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- Ruilope, LM, et al.
(författare)
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Design and Baseline Characteristics of the Finerenone in Reducing Cardiovascular Mortality and Morbidity in Diabetic Kidney Disease Trial
- 2019
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Ingår i: American journal of nephrology. - : S. Karger AG. - 1421-9670 .- 0250-8095. ; 50:5, s. 345-356
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Tidskriftsartikel (refereegranskat)abstract
- <b><i>Background:</i></b> Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. <b><i>Patients and</i></b> <b><i>Methods:</i></b> The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate ≥25 mL/min/1.73 m<sup>2</sup> and albuminuria (urinary albumin-to-creatinine ratio ≥30 to ≤5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level α = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. <b><i>Conclusions:</i></b> FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049.
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- Hudson, Lawrence N, et al.
(författare)
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The database of the PREDICTS (Projecting Responses of Ecological Diversity In Changing Terrestrial Systems) project
- 2017
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Ingår i: Ecology and Evolution. - : John Wiley & Sons. - 2045-7758. ; 7:1, s. 145-188
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Tidskriftsartikel (refereegranskat)abstract
- The PREDICTS project-Projecting Responses of Ecological Diversity In Changing Terrestrial Systems (www.predicts.org.uk)-has collated from published studies a large, reasonably representative database of comparable samples of biodiversity from multiple sites that differ in the nature or intensity of human impacts relating to land use. We have used this evidence base to develop global and regional statistical models of how local biodiversity responds to these measures. We describe and make freely available this 2016 release of the database, containing more than 3.2 million records sampled at over 26,000 locations and representing over 47,000 species. We outline how the database can help in answering a range of questions in ecology and conservation biology. To our knowledge, this is the largest and most geographically and taxonomically representative database of spatial comparisons of biodiversity that has been collated to date; it will be useful to researchers and international efforts wishing to model and understand the global status of biodiversity.
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| 9. |
- Adam, A, et al.
(författare)
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Abstracts from Hydrocephalus 2016.
- 2017
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Ingår i: Fluids and Barriers of the CNS. - : Springer Science and Business Media LLC. - 2045-8118. ; 14:Suppl 1
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Tidskriftsartikel (refereegranskat)
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- Nagaraja, Ch., et al.
(författare)
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Opening remarks
- 2016
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Konferensbidrag (refereegranskat)
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- Tiegs, Scott D., et al.
(författare)
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Global patterns and drivers of ecosystem functioning in rivers and riparian zones
- 2019
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Ingår i: Science Advances. - Washington : American Association of Advancement in Science. - 2375-2548. ; 5:1
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Tidskriftsartikel (refereegranskat)abstract
- River ecosystems receive and process vast quantities of terrestrial organic carbon, the fate of which depends strongly on microbial activity. Variation in and controls of processing rates, however, are poorly characterized at the global scale. In response, we used a peer-sourced research network and a highly standardized carbon processing assay to conduct a global-scale field experiment in greater than 1000 river and riparian sites. We found that Earth's biomes have distinct carbon processing signatures. Slow processing is evident across latitudes, whereas rapid rates are restricted to lower latitudes. Both the mean rate and variability decline with latitude, suggesting temperature constraints toward the poles and greater roles for other environmental drivers (e.g., nutrient loading) toward the equator. These results and data set the stage for unprecedented "next-generation biomonitoring" by establishing baselines to help quantify environmental impacts to the functioning of ecosystems at a global scale.
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- Caballero-Garcia, M. D., et al.
