| 1. |
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
- Wang, Faming, et al.
(author)
-
Does PHS Model Predict Acceptable Skin and Core Temperatures While Wearing Protective Clothing.
- 2010
-
In: ; , s. 1-5
-
Conference paper (peer-reviewed)abstract
- Mathematical modeling is very important when experimental settings with human subjects are restricted to thermal limits necessary to protect the individual. The predicted heat strain (PHS) model has been published AS ISO 7933 for about six years. It describes a method for predicting the sweat rate and internal core temperature that the human body will develop in response to the working conditions. The PHS model was developed based on thousands of laboratory and field experiments collected from eight European laboratories. However, most of the laboratory and field tests were performed on human subjects with light clothing ensembles (0.38±0.34 clo < Icl < 0.77±0.18 clo). The prediction of physiological responses while human wearing highly insulating protective clothing might be weak. In order to check the prediction accuracy of current PHS model while using protective clothing, we conducted totally series of human subject tests at a simulated hot environment. The results of 18 tests involving the high visibility (HV), military (MIL) and firefighting (FIRE) clothing are reported here. Six human subjects were asked to walk on a treadmill at 4.5 km/h at 40 oC for 70 min. Two humidity levels were chosen: 2 kPa (RH = 27 %) and 3 kPa (RH = 41 %) depending on the garment. The rectal temperature, skin temperature, heart rate and metabolic rate were measured. The clothing and the subjects were weighed before and after the exposure in order to calculate the sweat and evaporation rate. The observed and predicted rectal temperatures and mean skin temperatures were compared. The PHS model failed to predict the final rectal temperature in FIRE and the predicted estimate was 1.83 oC higher than the observed value after 63-min exposure. The predicted curve showed a much deeper linear increase during the whole exercise. None of the predicted mean skin temperatures during the three testing scenarios were accurately predicted. The PHS model was consistently providing conservative mean skin temperature evaluations. The predicted curve in HV and MIL showed a much shallower increase during the early portion of the exposure and plateaued at temperatures lower than ever achieved by the subjects. The observed sweat rates were 556±110 g/h in HV, 717±200 g/h in MIL, and 834±274 g/h in FIRE. There was no significant difference between the predicted total sweat values and the experimental data (P=0.073). In summary, the PHS model produce prediction of core temperature which has an unacceptable error when human wore thick protective clothing. The weak prediction on the mean skin temperature in HV and MIL was in agreement with the empirical prediction equation in the source codes has the poorest and lowest correlation when a clothed human subject exercised at the humidity level above 2 kPa. It is therefore recommended that the PHS model should be amended to development and validated by manipulation of individual algorithms or physical (or physiological) parameters.
|
|
| 5. |
- Stamatiou, Georgios, 1984, et al.
(author)
-
Power-dependent droop-based control strategy for multi-terminal HVDC transmission grids
- 2017
-
In: IET Generation, Transmission and Distribution. - : Institution of Engineering and Technology (IET). - 1751-8687 .- 1751-8695. ; 11:2, s. 383 - 391
-
Journal article (peer-reviewed)abstract
- The concept of voltage source converter based multi-terminal high-voltage direct current (MTDC) grids, represents both challenges and opportunities for the future of large power transfer and integration of renewable energy sources. For this kind of grids, the control aspect is of great importance, with voltage-droop based methods considered as one of the most attractive solutions. All existing strategies are designed to maintain the level of voltage in the MTDC grid constant during unexpected events, thus sacrificing the power flow. The aim of this study is to propose a new droop controller structure that maintains the dc-grid voltage close to the nominal value and at the same time tries to preserve the power flow in the dc grid, following events such as faults or disconnection of stations. The control scheme is presented and simulations are carried out in a four- and five-terminal MTDC grid, proving the validity of the concept.
|
|
| 6. |
|
|
| 7. |
- Lowe, Robert, et al.
