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Sökning: WFRF:(Ekberg Lars)

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1.
  • Ekberg, Lars Peter, 1955- (författare)
  • Development of ultra-precision tools for metrology and lithography of large area photomasks and high definition displays
  • 2013
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • Large area flat displays are nowadays considered being a commodity. After the era of bulky CRT TV technology, LCD and OLED have taken over as the most prevalent technologies for high quality image display devices. An important factor underlying the success of these technologies has been the development of high performance photomask writers in combination with a precise photomask process. Photomask manufacturing can be regarded as an art, highly dependent on qualified and skilled workers in a few companies located in Asia. The manufacturing yield in the photomask process depends to a great extent on several steps of measurements and inspections. Metrology, which is the focus of this thesis, is the science of measurement and is a prerequisite for maintaining high quality in all manufacturing processes. The details and challenges of performing critical measurements over large area photomasks of square meter sizes will be discussed. In particular the development of methods and algorithms related to the metrology system MMS15000, the world standard for large area photomask metrology today, will be presented.The most important quality of a metrology system is repeatability. Achieving good repeatability requires a stable environment, carefully selected materials, sophisticated mechanical solutions, precise optics and capable software. Attributes of the air including humidity, CO2 level, pressure and turbulence are other factors that can impact repeatability and accuracy if not handled properly. Besides the former qualities, there is also the behavior of the photomask itself that needs to be carefully handled in order to achieve a good correspondence to the Cartesian coordinate system. An uncertainty specification below 100 nm (3σ) over an area measured in square meters cannot be fulfilled unless special care is taken to compensate for gravity-induced errors from the photomask itself when it is resting on the metrology tool stage. Calibration is therefore a considerable challenge over these large areas. A novel method for self-calibration will be presented and discussed in the thesis. This is a general method that has proven to be highly robust even in cases when the self-calibration problem is close to being underdetermined.A random sampling method based on massive averaging in the time domain will be presented as the solution for achieving precise spatial measurements of the photomask patterns. This method has been used for detection of the position of chrome or glass edges on the photomask with a repeatability of 1.5 nm (3σ), using a measurement time of 250 ms. The method has also been used for verification of large area measurement repeatability of approximately 10 nm (3σ) when measuring several hundred measurement marks covering an area of 0.8 x 0.8 m2.The measurement of linewidths, referred to in the photomask industry as critical dimension (CD) measurements, is another important task for the MMS15000 system. A threshold-based inverse convolution method will be presented that enhances resolution down to 0.5 µm without requiring a change to the numerical aperture of the system.As already mentioned, metrology is very important for maintaining high quality in a manufacturing environment. In the mask manufacturing industry in particular, the cost of poor quality (CoPQ) is extremely high. Besides the high materials cost, there are also the stringent requirements placed on CD and mask overlay, along with the need for zero defects that make the photomask industry unique. This topic is discussed further, and is shown to be a strong motivation for the development of the ultra-precision metrology built into the MMS15000 system.
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3.
  • Bondemark, Lars, et al. (författare)
  • Funktionsstörningar och smärta
  • 2008
  • Ingår i: Tandläkartidningen. - 0039-6982. ; 100:9-10, s. 64-68
  • Tidskriftsartikel (populärvet., debatt m.m.)abstract
    • Orofaciala funktionsstörningar och smärta är en sammanfattning av kliniska problem och sjukdomar som involverar bett, käkar, tuggmuskulatur, käkleder och omgivande strukturer. Orsakerna är oftast multifaktoriella för de barn, ungdomar och vuxna som drabbas.
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4.
  • Ekberg, Ewacarin, et al. (författare)
  • Can MRI Observations Predict Treatment Outcome of Lavage in Patients with Painful TMJ Disc Displacement without Reduction?
  • 2015
  • Ingår i: Journal of Oral & Maxillofacial Research. - : Kaunas University of Medicine. - 2029-283X. ; 30:1
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVES: The purpose of this study was to examine magnetic resonance imaging findings in patients with painful disc displacement without reduction of the temporomandibular joint to determine whether the findings were able to predict treatment outcome of lavage and a control group treated with local anaesthesia without lavage in a short-term: 3-month perspective. MATERIAL AND METHODS: Bilateral magnetic resonance images were taken of 37 patients with the clinical diagnosis of painful disc displacement without reduction. Twenty-three patients received unilateral extra-articular local anaesthetics and 14 unilateral lavage and extra-articular local anaesthetics. The primary treatment outcome defining success was reduction in pain intensity of at least 30% during jaw movement at the 3-month follow-up. RESULTS: Bilateral disc displacement was found in 30 patients. In 31 patients the disc on the treated side was deformed, and bilaterally in 19 patients. Osteoarthritis was observed in 28 patients, and 13 patients had bilateral changes. Thirty patients responded to treatment and 7 did not, with no difference between the two treated groups. In neither the treated nor the contralateral temporomandibular joint did treatment outcome depend on disc diagnosis, disc shape, joint effusion, or osseous diagnoses. Magnetic resonance imaging findings of disc position, disc shape, joint effusion or osseous diagnosis on the treated or contralateral side did not give information of treatment outcome. CONCLUSIONS: Magnetic resonance imaging findings could not predict treatment outcome in patients treated with either local anaesthetics or local anaesthetics and lavage.
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6.
  • Ekberg, Peter, et al. (författare)
  • A Large-area ultra-precision 2D geometrical measurement technique based on statistical random phase detection
  • 2012
  • Ingår i: Measurement science and technology. - : Institute of Physics Publishing (IOPP). - 0957-0233 .- 1361-6501. ; 23:3
  • Tidskriftsartikel (refereegranskat)abstract
    • The manufacturing of high-quality chrome masks used in the display industry for the manufacturing of liquid crystals, organic light emission diodes and other display devices would not be possible without high-precision large-area metrology. In contrast to the semiconductor industry where 6' masks are most common, the quartz glass masks for the manufacturing of large area TVs can have sizes of up to 1.6 x 1.8 m(2). Besides the large area, there are demands of sub-micrometer accuracy in 'registration', i.e. absolute dimensional measurements and nanometer requirements for 'overlay', i.e. repeatability. The technique for making such precise measurements on large masks is one of the most challenging tasks in dimensional metrology today. This paper presents a new approach to two-dimensional (2D) ultra-precision measurements based on random sampling. The technique was recently presented for ultra-precise one-dimensional (1D) measurement. The 1D method relies on timing the scanning of a focused laser beam 200 mu m in the Y-direction from an interferometrically determined reference position. This microsweep is controlled by an acousto-optical deflector. By letting the microsweep scan from random X-positions, we can build XY-recordings through a time-to-space conversion that gives very precise maps of the feature edges of the masks. The method differs a lot from ordinary image processing methods using CCD or CMOS sensors for capturing images in the spatial domain. We use events grabbed by a single detector in the time domain in both the X-and Y-directions. After a simple scaling, we get precise and repeatable spatial information. Thanks to the extremely linear microsweep and its precise power control, spatial and intensity distortions, common in ordinary image processing systems using 2D optics and 2D sensors, can be practically eliminated. Our 2D method has proved to give a standard deviation in repeatability of less than 4 nm (1 sigma) in both the X-and Y-directions over an area of approximately 0.8 x 0.8 m(2). Only feature edges are recorded, so all irrelevant information in areas containing constant intensity are filtered out already by the hardware. This relaxes the demands and complexity of the data channel dramatically compared to conventional imaging systems.
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7.
  • Ekberg, Peter, et al. (författare)
  • A new general approach for solving the self-calibration problem on large area 2D ultra-precision coordinate measurement machines
  • 2014
  • Ingår i: Measurement science and technology. - : IOP Publishing. - 0957-0233 .- 1361-6501. ; 25:5, s. 055001-
  • Tidskriftsartikel (refereegranskat)abstract
    • The manufacturing of flat panel displays requires a number of photomasks for the placement of pixel patterns and supporting transistor arrays. For large area photomasks, dedicated ultra-precision writers have been developed for the production of these chromium patterns on glass or quartz plates. The dimensional tolerances in X and Y for absolute pattern placement on these plates, with areas measured in square meters, are in the range of 200-300 nm (3 sigma). To verify these photomasks, 2D ultra-precision coordinate measurement machines are used having even tighter tolerance requirements. This paper will present how the world standard metrology tool used for verifying large masks, the Micronic Mydata MMS15000, is calibrated without any other references than the wavelength of the interferometers in an extremely well-controlled temperature environment. This process is called self-calibration and is the only way to calibrate the metrology tool, as no square-meter-sized large area 2D traceable artifact is available. The only parameter that cannot be found using self-calibration is the absolute length scale. To make the MMS15000 traceable, a 1D reference rod, calibrated at a national metrology lab, is used. The reference plates used in the calibration of the MMS15000 may have sizes up to 1 m(2) and a weight of 50 kg. Therefore, standard methods for self-calibration on a small scale with exact placements cannot be used in the large area case. A new, more general method had to be developed for the purpose of calibrating the MMS15000. Using this method, it is possible to calibrate the measurement tool down to an uncertainty level of <90 nm (3 sigma) over an area of (0.8 x 0.8) m(2). The method used, which is based on the concept of iteration, does not introduce any more noise than the random noise introduced by the measurements, resulting in the lowest possible noise level that can be achieved by any self-calibration method.
