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Serum fatty acid pa...
Serum fatty acid patterns, insulin sensitivity and the metabolic syndrome in individuals with chronic kidney disease
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- Huang, X (författare)
- Karolinska Institutet
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- Sjögren, Per (författare)
- Uppsala universitet,Klinisk nutrition och metabolism
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- Ärnlöv, Johan, 1970- (författare)
- Uppsala universitet,Högskolan Dalarna,Medicinsk vetenskap,Department of Public Health and Caring Sciences, Section of Geriatrics, Uppsala University, Uppsala, Sweden,Geriatrik
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- Cederholm, Tommy (författare)
- Uppsala universitet,Karolinska Institutet,Klinisk nutrition och metabolism
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- Lind, Lars (författare)
- Uppsala universitet,Kardiovaskulär epidemiologi
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- Stenvinkel, P (författare)
- Karolinska Institutet
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- Lindholm, B (författare)
- Karolinska Institutet
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- Risérus, Ulf (författare)
- Uppsala universitet,Klinisk nutrition och metabolism
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- Carrero, J J (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2013-09-24
- 2014
- Engelska.
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Ingår i: Journal of Internal Medicine. - : Wiley. - 0954-6820 .- 1365-2796. ; 275:1, s. 71-83
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- OBJECTIVES: The causes of the multiple metabolic disorders of individuals with chronic kidney disease (CKD) are not fully known. We investigated the relationships between dietary fat quality, the metabolic syndrome (MetS), insulin sensitivity and inflammation in individuals with CKD.SUBJECTS: Two population-based surveys were conducted in elderly Swedish individuals (aged 70 years) with serum cystatin C-estimated glomerular filtration rate <60 mL min(-1) /1.73 m(2) : the Uppsala Longitudinal Study of Adult Men (ULSAM) and the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) surveys. The present population comprised 274 men and 187 subjects (63% women) from the ULSAM and PIVUS cohorts, respectively.DESIGN: Factor analyses of serum fatty acids were used to evaluate dietary fat quality. Insulin sensitivity was measured by homeostasis model assessment of insulin resistance (IR) and, in ULSAM, also by euglycaemic clamp.RESULTS: Factor analyses generated two fatty acid patterns of (i) low linoleic acid (LA)/high saturated fatty acid (SFA) or (ii) high n-3 polyunsaturated fatty acid (n-3 PUFA) levels. In both surveys, the low LA/high SFA pattern increased the odds of having MetS [adjusted odds ratio 0.60 [95% confidence interval (CI) 0.44-0.81] and 0.45 (95% CI 0.30-0.67) per SD decrease in factor score in the ULSAM and PIVUS surveys, respectively] and was directly associated with both IR and C-reactive protein. The n-3 PUFA pattern was not consistently associated with these risk factors.CONCLUSIONS: A serum fatty acid pattern reflecting low LA and high SFA was strongly associated with MetS, IR and inflammation in two independent surveys of elderly individuals with CKD. At present, there are no specific dietary guidelines for individuals with CKD; however, these findings indirectly support current recommendations to replace SFAs with PUFAs from vegetable oils.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- Hälsa och välfärd
- Health and Welfare
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Huang, X
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Sjögren, Per
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Ärnlöv, Johan, 1 ...
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Cederholm, Tommy
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Lind, Lars
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Stenvinkel, P
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visa fler...
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Lindholm, B
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Risérus, Ulf
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Carrero, J J
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
- Artiklar i publikationen
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Journal of Inter ...
- Av lärosätet
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Högskolan Dalarna
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Karolinska Institutet
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Uppsala universitet