Sökning: onr:"20195160" > Meta-analysis of ge...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 07242naa a22018973a 4500 | |
001 | 20195160 | |
003 | SE-LIBR | |
005 | 20170323192050.0 | |
007 | cr|||||||||||| | |
008 | 170323s2016 sw |||| o |||| ||eng c | |
024 | 7 | a http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2828322 uri |
024 | 7 | a urn:nbn:se:uu:diva-2828322 urn |
024 | 7 | a 10.1038/ncomms109332 doi |
040 | a S | |
041 | 0 | a eng |
042 | 9 EPLK | |
100 | 1 | a Berndt, Sonja I.4 aut |
245 | 1 0 | a Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemiah [Elektronisk resurs] |
260 | c 2016 | |
500 | a Published | |
500 | a Cancerfonden [02 6661] | |
500 | a Stockholms läns landsting [20110209] | |
506 | 0 | a gratis |
520 | a Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genome-wide association studies (GWAS) composed of 3,100 cases and 7,667 controls with follow-up replication in 1,958 cases and 5,530 controls. Here we report three new loci at 3p24.1 (rs9880772, EOMES, P = 2.55 x 10(-11)), 6p25.2 (rs73718779, SERPINB6, P = 1.97 x 10(-8)) and 3q28 (rs9815073, LPP, P = 3.62 x 10(-8)), as well as a new independent SNP at the known 2q13 locus (rs9308731, BCL2L11, P = 1.00 x 10(-11)) in the combined analysis. We find suggestive evidence (P<5 x 10(-7)) for two additional new loci at 4q24 (rs10028805, BANK1, P = 7.19 x 10(-8)) and 3p22.2 (rs1274963, CSRNP1, P = 2.12 x 10(-7)). Pathway analyses of new and known CLL loci consistently show a strong role for apoptosis, providing further evidence for the importance of this biological pathway in CLL susceptibility. | |
650 | 7 | a Medical and Health Sciences2 hsv |
650 | 7 | a Medicin och hälsovetenskap2 hsv |
700 | 1 | a Camp, Nicola J.4 aut |
700 | 1 | a Skibola, Christine F.4 aut |
700 | 1 | a Vijai, Joseph4 aut |
700 | 1 | a Wang, Zhaoming4 aut |
700 | 1 | a Gu, Jian4 aut |
700 | 1 | a Nieters, Alexandra4 aut |
700 | 1 | a Kelly, Rachel S.4 aut |
700 | 1 | a Smedby, Karin E.4 aut |
700 | 1 | a Monnereau, Alain4 aut |
700 | 1 | a Cozen, Wendy4 aut |
700 | 1 | a Cox, Angela4 aut |
700 | 1 | a Wang, Sophia S.4 aut |
700 | 1 | a Lan, Qing4 aut |
700 | 1 | a Teras, Lauren R.4 aut |
700 | 1 | a Machado, Moara4 aut |
700 | 1 | a Yeager, Meredith4 aut |
700 | 1 | a Brooks-Wilson, Angela R.4 aut |
700 | 1 | a Hartge, Patricia4 aut |
700 | 1 | a Purdue, Mark P.4 aut |
700 | 1 | a Birmann, Brenda M.4 aut |
700 | 1 | a Vajdic, Claire M.4 aut |
700 | 1 | a Cocco, Pierluigi4 aut |
700 | 1 | a Zhang, Yawei4 aut |
700 | 1 | a Giles, Graham G.4 aut |
700 | 1 | a Zeleniuch-Jacquotte, Anne4 aut |
700 | 1 | a Lawrence, Charles4 aut |
700 | 1 | a Montalvan, Rebecca4 aut |
700 | 1 | a Burdett, Laurie4 aut |
700 | 1 | a Hutchinson, Amy4 aut |
700 | 1 | a Ye, Yuanqing4 aut |
700 | 1 | a Call, Timothy G.4 aut |
700 | 1 | a Shanafelt, Tait D.4 aut |
700 | 1 | a Novak, Anne J.4 aut |
700 | 1 | a Kay, Neil E.4 aut |
700 | 1 | a Liebow, Mark4 aut |
700 | 1 | a Cunningham, Julie M.4 aut |
700 | 1 | a Allmer, Cristine4 aut |
700 | 1 | a Hjalgrim, Henrik4 aut |
700 | 1 | a Adami, Hans-Olov4 aut |
700 | 1 | a Melbye, Mads4 aut |
700 | 1 | a Glimelius, Bengt4 aut |
700 | 1 | a Chang, Ellen T.4 aut |
700 | 1 | a Glenn, Martha4 aut |
700 | 1 | a Curtin, Karen4 aut |
700 | 1 | a Cannon-Albright, Lisa A.4 aut |
700 | 1 | a Diver, W. Ryan4 aut |
700 | 1 | a Link, Brian K.4 aut |
700 | 1 | a Weiner, George J.4 aut |
700 | 1 | a Conde, Lucia4 aut |
