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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 13097naa a22035893a 4500 | |
| 001 | 22099448 | |
| 003 | SE-LIBR | |
| 005 | 20171211081716.0 | |
| 007 | cr|||||||||||| | |
| 008 | 171211s2013 sw |||| o |||| ||eng c | |
| 024 | 7 | a http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2086772 uri |
| 024 | 7 | a urn:nbn:se:uu:diva-2086772 urn |
| 024 | 7 | a 10.1371/journal.pgen.10035002 doi |
| 040 | a S | |
| 041 | 0 | a eng |
| 042 | 9 EPLK | |
| 100 | 1 | a Randall, Joshua C.4 aut |
| 245 | 1 0 | a Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traitsh [Elektronisk resurs] |
| 260 | c 2013 | |
| 500 | a Published | |
| 506 | 0 | a gratis |
| 520 | a Given the anthropometric differences between men and women and previous evidence of sex-difference in genetic effects, we conducted a genome-wide search for sexually dimorphic associations with height, weight, body mass index, waist circumference, hip circumference, and waist-to-hip-ratio (133,723 individuals) and took forward 348 SNPs into follow-up (additional 137,052 individuals) in a total of 94 studies. Seven loci displayed significant sex-difference (FDR<5%), including four previously established (near GRB14/COBLL1, LYPLAL1/SLC30A10, VEGFA, ADAMTS9) and three novel anthropometric trait loci (near MAP3K1, HSD17B4, PPARG), all of which were genome-wide significant in women (P<5x10(-8)), but not in men. Sex-differences were apparent only for waist phenotypes, not for height, weight, BMI, or hip circumference. Moreover, we found no evidence for genetic effects with opposite directions in men versus women. The PPARG locus is of specific interest due to its role in diabetes genetics and therapy. Our results demonstrate the value of sex-specific GWAS to unravel the sexually dimorphic genetic underpinning of complex traits. | |
| 650 | 7 | a Medical and Health Sciences2 hsv |
| 650 | 7 | a Medicin och hälsovetenskap2 hsv |
| 700 | 1 | a Winkler, Thomas W.4 aut |
| 700 | 1 | a Kutalik, Zoltan4 aut |
| 700 | 1 | a Berndt, Sonja I.4 aut |
| 700 | 1 | a Jackson, Anne U.4 aut |
| 700 | 1 | a Monda, Keri L.4 aut |
| 700 | 1 | a Kilpelaeinen, Tuomas O.4 aut |
| 700 | 1 | a Esko, Tonu4 aut |
| 700 | 1 | a Maegi, Reedik4 aut |
| 700 | 1 | a Li, Shengxu4 aut |
| 700 | 1 | a Workalemahu, Tsegaselassie4 aut |
| 700 | 1 | a Feitosa, Mary F.4 aut |
| 700 | 1 | a Croteau-Chonka, Damien C.4 aut |
| 700 | 1 | a Day, Felix R.4 aut |
| 700 | 1 | a Fall, Tove4 aut |
| 700 | 1 | a Ferreira, Teresa4 aut |
| 700 | 1 | a Gustafsson, Stefan4 aut |
| 700 | 1 | a Locke, Adam E.4 aut |