(author)
-
Vicarious value learning by differential outcomes training: A social transfer of control methodology
- 2021
-
In: MethodsX. - : Elsevier BV. - 2215-0161. ; 8
-
Journal article (peer-reviewed)abstract
- This article adapts an existing experimental protocol for assessing individuals’ ability to transfer knowledge across instrumental and pavlovian learning stages. The protocol (Transfer of Control using differential outcomes learning) is adapted to fit social contexts wherein the pavlovian learning phase is modulated so that individuals are able to observe, and potentially learn from, the stimulus associated with reinforcing outcomes presented to another (observable) individual. Transfer of Control concerns participants combining knowledge of learned instrumental and pavlovian (stimulus, response, outcome) associations in order to ground the learning of new associations. The article describes the theoretical and procedural underpinnings of a novel Social Transfer of Control methodology. The use of such a methodology is two-fold: i) to serve as a guide to researchers interested in evaluating how individuals can learn from others in a partially observable setting, i.e. when behavioural and reinforcing outcome information is hidden, and bring to bear this knowledge on their own instrumental decision making; ii), to facilitate investigation of the routes of cognitive and emotional empathy, with potential applications for educational and clinical settings. • Three stage Transfer of Control behavioural methodology is adapted to include a social (pavlovian) learning stage. • Hypotheses can be tested that concern learning rewarding instrumental responses achieved by observation of others’ emotionally expressive reactions to differentially rewarding outcomes. • Methodological and validation considerations for evaluating the above are presented
|
|
| 8. |
|
|
| 9. |
|
|
| 10. |
|
|
| 11. |
- Kyrki, Ville, et al.
(author)
-
Action Recognition and Understanding using Motor Primitives
- 2007
-
In: 2007 RO-MAN. - 9781424416349 ; , s. 1113-1118
-
Conference paper (peer-reviewed)abstract
- We investigate modeling and recognition of arm manipulation actions of different levels of complexity. To model the process, we are using a combination of discriminative support vector machines and generative hidden Markov models. The experimental evaluation, performed with 10 people, investigates both definition and structure of primitive motions as well as the validity of the modeling approach taken.
|
|
| 12. |
- Tuomela, Johanna, et al.
(author)
-
Overexpression of vascular endothelial growth factor C increases growth and alters the metastatic pattern of orthotopic PC-3 prostate tumors
- 2009
-
In: BMC Cancer. - : Springer Science and Business Media LLC. - 1471-2407. ; 9
-
Journal article (peer-reviewed)abstract
- Background: Prostate cancer metastasizes to regional lymph nodes and distant sites but the roles of lymphatic and hematogenous pathways in metastasis are not fully understood. Methods: We studied the roles of VEGF-C and VEGFR3 in prostate cancer metastasis by blocking VEGFR3 using intravenous adenovirus-delivered VEGFR3-Ig fusion protein (VEGFR3-Ig) and by ectopic expression of VEGF-C in PC-3 prostate tumors in nude mice. Results: VEGFR3- Ig decreased the density of lymphatic capillaries in orthotopic PC-3 tumors (p < 0.05) and inhibited metastasis to iliac and sacral lymph nodes. In addition, tumor volumes were smaller in the VEGFR3-Ig-treated group compared with the control group (p < 0.05). Transfection of PC-3 cells with the VEGF-C gene led to a high level of 29/31 kD VEGF-C expression in PC-3 cells. The size of orthotopic and subcutaneous PC-3/VEGF-C tumors was significantly greater than that of PC-3/mock tumors (both p < 0.001). Interestingly, while most orthotopic PC-3 and PC-3/mock tumors grown for 4 weeks metastasized to prostate-draining lymph nodes, orthotopic PC3/VEGF-C tumors primarily metastasized to the lungs. PC-3/VEGF-C tumors showed highly angiogenic morphology with an increased density of blood capillaries compared with PC-3/mock tumors (p < 0.001). Conclusion: The data suggest that even though VEGF-C/VEGFR3 pathway is primarily required for lymphangiogenesis and lymphatic metastasis, an increased level of VEGF-C can also stimulate angiogenesis, which is associated with growth of orthotopic prostate tumors and a switch from a primary pattern of lymph node metastasis to an increased proportion of metastases at distant sites.
|
|
| 13. |
|
|
| 14. |
- Wang, Faming, et al.
(author)
-
CLOTHING REAL EVAPORATIVE RESISTANCE DETERMINED BY MEANS OF A SWEATING THERMAL MANIKIN: A NEW ROUND-ROBIN STUDY
- 2014
-
In: Proceedings of Ambience 14&10i3m : Scientific Conference for Smart and Functional Textiles, Well-Being, Thermal Comfort in Clothing, Design, Thermal Manikins and Modellin, 7-9 September 2014, Tampere, Finland - Scientific Conference for Smart and Functional Textiles, Well-Being, Thermal Comfort in Clothing, Design, Thermal Manikins and Modellin, 7-9 September 2014, Tampere, Finland. - 2342-4540. - 9789521532696 ; 1
-
Conference paper (peer-reviewed)abstract
- The previous round-robin (RR) study on clothing evaporative resistance (Ret) has shown that the repeatability and reproducibility of clothing Ret measurements on sweating manikins were rather low. To further examine and enhance the measurement accuracy, a new strict but feasible test protocol was proposed and thoroughly examined in a new round-robin test. Eight laboratories participated in this study and three types of sweating manikins were used. Six clothing ensembles including body mapping cycling wear, light summer workwear, typical spring and autumn clothing for people living in subtropical regions, cold protective clothing and functional Gore-Tex coverall were selected. The measurement repeatability and reproducibility are analysed. The ultimate goal of the RR study is to provide solid support for amending ASTM F2370 standard and/or drafting a new ISO/EN standard.
|
|
| 15. |
- Abbasi, R., et al.
