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- Ayesa, S., et al.
(författare)
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CYSTEINE PROTEASE INHIBITORS
- 2011
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Patent (populärvet., debatt m.m.)abstract
- Compounds of the formula IwhereinR1a is H; and R1b is C1-C6 alkyl, Carbocyclyl or Het; orR1a and R1b together define a saturated cyclic amine with 3-6 ring atoms;R2a and R2b are H, halo, C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy; orR2a and R2b together with the carbon atom to which they are attached form a C3-C6cycloalkyl;R3 is a branched C5-C10alkyl chain, C2-C4haloalkyl or C3-C7cycloalkylmethyl,R4 is Het, Carbocyclyl,optionally substituted as defined in the specification and pharmaceutically acceptable salts,hydrates and N-oxides thereof; are inhibitors of cathepsin S and have utility in the treatment of psoriasis, autoimmune disorders and other disorders such as asthma, arteriosclerosis, COPD and chronic pain.
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- Fagerquist, M., et al.
(författare)
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The transverse section of the fetus urinary bladder is circular and, for volume estimation, an appropriate longitudinal section is sufficient
- 2013
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Ingår i: Archives of Gynecology and Obstetrics. - : Springer Science and Business Media LLC. - 0932-0067 .- 1432-0711. ; 287:4, s. 647-651
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Tidskriftsartikel (refereegranskat)abstract
- Purpose The purpose was to investigate the transverse shape of the fetal urinary bladder. Methods Using 3D ultrasound, an appropriate longitudinal image of fetal urinary bladders was chosen. Perpendicular sections were examined and the transverse bladder image with a minimum of shadows was selected, documented and transferred to a PC. The contour of the transverse bladder image was marked manually and recorded electronically. The mean of radii distances from the centre pixel to each border pixel outlining this bladder image was calculated for each fetus. Results In the material comprising 20 fetuses, the range of mean radii was 2.6–18.4 mm and the SD 0.4 mm. The mean wall thickness of the bladders was 2.7 mm and the distance represented by one pixel for different selected depths was 0.3 mm on average. Conclusions In view of the current technical limitations, an aberration from the circular shape may not be discernible. For this reason, the transverse shape of the fetal urinary bladder can be regarded as a circle. This means that, for bladder volume estimation, only an appropriate longitudinal section is necessary.
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