Search: onr:"22081010" > Meta-Analysis of Ge...
Fältnamn | Indikatorer | Metadata |
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000 | 06605naa a22016693a 4500 | |
001 | 22081010 | |
003 | SE-LIBR | |
005 | 20171207151605.0 | |
007 | cr|||||||||||| | |
008 | 171207s2013 sw |||| o |||| ||eng c | |
024 | 7 | a http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2102562 uri |
024 | 7 | a urn:nbn:se:uu:diva-2102562 urn |
024 | 7 | a 10.1371/journal.pgen.10037962 doi |
040 | a S | |
041 | 0 | a eng |
042 | 9 EPLK | |
100 | 1 | a O'Seaghdha, Conall M.4 aut |
245 | 1 0 | a Meta-Analysis of Genome-Wide Association Studies Identifies Six New Loci for Serum Calcium Concentrationsh [Elektronisk resurs] |
260 | c 2013 | |
500 | a Published | |
506 | 0 | a gratis |
520 | a Calcium is vital to the normal functioning of multiple organ systems and its serum concentration is tightly regulated. Apart from CASR, the genes associated with serum calcium are largely unknown. We conducted a genome-wide association meta-analysis of 39,400 individuals from 17 population-based cohorts and investigated the 14 most strongly associated loci in <= 21,679 additional individuals. Seven loci (six new regions) in association with serum calcium were identified and replicated. Rs1570669 near CYP24A1 (P = 9.1E-12), rs10491003 upstream of GATA3 (P = 4.8E-09) and rs7481584 in CARS (P = 1.2E-10) implicate regions involved in Mendelian calcemic disorders: Rs1550532 in DGKD (P = 8.2E-11), also associated with bone density, and rs7336933 near DGKH/KIAA0564 (P = 9.1E-10) are near genes that encode distinct isoforms of diacylglycerol kinase. Rs780094 is in GCKR. We characterized the expression of these genes in gut, kidney, and bone, and demonstrate modulation of gene expression in bone in response to dietary calcium in mice. Our results shed new light on the genetics of calcium homeostasis. | |
650 | 7 | a Medical and Health Sciences2 hsv |
650 | 7 | a Medicin och hälsovetenskap2 hsv |
700 | 1 | a Wu, Hongsheng4 aut |
700 | 1 | a Yang, Qiong4 aut |
700 | 1 | a Kapur, Karen4 aut |
700 | 1 | a Guessous, Idris4 aut |
700 | 1 | a Zuber, Annie Mercier4 aut |
700 | 1 | a Koettgen, Anna4 aut |
700 | 1 | a Stoudmann, Candice4 aut |
700 | 1 | a Teumer, Alexander4 aut |
700 | 1 | a Kutalik, Zoltan4 aut |
700 | 1 | a Mangino, Massimo4 aut |
700 | 1 | a Dehghan, Abbas4 aut |
700 | 1 | a Zhang, Weihua4 aut |
700 | 1 | a Eiriksdottir, Gudny4 aut |
700 | 1 | a Li, Guo4 aut |
700 | 1 | a Tanaka, Toshiko4 aut |
700 | 1 | a Portas, Laura4 aut |
700 | 1 | a Lopez, Lorna M.4 aut |
700 | 1 | a Hayward, Caroline4 aut |
700 | 1 | a Lohman, Kurt4 aut |
700 | 1 | a Matsuda, Koichi4 aut |
700 | 1 | a Padmanabhan, Sandosh4 aut |
700 | 1 | a Firsov, Dmitri4 aut |
700 | 1 | a Sorice, Rossella4 aut |
700 | 1 | a Ulivi, Sheila4 aut |
700 | 1 | a Brockhaus, A. Catharina4 aut |
700 | 1 | a Kleber, Marcus E.4 aut |
700 | 1 | a Mahajan, Anubha4 aut |
700 | 1 | a Ernst, Florian D.4 aut |
700 | 1 | a Gudnason, Vilmundur4 aut |
700 | 1 | a Launer, Lenore J.4 aut |
700 | 1 | a Mace, Aurelien4 aut |
700 | 1 | a Boerwinckle, Eric4 aut |
700 | 1 | a Arking, Dan E.4 aut |
700 | 1 | a Tanikawa, Chizu4 aut |
700 | 1 | a Nakamura, Yusuke4 aut |
700 | 1 | a Brown, Morris J.4 aut |
