| 1. |
- Johansson, Jan, 1949-, et al.
(author)
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Attracting young people to the mining industry : six recommendations
- 2018
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In: International Journal of Mining and Mineral Engineering. - : InderScience Publishers. - 1754-890X .- 1754-8918. ; 9:2, s. 94-108
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Journal article (peer-reviewed)abstract
- The present workforce in the mining industry is ageing, and mining companies have difficulties recruiting young people who are not particularly interested in working in the industry. Simultaneously, mining companies tend to rely on contractors that offer volume flexibility and expertise, often in a combination that is economically appealing. This makes recruitment and development of the whole of the mining workforce complex. To recruit the right workforce, mining companies and their contractors need to cooperate and improve their knowledge about both attractive and repelling work features so that they can make wiser strategic decisions based on facts. On the basis of a Swedish context, we discuss different aspects of attractive workplaces and summarise our 'lessons learned' in six recommendations dealing with general health and safety issues, work organisation, competence development, gender equality, social responsibility and outsourcing.
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| 2. |
- Lööw, Joel, et al.
(author)
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Designing Ergonomic, Safe, and Attractive Mining Workplaces
- 2018. - 1
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Book (other academic/artistic)abstract
- The mining industry has experienced important improvements with regard to its safety record and work environment. But there is still room for further improvement and the mining industry now faces the challenge of securing a future workforce: The current workforce is aging, and mining work increasingly requires a more qualified workforce. Designing Ergonomic, Safe, and Attractive Mining Workplaces seeks to give an understanding of what must be considered in the design of mining workplaces. By reviewing and discussing the historic and current development of the mining industry as well as problems related to the safety, ergonomics, and attractiveness of mining workplaces, it demonstrates that the challenges facing the mining industry often need to be solved on a case-to-case basis.The processes through which these issues are managed are of significant importance. To facilitate a proactive approach, the book covers the principles of systematic work environment management, together with examples of methods for risk management and work environment monitoring. It introduces a systematic and iterative design and planning method for the mining industry. This method acknowledges that all relevant stakeholders must be able to influence the design of ergonomic, safe, and attractive mining workplaces.
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| 3. |
- Rosqvist, Fredrik, 1985-, et al.
(author)
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Overeating saturated fat promotes fatty liver and ceramides compared to polyunsaturated fat : a randomized trial
- 2019
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In: Journal of Clinical Endocrinology and Metabolism. - : Oxford University Press. - 0021-972X .- 1945-7197. ; 104:12, s. 6207-6219
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Journal article (peer-reviewed)abstract
- CONTEXT: Saturated fat (SFA) versus polyunsaturated fat (PUFA) may promote non-alcoholic fatty liver disease (NAFLD) by yet unclear mechanisms.OBJECTIVE: To investigate if overeating SFA- and PUFA-enriched diets lead to differential liver fat accumulation in overweight and obese humans.DESIGN: Double-blind randomized trial (LIPOGAIN-2). Overfeeding SFA vs PUFA for 8 weeks, followed by 4 weeks of caloric restriction.SETTING: General community.Participants: n=61 overweight or obese men and women.INTERVENTION: Muffins high in either palm (SFA)- or sunflower oil (PUFA) were added to the habitual diet.MAIN OUTCOME MEASURE: Lean tissue mass (not reported here). Secondary and exploratory outcomes included liver and ectopic fat depots.RESULTS: By design, body weight gain was similar in SFA (2.31±1.38 kg) and PUFA (2.01±1.90 kg) groups, P=0.50. SFA markedly induced liver fat content (50% relative increase) along with liver enzymes and atherogenic serum lipids. In contrast, despite similar weight gain, PUFA did not increase liver fat or liver enzymes or cause any adverse effects on blood lipids. SFA had no differential effect on the accumulation of visceral fat, pancreas fat or total body fat compared with PUFA. SFA consistently increased, while PUFA reduced circulating ceramides; changes that were moderately associated with liver fat changes and proposed markers of hepatic lipogenesis. The adverse metabolic effects of SFA were reversed by calorie restriction.CONCLUSIONS: Saturated fat markedly induces liver fat and serum ceramides whereas dietary polyunsaturated fat prevent liver fat accumulation, reduce ceramides and hyperlipidemia during excess energy intake and weight gain in overweight individuals.
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| 4. |
- Simonson, Oscar E., et al.
(author)
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In Vivo Effects of Mesenchymal Stromal Cells in Two Patients With Severe Acute Respiratory Distress Syndrome
- 2015
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In: Stem Cells Translational Medicine. - : Oxford University Press (OUP). - 2157-6564 .- 2157-6580. ; 4:10, s. 1199-1213
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Journal article (peer-reviewed)abstract
- Mesenchymal stromal cells (MSCs) have been investigated as a treatment for various inflammatory diseases because of their immunomodulatory and reparative properties. However, many basic questions concerning their mechanisms of action after systemic infusion remain unanswered. We performed a detailed analysis of the immunomodulatory properties and proteomic profile of MSCs systemically administered to two patients with severe refractory acute respiratory distress syndrome (ARDS) on a compassionate use basis and attempted to correlate these with in vivo anti-inflammatory actions. Both patients received 2 x 10(6) cells per kilogram, and each subsequently improved with resolution of respiratory, hemodynamic, and multiorgan failure. In parallel, a decrease was seen in multiple pulmonary and systemic markers of inflammation, including epithelial apoptosis, alveolar-capillary fluid leakage, and proinflammatory cytokines, microRNAs, and chemokines. In vitro studies of the MSCs demonstrated a broad anti-inflammatory capacity, including suppression of T-cell responses and induction of regulatory phenotypes in T cells, monocytes, and neutrophils. Some of these in vitro potency assessments correlated with, and were relevant to, the observed in vivo actions. These experiences highlight both the mechanistic information that can be gained from clinical experience and the value of correlating in vitro potency assessments with clinical effects. The findings also suggest, but do not prove, a beneficial effect of lung protective strategies using adoptively transferred MSCs in ARDS. Appropriate randomized clinical trials are required to further assess any potential clinical efficacy and investigate the effects on in vivo inflammation. STEM CELLS TRANSLATIONAL MEDICINE 2015;4:1199-1213
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| 5. |
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| 6. |
- Abbass, Allan, et al.
(author)
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Long-term healthcare cost reduction with Intensive Short-term Dynamic Psychotherapy in a tertiary psychiatric service
- 2015
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In: Journal of Psychiatric Research. - : Elsevier. - 0022-3956 .- 1879-1379. ; 64, s. 114-120
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Journal article (peer-reviewed)abstract
- Objective: To evaluate whether a mixed population of patients treated with Intensive Short-term Dynamic Psychotherapy (ISTDP) would exhibit reduced healthcare costs in long-term follow-up. Methods: A quasi-experimental design was employed in which data on pre- and post-treatment healthcare cost were compared for all ISTDP cases treated in a tertiary care service over a nine year period. Observed cost changes were compared with those of a control group of patients referred but never treated. Physician and hospital costs were compared to treatment cost estimates and normal population cost figures. Results: 1082 patients were included; 890 treated cases for a broad range of somatic and psychiatric disorders and 192 controls. The treatment averaged 7.3 sessions and measures of symptoms and interpersonal problems significantly improved. The average cost reduction per treated case was $12,628 over 3 follow-up years: this compared favorably with the estimated treatment cost of $708 per patient. Significant differences were seen between groups for follow-up hospital costs. Conclusions: ISTDP in this setting appears to facilitate reductions in healthcare costs, supporting the notion that brief dynamic psychotherapy provided in a tertiary setting can be beneficial to health care systems overall. (C) 2015 Elsevier Ltd. All rights reserved.