(author)
-
IceCube high-energy starting event sample : Description and flux characterization with 7.5 years of data
- 2021
-
In: Physical Review D. - : American Physical Society. - 2470-0010 .- 2470-0029. ; 104:2
-
Journal article (peer-reviewed)abstract
- The IceCube Neutrino Observatory has established the existence of a high-energy all-sky neutrino flux of astrophysical origin. This discovery was made using events interacting within a fiducial region of the detector surrounded by an active veto and with reconstructed energy above 60 TeV, commonly known as the high-energy starting event sample (HESE). We revisit the analysis of the HESE sample with an additional 4.5 years of data, newer glacial ice models, and improved systematics treatment. This paper describes the sample in detail, reports on the latest astrophysical neutrino flux measurements, and presents a source search for astrophysical neutrinos. We give the compatibility of these observations with specific isotropic flux models proposed in the literature as well as generic power-law-like scenarios. Assuming v(e): v(mu): v(tau) = 1:1:1, and an equal flux of neutrinos and antineutrinos, we find that the astrophysical neutrino spectrum is compatible with an unbroken power law, with a preferred spectral index of 2.87(-0.19)(+0.20) for the 68% confidence interval.
|
|
| 16. |
|
|
| 17. |
- Escandell Montiel, Daniel
(author)
-
Cinetextos, logoemesis y textovisualidades de las autoras digitales españolas
- 2023
-
In: Bulletin of Spanish Studies. - 1475-3820 .- 1478-3428.
-
Journal article (peer-reviewed)abstract
- El uso de la escritura como objeto artístico escribe su propia historia en los medios digitales gracias a la interacción con el receptor de la obra, que es lector y usuario. A través, fundamentalmente, de los marcos de referencia de la logofagia y la logoemesis abordamos el espacio del arte textovisual interactivo. Con ello afrontamos un corpus seleccionado y representativo de autoras digitales en lengua española, lo que es también un acto reivindicativo intrínseco: sus obras son relevantes y significativas como práctica tecnoartística y literaria, aunque en ocasiones han sido obviadas por su género.
|
|
| 18. |
- Jones, Christopher, et al.
(author)
-
Reactive nitrogen restructures and weakens microbial controls of soil N2O emissions
- 2022
-
In: Communications biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 5
-
Journal article (peer-reviewed)abstract
- Long-term, replicated fertilization field trials show that increased potential N2O production is associated with specific phylogenetic shifts in communities of frequently occurring soil microbes. This sheds light on the link between legacy effects of reactive nitrogen on microbial communities and altered regulation of N2O emissions.The global surplus of reactive nitrogen (N-r) in agricultural soils is accelerating nitrous oxide (N2O) emission rates, and may also strongly influence the microbial controls of this greenhouse gas resulting in positive feedbacks that further exacerbate N2O emissions. Yet, the link between legacy effects of N-r on microbial communities and altered regulation of N2O emissions is unclear. By examining soils with legacies of N-r-addition from 14 field experiments with different edaphic backgrounds, we show that increased potential N2O production is associated with specific phylogenetic shifts in communities of frequently occurring soil microbes. Inputs of N-r increased the complexity of microbial co-association networks, and altered the relative importance of biotic and abiotic predictors of potential N2O emissions. Our results provide a link between the microbial legacy of N-r addition and increased N2O emissions by demonstrating that biological controls of N2O emissions were more important in unfertilized soils and that these controls are weakened by increasing resource levels in soil.
|
|
| 19. |
- Sunny, SK, et al.