700 | 1 | a Gaspoz, Jean-Michel4 aut |
700 | 1 | a Theler, Jean-Marc4 aut |
700 | 1 | a Siscovick, David S.4 aut |
700 | 1 | a Psaty, Bruce M.4 aut |
700 | 1 | a Bergmann, Sven4 aut |
700 | 1 | a Vollenweider, Peter4 aut |
700 | 1 | a Vitart, Veronique4 aut |
700 | 1 | a Wright, Alan F.4 aut |
700 | 1 | a Zemunik, Tatijana4 aut |
700 | 1 | a Boban, Mladen4 aut |
700 | 1 | a Kolcic, Ivana4 aut |
700 | 1 | a Navarro, Pau4 aut |
700 | 1 | a Brown, Edward M.4 aut |
700 | 1 | a Estrada, Karol4 aut |
700 | 1 | a Ding, Jingzhong4 aut |
700 | 1 | a Harris, Tamara B.4 aut |
700 | 1 | a Bandinelli, Stefania4 aut |
700 | 1 | a Hernandez, Dena4 aut |
700 | 1 | a Singleton, Andrew B.4 aut |
700 | 1 | a Girotto, Giorgia4 aut |
700 | 1 | a Ruggiero, Daniela4 aut |
700 | 1 | a d'Adamo, Adamo Pio4 aut |
700 | 1 | a Robino, Antonietta4 aut |
700 | 1 | a Meitinger, Thomas4 aut |
700 | 1 | a Meisinger, Christa4 aut |
700 | 1 | a Davies, Gail4 aut |
700 | 1 | a Starr, John M.4 aut |
700 | 1 | a Chambers, John C.4 aut |
700 | 1 | a Boehm, Bernhard O.4 aut |
700 | 1 | a Winkelmann, Bernhard R.4 aut |
700 | 1 | a Huang, Jie4 aut |
700 | 1 | a Murgia, Federico4 aut |
700 | 1 | a Wild, Sarah H.4 aut |
700 | 1 | a Campbell, Harry4 aut |
700 | 1 | a Morris, Andrew P.4 aut |
700 | 1 | a Franco, Oscar H.4 aut |
700 | 1 | a Hofman, Albert4 aut |
700 | 1 | a Uitterlinden, Andre G.4 aut |
700 | 1 | a Rivadeneira, Fernando4 aut |
700 | 1 | a Voelker, Uwe4 aut |
700 | 1 | a Hannemann, Anke4 aut |
700 | 1 | a Biffar, Reiner4 aut |
700 | 1 | a Hoffmann, Wolfgang4 aut |
700 | 1 | a Shin, So-Youn4 aut |
700 | 1 | a Lescuyer, Pierre4 aut |
700 | 1 | a Henry, Hughes4 aut |
700 | 1 | a Schurmann, Claudia4 aut |
700 | 1 | a Munroe, Patricia B.4 aut |
700 | 1 | a Gasparini, Paolo4 aut |
700 | 1 | a Pirastu, Nicola4 aut |
700 | 1 | a Ciullo, Marina4 aut |
700 | 1 | a Gieger, Christian4 aut |
700 | 1 | a Maerz, Winfried4 aut |
700 | 1 | a Lind, Lars4 aut |
700 | 1 | a Spector, Tim D.4 aut |
700 | 1 | a Smith, Albert V.4 aut |
700 | 1 | a Rudan, Igor4 aut |
700 | 1 | a Wilson, James F.4 aut |
700 | 1 | a Polasek, Ozren4 aut |
700 | 1 | a Deary, Ian J.4 aut |
700 | 1 | a Pirastu, Mario4 aut |
700 | 1 | a Ferrucci, Luigi4 aut |
700 | 1 | a Liu, Yongmei4 aut |
700 | 1 | a Kestenbaum, Bryan4 aut |
700 | 1 | a Kooner, Jaspal S.4 aut |
700 | 1 | a Witteman, Jacqueline C. M.4 aut |
700 | 1 | a Nauck, Matthias4 aut |
700 | 1 | a Kao, W. H. Linda4 aut |
700 | 1 | a Wallaschofski, Henri4 aut |
700 | 1 | a Bonny, Olivier4 aut |
700 | 1 | a Fox, Caroline S.4 aut |
700 | 1 | a Bochud, Murielle4 aut |
710 | 1 2 | a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl |
772 | 1 8 | i channel recordw 19753896 |
773 | 0 8 | i Värdpublikationt PLOS Geneticsg 9:9, e1003796x 1553-7390 |
856 | 4 0 | u http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-210256 |
856 | 4 0 | u http://dx.doi.org/10.1371/journal.pgen.1003796 |
856 | 4 0 | u http://uu.diva-portal.org/smash/get/diva2:661889/FULLTEXT01 |
841 | 5 APISa x ab 171207||0000|||||001||||||000000e 1 | |
024 | 7 | 5 APISa urn:nbn:se:uu:diva-2102562 urn |
852 | 5 APISb APIS | |
856 | 4 0 | 5 APISu http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-210256 |
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