Sökning: onr:"20187792" >
Neurally adjusted v...
Neurally adjusted ventilatory assist in patients with acute respiratory failure study protocol for a randomized controlled trial
-
Villar, Jesus (författare)
-
Belda, Javier (författare)
-
Blanco, Jesus (författare)
-
visa fler...
-
Suarez-Sipmann, Fernando (författare)
-
Manuel Anon, Jose (författare)
-
Perez-Mendez, Lina (författare)
-
Ferrando, Carlos (författare)
-
Parrilla, Dacil (författare)
-
Montiel, Raquel (författare)
-
Corpas, Ruth (författare)
-
Gonzalez-Higueras, Elena (författare)
-
Pestana, David (författare)
-
Martinez, Domingo (författare)
-
Fernandez, Lorena (författare)
-
Soro, Marina (författare)
-
Angel Garcia-Bello, Miguel (författare)
-
Lidia Fernandez, Rosa (författare)
-
Kacmarek, Robert M. (författare)
-
visa färre...
- 2016
- 2016
- Engelska.
-
Ingår i: Trials. - 1745-6215. ; 17
Abstract
Ämnesord
Stäng
- Background: Patient-ventilator asynchrony is a common problem in mechanically ventilated patients with acute respiratory failure. It is assumed that asynchronies worsen lung function and prolong the duration of mechanical ventilation (MV). Neurally Adjusted Ventilatory Assist (NAVA) is a novel approach to MV based on neural respiratory center output that is able to trigger, cycle, and regulate the ventilatory cycle. We hypothesized that the use of NAVA compared to conventional lung-protective MV will result in a reduction of the duration of MV. It is further hypothesized that NAVA compared to conventional lung-protective MV will result in a decrease in the length of ICU and hospital stay, and mortality. Methods/design: This is a prospective, multicenter, randomized controlled trial in 306 mechanically ventilated patients with acute respiratory failure from several etiologies. Only patients ventilated for less than 5 days, and who are expected to require prolonged MV for an additional 72 h or more and are able to breathe spontaneously, will be considered for enrollment. Eligible patients will be randomly allocated to two ventilatory arms: (1) conventional lung-protective MV (n = 153) and conventional lung-protective MV with NAVA (n = 153). Primary outcome is the number of ventilator-free days, defined as days alive and free from MV at day 28 after endotracheal intubation. Secondary outcomes are total length of MV, and ICU and hospital mortality. Discussion: This is the first randomized clinical trial examining, on a multicenter scale, the beneficial effects of NAVA in reducing the dependency on MV of patients with acute respiratory failure.
Ämnesord
- Medical and Health Sciences (hsv)
- Clinical Medicine (hsv)
- Surgery (hsv)
- Medicin och hälsovetenskap (hsv)
- Klinisk medicin (hsv)
- Kirurgi (hsv)
- Respiratory Medicine and Allergy (hsv)
- Lungmedicin och allergi (hsv)
Nyckelord
- Acute respiratory failure
- Neurally adjusted ventilatory assist
- Ventilator-free days
- Lung-protective ventilation
- Assist ventilation
- Liberation from mechanical ventilation
Hitta via bibliotek
-
Trials
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- Av författaren/redakt...
-
Villar, Jesus
-
Belda, Javier
-
Blanco, Jesus
-
Suarez-Sipmann, ...
-
Manuel Anon, Jos ...
-
Perez-Mendez, Li ...
-
visa fler...
-
Ferrando, Carlos
-
Parrilla, Dacil
-
Montiel, Raquel
-
Corpas, Ruth
-
Gonzalez-Higuera ...
-
Pestana, David
-
Martinez, Doming ...
-
Fernandez, Loren ...
-
Soro, Marina
-
Angel Garcia-Bel ...
-
Lidia Fernandez, ...
-
Kacmarek, Robert ...
-
visa färre...
- Av lärosätet
-
Swepub_uni:_t