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- He, YQ, et al.
(författare)
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A polygenic risk score for nasopharyngeal carcinoma shows potential for risk stratification and personalized screening
- 2022
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 13:1, s. 1966-
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Tidskriftsartikel (refereegranskat)abstract
- Polygenic risk scores (PRS) have the potential to identify individuals at risk of diseases, optimizing treatment, and predicting survival outcomes. Here, we construct and validate a genome-wide association study (GWAS) derived PRS for nasopharyngeal carcinoma (NPC), using a multi-center study of six populations (6 059 NPC cases and 7 582 controls), and evaluate its utility in a nested case-control study. We show that the PRS enables effective identification of NPC high-risk individuals (AUC = 0.65) and improves the risk prediction with the PRS incremental deciles in each population (Ptrend ranging from 2.79 × 10−7 to 4.79 × 10−44). By incorporating the PRS into EBV-serology-based NPC screening, the test’s positive predictive value (PPV) is increased from an average of 4.84% to 8.38% and 11.91% in the top 10% and 5% PRS, respectively. In summary, the GWAS-derived PRS, together with the EBV test, significantly improves NPC risk stratification and informs personalized screening.
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- Jia, ZS, et al.
(författare)
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Acid-catalyzed solvolytic elimination (aromatization) of allylic ethers and alcohols
- 2001
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Ingår i: JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2. - : ROYAL SOC CHEMISTRY. - 1472-779X. ; :3, s. 247-251
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Tidskriftsartikel (refereegranskat)abstract
- Acid-catalyzed solvolysis of 1-methoxy-1-methyl-1,4-dihydronaphthalene (1-OMe) in 50 vol% acetonitrile in water yields exclusively the elimination product 1-methylnaphthalene (3). Neither intramolecular rearrangement giving 2-methoxy-4-methyl-1,2-dihydron
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- Jia, ZS, et al.
(författare)
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Is benzene oxide homoaromatic? A microcalorimetric study
- 2001
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Ingår i: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. - : AMER CHEMICAL SOC. - 0002-7863. ; 123:42, s. 10147-10152
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Tidskriftsartikel (refereegranskat)abstract
- Rate constants and heats of reaction for the aromatization of benzene oxide (1) and the acid-catalyzed aromatization of benzene hydrate (2) in highly aqueous solution (giving phenol and benzene, respectively, have been measured by heat-flow microcalorimet
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