, quantified geographical inequality and assessed vaccination status by geographical remoteness. After widespread MCV1 gains from 2000 to 2010, coverage regressed in more than half of the districts between 2010 and 2019, leaving many LMICs far from the GVAP goal of 80% coverage in all districts by 2019. MCV1 coverage was lower in rural than in urban locations, although a larger proportion of unvaccinated children overall lived in urban locations; strategies to provide essential vaccination services should address both geographical contexts. These results provide a tool for decision-makers to strengthen routine MCV1 immunization programmes and provide equitable disease protection for all children.
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| 6. |
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| 7. |
- Gawdiya, Sandeep, et al.
(författare)
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Field Screening of Wheat Cultivars for Enhanced Growth, Yield, Yield Attributes, and Nitrogen Use Efficiencies
- 2023
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Ingår i: Agronomy. - : MDPI. - 2073-4395. ; 13:8
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Tidskriftsartikel (refereegranskat)abstract
- Optimizing nitrogen (N) inputs is crucial for maximizing wheat yield and ensuring environmental sustainability. Wheat’s economic significance in India calls for a comprehensive evaluation of its ecological implications to develop a resilient production system. This study aimed to identify and evaluate ten wheat cultivars for their yield and N-use efficiency under varying nitrogen inputs (control (N0), half of the recommended nitrogen (N75), and the recommended nitrogen (N150)) using the surface application of neem-oil-coated urea. All N inputs were applied in three splits, basal, crown root initiation, and tillering stages, and an experiment was conducted in a split-plot design. The application of N150 gave the highest dry matter accumulation (DMA) at harvesting stage (AHS) (871 g m−2), seed/spike (60), grain yield (GY = 7.4 t ha−1), straw yield (SY = 8.9 t ha−1), harvest index (HI = 45.2%), protein (12.5%), and total uptake of N (TUN) (223 kg ha−1) by the cultivar ‘HD 3249’, being closely followed by the cultivar ‘HD3117’. Six cultivars (‘HD 3298’, ‘HD 3117’, ‘HD 3249’, ‘PBW 550’, ‘HD 3086’, ‘HD 2967’) out of the ten cultivars evaluated responded well to different input treatments with respect to the grain yield efficiency index (GYEI ≥ 1). Regarding N input, N75 and N150 recorded the highest increases in plant height, AHS (16.5%; 21.2%), dry matter accumulation (DMA) at 30 days after sowing (DAS) (37.5%; 64%), DMA-60 DAS (42%; 53%), DMA-90 DAS (39.5%; 52.5%), TILL-30 DAS (19.8%; 26.4%), TILL-60 DAS (33.3%; 44%), TILL-90 DAS (37.2%; 47.2%), seed/spike (8%; 10%), 1000-grain weight (7.8%; 12.2%), and protein content (23.3%; and 33%) when compared with N0. Furthermore, the application of N75 and N150 improved GY (72.1%; 142.6%), SY (61.1%; 110.6%), BY (65.5%; 123%), and HI by 4.4% and 9%, respectively, over N0. Nitrogen addition (N75 and N150) also significantly increased total nitrogen uptake (104.7%; 205.6%), respectively, compared to N0. The correlation analysis revealed a positive association among most of the crop parameters. Overall, our research results suggest that the cultivars ‘HD 3249’ and ‘HD 3117’ have the potential to be effective options for improving N utilization efficiency, grain yield, and GYEI in North-West India.
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| 8. |
- Kar, Ashish Kumar, et al.
