| 1. |
- Baranowska, Izabella, et al.
(författare)
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Sensory ataxic neuropathy in golden retriever dogs is caused by a deletion in the mitochondrial tRNATyr gene
- 2009
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Ingår i: PLoS Genetics. - : Public Library of Science (PLoS). - 1553-7390 .- 1553-7404. ; 5:5, s. e1000499-
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Tidskriftsartikel (refereegranskat)abstract
- Sensory ataxic neuropathy (SAN) is a recently identified neurological disorder in golden retrievers. Pedigree analysis revealed that all affected dogs belong to one maternal lineage, and a statistical analysis showed that the disorder has a mitochondrial origin. A one base pair deletion in the mitochondrial tRNA(Tyr) gene was identified at position 5304 in affected dogs after re-sequencing the complete mitochondrial genome of seven individuals. The deletion was not found among dogs representing 18 different breeds or in six wolves, ruling out this as a common polymorphism. The mutation could be traced back to a common ancestor of all affected dogs that lived in the 1970s. We used a quantitative oligonucleotide ligation assay to establish the degree of heteroplasmy in blood and tissue samples from affected dogs and controls. Affected dogs and their first to fourth degree relatives had 0-11% wild-type (wt) sequence, while more distant relatives ranged between 5% and 60% wt sequence and all unrelated golden retrievers had 100% wt sequence. Northern blot analysis showed that tRNA(Tyr) had a 10-fold lower steady-state level in affected dogs compared with controls. Four out of five affected dogs showed decreases in mitochondrial ATP production rates and respiratory chain enzyme activities together with morphological alterations in muscle tissue, resembling the changes reported in human mitochondrial pathology. Altogether, these results provide conclusive evidence that the deletion in the mitochondrial tRNA(Tyr) gene is the causative mutation for SAN.
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| 2. |
- Andersson, Ann-Christin, et al.
(författare)
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Föräldrars upplevda erfarenheter av att tillfrågas om medverkan i forskning för sitt prematura barns räkning
- 2005
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Ingår i: Vård i Norden. - 0107-4083. ; 25:77, s. 29-32
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Tidskriftsartikel (refereegranskat)abstract
- Clinical research, when children involved, may cause difficult ethical problems for both caregivers and parents. Informed consent has to be obtained from the parents and from the child depending on age and maturity. The concept of informed consent is complicated and depending on the ability of communication between the professionals and the parents. The aim of the study was to illuminate parents lived experiences when being asked to volunteer their new-born premature child to a clinical research study. Parents of fifteen children were interviewed concerning their experiences and a phenomenological based analysis was carried out. Three themes were found: experience of exposure, experience of insufficiency and experience of possibilities. The parents expired themselves being in a state of shock and their statements were characterised by the existing chaos. Despite this, the parents experienced that they could do something good for others in the future. Researchers have to be aware of the parents’ exposure, and attentive to their individual needs.
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| 3. |
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| 4. |
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| 5. |
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| 6. |
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| 7. |
- Andersson, Eva, 1957, et al.
(författare)
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Learning at distance - between studies and everyday life
- 2005
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Ingår i: Paper presented at the conference Adult Education - Liberty, Fraternity, Equality, 13-14 May 2005 in Turku, Finland.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 8. |
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| 9. |
- Andersson, Eva, 1957, et al.
(författare)
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Learning at distance within popular adult education - where is the context?
- 2007
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Ingår i: R. Rinne, A. Heikkinen & P. Salo (Eds.), Adult Education - Liberty, Fraternity, Equality? Nordic views on lifelong learning. (Research in Educa-tional Sciences 28). - Turku : Finnish Educational Research Association. ; , s. 359-377
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 10. |
- Andersson, Eva, et al.
(författare)
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Learning at Distance within Popular Adult Education - Where is the Context?