(author)
-
Changes of DNA methylation are associated with changes in lung function during adolescence
- 2020
-
In: Respiratory research. - : Springer Science and Business Media LLC. - 1465-993X. ; 21:1, s. 80-
-
Journal article (peer-reviewed)abstract
- BackgroundAdolescence is a significant period for the gender-dependent development of lung function. Prior studies have shown that DNA methylation (DNA-M) is associated with lung function and DNA-M at some cytosine-phosphate-guanine dinucleotide sites (CpGs) changes over time. This study examined whether changes of DNA-M at lung-function-related CpGs are associated with changes in lung function during adolescence for each gender, and if so, the biological significance of the detected CpGs.MethodsGenome-scale DNA-M was measured in peripheral blood samples at ages 10 (n = 330) and 18 years (n = 476) from the Isle of Wight (IOW) birth cohort in United Kingdom, using Illumina Infinium arrays (450 K and EPIC). Spirometry was conducted at both ages. A training and testing method was used to screen 402,714 CpGs for their potential associations with lung function. Linear regressions were applied to assess the association of changes in lung function with changes of DNA-M at those CpGs potentially related to lung function. Adolescence-related and personal and family-related confounders were included in the model. The analyses were stratified by gender. Multiple testing was adjusted by controlling false discovery rate of 0.05. Findings were further examined in two independent birth cohorts, the Avon Longitudinal Study of Children and Parents (ALSPAC) and the Children, Allergy, Milieu, Stockholm, Epidemiology (BAMSE) cohort. Pathway analyses were performed on genes to which the identified CpGs were mapped.ResultsFor females, 42 CpGs showed statistically significant associations with change in FEV1/FVC, but none for change in FEV1or FVC. No CpGs were identified for males. In replication analyses, 16 and 21 of the 42 CpGs showed the same direction of associations among the females in the ALSPAC and BAMSE cohorts, respectively, with 11 CpGs overlapping across all the three cohorts. Through pathway analyses, significant biological processes were identified that have previously been related to lung function development.ConclusionsThe detected 11 CpGs in all three cohorts have the potential to serve as the candidate epigenetic markers for changes in lung function during adolescence in females.
|
|
| 20. |
|
|
| 21. |
- Thoman, Peter, et al.
(author)
-
A taxonomy of task-based parallel programming technologies for high-performance computing
- 2018
-
In: Journal of Supercomputing. - : SPRINGER. - 0920-8542 .- 1573-0484. ; 74:4, s. 1422-1434
-
Journal article (peer-reviewed)abstract
- Task-based programming models for shared memory-such as Cilk Plus and OpenMP 3-are well established and documented. However, with the increase in parallel, many-core, and heterogeneous systems, a number of research-driven projects have developed more diversified task-based support, employing various programming and runtime features. Unfortunately, despite the fact that dozens of different task-based systems exist today and are actively used for parallel and high-performance computing (HPC), no comprehensive overview or classification of task-based technologies for HPC exists. In this paper, we provide an initial task-focused taxonomy for HPC technologies, which covers both programming interfaces and runtime mechanisms. We demonstrate the usefulness of our taxonomy by classifying state-of-the-art task-based environments in use today.
|
|
| 22. |
- Aad, G., et al.
(author)
-
- 2013
-
Journal article (peer-reviewed)
|
|
| 23. |
|
|
| 24. |
- Marner, Anders, 1949-
(author)
-
Konferensrapport
- 2002
-
In: Tidskrift för lärarutbildning och forskning. - Umeå : Fakultetsnämnden för lärarutbildning, Umeå universitet. ; 9:3, s. 65-66
-
Journal article (other academic/artistic)
|
|
| 25. |
- Moia, Davide, et al.
(author)
-
The Role of Hole Transport between Dyes in Solid-State Dye-Sensitized Solar Cells
- 2015
-
In: The Journal of Physical Chemistry C. - : AMER CHEMICAL SOC. - 1932-7447 .- 1932-7455. ; 119:33, s. 18975-18985
-
Journal article (peer-reviewed)abstract
- In dye-sensitized solar cells (DSSCs) photo-generated positive charges are normally considered to be carried away from the dyes by a separate phase of hole-transporting material (HTM). We show that there can also be significant transport within the dye monolayer itself before the hole reaches the HTM. We quantify the fraction of dye regeneration in solid-state DSSCs that can be attributed to this process. By using cyclic voltammetry and transient anisotropy spectroscopy, we demonstrate that the rate of interdye hole transport is prevented both on micrometer and nanometer length scales by reducing the dye loading on the TiO2 surface. The dye regeneration yield is quantified for films with high and low dye loadings (with and without hole percolation in the dye monolayer) infiltrated with varying levels of HTM. Interdye hole transport can account for >50% of the overall dye regeneration with low HTM pore filling. This is reduced to about 5% when the infiltration of the HTM in the pores is optimized in 2 mu m thick films. Finally, we use hole transport in the dye monolayer to characterize the spatial distribution of the HTM phase in the pores of the dyed mesoporous TiO2.