| 700 | 1 | a Mathieson, Iain4 aut |
| 700 | 1 | a Scherag, Andre4 aut |
| 700 | 1 | a Vedantam, Sailaja4 aut |
| 700 | 1 | a Wood, Andrew R.4 aut |
| 700 | 1 | a Liang, Liming4 aut |
| 700 | 1 | a Steinthorsdottir, Valgerdur4 aut |
| 700 | 1 | a Thorleifsson, Gudmar4 aut |
| 700 | 1 | a Dermitzakis, Emmanouil T.4 aut |
| 700 | 1 | a Dimas, Antigone S.4 aut |
| 700 | 1 | a Karpe, Fredrik4 aut |
| 700 | 1 | a Min, Josine L.4 aut |
| 700 | 1 | a Nicholson, George4 aut |
| 700 | 1 | a Clegg, Deborah J.4 aut |
| 700 | 1 | a Person, Thomas4 aut |
| 700 | 1 | a Krohn, Jon P.4 aut |
| 700 | 1 | a Bauer, Sabrina4 aut |
| 700 | 1 | a Buechler, Christa4 aut |
| 700 | 1 | a Eisinger, Kristina4 aut |
| 700 | 1 | a Bonnefond, Amelie4 aut |
| 700 | 1 | a Froguel, Philippe4 aut |
| 700 | 1 | a Hottenga, Jouke-Jan4 aut |
| 700 | 1 | a Prokopenko, Inga4 aut |
| 700 | 1 | a Waite, Lindsay L.4 aut |
| 700 | 1 | a Harris, Tamara B.4 aut |
| 700 | 1 | a Smith, Albert Vernon4 aut |
| 700 | 1 | a Shuldiner, Alan R.4 aut |
| 700 | 1 | a McArdle, Wendy L.4 aut |
| 700 | 1 | a Caulfield, Mark J.4 aut |
| 700 | 1 | a Munroe, Patricia B.4 aut |
| 700 | 1 | a Gronberg, Henrik4 aut |
| 700 | 1 | a Chen, Yii-Der Ida4 aut |
| 700 | 1 | a Li, Guo4 aut |
| 700 | 1 | a Beckmann, Jacques S.4 aut0 39418 |
| 700 | 1 | a Johnson, Toby4 aut |
| 700 | 1 | a Thorsteinsdottir, Unnur4 aut |
| 700 | 1 | a Teder-Laving, Maris4 aut |
| 700 | 1 | a Khaw, Kay-Tee4 aut |
| 700 | 1 | a Wareham, Nicholas J.4 aut |
| 700 | 1 | a Zhao, Jing Hua4 aut |
| 700 | 1 | a Amin, Najaf4 aut |
| 700 | 1 | a Oostra, Ben A.4 aut |
| 700 | 1 | a Kraja, Aldi T.4 aut |
| 700 | 1 | a Province, Michael A.4 aut |
| 700 | 1 | a Cupples, L. Adrienne4 aut |
| 700 | 1 | a Heard-Costa, Nancy L.4 aut |
| 700 | 1 | a Kaprio, Jaakko4 aut |
| 700 | 1 | a Ripatti, Samuli4 aut |
| 700 | 1 | a Surakka, Ida4 aut |
| 700 | 1 | a Collins, Francis S.4 aut0 375177 |
| 700 | 1 | a Saramies, Jouko4 aut |
| 700 | 1 | a Tuomilehto, Jaakko4 aut |
| 700 | 1 | a Jula, Antti4 aut |
| 700 | 1 | a Salomaa, Veikko4 aut |
| 700 | 1 | a Erdmann, Jeanette4 aut |
| 700 | 1 | a Hengstenberg, Christian4 aut |
| 700 | 1 | a Loley, Christina4 aut |
| 700 | 1 | a Schunkert, Heribert4 aut |
| 700 | 1 | a Lamina, Claudia4 aut |
| 700 | 1 | a Wichmann, H. Erich4 aut |
| 700 | 1 | a Albrecht, Eva4 aut |
| 700 | 1 | a Gieger, Christian4 aut |
| 700 | 1 | a Hicks, Andrew A.4 aut |
| 700 | 1 | a Johansson, Åsa4 aut0 320150 |
| 700 | 1 | a Pramstaller, Peter P.4 aut |
| 700 | 1 | a Kathiresan, Sekar4 aut |
| 700 | 1 | a Speliotes, Elizabeth K.4 aut |
| 700 | 1 | a Penninx, Brenda4 aut |
