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Träfflista för sökning "WFRF:(Shen X) srt2:(1993-1994)"

Search: WFRF:(Shen X) > (1993-1994)

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  • Shen, X L, et al. (author)
  • Inhibition of [methyl-3H]diazepam binding to rat brain membranes in vitro by dinatin and skrofulein
  • 1994
  • In: Zhongguo Yaoli Xuebao (China). - 0253-9756. ; 15:5, s. 385-388
  • Journal article (peer-reviewed)abstract
    • Two flavones, 4',5,7-trihydroxy-6-methoxy flavone (dinatin) and 4',5-dihydroxy-6, 7-dimethoxy flavone (skrofulein), were extracted from Artemisia herba alba L. Dinatin and skrofulein inhibited the binding of [methyl-3H]diazepam to rat brain membranes in vitro with IC50 of 1.3 and 23 mumol.L-1, respectively. The GABA-ratios (the ratio of IC50 values in the absence/presence of GABA in the binding assay) were 1.1 and 1.2 for dinatin and skrofulein, respectively. Both flavones induced a slight increase in [35S] TBPS binding. The data suggest that the flavones are antagonists or partial agonists of benzodiazepine receptors.
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  • Result 1-2 of 2
Type of publication
journal article (2)
Type of content
peer-reviewed (2)
Author/Editor
Sterner, Olov (2)
Nielsen, M. (2)
Shen, X.-L. (2)
Witt, M R (2)
Bergendorff, Ola (1)
Bergendorff, O. (1)
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Khayyal, M.T. (1)
El- Alfy, T.S. (1)
El-Gohary, H. (1)
Khayyal, M (1)
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University
Lund University (2)
Language
English (2)
Research subject (UKÄ/SCB)
Medical and Health Sciences (2)

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