(författare)
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Unveiling and understanding the remarkable enhancement in the catalytic activity by the defect creation in UIO-66 during the catalytic transfer hydrodeoxygenation of vanillin with isopropanol
- 2023
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Ingår i: Applied Catalysis B. - : Elsevier. - 0926-3373 .- 1873-3883. ; 325
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Tidskriftsartikel (refereegranskat)abstract
- The catalytic transfer hydrodeoxygenation of vanillin is generally achieved using noble metal-based catalysts. Herein, we report a mechanistic investigation of the catalytic transfer hydrodeoxygenation (CTHDO) of vanillin over a defect-induced UIO-66 MOF. The remarkable enhancement in the CTHDO of vanillin was due to the unique structural features of the defect-induced UIO-66 MOF. The defect creation was confirmed using PXRD, N2 -sorption, FT-IR, XPS, HRTEM, dissolution 1H NMR, and quantified by TGA. The linker deficiency created Lewis acid and dynamic Bronsted acid and was confirmed by the NH3-TPD and CD3CN drift FT-IR. The periodic density functional theory calculations were conducted to elucidate the reaction pathway and mechanism. Density function theory, poisoning studies, control reactions, and quantified defect sites elucidate the active sites of the UIO-66def involved in the CTHDO of vanillin with isopropanol. The catalyst was efficiently recycled and retained its activity and structural features after multiple recycles.
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| 9. |
- Karn, Arodh Lal, et al.
(författare)
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An integrated approach for sustainable development of wastewater treatment and management system using IoT in smart cities
- 2023
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Ingår i: Soft Computing - A Fusion of Foundations, Methodologies and Applications. - : Springer. - 1432-7643 .- 1433-7479. ; 27, s. 5159-5175
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Tidskriftsartikel (refereegranskat)abstract
- The present world is intimidated by the problem of water scarcity that is to be addressed immediately. So, it is wise to treat wastewater to meet the massive need for drinking water for the fast-growing population. The magnificent application of Internet of Things (IoT) technology in many smart cities has derived fruitful results. This research study has proposed a real-time system using IoT that regularly monitors specific crucial parameters of a wastewater treatment plant and informs any plant's dysfunction to the operator. Furthermore, the large stream of data sets generated by IoT sensors in real-time can be analyzed and processed by complex event processing (CEP). This study was experimented with Smart Treatment (SMARTreat) architecture and its application in a simple water system of an industrial estate in South India. The proposed architecture showed outstanding results and has received positive comments from the water treatment plant managers.
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| 10. |
- Kumar, Ravi, et al.
(författare)
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Electrical noise spectroscopy of magnons in a quantum Hall ferromagnet
- 2024
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Ingår i: Nature Communications. - 2041-1723 .- 2041-1723. ; 15:1
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Tidskriftsartikel (refereegranskat)abstract
- Collective spin-wave excitations, magnons, are promising quasi-particles for next-generation spintronics devices, including platforms for information transfer. In a quantum Hall ferromagnets, detection of these charge-neutral excitations relies on the conversion of magnons into electrical signals in the form of excess electrons and holes, but if the excess electron and holes are equal, detecting an electrical signal is challenging. In this work, we overcome this shortcoming by measuring the electrical noise generated by magnons. We use the symmetry-broken quantum Hall ferromagnet of the zeroth Landau level in graphene to launch magnons. Absorption of these magnons creates excess noise above the Zeeman energy and remains finite even when the average electrical signal is zero. Moreover, we formulate a theoretical model in which the noise is produced by equilibration between edge channels and propagating magnons. Our model also allows us to pinpoint the regime of ballistic magnon transport in our device.
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| 11. |
- Kumar, Ravi, et al.
(författare)
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Observation of ballistic upstream modes at fractional quantum Hall edges of graphene
- 2022
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723 .- 2041-1723. ; 13:1
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Tidskriftsartikel (refereegranskat)abstract
- The presence of “upstream” modes, moving against the direction of charge current flow in the fractional quantum Hall (FQH) phases, is critical for the emergence of renormalized modes with exotic quantum statistics. Detection of excess noise at the edge is a smoking gun for the presence of upstream modes. Here, we report noise measurements at the edges of FQH states realized in dual graphite-gated bilayer graphene devices. A noiseless dc current is injected at one of the edge contacts, and the noise generated at contacts at length, L = 4 μm and 10 μm away along the upstream direction is studied. For integer and particle-like FQH states, no detectable noise is measured. By contrast, for “hole-conjugate” FQH states, we detect a strong noise proportional to the injected current, unambiguously proving the existence of upstream modes. The noise magnitude remains independent of length, which matches our theoretical analysis demonstrating the ballistic nature of upstream energy transport, quite distinct from the diffusive propagation reported earlier in GaAs-based systems.