| 700 | 1 | a Hartikainen, Anna-Liisa4 aut |
| 700 | 1 | a Jarvelin, Marjo-Riitta4 aut |
| 700 | 1 | a Gyllensten, Ulf4 aut |
| 700 | 1 | a Boomsma, Dorret I.4 aut |
| 700 | 1 | a Campbell, Harry4 aut |
| 700 | 1 | a Wilson, James F.4 aut |
| 700 | 1 | a Chanock, Stephen J.4 aut |
| 700 | 1 | a Farrall, Martin4 aut |
| 700 | 1 | a Goel, Anuj4 aut |
| 700 | 1 | a Medina-Gomez, Carolina4 aut |
| 700 | 1 | a Rivadeneira, Fernando4 aut |
| 700 | 1 | a Estrada, Karol4 aut |
| 700 | 1 | a Uitterlinden, Andre G.4 aut |
| 700 | 1 | a Hofman, Albert4 aut |
| 700 | 1 | a Zillikens, M. Carola4 aut |
| 700 | 1 | a den Heijer, Martin4 aut |
| 700 | 1 | a Kiemeney, Lambertus A.4 aut |
| 700 | 1 | a Maschio, Andrea4 aut |
| 700 | 1 | a Hall, Per4 aut |
| 700 | 1 | a Tyrer, Jonathan4 aut |
| 700 | 1 | a Teumer, Alexander4 aut |
| 700 | 1 | a Voelzke, Henry4 aut |
| 700 | 1 | a Kovacs, Peter4 aut |
| 700 | 1 | a Toenjes, Anke4 aut |
| 700 | 1 | a Mangino, Massimo4 aut |
| 700 | 1 | a Spector, Tim D.4 aut |
| 700 | 1 | a Hayward, Caroline4 aut |
| 700 | 1 | a Rudan, Igor4 aut |
| 700 | 1 | a Hall, Alistair S.4 aut |
| 700 | 1 | a Samani, Nilesh J.4 aut |
| 700 | 1 | a Attwood, Antony Paul4 aut |
| 700 | 1 | a Sambrook, Jennifer G.4 aut |
| 700 | 1 | a Hung, Joseph4 aut |
| 700 | 1 | a Palmer, Lyle J.4 aut |
| 700 | 1 | a Lokki, Marja-Liisa4 aut |
| 700 | 1 | a Sinisalo, Juha4 aut |
| 700 | 1 | a Boucher, Gabrielle4 aut |
| 700 | 1 | a Huikuri, Heikki4 aut |
| 700 | 1 | a Lorentzon, Mattias4 aut |
| 700 | 1 | a Ohlsson, Claes4 aut |
| 700 | 1 | a Eklund, Niina4 aut |
| 700 | 1 | a Eriksson, Johan G.4 aut |
| 700 | 1 | a Barlassina, Cristina4 aut |
| 700 | 1 | a Rivolta, Carlo4 aut |
| 700 | 1 | a Nolte, Ilja M.4 aut |
| 700 | 1 | a Snieder, Harold4 aut |
| 700 | 1 | a Van der Klauw, Melanie M.4 aut |
| 700 | 1 | a Van Vliet-Ostaptchouk, Jana V.4 aut |
| 700 | 1 | a Gejman, Pablo V.4 aut |
| 700 | 1 | a Shi, Jianxin4 aut |
| 700 | 1 | a Jacobs, Kevin B.4 aut |
| 700 | 1 | a Wang, Zhaoming4 aut |
| 700 | 1 | a Bakker, Stephan J. L.4 aut |
| 700 | 1 | a Leach, Irene Mateo4 aut |
| 700 | 1 | a Navis, Gerjan4 aut |
| 700 | 1 | a van der Harst, Pim4 aut |
| 700 | 1 | a Martin, Nicholas G.4 aut |
| 700 | 1 | a Medland, Sarah E.4 aut |
| 700 | 1 | a Montgomery, Grant W.4 aut |
| 700 | 1 | a Yang, Jian4 aut |
| 700 | 1 | a Chasman, Daniel I.4 aut |
| 700 | 1 | a Ridker, Paul M.4 aut |
| 700 | 1 | a Rose, Lynda M.4 aut |
| 700 | 1 | a Lehtimaki, Terho4 aut |
| 700 | 1 | a Raitakari, Olli4 aut |
| 700 | 1 | a Absher, Devin4 aut |
| 700 | 1 | a Iribarren, Carlos4 aut |
| 700 | 1 | a Basart, Hanneke4 aut |
| 700 | 1 | a Hovingh, Kees G.4 aut |
