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| 8. |
- Sun, W. J., et al.
(författare)
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A Comparative Study of the Proton Properties of Magnetospheric Substorms at Earth and Mercury in the Near Magnetotail
- 2018
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Ingår i: Geophysical Research Letters. - : American Geophysical Union (AGU). - 0094-8276 .- 1944-8007. ; 45:16, s. 7933-7941
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Tidskriftsartikel (refereegranskat)abstract
- The variations of plasma sheet proton properties during magnetospheric substorms at Earth and Mercury are comparatively studied. This study utilizes kappa distributions to interpret proton properties at both planets. Proton number densities are found to be around an order of magnitude higher, temperatures several times smaller, and kappa values broader at Mercury than at Earth. Protons become denser and cooler during the growth phase, and are depleted and heated after the dipolarizations in both magnetospheres. The changes of kappa at Earth are generally small (<20%), indicating that spectrum-preserving processes, like adiabatic betatron acceleration, play an important role there, while variations of kappa at Mercury are large (>60%), indicating the importance of spectrum-altering processes there, such as acceleration due to nonadiabatic cross-tail particle motions and wave-particle interactions. This comparative study reveals important intrinsic properties on the energization of protons in both magnetospheres. Plain Language Summary Earth and Mercury are the only two planets possessing global intrinsic magnetic fields among the four inner planets, which are Mercury, Venus, Earth, and Mars, within the solar system. The interactions between the intrinsic magnetic fields and the continual flow of high-speed solar wind from the Sun form similar magnetospheres at the two planets, although the scale of the magnetosphere is much smaller at Mercury than at Earth. Magnetospheric substorms, a result of solar wind-magnetosphere coupling, occur in both magnetospheres. Comparative study of a similar process between different planets is meaningful as it can help us in understanding the specific process further as well as help us in understanding the intrinsic properties of the magnetospheres. This research paper characterizes the proton properties of magnetospheric substorms of both planets, revealing that different mechanisms control the behavior of protons during the magnetospheric substorms of the two planets.
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| 9. |
- Wang, BA, et al.
(författare)
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Bivariate genomic analysis identifies a hidden locus associated with bacteria hypersensitive response in Arabidopsis thaliana
- 2017
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Ingår i: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 7, s. 45281-
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Tidskriftsartikel (refereegranskat)abstract
- Multi-phenotype analysis has drawn increasing attention to high-throughput genomic studies, whereas only a few applications have justified the use of multivariate techniques. We applied a recently developed multi-trait analysis method on a small set of bacteria hypersensitive response phenotypes and identified a single novel locus missed by conventional single-trait genome-wide association studies. The detected locus harbors a minor allele that elevates the risk of leaf collapse response to the injection of avrRpm1-modified Pseudomonas syringae (P = 1.66e-08). Candidate gene AT3G32930 with in the detected region and its co-expressed genes showed significantly reduced expression after P. syringae interference. Our results again emphasize that multi-trait analysis should not be neglected in association studies, as the power of specific multi-trait genotype-phenotype maps might only be tractable when jointly considering multiple phenotypes.
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| 10. |
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- 2019
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Tidskriftsartikel (refereegranskat)
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| 11. |
- Chen, X., et al.
(författare)
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Achieving memory access equalization via round-trip routing latency prediction in 3D many-core NoCs
- 2015
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Ingår i: Proceedings of IEEE Computer Society Annual Symposium on VLSI, ISVLSI. - : IEEE. ; , s. 398-403
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Konferensbidrag (refereegranskat)abstract
- 3D many-core NoCs are emerging architectures for future high-performance single chips due to its integration of many processor cores and memories by stacking multiple layers. In such architecture, because processor cores and memories reside in different locations (center, corner, edge, etc.), memory accesses behave differently due to their different communication distances, and the performance (latency) gap of different memory accesses becomes larger as the network size is scaled up. This phenomenon may lead to very high latencies suffered from by some memory accesses, thus degrading the system performance. To achieve high performance, it is crucial to reduce the number of memory accesses with very high latencies. However, this should be done with care since shortening the latency of one memory access can worsen the latency of another as a result of shared network resources. Therefore, the goal should focus on narrowing the latency difference of memory accesses. In the paper, we address the goal by proposing to prioritize the memory access packets based on predicting the round-trip routing latencies of memory accesses. The communication distance and the number of the occupied items in the buffers in the remaining routing path are used to predict the round-trip latency of a memory access. The predicted round-trip routing latency is used as the base to arbitrate the memory access packets so that the memory access with potential high latency can be transferred as early and fast as possible, thus equalizing the memory access latencies as much as possible. Experiments with varied network sizes and packet injection rates prove that our approach can achieve the goal of memory access equalization and outperforms the classic round-robin arbitration in terms of maximum latency, average latency, and LSD1. In the experiments, the maximum improvement of the maximum latency, the average latency and the LSD are 80%, 14%, and 45% respectively.