- 2007
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Ingår i: Adult Education - Liberty, Fraternity, Equality? Nordic Views on Lifelong Learning. - Turku : Finnish Educational Research Association. - 9789525401288 - 9525401286 ; , s. 359-377
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Liberté, Egalité, Fraternité were the symbolic words and shouts of millions and millions hopes in the mouths of millions and millions people all around the world in the 18th and 19th century. Liberté, Egalité, Fraternité are still the symbols of democracy during the 20th and 21st century. These wishful words have not lost their meaning during the centuries, although they historically represent the birth of the modern world and reflect the thoughts of enlightenment already in the 18th century. They were realized in the French revolution and the tricolor flag. The Nordic countries have taken seriously the whispers of the enlightenment. They have transferred the words into the field of education. In the name of enlightenment Nordic countries were among the first to develop a wide adult education system in order to cultivate their adult population. They believed, that it is education which gives the people the liberty, equality and fraternity. The very core of the idea of the Nordic welfare state is educational equality as the spearhead to the social equality of the whole nation. In this book we reflect together the state of the art of adult education research in the Nordic countries in the beginning of the third millenium. What is left of the historical tradition of enlightenment and the hopes of the people? Has there been a change in the politics of Nordic adult education research towards the neo-liberalism? What are the challenges of today and how they may be answered? What has the Nordic adult education research to offer to the wider audience of the globalising world? Some answers to these questions are suggested in this book. The answers are presented by the most eminent as well as by junior researchers within the field in Nordic adult education research. Have a seat and read.
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| 11. |
- Andersson, Eva, 1957, et al.
(författare)
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Lärande och vardag
- 2006
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Ingår i: I Andersson, E., Landström, I. & Laginder, A-M. (red), Lärande, IKT och samhällsomvandling. Två rapporter om folkbildning på distans. - Stockholm : Folkbildningsrådet. - 91 88692 38 8 ; , s. 10-117
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 12. |
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| 13. |
- Andersson, Eva, et al.
(författare)
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Lärande och vardag. Om gränsöverskridande i folkbildning på distans
- 2006
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Ingår i: Lärande, IKT och samhällsomvandling. Två rapporter om folkbildning på distans. - Stockholm : Folkbildningsrådet. - 9188692388 - 9789188692382 ; , s. -156
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Att studera på distans blir allt vanligare, även inom studieförbund och folkhögskolor. Men vad innebär egentligen detta för deltagarna? Frågan belyses i denna rapport, som bygger på intervjuer med ett tjugotal deltagare i distansorganiserad och IKT-baserad folkbildning.I rapportens första del, Lärande och vardag. Om gränsöverskridande i folkbildning på distans , diskuteras gränserna mellan deltagarnas studier och deras vardagsverksamheter – och vad ett eventuellt överskridande av dessa gränser får för konsekvenser. I den andra delen, Datorkunskaper på köpet. Om folkbildning på distans, IKT och samhälle , fokuseras på distansstudiernas roll, när det gäller deltagarnas motivation, tillgång till och förmåga att använda digital teknik. Lärande, IKT och samhällsomvandling ingår i forskningsprojektet Distans, IKT, folkbildning och vardag. Rapporten är utgiven av Folkbildningsrådet, som fi - nansierat projektet i samarbete med KK-stiftelsens forskningsprogram LearnIT. Inom projektet har tidigare utgivits rapportenDeltagarröster om folkbildning på distans . Eva Andersson är universitetslektor i pedagogik vid Institutionen för pedagogik och didaktik, Göteborgs universitet. Hon är där knuten till Enheten för lärande i vuxenliv. Eva Andersson har arbetat med folkbildningsforskning sedan mitten på 1990-talet, senast i projektetDistanspedagogik bland folkbildare (2001–2004).Ann-Marie Laginder är fi losofi e doktor i teknik och social förändring. Hon är universitetslektor vid Institutionen för beteendevetenskap, Linköpings universitet och föreståndare för Mimer – nationellt program för folkbildningsforskning. Hon har tidigare forskat bland annat om studiecirklars betydelse för deltagare och lokalsamhälle.Inger Landström är fi losofi e doktor i pedagogik och forskarassistent vid Institutionen för beteendevetenskap, Linköpings universitet. Hennes senare forskning gäller hur informations- och kommunikationstekniken (IKT) används och påverkar folkbildningsorganisationernas verksamhet och identitet.
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| 14. |
- Andersson, Eva, 1957, et al.
(författare)
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Möjligheter och dilemman : om folkbildning på distans
- 2007
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Ingår i: Årsbok om folkbildning. - Stockholm : Föreningen för folkbildningsforskning. - 9197452858 ; , s. 202-221, s. 202-221
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 15. |
- Andersson, Inger
(författare)
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Catalysis and regulation in Rubisco.