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| 12. |
- Sharma, Ravi Kumar, et al.
(författare)
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Identification of proteinase 3 autoreactive CD4+T cells and their T-cell receptor repertoires in antineutrophil cytoplasmic antibody-associated vasculitis
- 2023
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Ingår i: Kidney International. - : ELSEVIER SCIENCE INC. - 0085-2538 .- 1523-1755. ; 103:5, s. 973-985
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Tidskriftsartikel (refereegranskat)abstract
- Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is an autoimmune disease involving autoreactivity to proteinase 3 (PR3) as demonstrated by presence of ANCAs. While autoantibodies are screened for diagnosis, autoreactive T cells and their features are less well-studied. Here, we investigated PR3-specific CD4+T cell responses and features of autoreactive T cells in patients with PR3-AAV, using a cohort of 72 patients with either active or inactive disease. Autoreactive PR3-specific CD4+T cells producing interferon g in response to protein stimulation were found to express the G-protein coupled receptor 56 (GPR56), a cell surface marker that distinguishes T cells with cytotoxic capacity. GPR56+CD4+T cells were significantly more prominent in the blood of patients with inactive as compared to active disease, suggesting that these cells were affected by immunosuppression and/or that they migrated from the circulation to sites of organ involvement. Indeed, GPR56+CD4+T cells were identified in T-cell infiltrates of affected kidneys and an association with immunosuppressive therapy was found. Moreover, distinct TCR gene segment usage and shared (public) T cell clones were found for the PR3-reactive TCRs. Shared T cell clones were found in different patients with AAV carrying the disease-associated HLA- DP allele, demonstrating convergence of the autoreactive T cell repertoire. Thus, we identified a CD4+T cell signature in blood and in affected kidneys that display PR3 autoreactivity and associates with T cell cytotoxicity. Our data provide a basis for novel rationales for both immune monitoring and future therapeutic intervention in PR3-AAV.
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| 13. |
- Srivastav, Saurabh Kumar, et al.
(författare)
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Determination of topological edge quantum numbers of fractional quantum Hall phases by thermal conductance measurements
- 2022
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723 .- 2041-1723. ; 13:1
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Tidskriftsartikel (refereegranskat)abstract
- To determine the topological quantum numbers of fractional quantum Hall (FQH) states hosting counter-propagating (CP) downstream (Nd) and upstream (Nu) edge modes, it is pivotal to study quantized transport both in the presence and absence of edge mode equilibration. While reaching the non-equilibrated regime is challenging for charge transport, we target here the thermal Hall conductance GQ, which is purely governed by edge quantum numbers Nd and Nu. Our experimental setup is realized with a hexagonal boron nitride (hBN) encapsulated graphite gated single layer graphene device. For temperatures up to 35 mK, our measured GQ at ν = 2/3 and 3/5 (with CP modes) match the quantized values of non-equilibrated regime (Nd + Nu)κ0T, where κ0T is a quanta of GQ. With increasing temperature, GQ decreases and eventually takes the value of the equilibrated regime ∣Nd - Nu∣κ0T. By contrast, at ν = 1/3 and 2/5 (without CP modes), GQ remains robustly quantized at Ndκ0T independent of the temperature. Thus, measuring the quantized values of GQ in two regimes, we determine the edge quantum numbers, which opens a new route for finding the topological order of exotic non-Abelian FQH states.
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| 14. |
- Srivastav, Saurabh Kumar, et al.
