| 1. |
- Moein, M. M., et al.
(författare)
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Nanomaterials for microextraction techniques in bioanalysis
- 2019
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Ingår i: Handbook of Nanomaterials in Analytical Chemistry. - : Elsevier BV. ; , s. 43-56
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- The analysis of biological samples (bioanalysis) always needs intensive sample cleanup (sample preparation) before it gets injected into the analytical instruments. In bioanalysis, sample preparation has an essential role because of the complexity of the biological matrix. Among popular sample preparation techniques, microextraction techniques received high attention because of needs of low volume of used solvent and sample. The sorbent may has high influence on the method selectivity and recovery. Because of their high surface area, ultra-small size, high physical and chemical stability properties, nanomaterials attained huge attention in sample preparation for analytical and bioanalytical trends. In this chapter, the different types and applications of nanomaterials in microextraction analysis and bioanalysis will be summarized and discussed. In addition, recently published papers on the relevance of nanomaterials as sorbents in microextraction for bioanalysis will be presented and the application of nanomaterials for online analysis procedures will be included.
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| 2. |
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| 3. |
- Bassyouni, Fatma, et al.
(författare)
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Synthesis and Antiviral Investigation of New Polynuclear Heterocyclic Compounds Containing Tetrahydroindazole Derivatives
- 2016
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Ingår i: Research Journal of Pharmaceutical, Biological and Chemical Sciences. - 0975-8585. ; 7:6, s. 24-37
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Tidskriftsartikel (refereegranskat)abstract
- The antiviral materials or compounds required for the treatment of viruses cause some infectious diseases such as Coxsackievirus B4 (CVB4), rotavirus Wa strain, and adenovirus type 7 are indispensable and of great necessity. The aim of the present study was to synthesize a new series of substituted indazole derivatives obtained from 2-(4-substituted-benzylidene)-4-phenylcyclohexanones and 2,6-bis (4-substituted-benzylidene)-4-phenylcyclohexanone derivatives. The products formed were reacted with 4-hydrazinylbenzoic acid or 2hydrazino- 6-methylbenzothiazole in the presence of cuprous oxide and Cs2CO3 as catalysts to give rise to a variety of indazole derivatives in a simple experimental procedure in good yields and short reaction time. The new compounds were fully characterized by spectroscopic and analytical methods. The synthesized compounds were evaluated for their antiviral activity against Coxsackievirus B4, adenovirus type 7 and rotavirus Wa strain. The bioassay results showed that the synthesized compounds possessed variable antiviral bioactivity. Compound (3-Fluoro-7-(fluoromethylene)-4,5,6,7-tetrahydro-2-(6-methylbenzo[d] thiazol-2-yl)-5phenyl-2H-indazole (24) exhibited moderate activity against both Coxsackievirus B4 and rotavius Wa strain and potentially promising activity against adenovirus type 7. On the other hand, 3-Chloro-7(chloromethylene)-4,5,6,7-tetrahydro-2-(6-methylbenzo[d] thiazol-2-yl)-5-phenyl-2H-indazole (25) and 7-(2,6-Dimethoxybenzylidene)-4,5,6,7-tetrahydro-3-(2,6-dimethoxyphenyl)-2-(6-methylbenzo[d]thiazol-2-yl)-5phenyl-2H-indazole (26) revealed potential promising activity against adenovirus type 7, while compounds 25 and 26 revealed promising activities against rotavirus Wa strain.
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| 4. |
- Moein, Mohammad M., et al.
(författare)
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Molecularly imprinted polymers for on-line extraction techniques
- 2015
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Ingår i: Bioanalysis. - : Future Science Ltd. - 1757-6180 .- 1757-6199. ; 7:17, s. 2145-2153
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Tidskriftsartikel (refereegranskat)abstract
- Recent years have seen an increasing interest in the use of molecularly imprinted polymers (MIPs) as a sorbent for different extraction methods and this is due to its high selectivity. The MIP is designed to show specificity for the analyte of interest. Moreover, MIPs show physical robustness, resistance to high temperatures and pressures, and stability in the presence of acids, bases and a wide range of organic solvents. In the present article, various novel sample preparation techniques which MIPs applied as sorbent and on-line connected with analytical instruments were highlighted and discussed. The future aspects of MIPs as well were described.
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| 5. |
- Ruokonen, Suvi-Katriina, et al.
(författare)
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Distribution of local anesthetics between aqueous and liposome phases
- 2017
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Ingår i: Journal of Chromatography A. - : Elsevier BV. - 0021-9673 .- 1873-3778. ; 1479, s. 194-203
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Tidskriftsartikel (refereegranskat)abstract
- Liposomes were used as biomimetic models in capillary electrokinetic chromatography (EKC) for the determination of distribution constants (K-D) of certain local anesthetics and a commonly used preservative. Synthetic liposomes comprised phosphatidylcholine and phosphatidylglycerol phospholipids with and without cholesterol. In addition, ghost liposomes made from red blood cell (RBC) lipid extracts were used as pseudostationary phase to acquire information on how the liposome composition affects the interactions between anesthetics and liposomes. These results were compared with theoretical distribution coefficients at pH 7.4. In addition to 25 degrees C, the distribution constants were determined at 37 and 42 degrees C to simulate physiological conditions. Moreover, the usability of five electroosmotic flow markers in liposome (LEKC) and micellar EKC (MEKC) was studied. LEKC was proven to be a convenient and fast technique for obtaining data about the distribution constants of local anesthetics between liposome and aqueous phase. RBC liposomes can be utilized for more representative model of cellular membranes, and the results indicate that the distribution constants of the anesthetics are greatly dependent on the used liposome composition and the amount of cholesterol, while the effect of temperature on the distribution constants is less significant.
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