- 2008
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Ingår i: Journal of Experimental Botany. - : Oxford University Press (OUP). - 0022-0957 .- 1460-2431. ; 59:7, s. 1555-1568
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Tidskriftsartikel (refereegranskat)abstract
- Ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) catalyses the incorporation of inorganic CO(2) into the organic molecules of life. Rubisco is extremely inefficient as a catalyst and its carboxylase activity is compromised by numerous side-reactions including oxygenation of its sugar phosphate substrate by atmospheric O(2). The reduction in the catalytic efficiency as a result of these processes has implications for crop yield, nitrogen and water usage, and for the global carbon cycle. Several aspects of Rubisco including its complex biosynthesis and multi-step catalytic reaction are subject to tight control involving light, cellular metabolites, and molecular chaperones. Numerous high-resolution crystal structures of different forms of Rubisco are now available, including structures of mutant enzymes. These provide a molecular framework for the understanding of these processes at the molecular level.
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| 16. |
- Andersson, Inger, 1964, et al.
(författare)
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Health-related quality of life in patients undergoing allogeneic stem cell
- 2009
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Ingår i: Cancer Nursing. - 0162-220X. ; 32:4
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this prospective study was to describe health-related quality of life (HRQOL) in patients during the first year after stem cell transplantation (SCT) who were undergoing reduced intensive conditioning (RIC) compared with patients undergoing myeloablative conditioning (MAC). Fifty-seven patients (25 for MAC and 32 for RIC) were enrolled in the study. HRQOL was assessed at 6 occasions during the first year after SCT using European Organization for Research and Treatment of Cancer Quality of Life Questionnaire and the 19-item treatment-specific module High-Dose Chemotherapy. Both groups reported most symptoms and worst functioning 1 month after SCT, but there were substantial differences. The MAC group deteriorated considerably in 20 symptom scales compared with 8 in the RIC group (score differences <10; P values ranged from .001 to .05). Dry mouth, sore mouth, appetite loss, and change of taste were among the most frequent symptoms in both groups. Thereafter, the functioning improved and the symptom scores decreased and returned to baseline in both groups, except dry mouth, which remained a worse problem for the MAC group. Overall, the RIC group regained health and QOL faster than the MAC group did. However, there were no significant differences in global QOL between the groups 1 year after SCT.
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| 17. |
- Andersson, Inger, 1964, et al.
(författare)
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Health related quality of life in stem cell transplantation: clinical and psychometric validation of the questionnaire module, High Dose Chemotherapy (HDC-19).
- 2008
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Ingår i: Acta oncologica (Stockholm, Sweden). - : Informa UK Limited. - 0284-186X .- 1651-226X. ; 47:2, s. 275-85
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Tidskriftsartikel (refereegranskat)abstract
- The objective of this study was to assess the psychometric properties of the HDC-19, a module questionnaire for assessing symptoms and problems of patients undergoing stem cell transplantation (SCT) following high-dose chemotherapy (HDC). It consists of 19 questions and was developed for use in conjunction with EORTC QLQ-C30. Psychometric evaluations were performed according to guidelines recommended by the EORTC. The principal component analyses suggested that nine of the HDC-19 items could be reduced to four components (sexual functioning, future health perspectives, skin irritations and joint/muscle pain). Multitrait scaling analysis showed that most item-scale correlation coefficients met the standards of convergent (>0.40) and discriminant validity. Test-retest reliability coefficients between assessments at inclusion and admission were high, indicating that perceived health status remained virtually unchanged during this period. As expected, correlations between admission and one month after transplantation were considerably lower. The internal consistency of the multi-item scales was also satisfactory, (Cronbach's alpha 0.59-0.87). Overall, the known-groups comparisons showed smaller differences between designated groups than expected. As expected, changes in the HDC-19 mirrored changes in QLQ-C30 'global quality of life'. These results lend support to the validity of the HDC-19 as a supplementary questionnaire for assessing specific health-related quality of life (HRQOL) issues relevant for SCT patients.
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| 18. |
- Andersson, Inger, et al.
(författare)
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Structure and function of Rubisco
- 2008
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Ingår i: Plant physiology and biochemistry (Paris). - : Elsevier BV. - 0981-9428 .- 1873-2690. ; 46:3, s. 275-291
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Tidskriftsartikel (refereegranskat)abstract
- Ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) is the major enzyme assimilating CO2 into the biosphere. At the same time Rubisco is an extremely inefficient catalyst and its carboxylase activity is compromised by an opposing oxygenase activity involving atmospheric O2. The shortcomings of Rubisco have implications for crop yield, nitrogen and water usage, and for the global carbon cycle. Numerous high-resolution crystal structures of different forms of Rubisco are now available, including structures of mutant enzymes. This review uses the information provided in these structures in a structure-based sequence alignment and discusses Rubisco function in the context of structural variations at all levels – amino acid sequence, fold, tertiary and quaternary structure – with an evolutionary perspective and an emphasis on the structural features of the enzyme that may determine its function as a carboxylase.