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- Forouzanfar, Mohammad H, et al.
(författare)
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Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013 : a systematic analysis for the Global Burden of Disease Study 2013.
- 2015
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Ingår i: The Lancet. - 0140-6736 .- 1474-547X. ; 386:10010, s. 2287-2323
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The Global Burden of Disease, Injuries, and Risk Factor study 2013 (GBD 2013) is the first of a series of annual updates of the GBD. Risk factor quantification, particularly of modifiable risk factors, can help to identify emerging threats to population health and opportunities for prevention. The GBD 2013 provides a timely opportunity to update the comparative risk assessment with new data for exposure, relative risks, and evidence on the appropriate counterfactual risk distribution.METHODS: Attributable deaths, years of life lost, years lived with disability, and disability-adjusted life-years (DALYs) have been estimated for 79 risks or clusters of risks using the GBD 2010 methods. Risk-outcome pairs meeting explicit evidence criteria were assessed for 188 countries for the period 1990-2013 by age and sex using three inputs: risk exposure, relative risks, and the theoretical minimum risk exposure level (TMREL). Risks are organised into a hierarchy with blocks of behavioural, environmental and occupational, and metabolic risks at the first level of the hierarchy. The next level in the hierarchy includes nine clusters of related risks and two individual risks, with more detail provided at levels 3 and 4 of the hierarchy. Compared with GBD 2010, six new risk factors have been added: handwashing practices, occupational exposure to trichloroethylene, childhood wasting, childhood stunting, unsafe sex, and low glomerular filtration rate. For most risks, data for exposure were synthesised with a Bayesian meta-regression method, DisMod-MR 2.0, or spatial-temporal Gaussian process regression. Relative risks were based on meta-regressions of published cohort and intervention studies. Attributable burden for clusters of risks and all risks combined took into account evidence on the mediation of some risks such as high body-mass index (BMI) through other risks such as high systolic blood pressure and high cholesterol.FINDINGS: All risks combined account for 57·2% (95% uncertainty interval [UI] 55·8-58·5) of deaths and 41·6% (40·1-43·0) of DALYs. Risks quantified account for 87·9% (86·5-89·3) of cardiovascular disease DALYs, ranging to a low of 0% for neonatal disorders and neglected tropical diseases and malaria. In terms of global DALYs in 2013, six risks or clusters of risks each caused more than 5% of DALYs: dietary risks accounting for 11·3 million deaths and 241·4 million DALYs, high systolic blood pressure for 10·4 million deaths and 208·1 million DALYs, child and maternal malnutrition for 1·7 million deaths and 176·9 million DALYs, tobacco smoke for 6·1 million deaths and 143·5 million DALYs, air pollution for 5·5 million deaths and 141·5 million DALYs, and high BMI for 4·4 million deaths and 134·0 million DALYs. Risk factor patterns vary across regions and countries and with time. In sub-Saharan Africa, the leading risk factors are child and maternal malnutrition, unsafe sex, and unsafe water, sanitation, and handwashing. In women, in nearly all countries in the Americas, north Africa, and the Middle East, and in many other high-income countries, high BMI is the leading risk factor, with high systolic blood pressure as the leading risk in most of Central and Eastern Europe and south and east Asia. For men, high systolic blood pressure or tobacco use are the leading risks in nearly all high-income countries, in north Africa and the Middle East, Europe, and Asia. For men and women, unsafe sex is the leading risk in a corridor from Kenya to South Africa.INTERPRETATION: Behavioural, environmental and occupational, and metabolic risks can explain half of global mortality and more than one-third of global DALYs providing many opportunities for prevention. Of the larger risks, the attributable burden of high BMI has increased in the past 23 years. In view of the prominence of behavioural risk factors, behavioural and social science research on interventions for these risks should be strengthened. Many prevention and primary care policy options are available now to act on key risks.FUNDING: Bill & Melinda Gates Foundation.
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| 14. |
- Li, Kun, et al.