|
|
| 26. |
- Moiane, Belisário
(author)
-
Evaluation of the Rift Valley fever vaccination program in Mozambican cattle
- 2013
-
Licentiate thesis (other academic/artistic)abstract
- Rift Valley fever (RVF) is a viral disease that is spread by various arthropods (primarily mosquitoes) and affects ruminants and humans. RVF has led to tremendous losses of livestock in many African countries, Saudi Arabia, and Yemen, and its zoonotic impact on human deaths has been documented in most of the endemic countries where large outbreaks have occurred. The RVF virus (RVFV) is composed of three single-stranded RNA gene segments (designated S, M, and L) with negative polarity, and it is transmitted mainly by mosquitoes of the genera Aedes and Culex, and various biting flies. Outbreaks are associated with heavy rainfall and expansion of vegetation, both of which favour increases in mosquito population and thus lead to a high risk of infection in livestock and humans. In Africa, control of RVF is based on immunization with the formalin- inactivated vaccine or the Smithburn attenuated vaccine, the former of which has been administered to cattle in Mozambique since 2002. In the first part of the present research project, we evaluated the effect of transportation and storage conditions on the efficacy of the formalin-inactivated vaccine in cattle: in Maputo Province, three groups were immunized with vaccine stored at 4 °C (group A), at 25 °C (group B), and at temperatures alternating between 4 and 25 °C (group C), respectively; in Zambezia Province, animals were vaccinated as stipulated by the Directorate of the National Veterinary Services (group D). Antibodies against RVFV were monitored by indirect enzyme-linked immunosorbent assay (ELISA), immunofluorescence assay (IFA), and the plaque reduction neutralization test (PRNT). Pre-vaccination screening of cattle for neutralizing antibodies showed seropositivity in 17% and 7% in Maputo and Zambezia Provinces, respectively, and those animals were excluded from the study. After initial inoculation with the RVFV vaccine, neutralizing antibodies were detected in more than 74% of the cattle in all groups, and levels of those antibodies were even higher after booster immunization. ELISA detected a response to anti-RVFV N protein antibody in about one third of the cattle in all groups after primary vaccination, and almost 80% of the animals were seropositive after booster immunization. Also, after both primary and booster vaccinations, the anti-RVFV N protein antibody titres were higher in group D compared to groups A, B, and C. These results demonstrate that the current storage and transportation conditions in Mozambique have no influence on the efficacy of the formalin-inactivated RVFV vaccine given to cattle. The second stage of the research focused on a cross-sectional study aimed at evaluating the circulation of RVFV, by detection of neutralizing antibodies by PRNT in 404 cattle serum samples collected from different herds in six districts in Maputo Province, during 2010-2011. The PRNT results revealed that 36.9% (95% CI 32.2%–41.6%; n=149), of cattle sera had RVFV neutralizing antibodies, which is high for an area where RVFV disease has not been reported for several decades. These findings suggest that RVFV is actively circulating among the cattle in the six districts.
|
|
| 27. |
- Schmalholz, Martin, et al.
(author)
-
Relationship between abundance and fecundity in the endangered grassland annual Euphrasia rostkoviana ssp.fennica
- 2007
-
In: Annales Botanici Fennici. - 0003-3847. ; 44, s. 194-203
-
Journal article (peer-reviewed)abstract
- We examined 18 populations of the endangered Euphrasia rostkoviana ssp. fennica situated in managed semi-natural grasslands or gravelled road verges in ten extant localities in south-eastern Sweden. The major threat to the subspecies is the steady decrease in habitat area and quality. In each population, abundance and fecundity of individuals were examined. Local factors (soil-pH, litter-layer depth and vascular species richness) and isolation were also measured. We specifically wanted to examine if there was a positive relationship between abundance (population size and density) and fecundity in the investigated taxon. LLarger populations of E. rostkoviana ssp. fennica were found to be more dense. Population size and density were both significantly positively related to fecundity. A higher variability in seed production was also detected for individuals in sparse populations. An Allee effect, i.e. a reduced fecundity in small and sparse populations, could thus be demonstrated for the subspecies.