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8.
  • Ekberg, Peter, et al. (författare)
  • Ultra-precision geometrical measurement technique based on a statistical random phase clock combined with acoustic-optical deflection
  • 2010
  • Ingår i: Measurement science and technology. - : IOP Publishing. - 0957-0233 .- 1361-6501. ; 21:12, s. 125103-
  • Tidskriftsartikel (refereegranskat)abstract
    • Mask writers and large area measurements systems are key systems for production of large liquid crystal displays (LCD) and image devices. With position tolerances in the sub-mu m range over square meter sized masks, the metrology challenges are indeed demanding. Most systems used for this type of measurement rely on a microscope camera imaging system, provided with a charge coupled device, a complementary metal-oxide-semiconductor sensor or a time delay and integration sensor to transform the optical image to a digital gray-level image. From this image, processing algorithms are used to extract information such as location of edges. The drawback of this technique is the vast amount of data captured but never used. This paper presents a new approach for ultra-high-precision lateral measurement at nm-levels of chrome/glass patterns separated by centimeters, so called registration marks, on masks used for the LCD manufacturing. Registration specifications demand a positioning accuracy <200 nm and critical dimensions, i.e. chrome line widths, which need to be accurate in the 80 nm range. This accuracy has to be achieved on glass masks of 2.4 x 1.6 m(2) size. Our new measurement method is based on nm-precise lateral scanning of a focused laser beam combined with statistical random phase sampling of the reflected signal. The precise scanning is based on an extremely accurate time measuring device controlling an acousto optic deflector crystal. The method has been successfully applied in measuring the 4 mu m pitch of reference gratings at standard deviations sigma of 0.5 nm and registration marks separated by several cm at standard deviations of 23 nm.
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9.
  • Ekberg, Peter, et al. (författare)
  • Z-correction, a method for achieving ultraprecise self-calibration on large area coordinate measurement machines for photomasks
  • 2014
  • Ingår i: Measurement science and technology. - : IOP Publishing. - 0957-0233 .- 1361-6501. ; 25:5, s. 055002-
  • Tidskriftsartikel (refereegranskat)abstract
    • High-quality photomasks are a prerequisite for the production of flat panel TVs, tablets and other kinds of high-resolution displays. During the past years, the resolution demand has become more and more accelerated, and today, the high-definition standard HD, 1920 x 1080 pixels(2), is well established, and already the next-generation so-called ultra-high-definition UHD or 4K display is entering the market. Highly advanced mask writers are used to produce the photomasks needed for the production of such displays. The dimensional tolerance in X and Y on absolute pattern placement on these photomasks, with sizes of square meters, has been in the range of 200-300 nm (3 sigma), but is now on the way to be <150 nm (3 sigma). To verify these photomasks, 2D ultra-precision coordinate measurement machines are used with even tighter tolerance requirements. The metrology tool MMS15000 is today the world standard tool used for the verification of large area photomasks. This paper will present a method called Z-correction that has been developed for the purpose of improving the absolute X, Y placement accuracy of features on the photomask in the writing process. However, Z-correction is also a prerequisite for achieving X and Y uncertainty levels <90 nm (3 sigma) in the self-calibration process of the MMS15000 stage area of 1.4 x 1.5 m(2). When talking of uncertainty specifications below 200 nm (3 sigma) of such a large area, the calibration object used, here an 8-16 mmthick quartz plate of size approximately a square meter, cannot be treated as a rigid body. The reason for this is that the absolute shape of the plate will be affected by gravity and will therefore not be the same at different places on the measurement machine stage when it is used in the self-calibration process. This mechanical deformation will stretch or compress the top surface (i.e. the image side) of the plate where the pattern resides, and therefore spatially deform the mask pattern in the X- and Y-directions. Errors due to this deformation can easily be several hundred nanometers. When Z-correction is used in the writer, it is also possible to relax the flatness demand of the photomask backside, leading to reduced manufacturing costs of the plates.
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10.
  • Moro, Elena, et al. (författare)
  • Long-Term Results of a Multicenter Study on Subthalamic and Pallidal Stimulation in Parkinson's Disease
  • 2010
  • Ingår i: Movement Disorders. - : Wiley. - 0885-3185. ; 25:5, s. 578-586
  • Tidskriftsartikel (refereegranskat)abstract
    • We report the 5 to 6 year follow-up of a multicenter study of bilateral subthalamic nucleus (STN) and globus pallidus internus (GPi) deep brain stimulation (DBS) in advanced Parkinson's disease (PD) patients. Thirty-live STN patients and 16 GPi patienis were assessed at 5 to 6 years after DBS surgery. Primary outcome measure was the stimulation effect on the motor Unified Parkinson's Disease Rating Scale (UPDRS) assessed with a prospective cross-over double-blind assessment without medications (stimulation was randomly switched on or off). Secondary outcomes were motor UPDRS changes with unblinded assessments in off- and on-medication states with and without stimulation, activities of daily living (ADL), anti-PD medications, and dyskinesias. In double-blind assessment, both STN and GPi DBS were significantly effective in improving the motor UPDRS scores (STN. P < 0.0001, 45.4%; GPi, P = 0.008, 20.0%) compared with of regardless of the sequence of stimulation. In open assessment. both STN- and GPi-DBS significantly improved the off-medication motor UPDRS when compared with before surgery (STN. P < 0.001, 50.5%; GPi, P = 0.002, 35.6%). Dyskinesias and ADL were significantly improved in both groups. Anti-PD medications were significantly reduced only in the STN group. Adverse events were more frequent in the STN group. These results confirm the long-term efficacy of STN and GPi DBS advanced PD. Although the surgical targets were not randomized, there was a trend to 1 better outcome of motor signs in the STN-DBS patients and fewer adverse events in the GPi-DBS group. (C) 2010 Movement Disorder Society
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11.
  • Nyqvist, Johanna, et al. (författare)
  • Differences in health related quality of life in the randomised ARTSCAN study; accelerated vs. conventional radiotherapy for head and neck cancer. A five year follow up
  • 2016
  • Ingår i: Radiotherapy and Oncology. - : Elsevier BV. - 0167-8140 .- 1879-0887. ; 118:2, s. 335-341
  • Tidskriftsartikel (refereegranskat)abstract
    • Background and purpose: Health related quality of life (HRQoL) was assessed in the randomised, prospective ARTSCAN study comparing conventional radiotherapy (CF) with accelerated radiotherapy (AF) for head and neck cancer. Material and methods: 750 patients with squamous cell carcinoma (of any grade and stage) in the oral cavity, oro-, or hypopharynx or larynx (except T1-2, NO glottic carcinoma) without distant metastases were randomised to either conventional fractionation (2 Gy/day, 5 days/week in 49 days, total dose 68 Gy) or accelerated fractionation (1.1 + 2.0 Gy/day, 5 days/week in 35 days, total dose 68 Gy). HRQoL was assessed with EORTC QLQ-C30, QLQ-H&N35 and HADS at baseline, at end of radiotherapy (eRT) and at 3 and 6 months and 1, 2 and 5 years after start of treatment. Results: The AF group reported HRQoL was significantly lower at eRT and at 3 months for most symptoms, scales and functions. Few significant differences were noted between the groups at 6 months and 5 years. Scores related to functional oral intake never reached baseline. Conclusion: In comparison to CF, AF has a stronger adverse effect on HRQoL in the acute phase.
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12.
