Sökning: onr:"22699041" > Glioma-related seiz...
Fältnamn | Indikatorer | Metadata |
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000 | 04437naa a22007693a 4500 | |
001 | 22699041 | |
003 | SE-LIBR | |
005 | 20180531113918.0 | |
007 | cr|||||||||||| | |
008 | 180531s2018 sw |||| o |||| ||eng c | |
024 | 7 | a http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3493792 uri |
024 | 7 | a urn:nbn:se:uu:diva-3493792 urn |
024 | 7 | a 10.1007/s00415-018-8857-02 doi |
040 | a S | |
041 | 0 | a eng |
042 | 9 EPLK | |
100 | 1 | a Berntsson, Shala G.d 1964-4 aut |
245 | 1 0 | a Glioma-related seizures in relation to histopathological subtypesh [Elektronisk resurs]b a report from the glioma international case-control study. |
260 | c 2018 | |
500 | a Epub ahead of print | |
506 | 0 | a gratis |
520 | a BACKGROUND: The purpose of this study was to evaluate the distribution of glioma-related seizures and seizure control at the time of tumor diagnosis with respect to tumor histologic subtypes, tumor treatment and patient characteristics, and to compare seizure history preceding tumor diagnosis (or study enrollment) between glioma patients and healthy controls. METHODS: The Glioma International Case Control study (GICC) risk factor questionnaire collected information on demographics, past medical/medication history, and occupational history. Cases from eight centers were also asked detailed questions on seizures in relation to glioma diagnosis; cases (n = 4533) and controls (n = 4171) were also asked about seizures less than 2 years from diagnosis and previous seizure history more than 2 years prior to tumor diagnosis, including childhood seizures. RESULTS: Low-grade gliomas (LGGs), particularly oligodendrogliomas/oligoastrocytomas, had the highest proportion of glioma-related seizures. Patients with low-grade astrocytoma demonstrated the most medically refractory seizures. A total of 83% of patients were using only one antiepileptic drug (AED), which was levetiracetam in 71% of cases. Gross total resection was strongly associated with reduced seizure frequency (p < 0.009). No significant difference was found between glioma cases and controls in terms of seizure occurring more than 2 years before diagnosis or during childhood. CONCLUSIONS: Our study showed that glioma-related seizures were most common in low-grade gliomas. Gross total resection was associated with lower seizure frequency. Additionally, having a history of childhood seizures is not a risk factor ***for developing glioma-related seizures or glioma. | |
650 | 7 | a Medical and Health Sciences2 hsv |
650 | 7 | a Clinical Medicine2 hsv |
650 | 7 | a Neurology2 hsv |
650 | 7 | a Medicin och hälsovetenskap2 hsv |
650 | 7 | a Klinisk medicin2 hsv |
650 | 7 | a Neurologi2 hsv |
653 | 0 | a Epileptic seizures |
653 | 0 | a Glioma-related seizures |
653 | 0 | a Observational study (cohort |
653 | 0 | a case–control) |
653 | 0 | a Primary brain tumor |
700 | 1 | a Merrell, Ryan T4 aut |
700 | 1 | a Amirian, E Susan4 aut |
700 | 1 | a Armstrong, Georgina N4 aut |
700 | 1 | a Lachance, Daniel4 aut |
700 | 1 | a Smits, Anja4 aut |
700 | 1 | a Zhou, Renke4 aut |
700 | 1 | a Jacobs, Daniel I4 aut |
700 | 1 | a Wrensch, Margaret R4 aut |
700 | 1 | a Olson, Sara H4 aut |
700 | 1 | a Il'yasova, Dora4 aut |
700 | 1 | a Claus, Elizabeth B4 aut |
700 | 1 | a Barnholtz-Sloan, Jill S4 aut |
700 | 1 | a Schildkraut, Joellen4 aut |
700 | 1 | a Sadetzki, Siegal4 aut |
700 | 1 | a Johansen, Christoffer4 aut |
700 | 1 | a Houlston, Richard S4 aut |
700 | 1 | a Jenkins, Robert B4 aut |
700 | 1 | a Bernstein, Jonine L4 aut |
700 | 1 | a Lai, Rose4 aut |
700 | 1 | a Shete, Sanjay4 aut |
700 | 1 | a Amos, Christopher I4 aut |
700 | 1 | a Bondy, Melissa L4 aut |
700 | 1 | a Melin, Beatrice S4 aut |
710 | 1 2 | a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl |
710 | 2 | a Neurology4 oth |
772 | 1 8 | i channel recordw 19753896 |
773 | 0 8 | i Värdpublikationt Journal of Neurologyx 0340-5354 |
856 | 4 0 | u http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-349379 |
856 | 4 0 | u http://dx.doi.org/10.1007/s00415-018-8857-0 |
856 | 4 0 | u http://uu.diva-portal.org/smash/get/diva2:1201573/FULLTEXT01 |
841 | 5 APISa x ab 180531||0000|||||001||||||000000e 1 | |
024 | 7 | 5 APISa urn:nbn:se:uu:diva-3493792 urn |
852 | 5 APISb APIS | |
856 | 4 0 | 5 APISu http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-349379 |
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