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| 7. |
- Abbass, Allan, et al.
(author)
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Sustained reduction in health care costs after adjunctive treatment of graded intensive short-term dynamic psychotherapy in patients with psychotic disorders
- 2015
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In: Psychiatry Research. - : ELSEVIER IRELAND LTD. - 0165-1781 .- 1872-7123. ; 228:3, s. 538-543
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Journal article (peer-reviewed)abstract
- The aim of this pilot study was to evaluate the changes in symptom severity and long-term health care cost after intensive short-term dynamic psychotherapy (ISTDP) individually tailored and administered to patients with psychotic disorders undergoing standard psychiatric care. Eleven therapists with different levels of expertise delivered an average of 13 one-hour sessions of graded ISTDP to 38 patients with psychotic disorders. Costs for health care services were compiled for a one-year period prior to the start of ISTDP (baseline) along with four one-year periods after termination. Two validated self-report scales, the Brief Symptom Inventory and the Inventory of Interpersonal Problems, were administered at intake and termination of ISTDP. Results revealed that health care cost reductions were significant for the one-year post-treatment period relative to baseline year, for both physician costs and hospital costs, and the reductions were sustained for the follow-up period of four post-treatment years. Furthermore, at treatment termination self-reported symptoms and interpersonal problems were significantly reduced. These preliminary findings suggest that this brief adjunctive psychotherapy may be beneficial and reduce costs in selected patients with psychotic disorders, and that gains are sustained in long-term follow-up. Future research directions are discussed. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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| 8. |
- Abbass, Allan, et al.
(author)
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Sustained Reduction in Health Care Service Usage after Adjunctive Treatment of Intensive Short-Term Dynamic Psychotherapy in Patients with Bipolar Disorder
- 2019
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In: Psychodynamic Psychiatry. - : Guilford Publications. - 2162-2590 .- 2162-2604. ; 47:1, s. 99-112
-
Journal article (peer-reviewed)abstract
- The aim of this study was to evaluate changes in long-term health care costs and symptom severity after adjunctive intensive short-term dynamic psychotherapy (ISTDP) individually tailored and administered to patients with bipolar disorder undergoing standard psychiatric care. Eleven therapists with different levels of expertise delivered an average of 4.6 one-hour sessions of ISTDP to 29 patients with bipolar disorders. Health care service costs were compiled for a one-year period prior to the start of ISTDP along with four one-year periods after termination. Two validated self-report scales, the Brief Symptom Inventory and the Inventory of Interpersonal Problems, were administered at intake and termination of ISTDP. Hospital cost reductions were significant for the one-year post-treatment period relative to baseline year, and all cost reductions were sustained for the follow-up period of four post-treatment years. Self-reported psychiatric symptoms and interpersonal problems were significantly reduced. These preliminary findings suggest that this brief adjunctive psychotherapy may be beneficial and cost-effective in select patients with bipolar disorders, and that gains may be sustained in long-term followup. Future research directions are discussed.
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| 9. |
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| 10. |
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| 11. |
- Amanullah, Rahman, et al.
(author)
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Diversity in extinction laws of Type Ia supernovae measured between 0.2 and 2 μm
- 2015
-
In: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 453:3, s. 3300-3328
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Journal article (peer-reviewed)abstract
- We present ultraviolet (UV) observations of six nearby Type Ia supernovae (SNe Ia) obtained with the Hubble Space Telescope, three of which were also observed in the near-IR (NIR) with Wide-Field Camera 3. UV observations with the Swift satellite, as well as ground-based optical and NIR data provide complementary information. The combined data set covers the wavelength range 0.2-2 mu m. By also including archival data of SN 2014J, we analyse a sample spanning observed colour excesses up to E(B - V) = 1.4 mag. We study the wavelength-dependent extinction of each individual SN and find a diversity of reddening laws when characterized by the total-to-selective extinction R-V. In particular, we note that for the two SNe with E(B - V) greater than or similar to 1 mag, for which the colour excess is dominated by dust extinction, we find R-V = 1.4 +/- 0.1 and R-V = 2.8 +/- 0.1. Adding UV photometry reduces the uncertainty of fitted R-V by similar to 50 per cent allowing us to also measure R-V of individual low-extinction objects which point to a similar diversity, currently not accounted for in the analyses when SNe Ia are used for studying the expansion history of the Universe.
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| 12. |
- André, Samuel, 1986-, et al.
(author)
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The design platform – a coherent platform description of heterogeneous design assets for suppliers of highly customised systems
- 2017
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In: Journal of engineering design (Print). - : Taylor & Francis. - 0954-4828 .- 1466-1837. ; 28:10-12, s. 599-626
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Journal article (peer-reviewed)abstract
- Companies developing highly customised products are continuously faced with fluctuating requirements during the early and late stages of the product development (PD) process. This differs from companies that develop end-consumer products, which uses fixed specifications and where product platforms have been a successful enabler for efficient customisation. However, in the past, product platforms have not been able to fully support companies working in an engineer-to-order business environment. This article outlines the results from a three-year collaborative research project between academics within the area of engineering design and practitioners from the engineer-to-order industry. The research introduces a design platform (DP) that aims to support the development of customised products when traditional platform concepts do not suffice. The platform approach provides a coherent environment for heterogeneous design assets to be used in PD by supporting both the design activity and the finished solutions. The needs and abilities regarding such a platform were investigated through a series of interviews and workshops at four companies. Then, the DP was modelled and support tools were developed. Finally, company representatives evaluated the complete DP and its applications, reporting promising results.
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| 13. |
- Andreasson, Philip, et al.
(author)
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Quantum error correction for the toric code using deep reinforcement learning
- 2019
-
In: Quantum. - : Verein zur Forderung des Open Access Publizierens in den Quantenwissenschaften. - 2521-327X. ; 3
-
Journal article (peer-reviewed)abstract
- We implement a quantum error correction algorithm for bit-flip errors on the topological toric code using deep reinforcement learning. An action-value Q-function encodes the discounted value of moving a defect to a neighboring site on the square grid (the action) depending on the full set of defects on the torus (the syndrome or state). The Q-function is represented by a deep convolutional neural network. Using the translational invariance on the torus allows for viewing each defect from a central perspective which significantly simplifies the state space representation independently of the number of defect pairs. The training is done using experience replay, where data from the algorithm being played out is stored and used for mini-batch upgrade of the Q-network. We find performance which is close to, and for small error rates asymptotically equivalent to, that achieved by the Minimum Weight Perfect Matching algorithm for code distances up to d=7. Our results show that it is possible for a self-trained agent without supervision or support algorithms to find a decoding scheme that performs on par with hand-made algorithms, opening up for future machine engineered decoders for more general error models and error correcting codes.