(författare)
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Vanishing Thermal Equilibration for Hole-Conjugate Fractional Quantum Hall States in Graphene
- 2021
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Ingår i: Physical Review Letters. - 1079-7114 .- 0031-9007. ; 126:21
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Tidskriftsartikel (refereegranskat)abstract
- Transport through edge channels is responsible for conduction in quantum Hall (QH) phases. Robust quantized values of charge and thermal conductances dictated by bulk topology appear when equilibration processes become dominant. We report on measurements of electrical and thermal conductances of integer and fractional QH phases, realized in hexagonal boron nitride encapsulated graphite-gated bilayer graphene devices for both electron and hole doped sides with different valley and orbital symmetries. Remarkably, for complex edges at filling factors ν=53 and 83, closely related to the paradigmatic hole-conjugate ν=23 phase, we find quantized thermal conductance whose values (3κ0T and 4κ0T, respectively where κ0T is the thermal conductance quantum) are markedly inconsistent with the values dictated by topology (1κ0T and 2κ0T, respectively). The measured thermal conductance values remain insensitive to different symmetries, suggesting its universal nature. Our findings are supported by a theoretical analysis, which indicates that, whereas electrical equilibration at the edge is established over a finite length scale, the thermal equilibration length diverges for strong electrostatic interaction. Our results elucidate the subtle nature of crossover from coherent, mesoscopic to topology-dominated transport.
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| 15. |
- Glasbey, JC, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 16. |
- Agrawal, Tarun Kumar, et al.
(författare)
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Blockchain-Based Secured Collaborative Model for Supply Chain Resource Sharing and Visibility
- 2020
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Ingår i: IFIP Advances in Information and Communication Technology. - Cham : Springer. ; , s. 259-266
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Konferensbidrag (refereegranskat)abstract
- Globalization, escalating competition, and demand for sustainable practices have required supply chain and production managers to consider various capabilities and value creation strategies for the customers. Rapid technological advancement in the current production environment calls for integrative and collaborative efforts for effective resource utilization and better visibility to gain competitive advantages. However, privacy risks and trust have always been a significant barrier for organizations’ efforts towards supply chain integration. Supply chain stakeholders fear these collaborate practices might weaken their bargaining power, accelerate risk of data manipulation and result in loss of information advantages. Addressing these issues, the study proposes a Blockchain-based collaborative model for production visibility and resource sharing. It demonstrates the framework for stakeholders’ interaction over a central procurement system backed with blockchain technology. The study further lays down the notion of production capacity backed smart contract rules. These smart contracts will run on the proposed blockchain network to reduce the possibilities of fraudulent transactions and capacity overbooking- leading to illegitimate subcontracting. The overall network will stimulate visibility and develop a technology-based trust among partners which ensuring sustainability by effective utilization of resources.
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| 17. |
- Agrawal, Tarun Kumar, et al.
(författare)
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Demonstration of a blockchain-based framework using smart contracts for supply chain collaboration
- 2023
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Ingår i: International Journal of Production Research. - : Informa UK Limited. - 0020-7543 .- 1366-588X. ; 61:5, s. 1497-1516
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Tidskriftsartikel (refereegranskat)abstract
- Blockchain technologies can support traceability, transparency and trust among participants. This has primarily been explored in established supply chains and not in the growing use of business networks or ecosystems, which is a notable limitation since supply chains typically are organised with a dominant actor that ensures common information systems and standards that negate blockchain benefits. Hence, this study explores the design of a blockchain-based collaborative framework for resource sharing using smart contracts. These are particularly well-suited for supporting operations in broader networks or ecosystems beyond supply chains with established collaborations and hierarchies. Based on a systematic literature review, a demonstrator framework was developed for stakeholder interactions through a procurement and distribution unit backed with blockchain technology. The framework consists of (a) network architecture to demonstrate partner interactions; (b) rules for network working principles based on supply collaboration requirements; (c) UML diagram to define smart contract interaction sequence; and (d) algorithm for smart contract network verification and validation. Applicability of these smart contracts was verified by deployment on an Ethereum blockchain. The demonstrator framework ensures quality and data authenticity in supply networks, so it is useful for effective resource utilisation in networks where outsourcing and production surpluses are major issues.
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| 18. |
- Agrawal, Tarun Kumar, et al.