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| 19. |
- Andersson, Liselott, et al.
(författare)
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Depression and anxiety during pregnancy and six months postpartum : a follow-up study
- 2006
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Ingår i: Acta Obstetricia et Gynecologica Scandinavica. - : Wiley. - 0001-6349 .- 1600-0412. ; 85:8, s. 937-944
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Tidskriftsartikel (refereegranskat)abstract
- AIMS: To investigate the relationship between antenatal and postpartum depression and anxiety and to explore associated maternal characteristics. METHODS: From a population-based sample of 1,555 women attending two obstetric clinics in Sweden, all women with an antenatal psychiatric diagnosis (n = 220) and a random selection of healthy women (n = 500) were contacted for a second assessment three to six months postpartum. The Primary Care Evaluation of Mental Disorders was used for evaluation on both occasions. RESULTS: Fewer cases of depressive and/or anxiety disorders were prevalent postpartum compared with the second trimester screening. Depression and/or anxiety were prevalent in 16.5% of postpartal women versus 29.2% of pregnant women. There was a significant shift from a majority of subthreshold diagnoses during pregnancy to full Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition) diagnoses during the postpartum period. A history of previous psychiatric disorder, living single, and obesity were significantly associated with a new-onset postpartum psychiatric disorder. The absence of a previous psychiatric disorder was significantly associated with a postpartum recovery of depression or anxiety. CONCLUSIONS: Depression and anxiety appear to be less common postpartum than during pregnancy.
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| 20. |
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| 21. |
- Andersson, Per, 1964-, et al.
(författare)
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Identitet & IKT i folkbildning
- 2005
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Ingår i: LearnIT:s konferens,2005.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 22. |
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| 23. |
- Andersson, Pia, 1955-, et al.
(författare)
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Kvalitetsindikatorer för munhälsa
- 2007
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Ingår i: Idvall, E. (red), Kvalitetsindikatorer inom omvårdnad. - Stockholm : Gothia. - 9789172055193 ; , s. 45-56
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 24. |
- Andersson, Pia, 1955-, et al.
(författare)
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Kvalitetsindikatorer för munhälsa
- 2007
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Ingår i: Kvalitetsindikatorer inom omvårdnad. - Stockholm : Gothia Förlag AB. - 9789172055193 ; , s. 45-56, s. 45-56
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 25. |
- Andersson, Susanne, et al.
(författare)
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It's up to me! Experiences of living with pre-diabetes and the increased risk of developing type 2 diabetes mellitus
- 2008
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Ingår i: Primary Care Diabetes. - Amsterdam : Elsevier. - 1751-9918 .- 1878-0210. ; 2:4, s. 187-193
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Tidskriftsartikel (refereegranskat)abstract
- Aims: To explore experiences of pre-diabetes and the associated increased risk of type 2 diabetes mellitus. Methods: Eight participants with pre-diabetes were interviewed for a 45-60 min period. The interviews were audio taped, transcribed verbatim and analysed using a phenomenological hermeneutic approach. Results: Living with pre-diabetes means existing on the borderline of being healthy and suffering from T2DM. Three themes were formulated; "seeing possibilities in an uncertain future", "facing obstacles and loss of liberty" and "balancing between possibilities and obstacles" Being on the borderline and balancing between possibilities and obstacles were interpreted as a distressing feeling of being at increased risk of developing T2DM, although this feeling can change to one of either facing possibilities or facing obstacles. Conclusions: Special focus must be directed towards persons with pre-diabetes, as they are caught between possibilities and obstacles. Advanced care in the form of health dialogues can convince these people of their own abilities to influence the outcome of pre-diabetes. The result of this study can guide health care practitioners in comprehending each participant's understanding of the situation, thus helping them to create pedagogical dialogues in which patients' experiences, conceptions, explanations as well as explicit and implicit questions are identified. © 2008 Primary Care Diabetes Europe.
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| 26. |
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| 27. |
- Arvidsson, Barbro, 1945-, et al.
