Sökning: onr:"20193769" > Histological charac...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 03485naa a22006013a 4500 | |
001 | 20193769 | |
003 | SE-LIBR | |
005 | 20170323173656.0 | |
007 | cr|||||||||||| | |
008 | 170323s2016 sw |||| o |||| ||eng c | |
024 | 7 | a http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2829512 uri |
024 | 7 | a urn:nbn:se:uu:diva-2829512 urn |
024 | 7 | a 10.1186/s12868-016-0274-72 doi |
040 | a S | |
041 | 0 | a eng |
042 | 9 EPLK | |
100 | 1 | a Roshanbin, Sahard 1984-4 aut0 395065 |
245 | 1 0 | a Histological characterization of orphan transporter MCT14 (SLC16A14) shows abundant expression in mouse CNS and kidneyh [Elektronisk resurs] |
260 | c 2016 | |
500 | a Published | |
500 | a Vetenskapsrådet | |
500 | a Hjärnfonden | |
500 | a Svenska Sällskapet för Medicinsk Forskning (SSMF) | |
500 | a Novo Nordisk | |
506 | 0 | a gratis |
520 | a Background: MCT14 (SLC16A14) is an orphan member of the monocarboxylate transporter (MCT) family, also known as the SLC16 family of secondary active transmembrane transporters. Available expression data for this transporter is limited, and in this paper we aim to characterize MCT14 with respect to tissue distribution and cellular localization in mouse brain. Results: Using qPCR, we found that Slc16a14 mRNA was highly abundant in mouse kidney and moderately in central nervous system, testis, uterus and liver. Using immunohistochemistry and in situ hybridization, we determined that MCT14 was highly expressed in excitatory and inhibitory neurons as well as epithelial cells in the mouse brain. The expression was exclusively localized to the soma of neurons. Furthermore, we showed with our phylogenetic analysis that MCT14 most closely relate to the aromatic amino acid- and thyroid-hormone transporters MCT8 (SLC16A2) and MCT10 (SLC16A10), in addition to the carnitine transporter MCT9 (SLC16A9). Conclusions: We provide here the first histological mapping of MCT14 in the brain and our data are consistent with the hypothesis that MCT14 is a neuronal aromatic-amino-acid transporter. | |
650 | 7 | a Medical and Health Sciences2 hsv |
650 | 7 | a Clinical Medicine2 hsv |
650 | 7 | a Neurology2 hsv |
650 | 7 | a Medicin och hälsovetenskap2 hsv |
650 | 7 | a Klinisk medicin2 hsv |
650 | 7 | a Neurologi2 hsv |
653 | 0 | a Monocarboxylate; Transporter; Mouse; Amino acid |
700 | 1 | a Lindberg, Frida4 aut |
700 | 1 | a Lekholm, Emilia4 aut |
700 | 1 | a Perland, Emelie4 aut |
700 | 1 | a Eriksson, Mikaela4 aut |
700 | 1 | a Åhlund, Johan4 aut0 302561 |
700 | 1 | a Raine, Amanda4 aut |
700 | 1 | a Fredriksson, Robert4 aut |
710 | 1 2 | a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl |
710 | 1 2 | a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl |
710 | 1 2 | a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl |
710 | 2 | a Molecular Neuropharmacology4 oth |
772 | 1 8 | i channel recordw 19753896 |
773 | 0 8 | i Värdpublikationt BMC neuroscience (Online)g 17x 1471-2202 |
856 | 4 0 | u http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-282951 |
856 | 4 0 | u http://dx.doi.org/10.1186/s12868-016-0274-7 |
856 | 4 0 | u http://uu.diva-portal.org/smash/get/diva2:918111/FULLTEXT01 |
841 | 5 APISa x ab 170323||0000|||||001||||||000000e 1 | |
024 | 7 | 5 APISa urn:nbn:se:uu:diva-2829512 urn |
852 | 5 APISb APIS | |
856 | 4 0 | 5 APISu http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-282951 |
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