(författare)
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Activity from the Be/X-ray binary system V0332+53 during its intermediate-luminosity outburst in 2008
- 2016
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 589
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Tidskriftsartikel (refereegranskat)abstract
- Aims. We present a study of the Be/X-ray binary system V 0332+53 with the main goal of characterizing its behaviour mainly during the intermediate-luminosity X-ray event in 2008. In addition, we aim to contribute to the understanding of the behaviour of the donor companion by including optical data from our dedicated campaign starting in 2006. Methods. V 0332+53 was observed by RXTE and Swift during the decay of the intermediate-luminosity X-ray outburst of 2008, and with Suzaku before the rising of the third normal outburst of the 2010 series. In addition, we present recent data from the Spanish ground-based astronomical observatories of El Teide (Tenerife), Roque de los Muchachos (La Palma), and Sierra Nevada (Granada), and since 2006 from the Turkish TUBITAK National Observatory (Antalya). We have performed temporal analyses to investigate the transient behaviour of this system during several outbursts. Results. Our optical study revealed that continuous mass ejection episodes from the Be star have been taking place since 2006 and another is currently ongoing. The broad-band 1-60 keV X-ray spectrum of the neutron star during the decay of the 2008 outburst was well fitted with standard phenomenological models that were enhanced by an absorption feature of unknown origin at about 10 keV and a narrow iron K-alpha fluorescence line at 6.4 keV. For the first time in V 0332+ 53 we tentatively see an increase in the cyclotron line energy with increasing flux (although further and more sensitive observations are needed to confirm this). The fast aperiodic variability shows a quasi-periodic oscillation (QPO) at 227 +/- 9 mHz only during the lowest luminosities, which might indicate that the inner regions surrounding the magnetosphere are more visible during the lowest flux states.
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| 19. |
- Fisher, Matthew C., et al.
(författare)
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Development and worldwide use of non-lethal, and minimal population-level impact, protocols for the isolation of amphibian chytrid fungi
- 2018
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Ingår i: Scientific Reports. - : NATURE PUBLISHING GROUP. - 2045-2322. ; 8
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Tidskriftsartikel (refereegranskat)abstract
- Parasitic chytrid fungi have emerged as a significant threat to amphibian species worldwide, necessitating the development of techniques to isolate these pathogens into culture for research purposes. However, early methods of isolating chytrids from their hosts relied on killing amphibians. We modified a pre-existing protocol for isolating chytrids from infected animals to use toe clips and biopsies from toe webbing rather than euthanizing hosts, and distributed the protocol to researchers as part of the BiodivERsA project RACE; here called the RML protocol. In tandem, we developed a lethal procedure for isolating chytrids from tadpole mouthparts. Reviewing a database of use a decade after their inception, we find that these methods have been applied across 5 continents, 23 countries and in 62 amphibian species. Isolation of chytrids by the non-lethal RML protocol occured in 18% of attempts with 207 fungal isolates and three species of chytrid being recovered. Isolation of chytrids from tadpoles occured in 43% of attempts with 334 fungal isolates of one species (Batrachochytrium dendrobatidis) being recovered. Together, these methods have resulted in a significant reduction and refinement of our use of threatened amphibian species and have improved our ability to work with this group of emerging pathogens.
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| 20. |
- O'Hanlon, Simon J., et al.
(författare)
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Recent Asian origin of chytrid fungi causing global amphibian declines
- 2018
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 360:6389, s. 621-
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Tidskriftsartikel (refereegranskat)abstract
- Globalized infectious diseases are causing species declines worldwide, but their source often remains elusive. We used whole-genome sequencing to solve the spatiotemporal origins of themost devastating panzootic to date, caused by the fungus Batrachochytrium dendrobatidis, a proximate driver of global amphibian declines. We traced the source of B. dendrobatidis to the Korean peninsula, where one lineage, BdASIA-1, exhibits the genetic hallmarks of an ancestral population that seeded the panzootic. We date the emergence of this pathogen to the early 20th century, coinciding with the global expansion of commercial trade in amphibians, and we show that intercontinental transmission is ongoing. Our findings point to East Asia as a geographic hotspot for B. dendrobatidis biodiversity and the original source of these lineages that now parasitize amphibians worldwide.
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| 21. |
- Bouchard, F., et al.
(författare)
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Quantum metrology at the limit with extremal Majorana constellations
- 2017
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Ingår i: Optica. - : Optical Society of America. - 2334-2536. ; 4:11, s. 1429-1432
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Tidskriftsartikel (refereegranskat)abstract
- Quantum metrology allows for a tremendous boost in the accuracy of measurement of diverse physical parameters. The estimation of a rotation constitutes a remarkable example of this quantum-enhanced precision. The recently introduced Kings of Quantumness are especially germane for this task when the rotation axis is unknown, as they have a sensitivity independent of that axis and they achieve a Heisenberg-limit scaling. Here, we report the experimental realization of these states by generating up to 21-dimensional orbital angular momentum states of single photons, and confirm their high metrological abilities.