(författare)
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A nurse-led rheumatology clinic’s impact on empowering patients with rheumatoid arthritis : A qualitative study
- 2006
-
Ingår i: Nursing and Health Sciences. - Richmond, Australia : Wiley-Blackwell. - 1441-0745 .- 1442-2018. ; 8:133-9
-
Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to describe a nurse-led rheumatology clinic’s impact on empowering patients with rheumatoid arthritis (RA). Rheumatoid arthritis is a chronic, inflammatory disease that attacks many joints, causing considerable functional restrictions for patients. Consequently, these patients are dependent on a wide variety of health-care services. A descriptive, qualitative design inspired by phenomenography was chosen. The conceptions were collected through interviews with 16 strategically selected patients with RA. Three descriptive categories comprising eight conceptions emerged: teaching (gaining insight and receiving information), regular review (receiving security, realizing regularity, and achieving accessibility), and attention (getting a holistic assessment, receiving coordinated care, and getting sufficient time). A nurse-led rheumatology clinic can be a source for empowering patients with RA to adopt new stances to alternative actions and achieve a higher level of faith in their own abilities.
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| 28. |
- Asteberg, Inger, et al.
(författare)
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A food-borne streptococcal sore throat outbreak in a small community.
- 2006
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Ingår i: Scandinavian journal of infectious diseases. - : Informa UK Limited. - 0036-5548 .- 1651-1980. ; 38:11-12, s. 988-94
-
Tidskriftsartikel (refereegranskat)abstract
- Beta-haemolytic group A streptococci (GAS) is a common cause of sore throat, usually spread person-to-person. Outbreaks related to infected food have more seldom been reported. The bacteria may originate from the throat or from wounds on the hands of persons handling the food. An outbreak in Sätila, Sweden, in April/May 2003 involving 153 individuals who fell ill after eating contaminated 'sandwich-layer cakes' was investigated in a descriptive, retrospective cohort study. Questionnaires were distributed, one immediately after the outbreak and one 3 months later. The average attack rate was 72%. 143 individuals sought medical care and 137 were treated with antibiotics. 76 individuals were ill for more than 4 days. GAS isolates of identical T-type were obtained from the throats of the patients, wounds on the caterer's fingers and also from the cakes. PFGE banding patterns of 14 representative isolates were identical, as well as the emm-sequence type, emm 89, of 3 chosen isolates. The study shows that GAS from a small wound on a finger can cause illness in a large number of individuals. To prevent further outbreaks, it is important to increase public awareness of this type of transmission.
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| 29. |
- Benderix, Ylva, 1953-, et al.
(författare)
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Barn med neuropsykiatriskt funktionshinder
- 2009
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Ingår i: PEDIATRISK OMVÅRDNAD. - Stockholm : LIBER. - 9789147093274 ; , s. 309-315
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 30. |
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| 31. |
- Bivik, Cecilia, et al.
(författare)
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Wavelength specific effects on UVB induced apoptosis in melanocytes. A study of the Bcl-2/Bax expression and keratinocyte rescue effects
- 2005
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Ingår i: Melanoma Research. - : Ovid Technologies (Wolters Kluwer Health). - 0960-8931 .- 1473-5636. ; 15:1, s. 7-13
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Tidskriftsartikel (refereegranskat)abstract
- Apoptosis and alterations in Bcl-2 and Bax messenger RNA (mRNA) and protein expression were examined in cultured human epidermal melanocytes following UVB irradiation (50 mJ/cm2). The effects of various spectral ranges within UVB were investigated. A co-culture system was set up to study the interplay between melanocytes and keratinocytes in response to UVB. Melanocytes expressed high basal levels of the anti-apoptotic protein Bcl-2 compared with keratinocytes. Different wavelengths within the UVB spectrum induced diverse response patterns of Bcl-2 and Bax mRNA and had different apoptotic power. Both Bcl-2 and Bax mRNA were upregulated to preserve protein levels and only a slight increase in apoptosis was noted 24 h after UVB ([lambda]>305 nm). Increasing UVB between 280 and 305 nm enhanced apoptosis and upregulated Bcl-2, whilst Bax mRNA was unaltered. However, no change in protein levels was detected. A redistribution of Bax protein from different compartments within the cell may be more important than direct upregulation for the acceleration of apoptosis, but it cannot be excluded that other apoptotic pathways may be induced by shorter UVB wavelengths. The increase in apoptosis was significantly lower in melanocytes co-cultured with irradiated matched keratinocytes than in melanocytes from pure cultures, indicating that melanocytes are protected from UVB-induced apoptosis by the release of substance(s) from keratinocytes. This rescue response concurred with a fast and significant increase in Bcl-2 mRNA level in melanocytes.