  • Streichart, Lillian, et al. (författare)
  • Tocilizumab in chronic active antibody-mediated rejection : rationale and protocol of an in-progress randomized controlled open-label multi-center trial (INTERCEPT study)
  • 2024
  • Ingår i: Trials. - : BioMed Central (BMC). - 1745-6215. ; 25
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Chronic active antibody-mediated rejection (caAMR) in kidney transplants is associated with irreversible tissue damage and a leading cause of graft loss in the long-term. However, the treatment for caAMR remains a challenge to date. Recently, tocilizumab, a recombinant humanized monoclonal antibody directed against the human interleukin-6 (IL-6) receptor, has shown promise in the treatment of caAMR. However, it has not been systematically investigated so far underscoring the need for randomized controlled studies in this area.Methods: The INTERCEPT study is an investigator-driven randomized controlled open-label multi-center trial in kidney transplant recipients to assess the efficacy of tocilizumab in the treatment of biopsy-proven caAMR. A total of 50 recipients with biopsy-proven caAMR at least 12 months after transplantation will be randomized to receive either tocilizumab (n = 25) added to our standard of care (SOC) maintenance treatment or SOC alone (n = 25) for a period of 24 months. Patients will be followed for an additional 12 months after cessation of study medication. After the inclusion biopsies at baseline, protocol kidney graft biopsies will be performed at 12 and 24 months. The sample size calculation assumed a difference of 5 ml/year in slope of estimated glomerular filtration rate (eGFR) between the two groups for 80% power at an alpha of 0.05.The primary endpoint is the slope of eGFR at 24 months after start of treatment. The secondary endpoints include assessment of the following at 12, 24, and 36 months: composite risk score iBox, safety, evolution and characteristics of donor-specific antibodies (DSA), graft histology, proteinuria, kidney function assessed by measured GFR (mGFR), patient- and death-censored graft survival, and patient-reported outcomes that include transplant-specific well-being, adherence to immunosuppressive medications and perceived threat of the risk of graft rejection.Discussion: No effective treatment exists for caAMR at present. Based on the hypothesis that inhibition of IL-6 receptor by tocilizumab will reduce antibody production and reduce antibody-mediated damage, our randomized trial has a potential to provide evidence for a novel treatment strategy for caAMR, therewith slowing the decline in graft function in the long-term.
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13.
  • Streichart, Lillian, 1983, et al. (författare)
  • Tocilizumab in chronic active antibody-mediated rejection: rationale and protocol of an in-progress randomized controlled open-label multi-center trial (INTERCEPT study)
  • 2024
  • Ingår i: TRIALS. - : BioMed Central (BMC). - 1745-6215. ; 25:1
  • Tidskriftsartikel (refereegranskat)abstract
    • BackgroundChronic active antibody-mediated rejection (caAMR) in kidney transplants is associated with irreversible tissue damage and a leading cause of graft loss in the long-term. However, the treatment for caAMR remains a challenge to date. Recently, tocilizumab, a recombinant humanized monoclonal antibody directed against the human interleukin-6 (IL-6) receptor, has shown promise in the treatment of caAMR. However, it has not been systematically investigated so far underscoring the need for randomized controlled studies in this area.MethodsThe INTERCEPT study is an investigator-driven randomized controlled open-label multi-center trial in kidney transplant recipients to assess the efficacy of tocilizumab in the treatment of biopsy-proven caAMR. A total of 50 recipients with biopsy-proven caAMR at least 12 months after transplantation will be randomized to receive either tocilizumab (n = 25) added to our standard of care (SOC) maintenance treatment or SOC alone (n = 25) for a period of 24 months. Patients will be followed for an additional 12 months after cessation of study medication. After the inclusion biopsies at baseline, protocol kidney graft biopsies will be performed at 12 and 24 months. The sample size calculation assumed a difference of 5 ml/year in slope of estimated glomerular filtration rate (eGFR) between the two groups for 80% power at an alpha of 0.05.The primary endpoint is the slope of eGFR at 24 months after start of treatment. The secondary endpoints include assessment of the following at 12, 24, and 36 months: composite risk score iBox, safety, evolution and characteristics of donor-specific antibodies (DSA), graft histology, proteinuria, kidney function assessed by measured GFR (mGFR), patient- and death-censored graft survival, and patient-reported outcomes that include transplant-specific well-being, adherence to immunosuppressive medications and perceived threat of the risk of graft rejection.MethodsThe INTERCEPT study is an investigator-driven randomized controlled open-label multi-center trial in kidney transplant recipients to assess the efficacy of tocilizumab in the treatment of biopsy-proven caAMR. A total of 50 recipients with biopsy-proven caAMR at least 12 months after transplantation will be randomized to receive either tocilizumab (n = 25) added to our standard of care (SOC) maintenance treatment or SOC alone (n = 25) for a period of 24 months. Patients will be followed for an additional 12 months after cessation of study medication. After the inclusion biopsies at baseline, protocol kidney graft biopsies will be performed at 12 and 24 months. The sample size calculation assumed a difference of 5 ml/year in slope of estimated glomerular filtration rate (eGFR) between the two groups for 80% power at an alpha of 0.05.The primary endpoint is the slope of eGFR at 24 months after start of treatment. The secondary endpoints include assessment of the following at 12, 24, and 36 months: composite risk score iBox, safety, evolution and characteristics of donor-specific antibodies (DSA), graft histology, proteinuria, kidney function assessed by measured GFR (mGFR), patient- and death-censored graft survival, and patient-reported outcomes that include transplant-specific well-being, adherence to immunosuppressive medications and perceived threat of the risk of graft rejection.DiscussionNo effective treatment exists for caAMR at present. Based on the hypothesis that inhibition of IL-6 receptor by tocilizumab will reduce antibody production and reduce antibody-mediated damage, our randomized trial has a potential to provide evidence for a novel treatment strategy for caAMR, therewith slowing the decline in graft function in the long-term.
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14.
  • Zackrisson, Björn, et al. (författare)
  • Mature results from a Swedish comparison study of conventional versus accelerated radiotherapy in head and neck squamous cell carcinoma - The ARTSCAN trial
  • 2015
  • Ingår i: Radiotherapy and Oncology. - : Elsevier BV. - 0167-8140 .- 1879-0887. ; 117:1, s. 99-105
  • Tidskriftsartikel (refereegranskat)abstract
    • Background and purpose: This report contains the mature five-year data from the Swedish ARTSCAN trial including information on the influence of p16 positivity (p16+) for oropharyngeal cancers. Material and methods: Patients with previously untreated squamous cell carcinoma without distant metastases of the oral cavity, oropharynx, larynx (except T1-2, NO glottic cancers) and hypopharynx were included. Patients were randomised between accelerated fractionation (AF) (1.1 Gy + 2 Gy per day, 5 days/week for 4.5 weeks, total dose 68 Gy) and conventional fractionation (CF) (2 Gy per day, 5 days/week for 7 weeks, total dose 68 Gy). Human papillomavirus (HPV)-associated p16-expression was assessed retrospectively in tumour tissues from patients with oropharyngeal carcinoma. Results: There was no significant difference in loco-regional control (LRC) between AF and CF (log-rank test p = 0.75). LRC at 5 years was 65.5% for AF and 64.9% for CF. Overall survival (OS) was similar in both arms (p = 0.99). The estimated cancer specific survival (CSS) at 5 years was 62.2% (AF) and 63.3% (CF) (p = 0.99). 206 specimens were analysed for p16 with 153 specimens (74%) identified as p16+. P16 status did not discriminate for response to AF vs. CF with regard to LRC, OS or CSS. Patients with p16+ tumours had a statistically significant better overall prognosis compared with p16 tumours. Conclusion: This update confirms the results of the 2-year report. We failed to identify a positive effect resulting from AF with regards to LRC, OS and CSS. The addition of information on the HPV-associated p16 overexpression did not explain this lack of effect.
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15.
  • Zackrisson, Björn, et al. (författare)
  • Two-year results from a Swedish study on conventional versus accelerated radiotherapy in head and neck squamous cell carcinoma - The ARTSCAN study
  • 2011
  • Ingår i: Radiotherapy and Oncology. - : Elsevier. - 0167-8140 .- 1879-0887. ; 100:1, s. 41-48
  • Tidskriftsartikel (refereegranskat)abstract
    • Background and purpose: Studies on accelerated fractionation (AF) in head and neck cancer have shown increased local control and survival compared with conventional fractionation (CF), while others have been non-conclusive. In 1998 a national Swedish group decided to perform a randomised controlled clinical study of AF. Materials and methods: Patients with verified squamous cell carcinoma of the oral cavity, oropharynx, larynx (except glottic T1-T2, N0) and hypopharynx were included. Patients with prior chemotherapy or surgery were excluded. Patients were randomised to either CF (2Gy/day, 5days/week for 7 weeks, total dose 68Gy) or to AF (1.1Gy+2.0Gy/day, 5days/week for 4.5weeks, total dose 68Gy). An extensive quality assurance protocol was followed throughout the study. The primary end point was loco-regional tumour control (LRC) at two years after treatment. RESULTS: The study was closed in 2006 when 750 patients had been randomised. Eighty-three percent of the patients had stages III-IV disease. Forty eight percent had oropharyngeal, 21% laryngeal, 17% hypopharyngeal and 14% oral cancers. There were no significant differences regarding overall survival (OS) or LRC between the two regimens. The OS at two years was 68% for AF and 67% for CF. The corresponding figures for LRC were 71% and 67%, respectively. There was a trend towards improved LRC for oral cancers treated (p=0.07) and for large tumours (T3-T4) (p=0.07) treated with AF. The AF group had significantly worse acute reactions, while there was no significant increase in late effects. Conclusion: Overall the AF regimen did not prove to be more efficacious than CF. However, the trend towards improved results in AF for oral cancers needs to be further investigated.  