(författare)
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Enabling circularity of electric vehicle batteries-the need for appropriate traceability
- 2021
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Ingår i: 2021 IEEE International Conference on Technology Management, Operations and Decisions, ICTMOD 2021. - : Institute of Electrical and Electronics Engineers (IEEE).
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Konferensbidrag (refereegranskat)abstract
- With the increased electrification of transportation, there is a growth in the number of electric vehicles (EV) in use, and hence also discarded EV batteries. It is critical to trace the batteries so that the policy of electrification does not lead to a negative impact on sustainability. To achieve the goals of circular economy, it is necessary to consider the sustainable extended life cycle strategies of reduce, reuse and recycle. Information gathering and sharing through the supply chain is the key driver for enabling the tracking and tracing of materials and services needed. Traceability indicators across the value chain may enable the creation of a comprehensive database that aids the circular economy goals. In this study, we discuss three different circular economy business models and identify the key traceability indicators for enabling circularity in the lithium-ion battery application in the automotive sector. Insights are used to develop a framework for viable EV battery circularity, capturing three key circular economy elements and four traceability characteristics for different circularity types.
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| 19. |
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| 20. |
- Agrawal, Tarun Kumar, 1989-, et al.
(författare)
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Understanding Supply Chain Visibility Through Experts’ Perspective: A Delphi Based Approach
- 2021
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Ingår i: Advances in Production Management Systems. Artificial Intelligence for Sustainable and Resilient Production Systems. - Cham : Springer Nature. ; 633 IFIP, s. 189-196
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Konferensbidrag (refereegranskat)abstract
- Visibility in production logistics and across the supply chain has become a key concern for organizations. Its need has been further emphasized due to the current COVID 19 crisis. Organizations find it challenging to prepare the internal logistics and supply chain, and quickly respond to such unexpected events, due to low visibility. Against this backdrop, the paper, which is a work-in-progress, systematically documents different factors influencing supply chain visibility and crucial information that should be collected and shared among supply chain partners for better visibility. A Delphi analysis is being conducted with twenty-six supply chain experts from various globally recognized enterprises with manufacturing units located worldwide. The study starts with a short open-ended questioner to collect a comprehensive list of antecedents, drivers, barriers, effects, and visibility information based on the qualitative response from the experts. The preliminary results from the first round of the Delphi analysis indicate that risk management, environmental sustainability, and supply chain control are some of the key drivers. Lack of IT infrastructure and maturity are some of the barriers, integrated systems, and technology maturity are among the key antecedents and gaining planning capability and better customer service are some of the positive effects of supply chain visibility as per the experts’ opinion. In addition, information related to planning, supplier location, and deviation are among the crucial ones that require the collection and sharing for better supply chain visibility. This research study is among the few that empirically explores factors influencing supply chain visibility and generates new insights as to why the barriers can be difficult to overcome in complex supply chain settings.
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| 21. |
- Bhola, Shivam, et al.
(författare)
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Established and Emerging Producers of PHA : Redefining the Possibility
- 2021
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Ingår i: Applied Biochemistry and Biotechnology. - : Springer. - 0273-2289 .- 1559-0291. ; 193:11, s. 3812-3854
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Forskningsöversikt (refereegranskat)abstract
- The polyhydroxyalkanoate was discovered almost around a century ago. Still, all the efforts to replace the traditional non-biodegradable plastic with much more environmentally friendly alternative are not enough. While the petroleum-based plastic is like a parasite, taking over the planet rapidly and without any feasible cure, its perennial presence has made the ocean a floating island of life-threatening debris and has flooded the landfills with toxic towering mountains. It demands for an immediate solution; most resembling answer would be the polyhydroxyalkanoates. The production cost is yet one of the significant challenges that various corporate is facing to replace the petroleum-based plastic. To deal with the economic constrain better strain, better practices, and a better market can be adopted for superior results. It demands for systems for polyhydroxyalkanoate production namely bacteria, yeast, microalgae, and transgenic plants. Solely strains affect more than 40% of overall production cost, playing a significant role in both upstream and downstream processes. The highly modifiable nature of the biopolymer provides the opportunity to replace the petroleum plastic in almost all sectors from food packaging to medical industry. The review will highlight the recent advancements and techno-economic analysis of current commercial models of polyhydroxyalkanoate production. Bio-compatibility and the biodegradability perks to be utilized highly efficient in the medical applications gives ample reason to tilt the scale in the favor of the polyhydroxyalkanoate as the new conventional and sustainable plastic.