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| 32. |
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| 33. |
- Cicero, Giancarlo, et al.
(författare)
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Study of the oxidative half-reaction catalyzed by a non-heme ferrous catalytic center by means of structural and computational methodologies
- 2007
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Ingår i: International Journal of Quantum Chemistry. - : Wiley. - 0020-7608 .- 1097-461X. ; 107:6, s. 1514-1522
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Tidskriftsartikel (refereegranskat)abstract
- Deacetoxycephalosporin C synthase (DAOCS) is a mononuclear ferrous enzyme that catalyzes the expansion of the five-membered thiazolidine ring of the penicillin nucleus into the six-membered dihydrothiazine ring of the cephalosporins. In the first half-reaction with dioxygen and 2-oxoglutarate, a reactive iron-oxygen species is produced that can subsequently react with the penicillin substrate to yield the cephalosporin. We describe quantum mechanical calculations of the first part of the reaction based on the high-resolution structures of the active site of DAOCS and its complexes with ligands. These studies are aimed at understanding how the reactive species can be produced and contained in the active site of the enzyme. The results demonstrate the priming of the active site by the co-substrate for oxygen binding and hint to the presence of a stable iron-peroxo intermediate in equilibrium with a more reactive ferryl species and the formation of CO2 as a leaving group by decarboxylation of 2-oxoglutarate. A conclusion from these studies is that substitution of CO2 by the penicillin substrate triggers the oxidation reaction in a booby-trap-like mechanism.
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| 34. |
- Edén, Lena, 1940-, et al.
(författare)
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Characteristics of disability pensioners returning to work : an interview study among individuals with musculoskeletal disorders
- 2007
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Ingår i: Disability and Rehabilitation. - 0963-8288 .- 1464-5165. - 0963-8288 ; 29:22, s. 1720-1726
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Tidskriftsartikel (refereegranskat)abstract
- Purpose. To explore adaptation patterns among disability pensioners with musculoskeletal disorders returning to work by means of the Swedish law on 'resting disability pension'. Method. Qualitative analyses of interviews with 17 individuals going back to work. Results. Three adaptation patterns were identified: The Go- getter, the Realist and the Indifferent. These differed regarding influence factors, own expectations, motive, morals and mentality. Conclusion. Several actors may support a return to work for individuals who received a disability pension due to musculoskeletal disorders. In order to succeed, however, it is essential that the disability pensioner is motivated for a reconstruction of his/ her life.
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| 35. |
- Edén, Lena, et al.
(författare)
-
Characteristics of disability pensioners returning to work : an interview study among individuals with musculoskeletal disorders
- 2007
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Ingår i: Disability and Rehabilitation. - : Informa Healthcare. - 0963-8288 .- 1464-5165. ; 29:22, s. 1720-1726
-
Tidskriftsartikel (refereegranskat)abstract
- Purpose. To explore adaptation patterns among disability pensioners with musculoskeletal disorders returning to work by means of the Swedish law on 'resting disability pension'. Method. Qualitative analyses of interviews with 17 individuals going back to work. Results. Three adaptation patterns were identified: The Go- getter, the Realist and the Indifferent. These differed regarding influence factors, own expectations, motive, morals and mentality. Conclusion. Several actors may support a return to work for individuals who received a disability pension due to musculoskeletal disorders. In order to succeed, however, it is essential that the disability pensioner is motivated for a reconstruction of his/ her life.
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| 36. |
- Edén, Lena, et al.
(författare)
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Return to work still possible after several years as a disability pensioner due to musculoskeletal disorders : a population-based study after new legislation in Sweden permitting "resting disability pension"
- 2006
-
Ingår i: Work. - 1051-9815 .- 1875-9270. ; 26:2, s. 147-155
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Tidskriftsartikel (refereegranskat)abstract
- Different strategies have been used to stimulate a return to work (RTW) among individuals suffering from long-term ailments. In Sweden a new law on "resting disability pension" permits disability pensioners to go back to work without jeopardising their benefits. In this study different variables related to RTW during 2000 by means of this legislation were identified among disability pensioners with musculoskeletal disorders. Individuals in the study group, when compared to a control group, had more often been disability pensioners for several years, had additional education, estimated their previous job to have been physically strenuous to a lesser degree, were more satisfied with the treatment at the social insurance office and had a more positive self-image. This study shows that it may be meaningful to continue/resume rehabilitation efforts and to try to motivate an individual suffering from musculoskeletal disorders to return to work even after several years as a disability pensioner.