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16.
  • Åman, Johan, et al. (författare)
  • Recent developments in large-area photomasks for display applications
  • 2001
  • Ingår i: Journal of the Society for Information Display. - San Jose, CA : Wiley. - 1071-0922. ; 9:1, s. 3-8
  • Tidskriftsartikel (refereegranskat)abstract
    • One of the most critical areas in the manufacturing process for FPD panels or shadow masks for CRTs is lithography. Most existing lithography technologies require high-quality large-area photomasks. The requirements on these photomasks include positioning accuracy (registration) and repeatability (overlay), systematic image quality errors ("mura" or display quality), and resolution (minimum feature size). The general trend toward higher resolution and improved performance, e.g., for TFT desktop monitors, has put a strong focus on the specifications for large-area-display photomasks. This article intends to give an overview of the dominant issues for large-area-display photomasks, and illustrates differences compared with other applications. The article will also present state-of-the-art methods and trends. In particular, the aspects of positioning accuracy over large areas and systematic image-quality errors will be described. New qualitative and objective methods have been developed as means to capture systematic image-quality errors. Results indicating that errors below 25 nm can be found early in the manufacturing process is presented, thus allowing inspection for visual effects before the actual display is completed. Positioning accuracy below 400 nm (3 sigma) over 720 × 560 mm have been achieved. These results will in the future be extended up toward 1 × 1 m for generation 4 in TFT-LCD production.
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18.
  • Abrahamsson, Cecilia, et al. (författare)
  • Alterations of temporomandibular disorders before and after orthognathic surgery
  • 2007
  • Ingår i: Angle orthodontist. - : Angle Orthodontist. - 0003-3219 .- 1945-7103. ; 77:4, s. 729-734
  • Forskningsöversikt (övrigt vetenskapligt/konstnärligt)abstract
    • OBJECTIVE: To answer the question whether orthognathic surgery does affect the prevalence of signs and symptoms of temporomandibular disorders (TMDs). MATERIALS AND METHODS: A literature survey in the PubMed and Cochrane Library electronic databases was performed and covered the period from January 1966 to April 2006. The inclusion criteria were controlled, prospective or retrospective studies comparing TMDs before and after orthognathic surgery in patients with malocclusion. There were no language restrictions, and three reviewers selected and extracted the data independently. The quality of the retrieved articles was evaluated by four reviewers. RESULTS: The search strategy resulted in 467 articles, of which 3 met the inclusion criteria. Because of few studies with unambiguous results and heterogeneity in study design, the scientific evidence was insufficient to evaluate the effects that orthognathic surgery had on TMD. Moreover, the studies had problems with inadequate selection description, confounding factors, and lack of method error analysis. CONCLUSION: To obtain reliable scientific evidence, additional well-controlled and well-designed studies are needed to determine how and if orthognathic surgery alters signs and symptoms of TMD.
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19.
  • Abrahamsson, Cecilia, et al. (författare)
  • Masticatory function in patients with dentofacial deformities before and after orthognathic treatment : a prospective, longitudinal, and controlled study
  • 2015
  • Ingår i: European Journal of Orthodontics. - : Oxford University Press. - 0141-5387 .- 1460-2210. ; 37:1, s. 67-72
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVES: The aim of this study was to investigate the self-estimated masticatory ability and masticatory performance in patients with dentofacial deformities before and after orthognathic treatment; in comparison to an age- and gender-matched control group. SUBJECTS AND METHODS: The masticatory ability and masticatory performance were evaluated in 121 consecutive patients (treatment group), referred for orthognathic treatment. Eighteen months after treatment, 98 patients (81%) completed a follow-up examination. Masticatory ability was assessed on a visual analog scale, while the masticatory performance was evaluated by a masticatory test using round silicon tablets. Signs and symptoms of temporomandibular disorders (TMD) were registered by a clinical examination and a questionnaire. The control group comprised 56 age- and gender-matched subjects who were examined at baseline. RESULTS: At the baseline examination, the treatment group had a significantly lower masticatory ability and performance compared with the control group. After treatment, the masticatory ability significantly improved in the treatment group and reached the same level as in the control group. The masticatory performance index increased significantly but was still lower than in the control group. Both the masticatory ability and masticatory performance were affected by the number of occlusal contacts during maximal biting pressure and by the self-estimated overall symptoms of TMD. CONCLUSIONS: Patients with dentofacial deformities, corrected by orthognathic treatment, have a significant positive treatment outcome in respect of masticatory ability and masticatory performance. Furthermore, the occlusion and symptoms of TMD have an impact on both masticatory ability and masticatory performance.
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20.
  • Abrahamsson, Cecilia, et al. (författare)
  • TMD before and after correction of dentofacial deformities by orthodontic and orthognathic treatment
  • 2013
  • Ingår i: International Journal of Oral and Maxillofacial Surgery. - : Elsevier. - 0901-5027 .- 1399-0020. ; 46:6, s. 752-758
  • Tidskriftsartikel (refereegranskat)abstract
    • Abstract The aims of the study were to investigate the alteration of temporomandibular disorders (TMD) after correction of dentofacial deformities by orthodontic treatment in conjunction with orthognathic surgery; and to compare the frequency of TMD in patients with dentofacial deformities with an age and gender matched control group. TMD were evaluated in 121 consecutive patients (treatment group), referred for orthognathic surgery, by a questionnaire and a clinical examination. 18 months after treatment, 81% of the patients completed a follow-up examination. The control group comprised 56 age and gender matched subjects, of whom 68% presented for follow-up examination. TMD were diagnosed according to research diagnostic criteria for TMD. At baseline examination, the treatment group had a higher frequency of myofascial pain (P=.035) and arthralgia (P=.040) than the control group. At follow-up, the frequencies of myofascial pain, arthralgia and disc displacement had decreased in the treatment group (P=.050, P=.004, P=.041, respectively). The frequency of TMD was comparable in the two groups at follow-up. Patients with dentofacial deformities, corrected by orthodontic treatment in conjunction with orthognathic surgery, seem to have a positive treatment outcome in respect of TMD pain
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21.
  • Abrahamsson, Cecilia, et al. (författare)
  • TMD in consecutive patients referred for orthognathic surgery
  • 2009
  • Ingår i: Angle orthodontist. - : The Angle Orthodontist (EH Angle Education & Research Foundation). - 0003-3219 .- 1945-7103. ; 33:4, s. 201-226
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVE: To answer the question whether temporomandibular disorders (TMD) were more common in a group of individuals referred for orthognathic surgery than in a control group. The null hypothesis was that neither the frequency of signs and symptoms of TMD or diagnosed TMD would differ between the patient group and a control group. MATERIALS AND METHODS: A sample of 121 consecutive patients referred for orthognathic surgery at the Department of Oral Maxillofacial Surgery, Malmö University Hospital, Sweden, was interviewed and examined regarding signs and symptoms of TMD and headaches. A control group was formed by 56 age- and gender-matched individuals attending the Department of Oral Diagnosis, Faculty of Odontology, Malmö University, Sweden, and Public Dental Health Clinic in Oxie, County of Skane, Sweden. TMD diagnoses were used according to Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD). RESULTS: The patient group showed more myofascial pain without limited opening, disc displacement with reduction, and arthralgia according to RDC/TMD than the control group. The patient group also had more symptoms and signs of TMD in general. CONCLUSIONS: The null hypothesis was rejected because patients who were to be treated with orthognathic surgery had more signs and symptoms of TMD and higher frequency of diagnosed TMD compared with the matched control group.
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22.