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| 23. |
- González, E. V., et al.
(författare)
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Low-velocity impact and compression after impact response of thin ply based composite laminates
- 2015
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Ingår i: ICCM International Conferences on Composite Materials. - : International Committee on Composite Materials.
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Konferensbidrag (refereegranskat)abstract
- The advantage of using thin plies is a well-known feature in laminated composite plates, since the homogenized properties usually improve, and in turn, the performance of the structure. In the literature, several works deal with the study of the ply thickness effect for different structures and loading conditions. However, fewer studies have been performed to understand the structure response under out-of-plane loading, such as the low-velocity impact event. The apparition of high quality manufactured ultra-thin plies, such as the composite material product TeXtreme of Oxeon AB, requires a detailed analysis of their damage resistance and tolerance performance under impact loading. The present work deals with a discussion of a large experimental test campaign of drop-weight impact tests and Compression After Impact (CAI) tests on ultra-thin ply based composite laminates. The composite material analysed is a plain-weave fabric with HTS45 fibers and 20 mm wide yarns, used with HexFlow RTM 6 mono-component epoxy system, and manufactured out-of-autoclave. Two ply thicknesses are considered: 0.08 mm and 0.16 mm. For each case, the same laminate thickness and stacking sequence is considered in order to define the same in-plane stiffness. The study considers different impact energy levels.
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| 24. |
- Henrich, C., et al.
(författare)
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Coulomb excitation of 142Xe
- 2018
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Ingår i: Acta Physica Polonica B. - 0587-4254. ; 49:3, s. 529-533
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Tidskriftsartikel (refereegranskat)abstract
- The even-even nucleus 142Xe lies north-east of the doubly magic 132Sn on the neutron-rich side of the nuclear chart. In order to gain further information on the octupole collectivity and the evolution of quadrupole collectivity in this region, a "safe" Coulomb excitation experiment was carried out at the new HIE-ISOLDE facility (CERN) at the end of 2016. As the gamma-ray detector the Miniball spectrometer was used. Beam and target nuclei were detected using C-REX, i.e. an array of segmented Si detectors, covering forward as well as backward angles in the laboratory frame.
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| 25. |
- Jones, M. I., et al.
(författare)
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A hot Saturn on an eccentric orbit around the giant star K2-132
- 2018
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 613
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Tidskriftsartikel (refereegranskat)abstract
- Although the majority of radial velocity detected planets have been found orbiting solar-type stars, a fraction of them have been discovered around giant stars. These planetary systems have revealed different orbital properties when compared to solar-type star companions. In particular, radial velocity surveys have shown that there is a lack of giant planets in close-in orbits around giant stars, in contrast to the known population of hot Jupiters orbiting solar-type stars. It has been theorized that the reason for this distinctive feature in the semimajor axis distribution is the result of the stellar evolution and/or that it is due to the effect of a different formation/evolution scenario for planets around intermediate-mass stars. However, in the past few years a handful of transiting short-period planets (P less than or similar to 10 days) have been found around giant stars, thanks to the high-precision photometric data obtained initially by the Kepler mission, and later by its two-wheel extension K2. These new discoveries have allowed us for the first time to study the orbital properties and physical parameters of these intriguing and elusive substellar companions. In this paper we report on an independent discovery of a transiting planet in field 10 of the K2 mission, also reported recently by Grunblatt et al. (2017, AJ, 154, 254). The host star has recently evolved to the giant phase, and has the following atmospheric parameters: T-eff = 4878 +/- 70 K, log g = 3.289 +/- 0.004, and [Fe/H] = 0.11 +/- 0.05 dex. The main orbital parameters of K2-132 b, obtained with all the available data for the system are: P = 9.1708 +/- 0.0025 d, e = 0.290 +/- 0.049, M-p = 0.495 +/- 0.007 M-J and R-p = 1.089 +/- 0.006 R-J. This is the fifth known planet orbiting any giant star with a < 0 : 1, and the most eccentric one among them, making K2-132 b a very interesting object.
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