| 700 | 1 | a Hyppoenen, Elina4 aut |
| 700 | 1 | a Power, Chris4 aut |
| 700 | 1 | a Anderson, Denise4 aut |
| 700 | 1 | a Beilby, John P.4 aut |
| 700 | 1 | a Hui, Jennie4 aut |
| 700 | 1 | a Jolley, Jennifer4 aut |
| 700 | 1 | a Sager, Hendrik4 aut |
| 700 | 1 | a Bornstein, Stefan R.4 aut |
| 700 | 1 | a Schwarz, Peter E. H.4 aut |
| 700 | 1 | a Kristiansson, Kati4 aut |
| 700 | 1 | a Perola, Markus4 aut |
| 700 | 1 | a Lindstrom, Jaana4 aut |
| 700 | 1 | a Swift, Amy J.4 aut |
| 700 | 1 | a Uusitupa, Matti4 aut |
| 700 | 1 | a Atalay, Mustafa4 aut |
| 700 | 1 | a Lakka, Timo A.4 aut |
| 700 | 1 | a Rauramaa, Rainer4 aut |
| 700 | 1 | a Bolton, Jennifer L.4 aut |
| 700 | 1 | a Fowkes, Gerry4 aut |
| 700 | 1 | a Fraser, Ross M.4 aut |
| 700 | 1 | a Price, Jackie F.4 aut |
| 700 | 1 | a Fischer, Krista4 aut |
| 700 | 1 | a KrjutAikov, Kaarel4 aut |
| 700 | 1 | a Metspalu, Andres4 aut |
| 700 | 1 | a Mihailov, Evelin4 aut |
| 700 | 1 | a Langenberg, Claudia4 aut |
| 700 | 1 | a Luan, Jian'an4 aut |
| 700 | 1 | a Ong, Ken K.4 aut |
| 700 | 1 | a Chines, Peter S.4 aut |
| 700 | 1 | a Keinanen-Kiukaanniemi, Sirkka M.4 aut |
| 700 | 1 | a Saaristo, Timo E.4 aut |
| 700 | 1 | a Edkins, Sarah4 aut |
| 700 | 1 | a Franks, Paul W.4 aut |
| 700 | 1 | a Hallmans, Goran4 aut |
| 700 | 1 | a Shungin, Dmitry4 aut |
| 700 | 1 | a Morris, Andrew David4 aut |
| 700 | 1 | a Palmer, Colin N. A.4 aut |
| 700 | 1 | a Erbel, Raimund4 aut |
| 700 | 1 | a Moebus, Susanne4 aut |
| 700 | 1 | a Noethen, Markus M.4 aut |
| 700 | 1 | a Pechlivanis, Sonali4 aut |
| 700 | 1 | a Hveem, Kristian4 aut |
| 700 | 1 | a Narisu, Narisu4 aut |
| 700 | 1 | a Hamsten, Anders4 aut |
| 700 | 1 | a Humphries, Steve E.4 aut |
| 700 | 1 | a Strawbridge, Rona J.4 aut |
| 700 | 1 | a Tremoli, Elena4 aut |
| 700 | 1 | a Grallert, Harald4 aut |
| 700 | 1 | a Thorand, Barbara4 aut |
| 700 | 1 | a Illig, Thomas4 aut |
| 700 | 1 | a Koenig, Wolfgang4 aut |
| 700 | 1 | a Mueller-Nurasyid, Martina4 aut |
| 700 | 1 | a Peters, Annette4 aut |
| 700 | 1 | a Boehm, Bernhard O.4 aut |
| 700 | 1 | a Kleber, Marcus E.4 aut |
| 700 | 1 | a Maerz, Winfried4 aut |
| 700 | 1 | a Winkelmann, Bernhard R.4 aut |
| 700 | 1 | a Kuusisto, Johanna4 aut |
| 700 | 1 | a Laakso, Markku4 aut |
| 700 | 1 | a Arveiler, Dominique4 aut |
| 700 | 1 | a Cesana, Giancarlo4 aut |
| 700 | 1 | a Kuulasmaa, Kari4 aut |
| 700 | 1 | a Virtamo, Jarmo4 aut |
| 700 | 1 | a Yarnell, John W. G.4 aut |
| 700 | 1 | a Kuh, Diana4 aut |
| 700 | 1 | a Wong, Andrew4 aut |
| 700 | 1 | a Lind, Lars4 aut |
| 700 | 1 | a de Faire, Ulf4 aut |
| 700 | 1 | a Gigante, Bruna4 aut |