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| 22. |
- Dahlander, Petter, 1967, et al.
(författare)
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Particulates in a GDI Engine and Their Relation to Wall-Film and Mixing Quality
- 2022
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Ingår i: SAE Technical Papers. - 400 Commonwealth Drive, Warrendale, PA, United States : SAE International. - 0148-7191 .- 2688-3627.
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Konferensbidrag (refereegranskat)abstract
- This paper investigates how particulates number PN is influenced by fuel wall-film, liner wetting, and the mixing quality for different start of injection timings (SOI). Both experimental data with PN measurements, endoscope images from a high-speed camera from a single-cylinder engine, and CFD simulations were used for the analysis. Engine geometry was a spray-guided system with 300 bar fuel pressure and with single injections. Data was captured for 2000 rpm / 9 bar IMEPn. The results show that fuel film on the piston was only found to significantly increase PN for over-advanced SOI (in our engine geometry, earlier than -310 CAD). This results in luminescence from diffusion burn on the piston surface, which strongly contributes to PN. For an SOI timing of -310 CAD, fuel film on piston reaches a maximum of 3#x00025; of the injected fuel, vaporizes, and no remaining fuel film is found at the time of ignition. Approximately 0.5-1#x00025; of the fuel ends up on the liner. Because of the slower evaporation, the liner film is exposed to scraping by the piston rings late in the compression stroke. For tested SOI timings of -310 CAD and later, all piston film evaporates before combustion, and the mixing quality starts dominating the PN formation. The mixing time has the strongest effect, leading to the reduction in PN with earlier SOI up until -310 CAD. Spray-tumble flow interactions are also shown to have appreciable effects on the mixing quality, and the usefulness of these interactions varies depending on the SOI.
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| 23. |
- Dutta, Ravi Kumar, 1983-
(författare)
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Genetic and molecular alterations in aldosterone producing adenomas
- 2020
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Aldosterone producing tumors (APA, also known as Conn tumors) are adrenal tumors that overproduce aldosterone, a hormone that regulates the sodium levels in blood and contributes to blood pressure (BP) regulation. Excessive production of aldosterone causes hypertension and approximately 5-15% of hypertensive patients have hyperaldosteronism, known as primary aldosteronism (PA). Major causes of PA are bilateral adrenal hyperplasia (BAH) or aldosterone producing adenoma (APA) and about 30% of PA patients have APAs. In most cases, the disease is unilateral, in rare case bilateral. Patients with APA are often detected when they have elevated blood pressure (BP>160/100mmHg) or when BP cannot be controlled with drugs. Surgery dramatically normalizes or lowers BP in patients with APA.In this thesis, we first explored the mutation frequency in susceptibility genes in sporadic APAs. About 60% of APAs displayed complementary mutations in the KCNJ5, ATP1A1, ATP2B3, CTNNB1, CACNAID and CLCN2 genes (Paper I, II & III). Copy number variation analysis of 35 APAs identified amplification of chromosome 10q24.31 in two tumors, where CALHM1-3- genes encoding for potential calcium ion channels are located. Only CALHM2 is expressed in adrenals and sequencing of CALHM2 revealed three different heterozygous sequence variants; c.341_42delCT (CALHM2P114Rfs*12), c.286G>A (CALHM2A96T) and c.580G>A (CALHM2V194M) in 5 APAs. CALHM2 is expressed in the mitochondrial membranes and Ca2+ imaging revealed that CALHM2 has selection of another ion rather than Ca2+. The genetic variant CALHM2V194M converts CALHM2 into a non-selective channel and results in higher Ca2+ conductance in mitochondria. We further found that loss of CALHM2 function upregulates REELIN/LRP8 signaling activating β-catenin dependent transcription of target genes (Paper II). In Paper IV, we investigated Scandinavian APA cases (n=35) and Swedish controls (n=60) for GWAS and discovered a susceptibility locus on chromosome Xq13.3 in a 4 Mb region to be significantly associated with APAs. Significance level was still same after genotyping the sentinel SNP rs2224095 in a replication cohort of APAs (n=52) and controls (n=740). Sequencing of an adjacent gene of the sentinel SNP, MAGEE1, identified a rare variant in one APA, which is complementary to other mutations in our primary cohort. In Summary, our studies have increased the knowledge of molecular genetic events in APAs. The results may contribute to find future non-surgical treatments for APAs.