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| 14. |
- Boersma, Greta J., et al.
(author)
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Altered Glucose Uptake in Muscle, Visceral Adipose Tissue, and Brain Predict Whole-Body Insulin Resistance and may Contribute to the Development of Type 2 Diabetes: A Combined PET/MR Study
- 2018
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In: Hormone and Metabolic Research. - : Georg Thieme Verlag KG. - 0018-5043 .- 1439-4286. ; 50:8
-
Journal article (peer-reviewed)abstract
- We assessed glucose uptake in different tissues in type 2 diabetes (T2D), prediabetes, and control subjects to elucidate its impact in the development of whole-body insulin resistance and T2D. Thirteen T2D, 12 prediabetes, and 10 control subjects, matched for age and BMI, underwent OGTT and abdominal subcutaneous adipose tissue (SAT) biopsies. Integrated whole-body 18F-FDG PET and MRI were performed during a hyperinsulinemic euglycemic clamp to asses glucose uptake rate (MRglu) in several tissues. MRglu in skeletal muscle, SAT, visceral adipose tissue (VAT), and liver was significantly reduced in T2D subjects and correlated positively with M-values (r = 0.884, r = 0.574, r = 0.707 and r = 0.403, respectively). Brain MRglu was significantly higher in T2D and prediabetes subjects and had a significant inverse correlation with M-values (r = -0.616). Myocardial MRglu did not differ between groups and did not correlate with the M-values. A multivariate model including skeletal muscle, brain and VAT MRglu best predicted the M-values (adjusted r2 = 0.85). In addition, SAT MRglu correlated with SAT glucose uptake ex vivo (r = 0.491). In different stages of the development of T2D, glucose uptake during hyperinsulinemia is elevated in the brain in parallel with an impairment in peripheral organs. Impaired glucose uptake in skeletal muscle and VAT together with elevated glucose uptake in brain were independently associated with whole-body insulin resistance, and these tissue-specific alterations may contribute to T2D development.
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| 15. |
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| 16. |
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| 17. |
- Bosco, Stefano, et al.
(author)
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Simulating moving cavities in superconducting circuits
- 2019
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In: Physical Review A. - 2469-9934 .- 2469-9926. ; 100:2
-
Journal article (peer-reviewed)abstract
- We theoretically investigate the simulation of moving cavities in a superconducting circuit setup. In particular, we consider a recently proposed experimental scenario where the phase of the cavity field is used as a moving clock. By computing the error made when simulating the cavity trajectory with superconducting quantum interference devices (SQUIDs), we identify parameter regimes where the correspondence holds, and where time dilation and corrections due to clock size and to particle creation coefficients are observable. These findings may serve as a guideline when performing experiments on simulation of moving cavities in superconducting circuits.
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| 18. |
- Brynielsson, Joel, 1974-, et al.
(author)
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Message from the program chairs
- 2017
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In: Proceedings - 2016 European Intelligence and Security Informatics Conference, EISIC 2016. - : Institute of Electrical and Electronics Engineers (IEEE).
-
Conference paper (peer-reviewed)
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| 19. |
- Cao, Yi, et al.
(author)
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A strong ultraviolet pulse from a newborn type Ia supernova
- 2015
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 521:7552, s. 328-
-
Journal article (peer-reviewed)abstract
- Type Ia supernovae(1) are destructive explosions of carbon-oxygen white dwarfs(2,3). Although they are used empirically to measure cosmological distances(4-6), the nature of their progenitors remains mysterious(3). One of the leading progenitor models, called the single degenerate channel, hypothesizes that a white dwarf accretes matter from a companion star and the resulting increase in its central pressure and temperature ignites thermonuclear explosion(3,7,8). Here we report observations with the Swift Space Telescope of strong but declining ultraviolet emission from a type Ia supernova within four days of its explosion. This emission is consistent with theoretical expectations of collision between material ejected by the supernova and a companion star(9), and therefore provides evidence that some type Ia supernovae arise from the single degenerate channel.
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| 20. |
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| 21. |
- De, Kishalay, et al.
(author)
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iPTF 16hgs : A Double-peaked Ca-rich Gap Transient in a Metal-poor, Star-forming Dwarf Galaxy
- 2018
-
In: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 866:1
-
Journal article (peer-reviewed)abstract
- Calcium-rich gap transients represent an intriguing new class of faint and fast-evolving supernovae that exhibit strong [Ca II] emission in their nebular phase spectra. In this paper, we present the discovery and follow-up observations of a faint and fast-evolving transient, iPTF 16hgs, that exhibited a double-peaked light curve. Exhibiting a Type Ib spectrum in the photospheric phase and an early transition to a [Ca II] dominated nebular phase, iPTF 16hgs shows properties consistent with the class of Ca-rich gap transients, with two important exceptions. First, while the second peak of the light curve is similar to other Ca-rich gap transients, the first blue and fast-fading peak (declining over approximate to 2 days) is unique to this source. Second, we find that iPTF 16hgs occurred in the outskirts (projected offset of approximate to 6 kpc approximate to 1.9 R-eff) of a low-metallicity (approximate to 0.4 Z(circle dot)), star-forming, dwarf spiral galaxy. Deep limits from late-time radio observations suggest a low-density environment for the source. If iPTF 16hgs shares explosion physics with the class of Ca-rich gap transients, the first peak can be explained by the presence of 0.01 M-circle dot of Ni-56 in the outer layers the ejecta, reminiscent of some models of He-shell detonations on WDs. However, if iPTF 16hgs is physically unrelated to the class, the first peak is consistent with shock cooling emission (of an envelope with a mass of approximate to 0.08 M-circle dot and radius of approximate to 13 R-circle dot) in a core-collapse explosion of a highly stripped massive star in a close binary system.
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| 22. |
- Dhawan, Suhail, et al.
(author)
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iPTF16abc and the population of Type Ia supernovae : comparing the photospheric, transitional, and nebular phases
- 2018
-
In: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 480:2, s. 1445-1456
-
Journal article (peer-reviewed)abstract
- Key information about the progenitor system and the explosion mechanism of Type Ia supernovae (SNe Ia) can be obtained from early observations, within a few days from explosion. iPTF16abc was discovered as a young SN Ia with excellent early time data. Here, we present photometry and spectroscopy of the SN in the nebular phase. A comparison of the early time data with a sample of SNe Ia shows distinct features, differing from normal SNe Ia at early phases but similar to normal SNe Ia at a few weeks after maximum light (i.e. the transitional phase) and well into the nebular phase. The transparency time-scales (t0) for this sample of SNe Ia range between ∼25 and 41 d indicating a diversity in the ejecta masses. t0 also weakly correlates with the peak bolometric luminosity, consistent with the interpretation that SNe with higher ejecta masses would produce more 56Ni" role="presentation">56Ni . Comparing the t0 and the maximum luminosity, Lmax distribution of a sample of SNe Ia to predictions from a wide range of explosion models we find an indication that the sub-Chandrasekhar mass models span the range of observed values. However, the bright end of the distribution can be better explained by Chandrasekhar mass delayed detonation models, hinting at multiple progenitor channels to explain the observed bolometric properties of SNe Ia. iPTF16abc appears to be consistent with the predictions from the Mch models.