  • Afshari, A, et al. (författare)
  • Characterization of indoor sources of fine and ultrafine particles: a study conducted in a full scale chamber
  • 2005
  • Ingår i: Indoor Air. - : Hindawi Limited. - 1600-0668 .- 0905-6947. ; 15:2, s. 141-150
  • Tidskriftsartikel (refereegranskat)abstract
    • Humans and their activities are known to generate considerable amounts of particulate matter indoors. Some of the activities are cooking, smoking and cleaning. In this study 13 different particle sources were for the first time examined in a 32 m3 full-scale chamber with an air change rate of 1.7 ± 0.1/h. Two different instruments, a condensation particle counter (CPC) and an optical particle counter (OPC) were used to quantitatively determine ultrafine and fine particle emissions, respectively. The CPC measures particles from 0.02 μm to larger than 1.0 μm. The OPC was adjusted to measure particle concentrations in eight fractions between 0.3 and 1.0 μm. The sources were cigarette side-stream smoke, pure wax candles, scented candles, a vacuum cleaner, an air-freshener spray, a flat iron (with and without steam) on a cotton sheet, electric radiators, an electric stove, a gas stove, and frying meat. The cigarette burning, frying meat, air freshener spray and gas stove showed a particle size distribution that changed over time towards larger particles. In most of the experiments the maximum concentration was reached within a few minutes. Typically, the increase of the particle concentration immediately after activation of the source was more rapid than the decay of the concentration observed after deactivation of the source. The highest observed concentration of ultrafine particles was approximately 241,000 particles/cm 3 and originated from the combustion of pure wax candles. The weakest generation of ultrafine particles (1.17 × 107 particles per second) was observed when ironing without steam on a cotton sheet, which resulted in a concentration of 550 particles/cm3 in the chamber air. The highest generation rate (1.47 × 1010 particles per second) was observed in the radiator test.
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23.
  • Afshari, Alireza, 1956, et al. (författare)
  • Impact of Ventilation Rate, Ozone and Limonene on Perceived Air Quality in Offices
  • 2002
  • Ingår i: Proceedings of the Indoor Air 2002 Conference.
  • Konferensbidrag (refereegranskat)abstract
    • The objective of this study has been to clarify to what extent ozone (03) and 03 !limonene in interaction with surface materials has an impact on the indoor air quality in typical low-polluting offices at various, realistic air change rates. Changes of environmental conditions were performed seven days before the chemical sampling. Organic compounds were collected on Tenax TA adsorbent tubes and the samples were analysed by gas chromatography with flame ionisation and mass selective detectors. The concentration of Total Volatile Organic Compounds were asexpected found to be inversely proportional to air change rates. Aldehydes and organic acids werefound at increased levels when the air change rate was decreased from 1.0 h1 to 0.3 h1. Increased ventilation rate to 3.0 h1 did not induce additional changes in the chemical composition of aldehydes and organic acids. The fractions of aldehydes and organic acids relative to nonreactive alkanes indicated that chemical transformation in the indoor environment indeed took place; however, it could not be clearly specified whether the chemical changes were of homogeneous or heterogeneous character. The effects of 03 and 03 /limonene in interaction with surface materials in the offices over seven weeks showed different reaction pattems depending material and treatment.
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24.
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25.
  • Afshari, Alireza, 1956, et al. (författare)
  • Naborøg og overførsel af partielforurening
  • 2010
  • Ingår i: HVAC - Magasin for klima- og energiteknik, miljø, bygningsinstalltioner & -Netværk. ; 1:2010, s. 24-30
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
  •  
26.
  • Afshari, Alireza, 1956, et al. (författare)
  • Quantification of ultrafine particles from second-hand tobacco smoke infiltration
  • 2010
  • Ingår i: Proceedings of the CLIMA 2010 Conference: 10th REHVA World Congress 'Sustainable Energy use in Buildings', 8 pages.
  • Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
    • This paper presents some of the results of a second-hand tobacco smoke intervention studycarried out in 19 flats in four different buildings. Two of the investigated buildings were nonrenovatedand two others were renovated. The aim of the study was to quantify infiltration ofultrafine particles from a smoker's flat into a non-smoker's flat. In addition, several tests werecarried out to describe some solutions for reduction of particle concentrations in the smoker'sflat and the non-smoker's flat. The air change rates and the indoor particle concentrationswere measured continuously during the measuring periods. The particle sources (particlegenerating activities) were cigarette-burning in the un-occupied buildings and candle-burningin the occupied buildings. Reductions of the concentration of ultrafine particles using aircleaning devices were studied. Results showed that the transfer of ultrafine particles wasabout 9% when the source flat was located below the receiving flat, whereas the transfer was1-2% when the source flat was on the same floor as, or above, the receiving flat.
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27.
  • Angbratt, Marianne, et al. (författare)
  • Prediction of obesity from infancy to adolescence
  • 2011
  • Ingår i: Acta Paediatrica. - : Wiley-Blackwell. - 0803-5253 .- 1651-2227. ; 100:9, s. 1249-1252
  • Tidskriftsartikel (refereegranskat)abstract
    • Aim: To examine the development of childhood obesity and to determine the earliest age when estimating body mass using only weight and height data is associated with a corresponding estimate at the age of 15. less thanbrgreater than less thanbrgreater thanMethods: Subjects included are all children born in 1991 in Ostergotland County, Sweden. Weight and height data collected during regular check-ups at well-child centres and school health care assessments up to 15 years of age were assembled from health records. Correlations between childhood estimates of body mass and the body mass index (BMI) at 15 years of age were computed pairwise. Correlations with r andgt; 0.5 were defined as reliably strong. less thanbrgreater than less thanbrgreater thanResults: Complete data were available for 3579 children (62%). Fewer girls (2.6%; C.I. 1.9-3.3) than boys (4.6%; C.I. 3.7-5.5) were obese at 15 years of age. Correlations with BMI at 15 years of age were strong (significantly higher than 0.5) from 5 years of age. Only 23% of girls and 8% of boys found to be obese at 5 years of age were of normal weight at the age of 15. less thanbrgreater than less thanbrgreater thanConclusion: From 5 years of age, point estimates of body mass using only weight and height data are strongly associated with BMI at the age of 15. More data sources are needed to predict weight trajectories in younger children.
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28.
  • Anund Vogel, Jonas, et al. (författare)
  • Buildings post corona
  • 2023
  • Ingår i: The REHVA European HVAC Journal. - 1307-3729. ; 59:2, s. 19-21
  • Tidskriftsartikel (populärvet., debatt m.m.)abstract
    • Buildings Post Corona is a Swedish collaborative research project between Chalmers, KTH Royal Institute of Technology, Lund, and Umeå Universities. The project supports the building sector in designing and maintaining sustainable buildings with a healthy and good indoor environment. The COVID-19 crisis has stressed the importance and urge of this research.The scope of the project is to develop a methodology for the operation and design of buildings with an indoor environment that meets future health and climate challenges. The project’s overall goal is to establish an interdisciplinary platform to document existing experiences and knowledge and to gain new knowledge required for good building design and operation.
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29.
  • Anund Vogel, Jonas, et al. (författare)
  • Enbart avstånd och handhygien räcker inte
  • 2023
  • Ingår i: Fastighetstidningen. - 0348-5552.
  • Tidskriftsartikel (populärvet., debatt m.m.)abstract
    • I denna debattartikel lyfter sex forskare frågan att myndigheter och branschorganisationer delvis gav olika råd kring åtgärder för att begränsa risken för smittspridning inomhus. För att klara nästa pandemi krävs bättre samordning av riktlinjer kring ventilation och luftkvalitet.
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30.
  • Axelsson, Lars, et al. (författare)
  • Swedish National Multicenter Study on Head and Neck Cancer of Unknown Primary: Prognostic Factors and Impact of Treatment on Survival
  • 2021
  • Ingår i: International Archives of Otorhinolaryngology. - : Georg Thieme Verlag KG. - 1809-9777 .- 1809-4864. ; 25:3
  • Tidskriftsartikel (refereegranskat)abstract
    • Introduction Head and neck cancer of unknown primary (HNCUP) is a rare condition whose prognostic factors that are significant for survival vary between studies. No randomized treatment study has been performed thus far, and the optimal treatment is not established. Objective The present study aimed to explore various prognostic factors and compare the two main treatments for HNCUP: neck dissection and (chemo) radiation vs primary (chemo) radiation. Methods A national multicenter study was performed with data from the Swedish Head and Neck Cancer Register (SweHNCR) and from the patients' medical records from 2008 to 2012. Results Two-hundred and sixty HNCUP patients were included. The tumors were HPVpositive in 80%. The overall 5-year survival rate of patients treated with curative intent was 71%. Age (p < 0.001), performance status (p = 0.036), and N stage (p = 0.046) were significant factors for overall survival according to the multivariable analysis. Treatment with neck dissection and (chemo) radiation (122 patients) gave an overall 5-year survival of 73%, and treatment with primary (chemo) radiation (87 patients) gave an overall 5-year survival of 71%, with no significant difference in overall or disease-free survival between the 2 groups. Conclusions Age, performance status, and N stage were significant prognostic factors. Treatment with neck dissection and ( chemo) radiation and primary (chemo)
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31.
