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- Pham, Tuan D
(författare)
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Fractal characteristics of mass spectrometry based cancer data
- 2007
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Ingår i: WSEAS Transactions on Mathematics. - : World Scientific and Engineering Academy and Society. - 1109-2769 .- 2224-2880. ; , s. 30-35
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Tidskriftsartikel (refereegranskat)abstract
- This paper addresses the fractal analysis of mass spectrometry data for the prediction of complex diseases. We studied ovarian and prostate cancers as examples of the analysis. Experimental results show that the fractal dimensions of cancer states distinctively tend to have higher values than those of the control states. High values of the Hurst exponent of the mass spectrometry data under study suggest the persistent behavior of the datasets and the reliability of the fractal dimensions.
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- Mirzazadeh, Reza, et al.
(författare)
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Spatially resolved transcriptomic profiling of degraded and challenging fresh frozen samples
- 2023
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Ingår i: Nature Communications. - : Springer Nature. - 2041-1723. ; 14:1
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Tidskriftsartikel (refereegranskat)abstract
- Spatially resolved transcriptomics has enabled precise genome-wide mRNA expression profiling within tissue sections. The performance of methods targeting the polyA tails of mRNA relies on the availability of specimens with high RNA quality. Moreover, the high cost of currently available spatial resolved transcriptomics assays requires a careful sample screening process to increase the chance of obtaining high-quality data. Indeed, the upfront analysis of RNA quality can show considerable variability due to sample handling, storage, and/or intrinsic factors. We present RNA-Rescue Spatial Transcriptomics (RRST), a workflow designed to improve mRNA recovery from fresh frozen specimens with moderate to low RNA quality. First, we provide a benchmark of RRST against the standard Visium spatial gene expression protocol on high RNA quality samples represented by mouse brain and prostate cancer samples. Then, we test the RRST protocol on tissue sections collected from five challenging tissue types, including human lung, colon, small intestine, pediatric brain tumor, and mouse bone/cartilage. In total, we analyze 52 tissue sections and demonstrate that RRST is a versatile, powerful, and reproducible protocol for fresh frozen specimens of different qualities and origins.
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- Zhirnov, Ivan, et al.
(författare)
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Process quality assessment with imaging and acoustic monitoring during Laser Powder Bed Fusion
- 2022
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Ingår i: Procedia CIRP. - : Elsevier. - 2212-8271. ; 111, s. 363-367
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Tidskriftsartikel (refereegranskat)abstract
- Acoustic monitoring of laser powder bed fusion (LPBF) has shown a high sensitivity to stochastic defects, e.g., cracks, pores and lack of fusion (LOF), and melting instability. The advantage of this method is the possibility to filter raw data and extract acoustic signal features for the data analysis, thus minimizing data and computing time. In this research during the build of components from hot work tool steel powder, acoustic signals and powder bed images were acquired for post-process data analysis and search for correlations with LOF. Different densities caused by LOF were obtained by changing the shielding gas velocity. In the analysis, selected combinations of features with the relationship between the build phases and the final properties such as density and surface roughness, were investigated. For the current dataset prediction of the optimal state showed an accuracy of 98%. This investigation suggests the applicability of the smart data-centric machine learning method to predict the relationship of process parameters, monitoring signals, and material properties. © 2022 The Authors. Published by Elsevier B.V.
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- Tabansky, Inna, et al.
(författare)
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Temporally-patterned deep brain stimulation in a mouse model of multiple traumatic brain injury
- 2014
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Ingår i: Behavioural Brain Research. - : Elsevier. - 0166-4328 .- 1872-7549. ; 273, s. 123-132
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Tidskriftsartikel (refereegranskat)abstract
- We report that mice with closed-head multiple traumatic brain injury (TBI) show a decrease in the motoric aspects of generalized arousal, as measured by automated, quantitative behavioral assays. Further, we found that temporally-patterned deep brain stimulation (DBS) can increase generalized arousal and spontaneous motor activity in this mouse model of TBI. This arousal increase is input-pattern-dependent, as changing the temporal pattern of DBS can modulate its effect on motor activity. Finally, an extensive examination of mouse behavioral capacities, looking for deficits in this model of TBI, suggest that the strongest effects of TBI in this model are found in the initiation of any kind of movement.
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- Bensow, Rickard, 1972
(författare)
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Simulation of Unsteady Propeller Blade Loads Using OpenFOAM
- 2013
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Ingår i: Numerical Towing Tank Symposium.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Unsteady propeller blade loads are important to consider in the design of the propulsion system in order to avoid problems with noise and vibrations. This is normally done through an analysis of the average wake field flowing into the propulsor in order to correctly match the different components of the propulsion system. As computational resources increase, it now starts to become possible to better study the impact on the natural wake flow unsteadiness and how this influences the behaviour of the propeller. This work is a feasibility study to investigate different computational aspects regarding the flow around a propeller operating in a ship wake. The simulations are performed in OpenFOAM 2.2.x using LES, Large Eddy Simulation.The interest concerns both how the sliding mesh implementation in OpenFOAM performs and how large variation in the propeller flow that the resolved transient wake field incurs.
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