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| 23. |
- Doyle, Samuel H., et al.
(author)
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Amplified melt and flow of the Greenland ice sheet driven by late-summer cyclonic rainfall
- 2015
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In: Nature Geoscience. - 1752-0894 .- 1752-0908. ; 8:8, s. 647-
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Journal article (peer-reviewed)abstract
- Intense rainfall events significantly affect Alpine and Alaskan glaciers through enhanced melting, ice-flow acceleration and subglacial sediment erosion, yet their impact on the Greenland ice sheet has not been assessed. Here we present measurements of ice velocity, subglacial water pressure and meteorological variables from the western margin of the Greenland ice sheet during a week of warm, wet cyclonic weather in late August and early September 2011. We find that extreme surface runoff from melt and rainfall led to a widespread acceleration in ice flow that extended 140 km into the ice-sheet interior. We suggest that the late-season timing was critical in promoting rapid runoff across an extensive bare ice surface that overwhelmed a subglacial hydrological system in transition to a less-efficient winter mode. Reanalysis data reveal that similar cyclonic weather conditions prevailed across southern and western Greenland during this time, and we observe a corresponding ice-flow response at all land- and marine-terminating glaciers in these regions for which data are available. Given that the advection of warm, moist air masses and rainfall over Greenland is expected to become more frequent in the coming decades, our findings portend a previously unforeseen vulnerability of the Greenland ice sheet to climate change.
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| 24. |
- Elgh, Fredrik, et al.
(author)
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Design Platform : Setting the Scope and Introducing the Concept
- 2016
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In: Proceedings of the DESIGN 2016 14th International Design Conference, Dubrovnik, May 16-19, 2016.. - : The Design Society. ; , s. 1253-1264
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Conference paper (peer-reviewed)abstract
- Product platforms has been a successful enabler for efficient mass customization. However, they cannot fully support suppliers working in an engineer-to-order business environment. This work identifies the need and scope of a different platform model that supports customization and management of fluctuating requirements. A novel plaform model is introduced entitled Design Platform. The model is based on the current state and future target condition at four companies. The model provides a coherent environment for heterogeneous design assets to be used in product development.
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| 25. |
- Elgh, Fredrik, 1971-, et al.
(author)
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Design Platform - A Coherent Model for Management and Use of Mixed Design Assets
- 2017
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In: Transdisciplinary Engineering: A Paradigm Shift. - : IOS Press. - 9781614997788 - 9781614997795 ; , s. 703-712
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Conference paper (peer-reviewed)abstract
- For many companies, it is a challenge to balance product variety and cost, i.e. external and internal efficiency. Product platforms has been the dominant solution for a business targeting mass-customization. The main idea is to dived the product into modules that can be shared among different product variants. This has been a success on the consumer market, however, many manufacturing companies are engineer-to-order (ETO) oriented, such as original equipment suppliers (OES). They design a unique solution, often in close collaboration with other companies, based on different product concepts and/or core technologies. For these companies, there is a strategic need for a platform model influenced by the principles of masscustomization, although, not limited to only include modules. In this work, a novel platform model, called Design Platform is described. The model has been developed and applied in cooperation with four companies. The Design Platform provides a coherent environment for management of heterogeneous design assets to be used in product development and supports an improved ability to master fluctuating requirements and systematic introduction of new technologies.
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| 26. |
- Elgh, Fredrik, 1971-, et al.
(author)
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Platform Models for Agile Customization – What's Beyond Modularization?
- 2018
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In: Transdisciplinary Engineering Methods for Social Innovation of Industry 4.0. - : IOS Press. - 9781614998976 - 9781614998983 ; , s. 371-380
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Conference paper (peer-reviewed)abstract
- Many manufacturing companies are suppliers that deliver unique solutions to different business customers. Intense quotation work, with a high demand on accuracy and quick response, and development projects executed in close collaboration with customers and other actors characterize these companies. The projects can run for years or a few weeks depending on the business. Changes of requirements are frequent and technology development required for improved functionality, sustainability and competitiveness. The use of a product platform has been acknowledged as a strategic enabler for product family development and mass customization. However, companies struggle with adopting the common platform approach building upon pre-defined modules and components as it constraints the fulfilment of unique customer requirements and the introduction of new technology at high pace. This work reports the results from case studies conducted in collaboration with four companies. They are in many ways different but face the same challenges when it comes to customization, fluctuating requirements and need of high pace in technology advancement. The focus of this paper is on their initial states; including how they work with their product concept before the customer entry point, the work that is initiated when an order is accepted, the character of requirements and the adoption of product platforms. Criteria on, and identification of, new platforms models, termed Design Assets, are presented followed by a mapping to the Design Platform concept pointing out areas upcoming work, both scientifically and at the companies.
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| 27. |
- Elgh, Fredrik, 1971-, et al.
(author)
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Traceability of decisions in product realization processes of custom engineered products
- 2018
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In: DS92: Proceedings of the DESIGN 2018 15th International Design Conference. - : The Design Society. - 9789537738594 ; , s. 249-260
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Conference paper (peer-reviewed)abstract
- Custom engineered products require an engineer-to-order approach in development, quotation preparation and order processing. This work reports the result of a three-and-a-half-year project were the objective was to develop means for implementation and management of computer support for engineering design and production engineering of customized products. Efficient re-use is essential for success and decision is identified as the core concept to trace tasks executed, knowledge used, design rationale and artefacts developed throughout the product realization process.
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| 28. |
- Elmsjö, Albert, et al.
(author)
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NMR-based metabolic profiling in healthy individuals overfed different types of fat : links to changes in liver fat accumulation and lean tissue mass.
- 2015
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In: Nutrition & Diabetes. - : Springer Science and Business Media LLC. - 2044-4052. ; 5:19, s. e182-
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Journal article (peer-reviewed)abstract
- BACKGROUND: Overeating different dietary fatty acids influence the amount of liver fat stored during weight gain, however, the mechanisms responsible are unclear. We aimed to identify non-lipid metabolites that may differentiate between saturated (SFA) and polyunsaturated fatty acid (PUFA) overfeeding using a non-targeted metabolomic approach. We also investigated the possible relationships between plasma metabolites and body fat accumulation.METHODS: In a randomized study (LIPOGAIN study), n=39 healthy individuals were overfed with muffins containing SFA or PUFA. Plasma samples were precipitated with cold acetonitrile and analyzed by nuclear magnetic resonance (NMR) spectroscopy. Pattern recognition techniques were used to overview the data, identify variables contributing to group classification and to correlate metabolites with fat accumulation.RESULTS: We previously reported that SFA causes a greater accumulation of liver fat, visceral fat and total body fat, whereas lean tissue levels increases less compared with PUFA, despite comparable weight gain. In this study, lactate and acetate were identified as important contributors to group classification between SFA and PUFA (P<0.05). Furthermore, the fat depots (total body fat, visceral adipose tissue and liver fat) and lean tissue correlated (P(corr)>0.5) all with two or more metabolites (for example, branched amino acids, alanine, acetate and lactate). The metabolite composition differed in a manner that may indicate higher insulin sensitivity after a diet with PUFA compared with SFA, but this needs to be confirmed in future studies.CONCLUSION: A non-lipid metabolic profiling approach only identified a few metabolites that differentiated between SFA and PUFA overfeeding. Whether these metabolite changes are involved in depot-specific fat storage and increased lean tissue mass during overeating needs further investigation.