  • Baker, Z., et al. (författare)
  • Questionable effect of lavage for treatment of painful jaw movements at disc displacement without reduction : a 3-year randomised controlled follow-up
  • 2015
  • Ingår i: Journal of Oral Rehabilitation. - : John Wiley & Sons. - 1365-2842 .- 0305-182X. ; 42:10, s. 742-750
  • Tidskriftsartikel (refereegranskat)abstract
    • The present randomised controlled study compared the 3-year outcome of local anaesthetics with anaesthetics and lavage in patients suffering from painful temporomandibular joint (TMJ) locking. The study included 45 patients referred for treatment of temporomandibular disorders (TMD) to the Department of Orofacial Pain and Jaw Function, Faculty of Odontology, Malmo University, Malmo, Sweden. All patients received a history questionnaire and clinical examination according to the Research Diagnostic Criteria for TMD, panoramic radiographs and magnetic resonance imaging at baseline. Twenty-five patients were randomised to anaesthetics alone and 20 patients to anaesthetics and lavage. Three years after treatment, we sent the 37 patients who were available for follow-up a questionnaire that evaluated pain intensity, physical and emotional functioning, and global improvement. Thirty-four patients responded. The primary outcome was defined as >= 30% pain relief. In an intention-to-treat analysis, 28 of 45 patients (62%) reported >= 30% pain relief at the follow-up. At 3 years, improvement in pain relief, physical functioning, emotional functioning and global improvement differed non-significantly between local anaesthetics and anaesthetics and lavage. Compared with baseline, significant improvements (P < 0.05) in pain intensity, physical functioning, emotional functioning and global changes had occurred in both groups after 3 years. Because outcome measurements in the local anaesthetics and lavage and the local anaesthetics groups differed non-significantly 3 years after treatment of painful TMJ disc displacement without reduction, use of lavage (50 mL saline) has an equivalent effect as local anaesthetics.
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32.
  • Baumann, Pia, et al. (författare)
  • Factors important for efficacy of stereotactic body radiotherapy of medically inoperable stage I lung cancer. A retrospective analysis of patients treated in the Nordic countries.
  • 2006
  • Ingår i: Acta oncologica (Stockholm, Sweden). - : Informa UK Limited. - 0284-186X .- 1651-226X. ; 45:7, s. 787-95
  • Tidskriftsartikel (refereegranskat)abstract
    • We reviewed results of SBRT treatment of 138 patients with medically inoperable stage I NSCLC treated during 1996-2003 at five different centres in Sweden and Denmark. Mean age was 74 years (range 56-90) with 69 men and 72 women. SBRT was delivered using a 3D conformal multifield technique and a stereotactic body frame. Doses delivered were 30-48 Gy (65% isodose at the periphery of planning target volume, PTV) in 2-4 fractions. Equivalent dose in 2 Gy fractions (EQD2) was in the range of 50-100 Gy. Mean gross tumour volume (GTV) was 39 cm3 (2-436), and planning target volume was 101 cm3 (11-719). Overall response rate (CR, PR) was 61% (84/138). SD was noted in 36% (50/138). During a median follow-up period of 33 months (1-107), 16 (12%) local failures occurred, ten of which also included distant metastases. Local failure was associated with tumour size, target definition and central or pleura proximity. Distant metastases occurred in 25% (35/138) of the patients. Ninety-one (65%) patients died during follow-up of which 55 patients (60%) died of other causes than lung cancer. Three- and 5-year overall survival was 52 and 26% respectively. Lung cancer specific 3- and 5-year overall survival was 66 and 40% respectively. Fifty nine percent (83/138) of the patients had no side effects. Fourteen patients experienced grade 3-4 toxicity according to radiation therapy oncology group (RTOG). EQD2 (> v.s.<55.6 Gy) showed a statistically significant benefit survival for the higher doses. SBRT for stage I NSCLC results in favourable local control not inferior to fractionated RT and with acceptable toxicity.
  •  
33.
  • Baumann, Pia, et al. (författare)
  • Outcome in a prospective phase II trial of medically inoperable stage I non-small-cell lung cancer patients treated with stereotactic body radiotherapy.
  • 2009
  • Ingår i: Journal of clinical oncology : official journal of the American Society of Clinical Oncology. - 1527-7755 .- 0732-183X. ; 27:20, s. 3290-6
  • Tidskriftsartikel (refereegranskat)abstract
    • PURPOSE: The impact of stereotactic body radiotherapy (SBRT) on 3-year progression-free survival of medically inoperable patients with stage I non-small-cell lung cancer (NSCLC) was analyzed in a prospective phase II study. PATIENTS AND METHODS: Fifty-seven patients with T1NOMO (70%) and T2N0M0 (30%) were included between August 2003 and September 2005 at seven different centers in Sweden, Norway, and Denmark and observed up to 36 months. SBRT was delivered with 15 Gy times three at the 67% isodose of the planning target volume. RESULTS: Progression-free survival at 3 years was 52%. Overall- and cancer-specific survival at 1, 2, and 3 years was 86%, 65%, 60%, and 93%, 88%, 88%, respectively. There was no statistically significant difference in survival between patients with T1 or T2 tumors. At a median follow-up of 35 months (range, 4 to 47 months), 27 patients (47%) were deceased, seven as a result of lung cancer and 20 as a result of concurrent disease. Kaplan-Meier estimated local control at 3 years was 92%. Local relapse was observed in four patients (7%). Regional relapse was observed in three patients (5%). Nine patients (16%) developed distant metastases. The estimated risk of all failure (local, regional, or distant metastases) was increased in patients with T2 (41%) compared with those with T1 (18%) tumors (P = .027). CONCLUSION: With a 3-year local tumor control rate higher than 90% with limited toxicity, SBRT emerges as state-of-the-art treatment for medically inoperable stage I NSCLC and may even challenge surgery in operable instances.
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34.
  • Baumann, Pia, et al. (författare)
  • Stereotactic body radiotherapy for medically inoperable patients with stage I non-small cell lung cancer - a first report of toxicity related to COPD/CVD in a non-randomized prospective phase II study.
  • 2008
  • Ingår i: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. - : Elsevier BV. - 0167-8140 .- 1879-0887. ; 88:3, s. 359-67
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND AND AIMS: In a retrospective study using stereotactic body radiotherapy (SBRT) in medically inoperable patients with stage I NSCLC we previously reported a local control rate of 88% utilizing a median dose of 15Gyx3. This report records the toxicity encountered in a prospective phase II trial, and its relation to coexisting chronic obstructive pulmonary disease (COPD) and cardio vascular disease (CVD). MATERIAL AND METHODS: Sixty patients were entered in the study between August 2003 and September 2005. Fifty-seven patients (T1 65%, T2 35%) with a median age of 75 years (59-87 years) were evaluable. The baseline mean FEV1% was 64% and median Karnofsky index was 80. A total dose of 45Gy was delivered in three fractions at the 67% isodose of the PTV. Clinical, pulmonary and radiological evaluations were made at 6 weeks, 3, 6, 9, 12, 18, and 36 months post-SBRT. Toxicity was graded according to CTC v2.0 and performance status was graded according to the Karnofsky scale. RESULTS: At a median follow-up of 23 months, 2 patients had relapsed locally. No grade 4 or 5 toxicity was reported. Grade 3 toxicity was seen in 12 patients (21%). There was no significant decline of FEV1% during follow-up. Low grade pneumonitis developed to the same extent in the CVD 3/17 (18%) and COPD 7/40 (18%) groups. The incidence of fibrosis was 9/17 (53%) and pleural effusions was 8/17 (47%) in the CVD group compared with 13/40 (33%) and 5/40 (13%) in the COPD group. CONCLUSION: SBRT for stage I NSCLC patients who are medically inoperable because of COPD and CVD results in a favourable local control rate with a low incidence of grade 3 and no grade 4 or 5 toxicity.
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35.
  • Bengtsson, Henrik, et al. (författare)
  • A population based screening of abdominal aortic aneurysms (AAA)
  • 1991
  • Ingår i: European Journal of Vascular Surgery. - 0950-821X. ; 5:1, s. 53-57
  • Tidskriftsartikel (refereegranskat)abstract
    • The prevalence of abdominal aortic aneurysm (AAA) in a defined population of elderly men and its correlation to some risk factors were studied in the population cohort "men born in 1914 from Malmo". A total of 499 were invited to attend and 375 (75%) did so. The aorta could be visualised with ultrasound in 364 patients, 39 (10.7%) of whom had aneurysmal changes. The presence of an AAA was related to the findings at a general health examination undertaken 5 years previously. Tobacco and alcohol consumption, impaired lung function and a history of angina pectoris were related to the presence of an AAA. No relationship was found between an AAA and hypertension, hyperlipidaemia or hyperglycaemia. A decreased tissue elasticity as a common denominator for the lung function impairment and development of AAA is discussed.