(författare)
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Cold Ion Outflow Modulated by the Solar Wind Energy Input and Tilt of the Geomagnetic Dipole
- 2017
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Ingår i: Journal of Geophysical Research - Space Physics. - : American Geophysical Union (AGU). - 2169-9380 .- 2169-9402. ; 122:10, s. 10658-10668
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Tidskriftsartikel (refereegranskat)abstract
- The solar wind energy input into the Earth's magnetosphere-ionosphere system drives ionospheric outflow, which plays an important role in both the magnetospheric dynamics and evolution of the atmosphere. However, little is known about the cold ion outflow with energies lower than a few tens of eV, as the direct measurement of cold ions is difficult because a spacecraft gains a positive electric charge due to the photoemission effect, which prevents cold ions from reaching the onboard detectors. A recent breakthrough in the measurement technique using Cluster spacecraft revealed that cold ions dominate the ion population in the magnetosphere. This new technique yields a comprehensive data set containing measurements of the velocities and densities of cold ions for the years 2001-2010. In this paper, this data set is used to analyze the cold ion outflow from the ionosphere. We found that about 0.1% of the solar wind energy input is transformed to the kinetic energy of cold ion outflow at the topside ionosphere. We also found that the geomagnetic dipole tilt can significantly affect the density of cold ion outflow, modulating the outflow rate of cold ion kinetic energy. These results give us clues to study the evolution of ionospheric outflow with changing global magnetic field and solar wind condition in the history.
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| 15. |
- Liu, T., et al.
(författare)
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Heterodimer Nanostructures Induced Energy Focusing on Metal Film
- 2016
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Ingår i: Journal of Physical Chemistry C. - : American Chemical Society (ACS). - 1932-7447 .- 1932-7455. ; 120:14, s. 7778-7784
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Tidskriftsartikel (refereegranskat)abstract
- As a newly discovered surface plasmon resonance system, the nanoparticle dimer film structure provides a novel approach to enhance light power on a plane film due to the redistribution of the electromagnetic field. This structure has been widely applied in surface enhanced Raman scattering (SERS), solar cells, photocatalysis, etc., especially for the homodimer film case. However, the properties of heterodimers on film still remain unclear. In this work, the effect of particle size on electromagnetic field redistribution for a Ag nanoparticle dimer on Au film system is investigated first. The results obtained from the finite element method indicate that a smaller nanoparticle has much greater ability to focus light energy on Au film, and the corresponding energy can be 5 times stronger than that of the larger nanoparticle case. Further research indicates that this energy focusing ability has a strong relationship to the wavelength and the diameter ratio of the dimer. A similar focusing phenomenon has been found in the system of thick nanowire small nanoparticle on film. Then the SERS spectra collected in the small nanoparticle large nanowire system provide experimental evidence for this theoretical predication. Our results strengthen the understanding of surface plasmon on plane film and have potential applications in surface plasmon related fields.
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| 16. |
- Liu, X M, et al.
(författare)
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A tool for evaluating the quality of laminated particleboard countertop
- 2016
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Ingår i: Wood and Fiber Science. - 0735-6161. ; 48:4, s. 297-301
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Tidskriftsartikel (refereegranskat)abstract
- To evaluate the quality of laminated particleboard, a typical type of laminate was used in laminating particleboard with operational parameters similar to industry operation. Pull-off tests using Elcometer 510 were conducted. In addition, panel vertical density profiles (VDP) and the pH of particleboard at different layers were tested. The results showed that the laminated panel bonded by polyvinyl acetate (PVA) glue had higher pull-off strength than that of the phenol formaldehyde (PF) glue within corresponding sanding thickness. Sanding off 0.0762 mm resulted in higher pull-off strength than sanding off 0.0254 mm. The laminates had the highest pull-off strength when the PB were sanded off 0.0762 mm and glued by PVA. This has provided a solution to improve lamination pull-of strength for industry. The test results have also shown that the laminated panels produced in the manufactures have the potential to be improved. It also indicates that Elcometer 510 is a good tool to evaluate the particleboard lamination quality.
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| 18. |
- Vos, Theo, et al.