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| 29. |
- Ferretti, Raphael, et al.
(author)
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No Evidence of Circumstellar Gas Surrounding Type Ia Supernova SN 2017cbv
- 2017
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In: Astrophysical Journal Letters. - : American Astronomical Society. - 2041-8205 .- 2041-8213. ; 851:2
-
Journal article (peer-reviewed)abstract
- Nearby type Ia supernovae (SNe Ia), such as SN 2017cbv, are useful events to address the question of what the elusive progenitor systems of the explosions are. Hosseinzadeh et al. suggested that the early blue excess of the light curve of SN 2017cbv could be due to the supernova ejecta interacting with a non-degenerate companion star. Some SN Ia progenitor models suggest the existence of circumstellar (CS) environments in which strong outflows create low-density cavities of different radii. Matter deposited at the edges of the cavities should be at distances at which photoionization due to early ultraviolet (UV) radiation of SNe. Ia causes detectable changes to the observable Na I D and Ca II H&K absorption lines. To study possible narrow absorption lines from such material, we obtained a time series of high-resolution spectra of SN 2017cbv at phases between -14.8 and +83 days with respect to B-band maximum, covering the time at which photoionization is predicted to occur. Both narrow Na I D and Ca II H&K are detected in all spectra, with no measurable changes between the epochs. We use photoionization models to rule out the presence of Na I and Ca II gas clouds along the line of sight of SN 2017cbv between similar to 8 x 10(16)-2 x 10(19) cm and similar to 10(15)-10(17) cm, respectively. Assuming typical abundances, the mass of a homogeneous spherical CS gas shell with radius R must be limited to M-HI(CSM) < 3 x 10(-4) x (R/10(17)[cm(2)]) M-circle dot. The bounds point to progenitor models that deposit little gas in their CS environment.
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| 30. |
- Galván, Ignacio Fdez., et al.
(author)
-
OpenMolcas : From Source Code to Insight
- 2019
-
In: Journal of Chemical Theory and Computation. - : American Chemical Society (ACS). - 1549-9618 .- 1549-9626. ; 15:11, s. 5925-5964
-
Journal article (peer-reviewed)abstract
- In this Article we describe the OpenMolcas environment and invite the computational chemistry community to collaborate. The open-source project already includes a large number of new developments realized during the transition from the commercial MOLCAS product to the open-source platform. The paper initially describes the technical details of the new software development platform. This is followed by brief presentations of many new methods, implementations, and features of the OpenMolcas program suite. These developments include novel wave function methods such as stochastic complete active space self-consistent field, density matrix renormalization group (DMRG) methods, and hybrid multiconfigurational wave function and density functional theory models. Some of these implementations include an array of additional options and functionalities. The paper proceeds and describes developments related to explorations of potential energy surfaces. Here we present methods for the optimization of conical intersections, the simulation of adiabatic and nonadiabatic molecular dynamics, and interfaces to tools for semiclassical and quantum mechanical nuclear dynamics. Furthermore, the Article describes features unique to simulations of spectroscopic and magnetic phenomena such as the exact semiclassical description of the interaction between light and matter, various X-ray processes, magnetic circular dichroism, and properties. Finally, the paper describes a number of built-in and add-on features to support the OpenMolcas platform with postcalculation analysis and visualization, a multiscale simulation option using frozen-density embedding theory, and new electronic and muonic basis sets.
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| 31. |
- Goobar, Ariel, et al.
(author)
-
iPTF16geu : A multiply imaged, gravitationally lensed type Ia supernova
- 2017
-
In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 356:6335, s. 291-295
-
Journal article (peer-reviewed)abstract
- We report the discovery of a multiply imaged, gravitationally lensed type Ia supernova, iPTF16geu (SN 2016geu), at redshift z = 0.409. This phenomenon was identified because the light from the stellar explosion was magnified more than 50 times by the curvature of space around matter in an intervening galaxy. We used high-spatial-resolution observations to resolve four images of the lensed supernova, approximately 0.3 arc seconds from the center of the foreground galaxy. The observations probe a physical scale of ~1 kiloparsec, smaller than is typical in other studies of extragalactic gravitational lensing. The large magnification and symmetric image configuration imply close alignment between the lines of sight to the supernova and to the lens. The relative magnifications of the four images provide evidence for substructures in the lensing galaxy.
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| 32. |
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| 33. |
- Graff, M., et al.
(author)
-
Genome-wide physical activity interactions in adiposity. A meta-analysis of 200,452 adults
- 2017
-
In: PLoS Genet. - : Public Library of Science (PLoS). - 1553-7404 .- 1553-7390. ; 13:4
-
Journal article (peer-reviewed)abstract
- Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by similar to 30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.
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| 34. |
- Heikkinen, Tim, et al.
(author)
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Assessment of Simulation Ready CAD Models in a Set Based Concurrent Engineering Context
- 2016
-
In: Proceedings of the DESIGN 2016 14th International Design Conference, Dubrovnik, May 16-19, 2016.. - : The Design Society. ; , s. 649-658
-
Conference paper (peer-reviewed)abstract
- Set-based concurrent engineering (SBCE) has been pointed out as a means of enabling customisation and easy adaptation to fluctuating requirements. A feature and script based automation method of Finite Element Analysis has been proposed and developed by [Johansson, 2014] to help support SBCE. This article presents an assessment of the purposed method with respect to its industrial need, scientific novelty, and further work required. Outcomes of which include a new CAD-model tagging technique, positive industrial feedback and further work suggestions.
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| 35. |
- Heikkinen, Tim, et al.
(author)
-
Extended CAD-models – State of Practice within Three Companies
- 2017
-
In: IEEM2017, International Conference on Industrial Engineering and Engineering Management, 10-13 December, 2017, Singapore. - : IEEE. ; , s. 1089-1093
-
Conference paper (peer-reviewed)abstract
- Product platforms and product family design have been recognized as successful methods to enable masscustomization strategies. However, companies working with products where pre-defined product variants are not feasible require a more generic platform with re-usable components as well as engineering resources. Extended CAD-models is an approach where CAD-models are utilized as carriers of information to support re-usability of both geometric content and engineering activities, decreasing product development lead-time and enabling the definition of a product family within Engineer-To-Order business contexts. The following paper presents the approach in more detail and the results of a multi-case study where three Swedish industrial companies were interviewed. Results show that all companies store information within the CAD-models to support re-usability. Several challenges were expressed such as managing responsibilities and modeling flexible CAD-models. Future trends involve the concept, but to which extent is not clear.