| 700 | 1 | a Magnusson, Patrik K. E.4 aut |
| 700 | 1 | a Pedersen, Nancy L.4 aut |
| 700 | 1 | a Dedoussis, George4 aut |
| 700 | 1 | a Dimitriou, Maria4 aut |
| 700 | 1 | a Kolovou, Genovefa4 aut |
| 700 | 1 | a Kanoni, Stavroula4 aut |
| 700 | 1 | a Stirrups, Kathleen4 aut |
| 700 | 1 | a Bonnycastle, Lori L.4 aut |
| 700 | 1 | a Njolstad, Inger4 aut |
| 700 | 1 | a Wilsgaard, Tom4 aut |
| 700 | 1 | a Ganna, Andrea4 aut |
| 700 | 1 | a Rehnberg, Emil4 aut |
| 700 | 1 | a Hingorani, Aroon4 aut |
| 700 | 1 | a Kivimaki, Mika4 aut |
| 700 | 1 | a Kumari, Meena4 aut |
| 700 | 1 | a Assimes, Themistocles L.4 aut |
| 700 | 1 | a Barroso, Ine S.4 aut |
| 700 | 1 | a Boehnke, Michael4 aut |
| 700 | 1 | a Borecki, Ingrid B.4 aut |
| 700 | 1 | a Deloukas, Panos4 aut |
| 700 | 1 | a Fox, Caroline S.4 aut |
| 700 | 1 | a Frayling, Timothy4 aut |
| 700 | 1 | a Groop, Leif C.4 aut |
| 700 | 1 | a Haritunians, Talin4 aut |
| 700 | 1 | a Hunter, David4 aut |
| 700 | 1 | a Ingelsson, Erik4 aut |
| 700 | 1 | a Kaplan, Robert4 aut |
| 700 | 1 | a Mohlke, Karen L.4 aut |
| 700 | 1 | a O'Connell, Jeffrey R.4 aut |
| 700 | 1 | a Schlessinger, David4 aut |
| 700 | 1 | a Strachan, David P.4 aut |
| 700 | 1 | a Stefansson, Kari4 aut |
| 700 | 1 | a van Duijn, Cornelia M.4 aut |
| 700 | 1 | a Abecasis, Goncalo R.4 aut |
| 700 | 1 | a McCarthy, Mark I.4 aut |
| 700 | 1 | a Hirschhorn, Joel N.4 aut |
| 700 | 1 | a Qi, Lu4 aut |
| 700 | 1 | a Loos, Ruth J. F.4 aut |
| 700 | 1 | a Lindgren, Cecilia M.4 aut |
| 700 | 1 | a North, Kari E.4 aut |
| 700 | 1 | a Heid, Iris M.4 aut |
| 710 | 1 2 | a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl |
| 710 | 1 2 | a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl |
| 710 | 1 2 | a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl |
| 772 | 1 8 | i channel recordw 19753896 |
| 773 | 0 8 | i Värdpublikationt PLOS Geneticsg 9:6, e1003500x 1553-7390 |
| 856 | 4 0 | u http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-208677 |
| 856 | 4 0 | u http://dx.doi.org/10.1371/journal.pgen.1003500 |
| 856 | 4 0 | u http://uu.diva-portal.org/smash/get/diva2:653904/FULLTEXT01 |
| 900 | 1 s | 6 700a Beckmann, J. S.u Beckmann, Jacques S. |
| 900 | 1 s | 6 700a Collins, Francis Sellarsu Collins, Francis S. |
| 900 | 1 s | 6 700a Collins, Francis,d 1950-u Collins, Francis S. |
| 841 | 5 APISa x ab 171211||0000|||||001||||||000000e 1 | |
| 024 | 7 | 5 APISa urn:nbn:se:uu:diva-2086772 urn |
| 852 | 5 APISb APIS | |
| 856 | 4 0 | 5 APISu http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-208677 |
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