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36.
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37.
  • Bernfort, Lars, et al. (författare)
  • Supervisor ratings of productivity loss associated with presenteeism and sick leave due to musculoskeletal disorders and common mental disorders in Sweden
  • 2021
  • Ingår i: Work. - : IOS PRESS. - 1051-9815 .- 1875-9270. ; 68:4, s. 1091-1100
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: Health problems due to musculoskeletal disorders (MSD) and common mental disorders (CMD) result in costs due to lost productivity. OBJECTIVE: This study aimed to increase knowledge of employers productivity loss due to employees presenteeism and sickness absence. METHODS: A web questionnaire was sent to employers of workers who were sick-listed for more than 30 days due to MSD or CMD, response rate: 50%, n = 198. Presenteeism and the impact on productivity before and after sick leave, and the performance of work tasks by replacement workers during sick leave, were measured using supervisors ratings. RESULTS: The average loss of productivity per sick-leave case amounted to almost 10 weeks, 53% of productivity loss was attributable to presenteeism and 47% to lower productivity by replacement workers. Employees with a CMD diagnosis had significantly higher presenteeism-related productivity loss than those with MSD. CONCLUSIONS: Employers experienced substantial productivity loss associated with employees presenteeism and sick leave. Whether the supervisory rating of presenteeism is preferable to employee self-rating needs to be studied further. The long duration of presenteeism is counter-productive to resource-efficient organisations and indicates the need for improved supervisory skills to identify workers with poor health, both before and after sick leave.
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38.
  • Brännström, Mats, 1958, et al. (författare)
  • Livebirth after uterus transplantation.
  • 2015
  • Ingår i: Lancet. - 1474-547X. ; 385:9968, s. 607-616
  • Tidskriftsartikel (refereegranskat)abstract
    • Uterus transplantation is the first available treatment for absolute uterine infertility, which is caused by absence of the uterus or the presence of a non-functional uterus. Eleven human uterus transplantation attempts have been done worldwide but no livebirth has yet been reported.
  •  
39.
  • Cabovska, Blanka, 1990, et al. (författare)
  • A study on the relationship between energy performance and IEQ parameters in school buildings
  • 2021
  • Ingår i: E3S Web of Conferences. - : EDP Sciences. - 2555-0403 .- 2267-1242. ; 246
  • Konferensbidrag (refereegranskat)abstract
    • Over the last decades, strong focus has been placed on the energy efficiency of buildings; not least school buildings. Energy performance (EP) of buildings is nowadays in principle described by one single indicator based on purchased energy in kWh/year.m2. Another important building performance aspect is the indoor environmental quality. This study's overarching goal is to identify school buildings with a good balance between energy performance and indoor environment. Thus, this paper investigates possible correlations between information given in energy performance certificates (EPCs/e.g. energy use, year of construction, type of ventilation) and measured indoor environmental parameters. The work comprises investigation of approximately 20 school buildings with different ventilation systems in Gothenburg. In-situ investigations of the buildings' properties and ventilation systems were conducted. Indoor environmental parameters were recorded during one week in each classroom. In this paper, indoor temperature, absolute humidity added indoors and CO2 concentration data are compared with the corresponding school's energy performance data and ventilation type. Results suggest that mechanically ventilated buildings have clearer relationships between energy performance, building indicators and measured indoor environment. For buildings such as naturally ventilated, the relationships are usually weak, and the values spread over much wider ranges.
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40.
  • Cabovska, Blanka, 1990, et al. (författare)
  • Measured and perceived IEQ under different ventilation strategies in Swedish classrooms
  • 2022
  • Ingår i: 17th International Conference on Indoor Air Quality and Climate, INDOOR AIR 2022.
  • Konferensbidrag (refereegranskat)abstract
    • Indoor environmental quality was assessed in Swedish primary school classrooms grouped into three categories based on the ventilation system: 1) natural or exhaust ventilation, 2) balanced mechanical ventilation systems with constant air volume (CAV), 3) balanced mechanical ventilation systems with variable air volume (VAV). Measurements of NO2, ozone, TVOC, formaldehyde, PM10, and PM2.5 and a questionnaire survey were conducted. The concentrations of pollutants were integrated into Indoor Air Pollution Index allowing the rank comparison of classrooms. Children’s perception scores were calculated based on the questionnaire responses. Naturally ventilated classrooms had higher level of air pollution. No significant differences in pollutant levels were observed between classrooms with CAV and VAV systems. The type of ventilation system affected the subjective assessment of indoor air quality; it was worst in naturally ventilated classrooms.
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41.
  • Cabovska, Blanka, 1990, et al. (författare)
  • Ventilation strategies and indoor air quality in Swedish primary school classrooms
  • 2022
  • Ingår i: Building and Environment. - Göteborg : IVL Svenska Miljöinstitutet AB. - 0360-1323 .- 1873-684X. ; 226, s. 109744-109744
  • Tidskriftsartikel (refereegranskat)abstract
    • The present study aimed at investigating the effects of ventilation strategies on indoor air quality (IAQ) in schools. Measurements of thermal environment and IAQ were performed over 5 school days in 45 primary school classrooms in Gothenburg, Sweden, grouped into three categories according to their ventilation system: category A) natural or exhaust ventilation, or automated window opening; category B) balanced mechanical ventilationsystems with constant air volume (CAV) and category C) balanced mechanical ventilation systems with variable air volume (VAV). The classrooms performed equally well with respect to temperature and relative humidity regardless of the ventilation system. The concentrations of the air pollutants in all classrooms were generally below the respective guideline values. The concentrations of CO2, formaldehyde, PM10, and PM2.5 were lower in the B and C category classrooms with higher ventilation rates than in the A category classrooms. Indoor Air Pollution Index integrating concentrations of multiple pollutants was significantly higher the A category classrooms, reflecting poorer IAQ. Majority of the classrooms had lower ventilation rates than the Swedish ventilation requirements. The periodically reduced ventilation rates in the classrooms with VAV systems did not lead to substantial increase in the measured indoor pollutant concentrations.
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42.
  • Cedborg, Anna I. Hardemark, et al. (författare)
  • Co-ordination of spontaneous swallowing with respiratory airflow and diaphragmatic and abdominal muscle activity in healthy adult humans
  • 2009
  • Ingår i: Experimental Physiology. - : Wiley. - 1469-445X .- 0958-0670. ; 94:4, s. 459-468
  • Tidskriftsartikel (refereegranskat)abstract
    • Co-ordination of breathing and swallowing is essential for normal pharyngeal function and to protect the airway. To allow for safe passage of a bolus through the pharynx, respiration is interrupted (swallowing apnoea); however, the control of airflow and diaphragmatic activity during swallowing and swallowing apnoea are not fully understood. Here, we validated a new airflow discriminator for detection of respiratory airflow and used it together with diaphragmatic and abdominal electromyography (EMG), spirometry and pharyngeal and oesophageal manometry. Co-ordination of breathing and spontaneous swallowing was examined in six healthy volunteers at rest, during hypercapnia and when breathing at 30 breaths min(-1). The airflow discriminator proved highly reliable and enabled us to determine timing of respiratory airflow unambiguously in relation to pharyngeal and diaphragmatic activity. During swallowing apnoea, the passive expiration of the diaphragm was interrupted by static activity, i.e. an 'active breath holding', which preserved respiratory volume for expiration after swallowing. Abdominal EMG increased throughout pre- and post-swallowing expiration, more so during hyper- than normocapnia, possibly to assist expiratory airflow. In these six volunteers, swallowing was always preceded by expiration, and 93 and 85% of swallows were also followed by expiration in normo- and hypercapnia, respectively, indicating that, in man, swallowing during the expiratory phase of breathing may be even more predominant than previously believed. This co-ordinated pattern of breathing and swallowing potentially reduces the risk for aspiration. Insights from these measurements in healthy volunteers and the airflow discriminator will be used for future studies on airway protection and effects of disease, drugs and ageing.
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43.
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44.
  • Cedborg, Anna I Hårdemark, et al. (författare)
  • Pharyngeal Function and Breathing Pattern during Partial Neuromuscular Block in the Elderly: Effects on Airway Protection.
  • 2014
  • Ingår i: Anesthesiology. - 1528-1175. ; 120:2, s. 312-325
  • Tidskriftsartikel (refereegranskat)abstract
    • Intact pharyngeal function and coordination of breathing and swallowing are essential for airway protection and to avoid respiratory complications. Postoperative pulmonary complications caused by residual effects of neuromuscular-blocking agents occur more frequently in the elderly. Moreover, elderly have altered pharyngeal function which is associated with increased risk of aspiration. The purpose of this study was to evaluate effects of partial neuromuscular block on pharyngeal function, coordination of breathing and swallowing, and airway protection in individuals older than 65 yr.