700 | 1 | a Bracci, Paige M.4 aut |
700 | 1 | a Riby, Jacques4 aut |
700 | 1 | a Arnett, Donna K.4 aut |
700 | 1 | a Zhi, Degui4 aut |
700 | 1 | a Leach, Justin M.4 aut |
700 | 1 | a Holly, Elizabeth A.4 aut |
700 | 1 | a Jackson, Rebecca D.4 aut |
700 | 1 | a Tinker, Lesley F.4 aut |
700 | 1 | a Benavente, Yolanda4 aut |
700 | 1 | a Sala, Nuria4 aut |
700 | 1 | a Casabonne, Delphine4 aut |
700 | 1 | a Becker, Nikolaus4 aut |
700 | 1 | a Boffetta, Paolo4 aut |
700 | 1 | a Brennan, Paul4 aut |
700 | 1 | a Foretova, Lenka4 aut |
700 | 1 | a Maynadie, Marc4 aut |
700 | 1 | a McKay, James4 aut |
700 | 1 | a Staines, Anthony4 aut |
700 | 1 | a Chaffee, Kari G.4 aut |
700 | 1 | a Achenbach, Sara J.4 aut |
700 | 1 | a Vachon, Celine M.4 aut |
700 | 1 | a Goldin, Lynn R.4 aut |
700 | 1 | a Strom, Sara S.4 aut |
700 | 1 | a Leis, Jose F.4 aut |
700 | 1 | a Weinberg, J. Brice4 aut |
700 | 1 | a Caporaso, Neil E.4 aut |
700 | 1 | a Norman, Aaron D.4 aut |
700 | 1 | a De Roos, Anneclaire J.4 aut |
700 | 1 | a Morton, Lindsay M.4 aut |
700 | 1 | a Severson, Richard K.4 aut |
700 | 1 | a Riboli, Elio4 aut |
700 | 1 | a Vineis, Paolo4 aut |
700 | 1 | a Kaaks, Rudolph4 aut |
700 | 1 | a Masala, Giovanna4 aut |
700 | 1 | a Weiderpass, Elisabete4 aut |
700 | 1 | a Chirlaque, Maria-Dolores4 aut |
700 | 1 | a Vermeulen, Roel C. H.4 aut |
700 | 1 | a Travis, Ruth C.4 aut |
700 | 1 | a Southey, Melissa C.4 aut |
700 | 1 | a Milne, Roger L.4 aut |
700 | 1 | a Albanese, Demetrius4 aut |
700 | 1 | a Virtamo, Jarmo4 aut |
700 | 1 | a Weinstein, Stephanie4 aut |
700 | 1 | a Clavel, Jacqueline4 aut |
700 | 1 | a Zheng, Tongzhang4 aut |
700 | 1 | a Holford, Theodore R.4 aut |
700 | 1 | a Villano, Danylo J.4 aut |
700 | 1 | a Maria, Ann4 aut |
700 | 1 | a Spinelli, John J.4 aut |
700 | 1 | a Gascoyne, Randy D.4 aut |
700 | 1 | a Connors, Joseph M.4 aut |
700 | 1 | a Bertrand, Kimberly A.4 aut |
700 | 1 | a Giovannucci, Edward4 aut |
700 | 1 | a Kraft, Peter4 aut |
700 | 1 | a Kricker, Anne4 aut |
700 | 1 | a Turner, Jenny4 aut |
700 | 1 | a Ennas, Maria Grazia4 aut |
700 | 1 | a Ferri, Giovanni M.4 aut |
700 | 1 | a Miligi, Lucia4 aut |
700 | 1 | a Liang, Liming4 aut |
700 | 1 | a Ma, Baoshan4 aut |
700 | 1 | a Huang, Jinyan4 aut |
700 | 1 | a Crouch, Simon4 aut |
700 | 1 | a Park, Ju-Hyun4 aut |
700 | 1 | a Chatterjee, Nilanjan4 aut |
700 | 1 | a North, Kari E.4 aut |
700 | 1 | a Snowden, John A.4 aut |
700 | 1 | a Wright, Josh4 aut |
700 | 1 | a Fraumeni, Joseph F.4 aut |
700 | 1 | a Offit, Kenneth4 aut |
700 | 1 | a Wu, Xifeng4 aut |
700 | 1 | a de Sanjose, Silvia4 aut |
700 | 1 | a Cerhan, James R.4 aut |
700 | 1 | a Chanock, Stephen J.4 aut |
700 | 1 | a Rothman, Nathaniel4 aut |
700 | 1 | a Slager, Susan L.4 aut |
710 | 1 2 | a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl |
772 | 1 8 | i channel recordw 19753896 |
773 | 0 8 | i Värdpublikationt Nature Communicationsg 7x 2041-1723 |
856 | 4 0 | u http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-282832 |
856 | 4 0 | u http://dx.doi.org/10.1038/ncomms10933 |
856 | 4 0 | u http://uu.diva-portal.org/smash/get/diva2:917548/FULLTEXT01 |
841 | 5 APISa x ab 170323||0000|||||001||||||000000e 1 | |
024 | 7 | 5 APISa urn:nbn:se:uu:diva-2828322 urn |
852 | 5 APISb APIS | |
856 | 4 0 | 5 APISu http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-282832 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
Kopiera och spara länken för att återkomma till aktuell vy