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| 36. |
- Heikkinen, Tim, et al.
(author)
-
Extended design assets enabling automated tool development as a part of a product platform approach
- 2018
-
In: DS92: Proceedings of the DESIGN 2018 15th International Design Conference. - : The Design Society. - 9789537738594 ; , s. 757-768
-
Conference paper (peer-reviewed)abstract
- Product platform development is a well-established approach for reusing product knowledge in the form of geometry and its configuration rules and constraints. Explicitly defining all platform components is not always possible however. This is why a product platform approach where the processes of realising platform components also are supported is needed, instead of exclusively relying on their results. The work presented here works toward this, with a focus on automated tool development enabled by extending design assets from different tools.
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| 37. |
- Heikkinen, Tim, et al.
(author)
-
Review of CAD-model Capabilities and Restrictions for Multidisciplinary use
- 2017
-
In: Proceedings of CAD'17. - : CAD Solutions. ; , s. 337-341
-
Conference paper (peer-reviewed)abstract
- Product development is an iterative process, partially due to changes in both company internal and external product requirements, resulting in changes to the product under development. These changes might require recapitulation of design rationale and result in re-doing assessments and syntheses of different kinds. One way to support this work is to proactively model in such a way that as much as possible of the previous work can be re-used. Modelling for re-use can be done by documenting design rationale and formalising performed activities as design guidelines or computer scripts. To be able to find and effectively re-use design activities, the added support could be attached to or otherwise linked to the product features they relate to. This paper focuses on the native CAD-models which also has been utilized by others as carriers of information for different purposes. For instance, describes the use of annotations on CAD-models, an example is presented where both FEM and CAM specifics were added to the geometry enabling automatic FEA and blank casting geometry creation. The approach was later used to support both constraint based redesign activities and encapsulation of in-development/in-service information for throughout product lifecycle retrieval.
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| 38. |
- Heikkinen, Tim, et al.
(author)
-
Review of CAD-model Capabilities and Restrictions for Multidisciplinary use
- 2018
-
In: Computer-Aided Design and Applications. - : Taylor & Francis. - 1686-4360. ; 15:4, s. 509-519
-
Journal article (peer-reviewed)abstract
- Product development is an iterative process, partially due to changes in both company internal and external product requirements, resulting in changes to the product under development. These changes might require recapitulation of design rationale and result in re-doing assessments and syntheses of different kinds. One way to support this work is to proactively model in such a way that as much as possible of the previous work can be re-used. Not only within one product development project but also across and to future ones. Modelling for re-use can be done by documenting design rationale and formalising performed activities as design guidelines or computer scripts. To be able to find and re-use this information it could be attached to the product features which it relates to. Since geometry is such a core product characteristic, especially within the mechanical industry, and is often modelled as CAD-models, this paper presents a review of CAD-model capabilities and restrictions to serve as a carrier of multidisciplinary information. This is done by; enquiring three Swedish companies, exploring an automated Finite Element Analysis method utilising the CAD-model as a carrier of information, and reviewing different CAD software capabilities. Results show that there are at least seven extension techniques, out of which all are currently being used or considered to be in the future, by at least one company. Further, depending on the extension technique, extendibility and human-comprehension of the added information differ.
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| 39. |
- Hellrup, Joel, 1983-, et al.
(author)
-
Production and characterization of aluminium oxide nanoshells on spray dried lactose
- 2017
-
In: International Journal of Pharmaceutics. - : Elsevier BV. - 0378-5173 .- 1873-3476. ; 529:1-2, s. 116-122
-
Journal article (peer-reviewed)abstract
- Atomic layer deposition (ALD) enables deposition of dense nanometer thick metal oxide nanoshells on powder particles with precise thickness control. This leads to products with low weight fraction coating, also when depositing on nano- or micron sized powder particles. This study aimed at investigating the aluminium oxide nanoshell thickness required to prevent moisture sorption. The nanoshells were produced with ALD on spray-dried lactose, which is amorphous and extremely hygroscopic. The particles were studied with dynamic vapor sorption between 0 and 50% RH, light scattering, scanning electron microscopy, X-ray diffraction, differential scanning calorimetry, and polarized light microscopy. The ALD did not induce any recrystallization of the amorphous lactose. The dynamic vapor sorption indicated that the moisture sorption was almost completely inhibited by the nanoshell. Neat amorphous lactose rapidly recrystallized upon moisture exposure. However, only ca. 15% of the amorphous lactose particles recrystallized of a sample with 9% (by weight) aluminium oxide nanoshell at storage for six months upon 75% RH/40 degrees C, which indicate that the moisture sorption was completely inhibited in the majority of the particles. In conclusion, the aluminium oxide nanoshells prevented moisture sorption and dramatically improved the long term physical stability of amorphous lactose. This shows the potential of the ALD-technique to protect drug microparticles.
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| 40. |
- Hjertberg, Tim, et al.
(author)
-
Implementation and management of design systems for highly customized products – state of practice and future research
- 2015
-
In: Transdisciplinary lifecycle analysis of systems. - : IOS Press. - 9781614995432 - 9781614995449 ; , s. 165-174
-
Conference paper (peer-reviewed)abstract
- Individualized products, resource-smart design and production, and afocus on customer value have been pointed out as three opportunities for Swedishindustry to stay competitive on a globalized market. All these three opportunitiescan be gained by efficient design and manufacture of highly customized products.However, this requires the development and integration of the knowledge-basedenabling technologies of the future as pointed out by The European Factories ofthe Future Research Association (EFFRA). Highly custom engineered productsrequire an exercising of a very rich and diverse knowledge base about the products,their production and the required resources for design and manufacture. Thedevelopment and implementation of systems for automated design and productionpreparation of customized products is a significant investment in time and money.However, our experience from industry indicates that significant efforts arerequired to introduce and align these kinds of systems with existing operations,legacy systems and overall state of practice. In this paper, support for systemdevelopment in literature has been reviewed in combination with a survey on thestate of practice in four companies regarding implementation and management ofautomated systems for custom engineered products. A gap has been identified anda set of areas for further research are outlined.
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| 41. |
- Hosseinzadeh, Griffin, et al.