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| 37. |
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| 38. |
- Ekman, Inger, 1952, et al.
(författare)
-
Exploring symptoms in chronic heart failure
- 2005
-
Ingår i: European Journal of Heart Failure. - : Wiley. - 1388-9842. ; 7:5, s. 699-703
-
Tidskriftsartikel (refereegranskat)abstract
- Symptoms in patients with chronic heart failure (CHF) are the cry for help, reflecting not only the physical aspects of the disease but the impact on lifestyle, anxiety, depression and expectations of the patient. Studies consistently show a difference in patients' self-assessed functional classification compared to investigator reported NYHA classification. Moreover, patient self-assessed symptoms have recently been shown to independently predict hospitalisation and mortality over 5 years. Recognition of symptoms and appreciation of their importance justifies the use of a structured assessment in order to provide optimal medical care for patients with CHF. A model of how to structure symptom assessment equally with signs is presented in this paper.
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| 39. |
- Ekman, Inger, 1952, et al.
(författare)
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Self-assessed symptoms in chronic heart failure--important information for clinical management
- 2007
-
Ingår i: Eur J Heart Fail. - : Wiley. - 1388-9842. ; 9:4, s. 424-8
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Tidskriftsartikel (refereegranskat)abstract
- AIM: To compare the patients' self-assessment of the severity of their symptoms with a physicians assessment and to evaluate the ability of self-assessed symptoms and ejection fraction (EF) to predict long-term survival in heart failure patients. METHOD: Patients (n=332) evaluated symptoms using a self-administered functional classification scale (Specific Activity Scale, SAS), which is equivalent to the NYHA scale. EF and NYHA functional class was also recorded. All patients were followed over a 3-year period. RESULTS: Approximately 50% of patients classified themselves into SAS class I. In contrast, the cardiologists classified only 9% of the patients as NYHA class I. In patients with severe left ventricular dysfunction (EF
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| 40. |
- Eriksson, Björn, et al.
(författare)
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In-line application of electric field in capillary separation systems Part I: Joule heating, pH and conductivity
- 2008
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Ingår i: Journal of Chromatography A. - : Elsevier BV. - 0021-9673 .- 1873-3778. ; 75:1, s. 83-90
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Tidskriftsartikel (refereegranskat)abstract
- This study concerns the technique electric field-assisted capillary liquid chromatography. In this technique, an electric field is applied over the separation capillary in order to provide an additional selectivity. In this technique, the electric field is applied in-line in the separation capillary and here the electric current is the factor limiting the magnitude of applied electric field. The influence of Joule heating and other factors on the current in such systems has been investigated.The temperature in the capillary was first measured within a standard CE set-up, as function of effect per unit of length. Then the same cooling system was applied to an in-line set-up, to replicate the conditions between the two systems, and thus the temperature. Thus Joule heating effects could then be calculated within the in-line system. It was found that for systems applying an electric field in line, the direct influence from Joule heating was only relatively small.The pH in the capillary was measured in the in-line set-up using cresol red/TRIS solutions as pH probe. Significant changes in pH were observed and the results suggested that electrolysis of water is the dominant electrode reaction in the in-line system. In summary, the observed conductivity change in in-line systems was found to be mainly due to the pH change by hydrolysis of water, but primarily not due the temperature change in the capillary column.
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| 41. |
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| 42. |
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| 43. |
- García-Murria, María-Jesús, et al.
(författare)
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Structural and functional consequences of the replacement of proximal residues Cys(172) and Cys(192) in the large subunit of ribulose-1,5-bisphosphate carboxylase/oxygenase from Chlamydomonas reinhardtii.