|
|
| 28. |
|
|
| 29. |
- Wang, Lihui
(author)
-
Collaborative Design Approach for Holonic Manufacturing Systems
- 2000
-
In: Proceedings of the 10th International Conference on Flexible Automation and Intelligent Manufacturing. ; , s. 1146-1156
-
Conference paper (peer-reviewed)abstract
- Future manufacturing systems will be required to be agile, flexible, and fault-tolerant. Next generation manufacturing systems will be integrated networks of distributed resources simultaneously capable of combined knowledge processing and material processing. The objective of this research is to define a generic open architecture for such kind of distributed manufacturing systems, especially for holonic manufacturing systems (HMS). The primary focus will be given to its collaborative design and implementation approach based on agent technology and emerging function block standards. This paper will first address issues associated with HMS, and then discuss the two useful implementation techniques – agent technology and function block. Finally, a collaborative design approach for the next generation HMS will be proposed based on these implementation techniques. Emphasis will also be extended and given to metamorphic control of HMS using multi-agent negotiation and cooperation. The proposed approach, together with its open architecture, shows much promise for improving the entire manufacturing system performance under the ever-changing real-time and distributed environments.
|
|
| 30. |
|
|
| 31. |
|
|
| 32. |
|
|
| 33. |
- Bergström, Anna Lena, et al.
(author)
-
Intervju med biblioteksveteran Olle Ohlsson, Brevik
- 1985
-
Other publication (pop. science, debate, etc.)abstract
- Interview with the library veteran Olle Ohlsson, Brevik. The interview was conducted by Anna Lena Bergström, Eva Liljerehn and Gunilla Sundström-Hopf, students of the Swedish School of Library and Information Science in Borås, on February 12, 1985.
|
|
| 34. |
|
|
| 35. |
- Bohman, Tony, et al.
(author)
-
Predictive models for short-term and long-term improvement in women under physiotherapy for chronic disabling neck pain : a longitudinal cohort study.
- 2019
-
In: BMJ Open. - : BMJ. - 2044-6055. ; 9:4
-
Journal article (peer-reviewed)abstract
- OBJECTIVES: To develop predictive models for short-term and long-term clinically important improvement in women with non-specific chronic disabling neck pain during the clinical course of physiotherapy.DESIGN: Longitudinal cohort study based on data from a randomised controlled trial evaluating short-term and long-term effects on sensorimotor function over 11 weeks of physiotherapy.PARTICIPANTS AND SETTINGS: Eighty-nine women aged 31-65 years with non-specific chronic disabling neck pain from Gävle, Sweden.MEASURES: The outcome, clinically important improvement, was measured with the Patient Global Impression of Change Scale (PGICS) and the Neck Disability Index (NDI), assessed by self-administered questionnaires at 3, 9 and 15 months from the start of the interventions (baseline). Twelve baseline prognostic factors were considered in the analyses. The predictive models were built using random-effects logistic regression. The predictive ability of the models was measured by the area under the receiver operating characteristic curve (AUC). Internal validity was assessed with cross-validation using the bootstrap resampling technique.RESULTS: Factors included in the final PGICS model were neck disability and age, and in the NDI model, neck disability, depression and catastrophising. In both models, the odds for short-term and long-term improvement increased with higher baseline neck disability, while the odds decreased with increasing age (PGICS model), and with increasing level of depression (NDI model). In the NDI model, higher baseline levels of catastrophising indicated increased odds for short-term improvement and decreased odds for long-term improvement. Both models showed acceptable predictive validity with an AUC of 0.64 (95% CI 0.55 to 0.73) and 0.67 (95% CI 0.59 to 0.75), respectively.CONCLUSION: Age, neck disability and psychological factors seem to be important predictors of improvement, and may inform clinical decisions about physiotherapy in women with chronic neck pain. Before using the developed predictive models in clinical practice, however, they should be validated in other populations and tested in clinical settings.
|
|
| 36. |
|
|
| 37. |
- Hristova, Ivanka, et al.
(author)
-
Recognising archaeological food remains : archaeobotanical case studies from Bulgaria
- 2019
-
In: Bulgarian e-Journal of Archaeology. - : Association of Bulgarian Archaeologists (ABA). - 1314-5088. ; 9:2, s. 181-211
-
Journal article (peer-reviewed)abstract
- The paper discusses possible evidence for cereal food from seven Bulgarian archaeological sites spanning theEarly Neolithic to the Early Iron Age (6th millennium BC – 1st millennium BC). It aims to increase the awarenessof excavators towards such finds and to present the methods for collecting and extracting such remains fromarchaeological layers and their laboratory analysis. The studied remains are mainly cereal fragments, agglomerationsof fragments or amorphous/ porous masses with or without visible plant tissues. They were directlycollected from vessel contents or derived by means of flotation from bulk samples taken from floor layers closeto fireplaces/ cooking installations. The microscopic structure of the food remains is observed and described atplant tissue level under low magnification binocular, microscope with reflected light and Scanning Electron Microscope(SEM). These optical examinations were applied in order to detect alterations of the microstructure ofthe possible food remains and hence to trace the possible ways of food preparation. All the cereal food remainsfrom the Neolithic/Chalcolithic period represent coarsely ground cereals, while the later ones (Late Bronze Ageand Early Iron Age) have characteristics of finely ground cereal products and may suggest the introductionof new cooking/ baking techniques as well as shifts in food processing practices. Based on their field experienceand research results the authors strongly recommend careful sampling and documentation of any charredcrusts recognisable as such in vessel contents, and deposits around installations like ovens and fireplaces, whichcould be related to daily food preparation or ritual offerings. Such systematic study of archaeological food remainswill facilitate obtaining reliable information about food preparation and consumption in the past.