(author)
-
Type Ibn Supernovae Show Photometric Homogeneity and Spectral Diversity at Maximum Light
- 2017
-
In: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 836:2
-
Journal article (peer-reviewed)abstract
- Type Ibn supernovae (SNe) are a small yet intriguing class of explosions whose spectra are characterized by low-velocity helium emission lines with little to no evidence for hydrogen. The prevailing theory has been that these are the core-collapse explosions of very massive stars embedded in helium-rich circumstellar material (CSM). We report optical observations of six new SNe Ibn: PTF11rfh, PTF12ldy, iPTF14aki, iPTF15ul, SN 2015G, and iPTF15akq. This brings the sample size of such objects in the literature to 22. We also report new data, including a near-infrared spectrum, on the Type Ibn SN 2015U. In order to characterize the class as a whole, we analyze the photometric and spectroscopic properties of the full Type Ibn sample. We find that, despite the expectation that CSM interaction would generate a heterogeneous set of light curves, as seen in SNe IIn, most Type Ibn light curves are quite similar in shape, declining at rates around 0.1 mag day(-1) during the first month after maximum light, with a few significant exceptions. Early spectra of SNe Ibn come in at least two varieties, one that shows narrow P Cygni lines and another dominated by broader emission lines, both around maximum light, which may be an indication of differences in the state of the progenitor system at the time of explosion. Alternatively, the spectral diversity could arise from viewing-angle effects or merely from a lack of early spectroscopic coverage. Together, the relative light curve homogeneity and narrow spectral features suggest that the CSM consists of a spatially confined shell of helium surrounded by a less dense extended wind.
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| 42. |
- Hsiao, E. Y., et al.
(author)
-
Strong near-infrared carbon in the Type Ia supernova iPTF13ebh
- 2015
-
In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 578
-
Journal article (peer-reviewed)abstract
- We present near-infrared (NIR) time-series spectroscopy, as well as complementary ultraviolet (UV), optical, and NIR data, of the Type Ia supernova (SN Ia) iPTF13ebh, which was discovered within two days from the estimated time of explosion. The first NIR spectrum was taken merely 2 : 3 days after explosion and may be the earliest NIR spectrum yet obtained of a SN Ia. The most striking features in the spectrum are several NIR C I lines, and the C I lambda 1.0693 mu m line is the strongest ever observed in a SN Ia. Interestingly, no strong optical C II counterparts were found, even though the optical spectroscopic time series began early and is densely cadenced. Except at the very early epochs, within a few days from the time of explosion, we show that the strong NIR C I compared to the weaker optical C II appears to be general in SNe Ia. iPTF13ebh is a fast decliner with Delta m(15)(B) = 1.79 +/- 0.01, and its absolute magnitude obeys the linear part of the width-luminosity relation. It is therefore categorized as a transitional event, on the fast-declining end of normal SNe Ia as opposed to subluminous/91bg-like objects. iPTF13ebh shows NIR spectroscopic properties that are distinct from both the normal and subluminous/91bg-like classes, bridging the observed characteristics of the two classes. These NIR observations suggest that composition and density of the inner core are similar to that of 91bg-like events, and that it has a deep-reaching carbon burning layer that is not observed in more slowly declining SNe Ia. There is also a substantial difference between the explosion times inferred from the early-time light curve and the velocity evolution of the Si II lambda 0.6355 mu m line, implying a long dark phase of similar to 4 days.
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| 43. |
- Isgren, Anniella, et al.
(author)
-
Increased cerebrospinal fluid interleukin-8 in bipolar disorder patients associated with lithium and antipsychotic treatment.
- 2015
-
In: Brain, behavior, and immunity. - : Elsevier BV. - 1090-2139 .- 0889-1591. ; 43, s. 198-204
-
Journal article (peer-reviewed)abstract
- Inflammation has been linked to the pathophysiology of bipolar disorder based on studies of inflammation markers, such as cytokine concentrations, in plasma and serum samples from cases and controls. However, peripheral measurements of cytokines do not readily translate to immunological activity in the brain. The aim of the present study was to study brain immune and inflammatory activity. To this end, we analyzed cytokines in cerebrospinal fluid from 121 euthymic bipolar disorder patients and 71 age and sex matched control subjects. Concentrations of 11 different cytokines were determined using immunoassays. Cerebrospinal fluid IL-8 concentrations were significantly higher in patients as compared to controls. The other cytokines measured were only detectable in part of the sample. IL-8 concentrations were positively associated to lithium- and antipsychotic treatment. The findings might reflect immune aberrations in bipolar disorder, or be due to the effects of medication.
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| 44. |
- Jansson, Johan, et al.
(author)
-
An anisotropic non-linear material model for glass fibre reinforced plastics
- 2018
-
In: Composite structures. - : Elsevier. - 0263-8223 .- 1879-1085. ; 195, s. 93-98
-
Journal article (peer-reviewed)abstract
- This paper aims to present a methodology to predict the anisotropic and non-linear behaviour of glass fibre reinforced plastics using finite element methods. A material model is implemented in order to remedy the need of multiple material definitions, and to control the local plastic behaviour as a function of the fibre orientation. Injection moulding simulations traditionally provide second order orientation tensors, which are considered together with a homogenization scheme to compute local material properties. However, in the present study, fourth order tensors are used in combination with traditional methods to provide more accurate material properties. The elastic and plastic response of the material model is optimized to fit experimental test data, until simulations and experiments overlap. The proposed material model can support design engineers in making more informed decisions, allowing them to create smarter products without the need of excessive safety factors, leading to reduced component weight and environmental impact.
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| 45. |
- Jencson, J. E., et al.
(author)
-
SPIRITS 16tn in NGC 3556 : A Heavily Obscured and Low-luminosity Supernova at 8.8 Mpc
- 2018
-
In: Astrophysical Journal. - : Institute of Physics Publishing (IOPP). - 0004-637X .- 1538-4357. ; 863:1
-
Journal article (peer-reviewed)abstract
- We present the discovery by the SPitzer InfraRed Intensive Transients Survey (SPIRITS) of a likely supernova (SN) in NGC 3556 (M108) at only 8.8 Mpc that was not detected by optical searches. A luminous infrared (IR) transient at M [4.5] = −16.7 mag (Vega), SPIRITS 16tn is coincident with a dust lane in the inclined, star-forming disk of the host. Using observations in the IR, optical, and radio, we attempt to determine the nature of this event. We estimate A V ≈ 8–9 mag of extinction, placing it among the three most highly obscured IR-discovered SNe. The [4.5] light curve declined at a rate of 0.013 mag day−1, and the [3.6]–[4.5] color increased from 0.7 to 1.0 mag by 184.7 days post discovery. Optical/IR spectroscopy shows a red continuum but no clearly discernible features, preventing a definitive spectroscopic classification. Radio observations constrain the radio luminosity of SPIRITS 16tn to L ν 1024 erg s−1 Hz−1 between 3 and 15 GHz, excluding many varieties of core-collapse SNe. An SN Ia is ruled out by the observed IR color and lack of spectroscopic features from Fe-peak elements. SPIRITS 16tn was fainter at [4.5] than typical stripped-envelope SNe by ≈1 mag. Comparison of the spectral energy distribution to SNe II suggests that SPIRITS 16tn was both highly obscured and intrinsically dim, possibly akin to the low-luminosity SN 2005cs. We infer the presence of an IR dust echo powered by an initial peak luminosity of the transient of 5 × 1040 erg s−1 L peak 4 × 1043 erg s−1, consistent with the observed range for SNe II. This discovery illustrates the power of IR surveys to overcome the compounding effects of visible extinction and optically subluminous events in completing the inventory of nearby SNe.
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| 46. |
- Jencson, Jacob E., et al.