- 2008
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Ingår i: Biochemical Journal. - 0264-6021 .- 1470-8728. ; 411:2, s. 241-247
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Tidskriftsartikel (refereegranskat)abstract
- Proximal Cys(172) and Cys(192) in the large subunit of the photosynthetic enzyme Rubisco (ribulose-1,5-bisphosphate carboxylase/oxygenase; EC 4.1.1.39) are evolutionarily conserved among cyanobacteria, algae and higher plants. Mutation of Cys(172) has been shown to affect the redox properties of Rubisco in vitro and to delay the degradation of the enzyme in vivo under stress conditions. Here, we report the effect of the replacement of Cys(172) and Cys(192) by serine on the catalytic properties, thermostability and three-dimensional structure of Chlamydomonas reinhardtii Rubisco. The most striking effect of the C172S substitution was an 11% increase in the specificity factor when compared with the wild-type enzyme. The specificity factor of C192S Rubisco was not altered. The V(c) (V(max) for carboxylation) was similar to that of wild-type Rubisco in the case of the C172S enzyme, but approx. 30% lower for the C192S Rubisco. In contrast, the K(m) for CO(2) and O(2) was similar for C192S and wild-type enzymes, but distinctly higher (approximately double) for the C172S enzyme. C172S Rubisco showed a critical denaturation temperature approx. 2 degrees C lower than wild-type Rubisco and a distinctly higher denaturation rate at 55 degrees C, whereas C192S Rubisco was only slightly more sensitive to temperature denaturation than the wild-type enzyme. X-ray crystal structures reveal that the C172S mutation causes a shift of the main-chain backbone atoms of beta-strand 1 of the alpha/beta-barrel affecting a number of amino acid side chains. This may cause the exceptional catalytic features of C172S. In contrast, the C192S mutation does not produce similar structural perturbations.
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| 44. |
- Hansson, Maria, et al.
(författare)
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The mobile thylakoid phosphoprotein TSP9 interacts with the light harvesting complex II and the peripheries of both photosystems
- 2006
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Ingår i: Journal of Biological Chemistry. - 0021-9258. ; 282:22, s. 16214-16222
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Tidskriftsartikel (refereegranskat)abstract
- The localization of the plant-specific thylakoid-soluble phosphoprotein of 9 kDa, TSP9, within the chloroplast thylakoid membrane of spinach has been established by the combined use of fractionation, immunoblotting, cross-linking, and mass spectrometry. TSP9 was found to be exclusively confined to the thylakoid membranes, where it is enriched in the stacked grana membrane domains. After mild solubilization of the membranes, TSP9 migrated together with the major light-harvesting antenna (LHCII) of photosystem II (PSII) and with PSII-LHCII supercomplexes upon separation of the protein complexes by either native gel electrophoresis or sucrose gradient centrifugation. Studies with a cleavable cross-linking agent revealed the interaction of TSP9 with both major and minor LHCII proteins as identified by mass spectrometric sequencing. Cross-linked complexes that in addition to TSP9 contain the peripheral PSII subunits CP29, CP26, and PsbS, which form the interface between LHCII and the PSII core, were found. Our observations also clearly suggest an interaction of TSP9 with photosystem I (PSI) as shown by both immunodetection and mass spectrometry. Sequencing identified the peripheral PSI subunits PsaL, PsaF, and PsaE, originating from cross-linked protein complexes of around 30 kDa that also contained TSP9. The distribution of TSP9 among the cross-linked forms was found to be sensitive to conditions such as light exposure. An association of TSP9 with LHCII as well as the peripheries of the photosystems suggests its involvement in regulation of photosynthetic light harvesting.
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| 45. |
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| 46. |
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| 47. |
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| 48. |
- Jansson, Inger, et al.
(författare)
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Obtaining a Foundation for Nursing Care at the Time of Patient Admission : A Grounded Theory Study
- 2009
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Ingår i: Open Nursing Journal. - Hilversum : Bentham Science Publishers. - 1874-4346. ; 3, s. 56-64
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Tidskriftsartikel (refereegranskat)abstract
- The nursing process can be viewed as a problem-solving model, but we do not know whether use of the whole process including care plans with interventions based on nursing diagnoses improves nurses' ability to carry out assessments. Therefore, the aim of this study was to illuminate and describe the assessment and decision-making process performed by nurses who formulated individual care plans including nursing diagnosis, goals and interventions or who used standardized care plans when a patient was admitted to their ward for care, and those who did not. Data collection and analysis were carried out by means of Grounded theory. Nurses were observed while assessing patients, after which they were interviewed. The main concern of all nurses was to obtain a foundation for nursing care based on four strategies; building pre-understanding, creating a caring environment, collecting information on symptoms and signs and performing an analysis from different perspectives. It appeared that the most important aspect for nurses who did not employ care plans was the medical reason for the patient's admission. The nurses who employed care plans discussed their decisions in terms of nursing problems, needs and risks. The results indicate that nurses who formulated care plans were more aware of their professional role.
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| 49. |
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