|
|
| 38. |
|
|
| 39. |
- Lekman, Magnus, et al.
(author)
-
A significant risk locus on 19q13 for bipolar disorder identified using a combined genome-wide linkage and copy number variation analysis
- 2015
-
In: BioData Mining. - : Springer Science and Business Media LLC. - 1756-0381. ; 8
-
Journal article (peer-reviewed)abstract
- Background: The genetic background to bipolar disorder (BPD) has been attributed to different genetic and genomic risk factors. In the present study we hypothesized that inherited copy number variations (CNVs) contribute to susceptibility of BPD. We screened 637 BP-pedigrees from the NIMH Genetic Initiative and gave priority to 46 pedigrees. In this subsample we performed parametric and non-parametric genome-wide linkage analyses using similar to 21,000 SNP-markers. We developed an algorithm to test for linkage restricted to regions with CNVs that are shared within and across families. Results: For the combined CNV and linkage analysis, one region on 19q13 survived correction for multiple comparisons and replicates a previous BPD risk locus. The shared CNV map to the pregnancy-specific glycoprotein (PSG) gene, a gene-family not previously implicated in BPD etiology. Two SNPs in the shared CNV are likely transcription factor binding sites and are linked to expression of an F-box binding gene, a key regulator of neuronal pathways suggested to be involved in BPD etiology. Conclusions: Our CNV-weighted linkage approach identifies a risk locus for BPD on 19q13 and forms a useful tool to future studies to unravel part of the genetic vulnerability to BPD.
|
|
| 40. |
|
|
| 41. |
- Lindén, Karolina, et al.
(author)
-
A woman-centered web-support program during pregnancy and early motherhood for women with type 1 diabetes
- 2014
-
Conference paper (peer-reviewed)abstract
- Background: Midwives have the responsibility to strengthen normal birth and promote breastfeeding; this challenge also includes women with chronic illness, such as diabetes type 1. Due to a constant struggle to achieve normoglycemia normal pregnancy related processes may be neglected in pregnant women with type 1 diabetes. The medical risks during pregnancy and labor might increase stress, anxiety and feelings of hopelessness.Aim: To describe the design of a woman-centered web-support for pregnant women and new mothers with type 1 diabetes in order to strengthen wellbeing.Method: A web-support has been developed using participatory design. A research project management group had the responsibility of steering the project forward. Different stakeholders including, midwifery, medical, nursing and target group expertise participated in the development. The web-support is implemented through a randomized controlled trial.Result: The developed web-support consists of three parts: 1) Specific information about pregnancy, childbirth, and early motherhood in relation to type 1 diabetes, where the challenge is to balance the core values of normal childbearing with diabetes related issues. 2) A self-care diary, including a device for documenting and evaluating blood glucose levels, insulin doses, food intake and physical activities. This enables the woman to keep in control of her own health. 3) A forum for peer support through communication between women and mothers in pregnancy and early motherhood. This enables sharing of similar experiences and of strategies to handle daily life. Clinical relevance By addressing diabetes related health risks and problems in a manner that still emphasizes the normality of being pregnant, giving birth and breastfeeding, a balance between focusing on potential risks and the joy of childbearing, birth and motherhood could be achieved.
|
|
| 42. |
- Lyubomirskiy, Mikhail, et al.
(author)
-
Planar refractive lenses made of SiC for high intensity nanofocusing
- 2021
-
In: Optics Express. - 1094-4087. ; 29:9, s. 14025-14032
-
Journal article (peer-reviewed)abstract
- We report on the manufacturing and testing of the first nanofocusing refractive lenses made of single-crystal silicon carbide. We introduce the fabrication process based on lithography, followed by deep isotropic etching. The lenses were characterized at the energy of 12 keV at the beamline P06 of the synchrotron radiation source PETRA III. A focal spot of 186 nm x 275 nm has been achieved with a lens working distance of 29 mm.
|
|
| 43. |
|
|
| 44. |
- Odin, Elisabeth, 1955, et al.