(author)
-
The SPIRITS Sample of Luminous Infrared Transients : Uncovering Hidden Supernovae and Dusty Stellar Outbursts in Nearby Galaxies
- 2019
-
In: Astrophysical Journal. - : IOP PUBLISHING LTD. - 0004-637X .- 1538-4357. ; 886:1
-
Journal article (peer-reviewed)abstract
- We present a systematic study of the most luminous (M-IR [Vega magnitudes] brighter than ?14) infrared (IR) transients discovered by the SPitzer InfraRed Intensive Transients Survey (SPIRITS) between 2014 and 2018 in nearby galaxies (D < 35 Mpc). The sample consists of nine events that span peak IR luminosities of M-[4.5],M-peak between ?14 and ?18.2, show IR colors between 0.2;<;([3.6]?[4.5]);<;3.0, and fade on timescales between 55 days;t(fade);<;480 days. The two reddest events (A(V) > 12) show multiple, luminous IR outbursts over several years and have directly detected, massive progenitors in archival imaging. With analyses of extensive, multiwavelength follow-up, we suggest the following possible classifications: five obscured core-collapse supernovae (CCSNe), two erupting massive stars, one luminous red nova, and one intermediate-luminosity red transient. We define a control sample of all optically discovered transients recovered in SPIRITS galaxies and satisfying the same selection criteria. The control sample consists of eight CCSNe and one Type;Iax SN. We find that 7 of the 13 CCSNe in the SPIRITS sample have lower bounds on their extinction of 2;A(V);<;8. We estimate a nominal fraction of CCSNe in nearby galaxies that are missed by optical surveys as high as
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| 47. |
- Johansson, Emil, et al.
(author)
-
Whole-Body Imaging of Tissue-specific Insulin Sensitivity and Body Composition by Using an Integrated PET/MR System: A Feasibility Study
- 2018
-
In: Radiology. - : Radiological Society of North America (RSNA). - 0033-8419 .- 1527-1315. ; 286:1, s. 271-278
-
Journal article (peer-reviewed)abstract
- Purpose: To develop, evaluate, and demonstrate the feasibility of a whole-body protocol for simultaneous assessment of tissue-specific insulin-mediated fluorine 18 (F-18) fluorodeoxyglucose (FDG) influx rates, tissue depots, and whole-body insulin sensitivity (referred to as the M value). Materials and Methods: An integrated positron emission tomography (PET)/magnetic resonance (MR) imaging system combined with hyperinsulinemic euglycemic clamp (HEC) was used. Dynamic whole-body PET imaging was used to determine the insulin-mediated F-18-FDG tissue influx rate (K-i) in the whole-body region by using the Patlak method. M value was determined with the HEC method at PET imaging. Tissue depots were quantified by using water-fat separated MR imaging and manual segmentations. Feasibility of the imaging protocol was demonstrated by using five healthy control participants and five patients with type 2 diabetes. Associations between M value and K-i were studied in multiple tissues by using the Pearson correlation. Results: Positive correlations were found between M value and K-i in multiple tissues: the gluteus muscle (r = 0.875; P = .001), thigh muscle (r = 0.903; P < .001), calf muscle (r = 0.825; P = .003), and abdominal visceral adipose tissue (r = 0.820; P = .004). A negative correlation was found in the brain (r = 0.798; P = .006). The MR imaging-based method for quantification of tissue depots was feasible for determining adipose tissue volumes and fat fractions. Conclusion: This PET/MR imaging protocol may be feasible for simultaneous assessment of tissue-specific insulin-mediated F-18-FDG influx rates, tissue depots, and M value. (C) RSNA, 2017
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| 48. |
- Johansson, Hans-Erik, 1960-, et al.
(author)
-
Energy restriction in obese women suggest linear reduction of hepatic fat content and time-dependent metabolic improvements
- 2019
-
In: Nutrition & Diabetes. - : Springer Science and Business Media LLC. - 2044-4052. ; 9:1
-
Journal article (peer-reviewed)abstract
- Energy restriction reduces liver fat, improves hepatic insulin resistance and lipid metabolism. However, temporal data in which these metabolic improvements occur and their interplay is incomplete. By performing repeated MRI scans and blood analysis at day 0, 3, 7, 14 and 28 the temporal changes in liver fat and related metabolic factors were assessed at five times during a low-calorie diet (LCD, 800-1100 kcal/day) in ten obese non-diabetic women (BMI 41.7 ± 2.6 kg/m2) whereof 6 had NAFLD. Mean weight loss was 7.4 ± 1.2 kg (0.7 kg/day) and liver fat decreased by 51 ± 16%, resulting in only three subjects having NAFLD at day 28. Marked alteration of insulin, NEFA, ALT and 3-hydroxybuturate was evident 3 days after commencing LCD, whereas liver fat showed a moderate but a linear reduction across the 28 days. Other circulating-liver fat markers (e.g. triglycerides, adiponectin, stearoyl-CoA desaturase-1 index, fibroblast growth factor 21) demonstrated modest and variable changes. Marked elevations of NEFA, 3-hydroxybuturate and ALT concentrations occurred until day 14, likely reflecting increased tissue lipolysis, fat oxidation and upregulated hepatic fatty acid oxidation. In summary, these results suggest linear reduction in liver fat, time-specific changes in metabolic markers and insulin resistance in response to energy restriction.
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| 49. |
- Johansson, Joel, et al.
(author)
-
A Novel SMAD4 Mutation Causing Severe Juvenile Polyposis Syndrome with Protein Losing Enteropathy, Immunodeficiency, and Hereditary Haemorrhagic Telangiectasia.
- 2015
-
In: Case Reports in Gastrointestinal Medicine. - : Hindawi Limited. - 2090-6528 .- 2090-6536. ; 2015, s. 1-5
-
Journal article (peer-reviewed)abstract
- Juvenile polyposis syndrome (JPS) is a rare genetic disorder characterized by juvenile polyps of the gastrointestinal tract. We present a new pathogenic mutation of the SMAD4 gene and illustrate the need for a multidisciplinary health care approach to facilitate the correct diagnosis. The patient, a 47-year-old Caucasian woman, was diagnosed with anaemia at the age of 12. During the following 30 years, she developed numerous gastrointestinal polyps. The patient underwent several operations, and suffered chronic abdominal pain, malnutrition, and multiple infections. Screening of the SMAD4 gene revealed a novel, disease-causing mutation. In 2012, the patient suffered hypoalbuminemia and a large polyp in the small bowel was found. Gamma globulin was given but the patient responded with fever and influenza-like symptoms and refused more treatment. The patient underwent surgery in 2014 and made an uneventful recovery. At follow-up two months later albumin was 38 g/L and IgG was 6.9 g/L. Accurate diagnosis is essential for medical care. For patients with complex symptomatology, often with rare diseases, this is best provided by multidisciplinary teams including representatives from clinical genetics. Patients with a SMAD4 mutation should be followed up both for JPS and haemorrhagic hereditary telangiectasia and may develop protein loosing enteropathy and immunodeficiency.
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| 50. |
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