  •  
45.
  • Christiansen, Lars Breum, et al. (författare)
  • A comparative analysis of movement and physical activity in early childhood teacher education policy in five Nordic countries
  • 2024
  • Ingår i: Frontiers in sports and active living. - : Frontiers Media S.A.. - 2624-9367. ; 6
  • Tidskriftsartikel (refereegranskat)abstract
    • Introduction : The aim of this study is to investigate the integration of movement and physical activity (MoPA) within Early Childhood Teacher Education (ECTE) policies across Denmark, Finland, Iceland, Norway, and Sweden. This knowledge can inform the development of ECTE policies and practices that promote MoPA in Early Childhood Education and Care (ECEC) in Nordic countries and other countries worldwide.  Methods : In this study, a Nordic cross-national network of researchers collaborated in investigating policy documents at the national and university levels, which govern the education of ECEC teachers. This study was inspired by the Non-affirmative Theory of Education, which provides a framework for understanding the various influences on curricular development in higher education. Based on this, a four-step comparative analytical process of national and university documents across the Nordic countries was conducted. It included keyword search for MoPA related courses and a qualitative description of MoPA in ECTE. Thus, a combination of investigations of policy documents at the national and university level and expert knowledge set a solid foundation for international comparison.  Results : The comparative analysis of MoPA in ECTE reveals diverse approaches influenced by national and university policies. A central theme is the variability in MoPA integration across these nations. Finland and Norway prioritize MoPA with independent mandatory courses. In Iceland, compulsory MoPA courses exist at one of two universities, and in Sweden at three out of 19. All university colleges in Denmark offer an elective course. Furthermore, learning objectives related to MoPA are, to varying degrees, part of the internships in the countries, with Sweden being an exception. In the participating countries, the teachers decide the content of the MoPA courses with little guidance, support, and agreement on essential MoPA content within and across the ECTE's. Norway has established guidelines, and in Finland, there is a network of ECTE Physical Education (PE) educators, which, to some degree, increases the consistency and quality of MoPA in education.  Discussion : The Nordic countries present diverse MoPA integration approaches rooted in national policies and educational traditions. The findings emphasize the necessity of independent and mandatory MoPA courses, integration of MoPA into internships and promoting networks across the educational and academic sectors to equip future early childhood educators with competencies for fostering physical activity, motor development and children's well-being.
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46.
  • Daemi, Bita, et al. (författare)
  • Advanced image analysis verifies geometry performance of micro-milling systems
  • 2017
  • Ingår i: Applied Optics. - : OPTICAL SOC AMER. - 1559-128X .- 2155-3165. ; 56:10, s. 2912-2921
  • Tidskriftsartikel (refereegranskat)abstract
    • Accurate dimensional measurement of micro-milled items is a challenge and machine specifications do not include operational parameters in the workshop. Therefore, a verification test that shows the machine's overall geometrical performance over its working area would help machine users in the assessment and adjustment of their equipment. In this study, we present an optical technique capable of finding micro-milled features at submicron uncertainty over working areas > 10 cm(2). The technique relies on an ultra-precision measurement microscope combined with advanced image analysis to get the center of gravity of milled cross-shaped features at subpixel levels. Special algorithms had to be developed to handle the disturbing influence of burr and milling marks. The results show repeatability, reproducibility, and axis straightness for three micro-milling facilities and also discovered an unknown 2 mu m amplitude undulation in one of them.
  •  
47.
  • Daemi, Bita, 1982- (författare)
  • Enhanced image analysis, a tool for precision metrology in the micro and macro world
  • 2017
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • The need for high speed and cost efficient inspection in manufacturing lineshas led to a vast usage of camera-based vision systems. The performance ofthese systems is sufficient to determine shape and size, but hardly to an accuracylevel comparable with traditional metrology tools. To achieve highprecision shape/position/defect measurements, the camera techniques haveto be combined with high performance image metrology techniques whichare developed and adapted to the manufactured components. The focus ofthis thesis is the application of enhanced image analysis as a tool for highprecision metrology. Dedicated algorithms have been developed, tested andevaluated in three practical cases ranging from micro manufacturing at submicronprecision to meter sized aerospace components with precision requirementsin the 10 μm range.The latter measurement challenge was solved by low cost standard consumerproducts, i.e. digital cameras in a stereo configuration and structured lightfrom a gobo-projector. Combined with high-precision image analysis and anew approach in camera calibration and 3D reconstruction for precise 3Dshape measurement of meter sized surfaces, the achievement was fulfilledand verified by two conventional measurement systems; a high precisioncoordinate measurement machine and a laser scanner.The sub-micron challenge was the implementation of image metrology forverification of micro manufacturing installations within a joint Europeaninfrastructure network, EUMINAfab. The results were an unpleasant surprisefor some of the participating laboratories, but became a big step forwardto improve the dimensional accuracy of the investigated laser micromachining, micro milling and micro-printing systems, since the accuracy ofthese techniques are very difficult to assess.The third high precision metrology challenge was the measurement of longrange,low-amplitude topographic structures on specular (shiny) aerodynamicsurfaces. In this case Fringe Reflection Technique (FRT) was appliedand image analysis algorithms were used to evaluate the fringe deformationas a measure of the surface slopes to obtain high resolution data. The resultwas compared with an interferometric analysis showing height deviation inthe range of tens of micrometers over a lateral extension of several cm.
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48.
  • Daemi, Bita, 1982-, et al. (författare)
  • Lateral performance evaluation of laser micromachining by highprecision optical metrology and image analysis
  • 2017
  • Ingår i: Precision engineering. - : Elsevier. - 0141-6359 .- 1873-2372.
  • Tidskriftsartikel (refereegranskat)abstract
    • Today several techniques are available for micro-manufacturing. Yet, it is difficult to assess the precisionand lateral X,Y accuracy of these techniques. The available accuracy information is usually based on spec-ifications given by machine suppliers. This information is based on in-house laboratory tests performedby dedicated machine operators and within an adapted environment. In practice, the accuracy is likelyto vary due to environmental conditions, materials and operator skills. In order to check the specifica-tions in realistic environments the EUMINAfab infrastructure consortium initiated a set of independenthigh precision onsite verification tests on different laser micromachining installations. In addition toproviding performance verification, it gave the participating partners real capability information of theirequipment and possibilities to improve machining performance to a higher level. In this study a compre-hensive verification test was designed and carried out by using a high precision metrology method for 2Dmeasurements based on subpixel resolution image analysis. This methodology improved our knowledgeof the capabilities of three laser micromachining installations, and showed that specifications at singlemicron levels are hard to obtain.
  •  
49.
  • Daemi, Bita, 1982-, et al. (författare)
  • Performance Evaluation of Micro Milling Installations
  • 2013
  • Ingår i: Proceedings of the 10th International Conference on Multi-Material Micro Manufacture. - Singapore : Research Publishing Services. - 9789810772475 - 9810772475 ; , s. 213-216
  • Konferensbidrag (refereegranskat)abstract
    • Micro manufacturing has developed into many areas over the past decade. Several manufacturing technologies are available but the precision and accuracy of the techniques are still difficult to get access to. Typically the capability information of micro milling equipment is based on specifications given by the machine deliverers. The specified high accuracy is likely to be altered in practice because of environmental conditions and operator skills. So in practice the absolute performances of micro milling/machining equipment may be far off from their listed specifications. When forming the EUMINAfab infrastructure consortium it was decided that independent high precision verification testsshould be made on different installations to help the micro-manufacturers to get the real capability information of their equipment and be able to improve performance to a higher EUMINAfab level. In this study a comprehensive verification test was designed and carried out by using an ultra-precision metrology method for 2D measurements in order to establish more knowledge about the capabilities of micro milling equipment. The measurement results show the machine’s X,Y positioning accuracy, pseudo-repeatability, reproducibility and axis straightness of two different micro milling installations.
  •  
50.
  • Dalenbäck, Jan-Olof, 1954, et al. (författare)
  • Låg luftfuktighet i svenska bostäder – ett problem?
  • 2021
  • Ingår i: Energi & miljö. ; 10
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
    • Låg relativ luftfuktighet inomhus är ett problem i många svenska bostäder under uppvärmningssäsongen, mera i lägenheter än i småhus, i hus byggda efter 1985 och i de norra delarna av landet. Ventilation av nya bostäder blir en allt viktigare faktor med avseende på luftfuktigheten inomhus.
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