(author)
-
Rapid method for relative gene expression determination in human tissues using automated capillary gel electrophoresis and multicolor detection
- 1999
-
In: J Chromatogr B Biomed Sci Appl. - 1387-2273. ; 734:1, s. 47-53
-
Journal article (peer-reviewed)abstract
- The aim of this study was to evaluate a direct and automated post-polymerase chain reaction (PCR) detection system to simultaneously determine the relative gene expression levels of nine cancer-related human genes. Total RNA was prepared from flash-frozen biopsies derived from human colorectal tumors or normal mucosa and reverse-transcribed to cDNA which was PCR-amplified using primer pairs corresponding to the studied genes. In each reaction, the forward primer was labeled with a fluorescent dye. The PCR products were pooled and an internal size standard with a uniquely colored fluorescent dye was added. The samples were then subjected to automated capillary gel electrophoresis. Fragment analysis software was used to calculate the relative gene expression using beta-actin as the reference gene. We found that automated capillary gel electrophoresis with multicolor detection is a rapid, accurate and highly reproducible method for separation and quantification of PCR-amplified cDNA.
|
|
| 45. |
- Ribeiro, Tiago, et al.
(author)
-
Cytotoxicity of portoamides in human cancer cells and analysis of the molecular mechanisms of action
- 2017
-
In: PLOS ONE. - : PUBLIC LIBRARY SCIENCE. - 1932-6203. ; 12:12
-
Journal article (peer-reviewed)abstract
- Portoamides are cyclic peptides produced and released by the cyanobacterial strain Phormidium sp. presumably to interfere with other organisms in their ecosystems (" allelopathy"). Portoamides were previously demonstrated to have an antiproliferative effect on human lung carcinoma cells, but the underlying mechanism of this activity has not been described. In the present work, the effects of portoamides on proliferation were examined in eight human cancer cell lines and two non-carcinogenic cell lines, and major differences in sensitivities were observed. To generate hypotheses with regard to molecular mechanisms of action, quantitative proteomics using 2D gel electrophoresis and MALDI-TOF/ TOF were performed on the colon carcinoma cell line HT-29. The expression of proteins involved in energy metabolism (mitochondrial respiratory chain and pentose phosphate pathway) was found to be affected. The hypothesis of altered energy metabolism was tested in further experiments. Exposure to portoamides resulted in reduced cellular ATP content, likely due to decreased mitochondrial energy production. Mitochondrial hyperpolarization and reduced mitochondrial reductive capacity was observed in treated cells. Furthermore, alterations in the expression of peroxiredoxins (PRDX4, PRDX6) and components of proteasome subunits (PSB4, PSA6) were observed in portoamide-treated cells, but these alterations were not associated with detectable increases in oxidative stress. We conclude that the cytotoxic activity of portoamides is associated with disturbance of energy metabolism, and alterations in mitochondrial structure and function.
|
|
| 46. |
- Rogström, Lena, 1961
(author)
-
De bohuslänska runorna - en snabbkurs i runologi.
- 2008
-
In: "Vi ska alla vara välkomna!" Nordiska studier tillägnade Kristinn Jóhannesson. Meijerbergs arkiv för svensk ordforskning.. ; 35
-
Journal article (other academic/artistic)
|
|
| 47. |
|
|
| 48. |
|
|
| 49. |
|
|
| 50. |
- Aartsen, Marja, et al.
(author)
-
Ageing in the light of crises : Economic crisis, demographic change, and the search for meaning
- 2012
-
Reports (other academic/artistic)abstract
- Old age has many images, with the one of a crisis regaining momentum. While images of activity and opportunity gained ground during recent decades, this trend now seems to reverse. The current economic crisis drains the financial resources of older people, which increases old age poverty. Moreover, governments react to the double-pressure of economic crises and population ageing through budget cuts, which reduces support systems for older people. It, moreover, centers public discourses more strongly on social problems associated with old age. Both developments underline the needs associated with old age and draw our attention away from the potentials of old age. In other words, they bring discussions on old age back to the topic of crises. This working paper discusses how the economic crisis affects older people, how governments, labour markets, and families react to the double-pressure of population ageing and economic crisis, and how individuals perceive their old age. It concludes with reflections on the implications of growing crisis-centrism in discussions on old age. Such crisis-centrism can lead us to overlook social inequalities in old age and to neglect the subjective character of the perception of old age. The public image of old age might, thus, be stronger associated with the idea of crisis than what older people’s lived experience suggests.
|
|