(författare)
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Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013
- 2015
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Ingår i: The Lancet. - 1474-547X .- 0140-6736. ; 386:9995, s. 743-800
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Tidskriftsartikel (refereegranskat)abstract
- Background Up-to-date evidence about levels and trends in disease and injury incidence, prevalence, and years lived with disability (YLDs) is an essential input into global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013), we estimated these quantities for acute and chronic diseases and injuries for 188 countries between 1990 and 2013. Methods Estimates were calculated for disease and injury incidence, prevalence, and YLDs using GBD 2010 methods with some important refinements. Results for incidence of acute disorders and prevalence of chronic disorders are new additions to the analysis. Key improvements include expansion to the cause and sequelae list, updated systematic reviews, use of detailed injury codes, improvements to the Bayesian meta-regression method (DisMod-MR), and use of severity splits for various causes. An index of data representativeness, showing data availability, was calculated for each cause and impairment during three periods globally and at the country level for 2013. In total, 35 620 distinct sources of data were used and documented to calculated estimates for 301 diseases and injuries and 2337 sequelae. The comorbidity simulation provides estimates for the number of sequelae, concurrently, by individuals by country, year, age, and sex. Disability weights were updated with the addition of new population-based survey data from four countries. Findings Disease and injury were highly prevalent; only a small fraction of individuals had no sequelae. Comorbidity rose substantially with age and in absolute terms from 1990 to 2013. Incidence of acute sequelae were predominantly infectious diseases and short-term injuries, with over 2 billion cases of upper respiratory infections and diarrhoeal disease episodes in 2013, with the notable exception of tooth pain due to permanent caries with more than 200 million incident cases in 2013. Conversely, leading chronic sequelae were largely attributable to non-communicable diseases, with prevalence estimates for asymptomatic permanent caries and tension-type headache of 2.4 billion and 1.6 billion, respectively. The distribution of the number of sequelae in populations varied widely across regions, with an expected relation between age and disease prevalence. YLDs for both sexes increased from 537.6 million in 1990 to 764.8 million in 2013 due to population growth and ageing, whereas the age-standardised rate decreased little from 114.87 per 1000 people to 110.31 per 1000 people between 1990 and 2013. Leading causes of YLDs included low back pain and major depressive disorder among the top ten causes of YLDs in every country. YLD rates per person, by major cause groups, indicated the main drivers of increases were due to musculoskeletal, mental, and substance use disorders, neurological disorders, and chronic respiratory diseases; however HIV/AIDS was a notable driver of increasing YLDs in sub-Saharan Africa. Also, the proportion of disability-adjusted life years due to YLDs increased globally from 21.1% in 1990 to 31.2% in 2013. Interpretation Ageing of the world's population is leading to a substantial increase in the numbers of individuals with sequelae of diseases and injuries. Rates of YLDs are declining much more slowly than mortality rates. The non-fatal dimensions of disease and injury will require more and more attention from health systems. The transition to non-fatal outcomes as the dominant source of burden of disease is occurring rapidly outside of sub-Saharan Africa. Our results can guide future health initiatives through examination of epidemiological trends and a better understanding of variation across countries.
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| 19. |
- Wan, M, et al.
(författare)
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Biosynthesis of leukotriene B4
- 2017
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Ingår i: Seminars in immunology. - : Elsevier BV. - 1096-3618 .- 1044-5323. ; 33:C, s. 3-15
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Tidskriftsartikel (refereegranskat)
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| 21. |
- Wang, X. A., et al.
(författare)
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Impact of cold temperatures on the shear strength of Norway spruce & scots pine joints with different glues
- 2016
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Ingår i: WCTE 2016 - World Conference on Timber Engineering. - : Vienna University of Technology. - 9783903039001
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Konferensbidrag (refereegranskat)abstract
- As wood construction increasingly uses engineered wood products worldwide, concerns arise about the integrity of the wood and adhesives used. Bondline strength is a crucial issue for engineered wood applications, especially in cold climates. In this study, the impact of cold temperatures on the shear strength of Norway spruce (Picea abies) and Scots pine (Pinus sylvestris) joints (150 mm x 20 mm x 10 mm) bonded with seven commercially available adhesives was studied. The cold temperatures investigated were: 20, -20, -30, -40, -50, and -60 °C. Generally, within the temperature test range, temperature changes significantly affected the shear strength of solid wood and wood joints for both species. As the temperature decreased, the shear strength decreased. PUR adhesive in most cases resulted in the strongest shear strength and MUF adhesive resulted in the weakest. But different adhesives responded differently with Norway spruce and Scots pine.
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| 25. |
- Zaman, F., et al.
(författare)
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Humanin is a novel regulator of Hedgehog signaling and prevents glucocorticoid-induced bone growth impairment
- 2019
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Ingår i: Faseb Journal. - 0892-6638. ; 33:4, s. 4962-4974
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Tidskriftsartikel (refereegranskat)abstract
- Glucocorticoids (GCs) are frequently used to treat chronic disorders in children, including inflammation and cancer. Prolonged treatment with GCs is well known to impair bone growth, an effect linked to increased apoptosis and suppressed proliferation in growth plate chondrocytes. We hypothesized that the endogenous antiapoptotic protein humanin (HN) may prevent these effects. Interestingly, GC-induced bone growth impairment and chondrocyte apoptosis was prevented in HN overexpressing mice, HN-treated wild-type mice, and in HN-treated cultured rat metatarsal bones. GC-induced suppression of chondrocyte proliferation was also prevented by HN. Furthermore, GC treatment reduced Indian Hedgehog expression in growth plates of wild-type mice but not in HN overexpressing mice or HN-treated wild-type animals. A Hedgehog (Hh) antagonist, vismodegib, was found to suppress the growth of cultured rat metatarsal bones, and this effect was also prevented by HN. Importantly, HN did not interfere with the desired anti-inflammatory effects of GCs. We conclude that HN is a novel regulator of Hh signaling preventing GC-induced bone growth impairment without interfering with desired effects of GCs. Our data may open for clinical studies exploring a new possible strategy to prevent GC-induced bone growth impairment by cotreating with HN.
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