Use of Repeated Blood Pressure and Cholesterol Measurements to Improve Cardiovascular Disease Risk Prediction An Individual-Participant-Data Meta-Analysis

doi:10.1093/aje/kwx149

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Paige, Ellie (author)

Use of Repeated Blood Pressure and Cholesterol Measurements to Improve Cardiovascular Disease Risk Prediction An Individual-Participant-Data Meta-Analysis

E-article/E-chapterEnglish2017

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Oxford University Press2017

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LIBRIS-ID:22129913
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-142912uri
urn:nbn:se:umu:diva-142912urn
10.1093/aje/kwx149doi

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Language:English

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deldatabas:Eplk_tEPLK

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Published
gratis
The added value of incorporating information from repeated blood pressure and cholesterol measurements to predict cardiovascular disease (CVD) risk has not been rigorously assessed. We used data on 191,445 adults from the Emerging Risk Factors Collaboration (38 cohorts from 17 countries with data encompassing 1962-2014) with more than 1 million measurements of systolic blood pressure, total cholesterol, and high-density lipoprotein cholesterol. Over a median 12 years of follow-up, 21,170 CVD events occurred. Risk prediction models using cumulative mean values of repeated measurements and summary measures from longitudinal modeling of the repeated measurements were compared with models using measurements from a single time point. Risk discrimination (C-index) and net reclassification were calculated, and changes in C-indices were meta-analyzed across studies. Compared with the single-time-point model, the cumulative means and longitudinal models increased the C-index by 0.0040 (95% confidence interval (CI): 0.0023, 0.0057) and 0.0023 (95% CI: 0.0005, 0.0042), respectively. Reclassification was also improved in both models; compared with the single-time-point model, overall net reclassification improvements were 0.0369 (95% CI: 0.0303, 0.0436) for the cumulative-means model and 0.0177 (95% CI: 0.0110, 0.0243) for the longitudinal model. In conclusion, incorporating repeated measurements of blood pressure and cholesterol into CVD risk prediction models slightly improves risk prediction.

Subject headings and genre

Medical and Health Sciences hsv
Health Sciences hsv
Public Health, Global Health, Social Medicine and Epidemiology hsv
Medicin och hälsovetenskap hsv
Hälsovetenskaper hsv
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi hsv
cardiovascular disease
longitudinal measurements
repeated measurements
risk factors
risk prediction

Added entries (persons, corporate bodies, meetings, titles ...)

Barrett, Jessica (author)
Pennells, Lisa (author)
Sweeting, Michael (author)
Willeit, Peter (author)
Di Angelantonio, Emanuele (author)
Gudnason, Vilmundur (author)
Nordestgaard, Børge G. (author)
Psaty, Bruce M. (author)
Goldbourt, Uri (author)
Best, Lyle G. (author)
Assmann, Gerd (author)
Salonen, Jukka T. (author)
Nietert, Paul J. (author)
Verschuren, W. M. Monique (author)
Brunner, Eric J. (author)
Kronmal, Richard A. (author)
Salomaa, Veikko (author)
Bakker, Stephan J. L. (author)
Dagenais, Gilles R. (author)
Sato, Shinichi (author)
Jansson, Jan-Håkan (author)
Willeit, Johann (author)
Onat, Altan (author)
de la Cámara, Agustin Gómez (author)
Roussel, Ronan (author)
Völzke, Henry (author)
Dankner, Rachel (author)
Tipping, Robert W. (author)
Meade, Tom W. (author)
Donfrancesco, Chiara (author)
Kuller, Lewis H. (author)
Peters, Annette (author)
Gallacher, John (author)
Kromhout, Daan (author)
Iso, Hiroyasu (author)
Knuiman, Matthew (author)
Casiglia, Edoardo (author)
Kavousi, Maryam (author)
Palmieri, Luigi (author)
Sundström, Johan (author)
Davis, Barry R. (author)
Njølstad, Inger (author)
Couper, David (author)
Danesh, John (author)
Thompson, Simon G. (author)
Wood, Angela (author)
Umeå universitetMedicinska fakulteten268483 (publisher)

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In:VärdpublikationAmerican Journal of Epidemiology186:8, 899-9070002-9262

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By the author/editor: Paige, Ellie; Barrett, Jessica; Pennells, Lisa; Sweeting, Michae ...; Willeit, Peter; Di Angelantonio, ...; show more...; Gudnason, Vilmun ...; Nordestgaard, Bø ...; Psaty, Bruce M.; Goldbourt, Uri; Best, Lyle G.; Assmann, Gerd; Salonen, Jukka T ...; Nietert, Paul J.; Verschuren, W. M ...; Brunner, Eric J.; Kronmal, Richard ...; Salomaa, Veikko; Bakker, Stephan ...; Dagenais, Gilles ...; Sato, Shinichi; Jansson, Jan-Håk ...; Willeit, Johann; Onat, Altan; de la Cámara, Ag ...; Roussel, Ronan; Völzke, Henry; Dankner, Rachel; Tipping, Robert ...; Meade, Tom W.; Donfrancesco, Ch ...; Kuller, Lewis H.; Peters, Annette; Gallacher, John; Kromhout, Daan; Iso, Hiroyasu; Knuiman, Matthew; Casiglia, Edoard ...; Kavousi, Maryam; Palmieri, Luigi; Sundström, Johan; Davis, Barry R.; Njølstad, Inger; Couper, David; Danesh, John; Thompson, Simon ...; Wood, Angela; show less...

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