| 1. |
- Arheimer, Berit, et al.
(author)
-
The IAHS Science for Solutions decade, with Hydrology Engaging Local People IN a Global world (HELPING)
- 2024
-
In: Hydrological Sciences Journal. - 0262-6667 .- 2150-3435.
-
Journal article (peer-reviewed)abstract
- The new scientific decade (2023-2032) of the International Association of Hydrological Sciences (IAHS) aims at searching for sustainable solutions to undesired water conditions - may it be too little, too much or too polluted. Many of the current issues originate from global change, while solutions to problems must embrace local understanding and context. The decade will explore the current water crises by searching for actionable knowledge within three themes: global and local interactions, sustainable solutions and innovative cross-cutting methods. We capitalise on previous IAHS Scientific Decades shaping a trilogy; from Hydrological Predictions (PUB) to Change and Interdisciplinarity (Panta Rhei) to Solutions (HELPING). The vision is to solve fundamental water-related environmental and societal problems by engaging with other disciplines and local stakeholders. The decade endorses mutual learning and co-creation to progress towards UN sustainable development goals. Hence, HELPING is a vehicle for putting science in action, driven by scientists working on local hydrology in coordination with local, regional, and global processes.
|
|
| 2. |
- Nunes, Luís, et al.
(author)
-
Prognostic genome and transcriptome signatures in colorectal cancers
- 2024
-
In: Nature. - : Springer Nature. - 0028-0836 .- 1476-4687.
-
Journal article (peer-reviewed)abstract
- Colorectal cancer is caused by a sequence of somatic genomic alterations affecting driver genes in core cancer pathways1. Here, to understand the functional and prognostic impact of cancer-causing somatic mutations, we analysed the whole genomes and transcriptomes of 1,063 primary colorectal cancers in a population-based cohort with long-term follow-up. From the 96 mutated driver genes, 9 were not previously implicated in colorectal cancer and 24 had not been linked to any cancer. Two distinct patterns of pathway co-mutations were observed, timing analyses identified nine early and three late driver gene mutations, and several signatures of colorectal-cancer-specific mutational processes were identified. Mutations in WNT, EGFR and TGFβ pathway genes, the mitochondrial CYB gene and 3 regulatory elements along with 21 copy-number variations and the COSMIC SBS44 signature correlated with survival. Gene expression classification yielded five prognostic subtypes with distinct molecular features, in part explained by underlying genomic alterations. Microsatellite-instable tumours divided into two classes with different levels of hypoxia and infiltration of immune and stromal cells. To our knowledge, this study constitutes the largest integrated genome and transcriptome analysis of colorectal cancer, and interlinks mutations, gene expression and patient outcomes. The identification of prognostic mutations and expression subtypes can guide future efforts to individualize colorectal cancer therapy.
|
|
| 3. |
|
|
| 4. |
- Zhang, Zhongli, et al.
(author)
-
Research on the heat resistance and electrical properties of fluorinated polyimide/nano-Al2O3/nano-Si3N4 composite materials
- 2024
-
In: Polymer. - : Elsevier. - 0032-3861 .- 1873-2291. ; 294
-
Journal article (peer-reviewed)abstract
- Polyimide (PI) refers to a polymer containing an imide ring characteristic structure on the main chain. It has excellent thermal stability, insulation properties and other characteristics. The Tesla transformer is the core component of the primary pulse source of the high -current electron beam accelerator. It is also an essential component of the energy storage pulse power supply. Therefore, it has broad application prospects in the fields of national defense and civil industry. If the insulation performance of the turn -to -turn coils of the Tesla transformer does not meet the standards, it will break down during high -voltage corona discharge, causing transformer failure. Therefore, it is crucial to improve the insulation performance of Tesla transformer inter -turn wrapping materials. The incorporation of fluorinecontaining groups has proven to be a transformative strategy that significantly enhances the physical, chemical, optical, and electrical properties of PI films. In addition, numerous studies have demonstrated that introducing inorganic fillers into the polyimide matrix can substantially enhance the insulating properties of polyimide films. This paper specifically concentrates on elevating the insulating and thermal attributes of polyimide. Initially, a range of polyimide films was synthesized for performance assessment by employing various fluorinated dianhydride and diamine components, utilizing them as substrates. Then, we used nanosilicon nitride (nano-Si3N4) and nano -alumina (nano-Al2O3) as doping phases to prepare PI composite films, which reduced the dielectric constant and increased the breakdown strength.
|
|
