| 1. |
|
|
| 2. |
- Aboagye, Emmanuel, et al.
(författare)
-
Exhaustion and Impaired Work Performance in the Workplace : Associations With Presenteeism and Absenteeism
- 2019
-
Ingår i: Journal of Occupational and Environmental Medicine. - : Wolters Kluwer. - 1076-2752 .- 1536-5948. ; 61:11, s. 438-444
-
Tidskriftsartikel (refereegranskat)abstract
- Objective: The aim of this study was to investigate the association between presenteeism and absenteeism during the previous year and the current levels of exhaustion and impaired work performance in a Swedish university setting.Methods: In a study of 3525 employees, an ordinal logistic regression and general linear model was used to examine the association between presenteeism and absenteeism during the previous year and the current exhaustion and impaired work performance, respectively.Results: Presenteeism, but not absenteeism, during the previous year independently increased the risk of having moderate or severe exhaustion. Presenteeism, absenteeism, and exhaustion remained positively associated with impaired work performance when health status and other confounders had been adjusted for.Conclusions: Presenteeism, but not absenteeism, was associated with exhaustion. Both presenteeism and absenteeism were the salient correlates of impaired work performance.
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
- Ayyala, S, et al.
(författare)
-
Effect of corrosion inhibitors on grinding and flotation of a lead-zinc ore
- 1993
-
Ingår i: Minerals Engineering. - 0892-6875 .- 1872-9444. ; 6, s. 929-935
-
Tidskriftsartikel (refereegranskat)abstract
- Grinding and flotation experiments on a Pb-Zn ore were carried out to evaluate : 1) wear of the grinding media both in the presence and absence of an inhibitor and 2) effect of the inhibitor on the flotation of Pb-Zn minerals. The percentage reduction in the wear of the grinding media was observed to be between 25-36%, depending on the type of the inhibitor and its critical concentration. The inhibitors used in the investigation were sodium sulphite, sodium nitrite, sodium chromate and sodium silicate. The results indicate that a specific corrosion inhibitor, for example sodium sulphite, may give better recoveries and grades in flotation but is not as efficient as sodium chromate in inhibiting the wear of the grinding media. Pulp solutions (after grinding) analysed for metal ion concentrations showed low Fe. Iron released into the solution as a result of corrosion reactions subsequently forms insoluble hydroxy complexes and may coat the mineral surfaces. Such hydrophilic coatings may adversely affect the floatabilities of minerals. The particle size analysis of the ground product has been carried out and the results are discussed.
|
|
| 6. |
- Azzu, V., et al.
(författare)
-
Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression
- 2021
-
Ingår i: Molecular Metabolism. - : Elsevier BV. - 2212-8778. ; 48
-
Tidskriftsartikel (refereegranskat)abstract
- Objective: Non-alcoholic fatty liver disease (NAFLD) is a silent pandemic associated with obesity and the metabolic syndrome, and also increases cardiovascular- and cirrhosis-related morbidity and mortality. A complete understanding of adaptive compensatory metabolic programmes that modulate non-alcoholic steatohepatitis (NASH) progression is lacking. Methods and results: Transcriptomic analysis of liver biopsies in patients with NASH revealed that NASH progression is associated with rewiring of metabolic pathways, including upregulation of de novo lipid/cholesterol synthesis and fatty acid remodelling. The modulation of these metabolic programmes was achieved by activating sterol regulatory element-binding protein (SREBP) transcriptional networks; however, it is still debated whether, in the context of NASH, activation of SREBPs acts as a pathogenic driver of lipotoxicity, or rather promotes the biosynthesis of protective lipids that buffer excessive lipid accumulation, preventing inflammation and fibrosis. To elucidate the pathophysiological role of SCAP/SREBP in NASH and wound-healing response, we used an Insig1 deficient (with hyper-efficient SREBPs) murine model challenged with a NASH-inducing diet. Despite enhanced lipid and cholesterol biosynthesis, Insig1 KO mice had similar systemic metabolism and insulin sensitivity to Het/WT littermates. Moreover, activating SREBPs resulted in remodelling the lipidome, decreased hepatocellular damage, and improved wound-healing responses. Conclusions: Our study provides actionable knowledge about the pathways and mechanisms involved in NAFLD pathogenesis, which may prove useful for developing new therapeutic strategies. Our results also suggest that the SCAP/SREBP/INSIG1 trio governs transcriptional programmes aimed at protecting the liver from lipotoxic insults in NASH. (C) 2021 Published by Elsevier GmbH. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
|
|
| 7. |
- Barenbaum, Joshua, et al.
(författare)
-
The psychosocial aspects of children exposed to war : practice and policy initiatives.
- 2004
-
Ingår i: Journal of Child Psychology and Psychiatry. - 0021-9630 .- 1469-7610. ; 45:1, s. 41-62
-
Tidskriftsartikel (refereegranskat)abstract
- The atrocities of war have detrimental effects on the development and mental health of children that have been documented since World War II. To date, a considerable amount of knowledge about various aspects of this problem has been accumulated, including the ways in which trauma impacts child mental health and development, as well as intervention techniques, and prevention methods. Considering the large populations of civilians that experience the trauma of war, it is timely to review existing literature, summarize approaches for helping war-affected children, and suggest future directions for research and policy.
|
|
| 8. |
- Bender, Johanna, 1975, et al.