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| 24. |
- Dutta, Ravi Kumar, et al.
(författare)
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X-chromosome variants are associated with aldosterone producing adenomas
- 2021
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Ingår i: Scientific Reports. - : Nature Research. - 2045-2322. ; 11:1
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Tidskriftsartikel (refereegranskat)abstract
- Aldosterone-producing adenomas (APAs) are a major cause of primary aldosteronism (PA) and are characterized by constitutively producing aldosterone, which leads to hypertension. Several mutations have been identified in ion channels or ion channel-associated genes that result in APAs. To date, no studies have used a genome-wide association study (GWAS) approach to search for predisposing loci for APAs. Thus, we investigated Scandinavian APA cases (n=35) and Swedish controls (n=60) in a GWAS and discovered a susceptibility locus on chromosome Xq13.3 (rs2224095, OR=7.9, 95% CI=2.8-22.4, P=1x10(-7)) in a 4-Mb region that was significantly associated with APA. Direct genotyping of sentinel SNP rs2224095 in a replication cohort of APAs (n=83) and a control group (n=740) revealed persistently strong significance (OR=6.1, 95% CI=3.5-10.6, p<0.0005). We sequenced an adjacent gene, MAGEE1, of the sentinel SNP and identified a rare variant in one APA, p.Gly327Glu, which is complementary to other mutations in our primary cohort. Expression quantitative trait loci (eQTL) were investigated on the X-chromosome, and 24 trans-eQTL were identified. Some of the genes identified by trans-eQTL point towards a novel mechanistic explanation for the association of the SNPs with APAs. In conclusion, our study provides further insights into the genetic basis of APAs.
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| 25. |
- Kalaiarasan, Ravi, et al.
(författare)
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Requirements on Supply Chain Visibility : A Case on Inbound Logistics
- 2021
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Ingår i: Advances in Production Management Systems. Artificial Intelligence for Sustainable and Resilient Production Systems - IFIP WG 5.7 International Conference, APMS 2021, Proceedings. - Cham : Springer International Publishing. - 1868-4238 .- 1868-422X. - 9783030859015 ; 631 IFIP, s. 115-122, s. 115-122
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Konferensbidrag (refereegranskat)abstract
- Events such as Covid-19 have revealed the vulnerabilities that companies face due to low visibility. Consequently, companies experience impact on their supply chains in terms of disruptions of material supply, deliveries, productivity and revenue. Thus, the importance of Supply Chain Visibility (SCV) in global and competitive markets with increasing sustainability demands has received widespread recognition. Yet, the literature provides limited understanding of requirements to consider when developing a SCV system. Addressing the gap, this study presents the findings from a case study during the first months of 2021 at a global manufacturing company developing a SCV system to improve their inbound flow. Using a system engineering perspective, this study presents requirements highlighted during early stage for a SCV system. The results indicate the importance of ensuring SCV system requirements to enable data collection, handling and usage for decision making leading to both supply chain sustainability and resilience. This study contributes to the understanding of SCV by presenting and categorizing requirements considered for real-time case at a manufacturing company when developing a SCV system.
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