(författare)
-
Lipid cubic phases for improved topical drug delivery in photodynamic therapy.
- 2005
-
Ingår i: Journal of Controlled Release. - : Elsevier BV. - 0168-3659 .- 1873-4995. ; 106:3, s. 350-360
-
Tidskriftsartikel (refereegranskat)abstract
- We have evaluated the efficacy of lipid cubic phases, highly ordered self-assembly systems on the nanometer level, as drug delivery vehicles for in vivo topical administration of delta-aminolevulinic acid (ALA) and its methyl ester (m-ALA) on nude mice skin. ALA, a precursor of heme, induces the production of the photosensitizer protoporphyrin IX (PpIX) in living tissue. Measuring the PpIX fluorescence at the skin surface, after topical administration, makes indirect quantification of the penetration of ALA into the tissue possible. Cubic phases were formed of lipid (monoolein or phytantriol), water and drug. In some cases, propylene glycol was included in the cubic phase as well. The drug concentration was 3% (w/w, based on the total sample weight) in all investigated vehicles. When the formulations were applied for 1 h, the monoolein cubic systems and the three-component phytantriol sample showed higher fluorescence compared to the standard ointment during the 10 h of measurement. Both ALA and m-ALA yielded similar results, although the differences between the investigated vehicles were more pronounced when using m-ALA. For the 24-h applications, the monoolein cubic systems with m-ALA showed faster PpIX formation than the standard ointment, implying higher PpIX levels at short application times (less than 4 h). The systemic PpIX fluorescence of ALA was elevated by using the lipid cubic formulations. Notably, a small systemic effect was also observed for the monoolein cubic sample with m-ALA. These results imply improved PpIX formation when using the lipid cubic systems, most probably due to enhanced drug penetration.
|
|
| 9. |
- Berg, Lotta, et al.
(författare)
-
Scientific Opinion on canine leishmaniosis
- 2015
-
Ingår i: EFSA Journal. - : Wiley. - 1831-4732. ; 13
-
Tidskriftsartikel (refereegranskat)abstract
- This Scientific Opinion presents a characterisation of canine leishmaniosis (CanL) in Europe and its potential for spreading. The efficacy of available preventative measures to protect dogs against CanL was assessed, with the objective of mitigating the probability of introduction of CanL into free areas in the European Union through movement of infected dogs. Several systematic reviews (SRs) of literature were carried out to evaluate the efficacy of vaccines, topically applied insecticides and prophylactic medication. Additionally, SRs on the sensitivity of diagnostic tests and treatment efficacy were carried out to evaluate the possibility of testing and excluding or treating infected dogs to mitigate the risk of introduction into free areas. The probability of introduction and establishment of CanL in a non-endemic region with competent sandflies was estimated, using a stochastic simulation model. The probability of establishment defined as the local transmission of L. infantum from vector to host and vice versa, was very high. The most effective mitigation measure to reduce the probability of introduction and establishment of CanL was topically applied insecticide. Vaccination had only limited effect on the probability of establishment in a non-endemic region. Testing dogs before their introduction into a non-endemic area is of limited value if applied too soon after exposure to infected sandflies, because it takes several months to obtain a positive result after exposure. Test and treatment in the endemic area, prior to movement into a non-endemic area, does not appear to be an efficient and realistic option to mitigate the probability of introduction of CanL, as no treatment against CanL can guarantee to prevent future transmission. It was concluded that the main limitation to CanL spread is represented by the vectors. This reinforces the need for knowledge on the vectorial competence, distribution and abundance of potential vectors of CanL in the EU.
|
|
| 10. |
- Berg, Lotta, et al.
(författare)
-
Scientific opinion on electrical requirements for poultry waterbath stunning equipment
- 2014
-
Ingår i: EFSA Journal. - : Wiley. - 1831-4732. ; 12
-
Tidskriftsartikel (refereegranskat)abstract
- The European Commission (EC) requested that the EFSA Panel on Animal Health and Welfare (AHAW Panel) delivers a scientific opinion on a study that proposes parameters for poultry electrical waterbath stunning different to those laid down in Council Regulation (EC) No 1099/2009 on the protection of animals at the time of killing. The submitted study reports upon the use (mean + SD) of a current of 104.00 ± 3.88 mA, a voltage of 125.86 ± 3.28 V and a frequency of 589.78 ± 0.63 Hz using a square wave in alternating current (AC) with a 50 % duty cycle. These conditions were applied for 15 seconds to chickens under laboratory and slaughterhouse conditions. The submitted study was peer-reviewed by the AHAW Panel in the manner detailed in its ‘Guidance on the assessment criteria for studies evaluating the effectiveness of stunning intervention regarding animal protection at the time of killing'. The methodology and the data reported do not provide conclusive evidence that the combination of the proposed electrical frequency and current induced unconsciousness without exposing the chickens to avoidable pain and suffering. Further, some chickens did not remain unconscious for a sufficient time to prevent avoidable pain and suffering during slaughter. Because the information provided in the study was incomplete and insufficient, it did not pass the eligibility phase of the assessment. In the context of Directive 2010/63/EU on the protection of animals used for scientific purposes, and current scientific evidence, a frequency of 600 Hz with a current of 104 mA does not result in efficient stunning of poultry. Therefore, additional research into these stunning parameters is not recommended.
|
|
