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Validity and respon...
Validity and responsiveness of at-home touch-screen assessments in advanced Parkinson's disease
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- Memedi, Mevludin (författare)
- Högskolan Dalarna,Datateknik,School of Technology and Business Studies, Computer Engineering, Dalarna University, Falun, Sweden,Dalarna Univ, Sch Technol & Business Studies, Comp Engn, S-79188 Falun, Sweden.
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- Nyholm, Dag (författare)
- Uppsala universitet,Neurologi
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- Johansson, Anders (författare)
- Karolinska Institutet
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- Pålhagen, Sven (författare)
- Karolinska Institutet
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- Willows, Thomas (författare)
- Department of Neurology, Karolinska University Hospital, Stockholm, Sweden,Karolinska Univ Hosp, Dept Neurol, S-17177 Stockholm, Sweden.
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- Widner, Håkan (författare)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Linder, Jan (författare)
- Umeå universitet,Klinisk neurovetenskap,Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå, Sweden,Umea Univ, Dept Pharmacol & Clin Neurosci, S-90187 Umea, Sweden.
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- Westin, Jerker (författare)
- Högskolan Dalarna,Datateknik,School of Technology and Business Studies, Computer Engineering, Dalarna University, Falun, Sweden,Dalarna Univ, Sch Technol & Business Studies, Comp Engn, S-79188 Falun, Sweden.
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(creator_code:org_t)
- Institute of Electrical and Electronics Engineers (IEEE), 2015
- 2015
- Engelska.
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Ingår i: IEEE journal of biomedical and health informatics. - : Institute of Electrical and Electronics Engineers (IEEE). - 2168-2194 .- 2168-2208. ; 19:6, s. 1829-1834
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Abstract
Ämnesord
Stäng
- The aim of this study was to investigate if a telemetry test battery can be used to measure effects of Parkinson’s disease (PD) treatment intervention and disease progression in patients with fluctuations. Sixty-five patients diagnosed with advanced PD were recruited in an open longitudinal 36-month study; 35 treated with levodopa-carbidopa intestinal gel (LCIG) and 30 were candidates for switching from oral PD treatment to LCIG. They utilized a test battery, consisting of self-assessments of symptoms and fine motor tests (tapping and spiral drawings), four times per day in their homes during week-long test periods. The repeated measurements were summarized into an overall test score (OTS) to represent the global condition of the patient during a test period. Clinical assessments included ratings on Unified PD Rating Scale (UPDRS) and 39-item PD Questionnaire (PDQ-39) scales. In LCIG-naïve patients, mean OTS compared to baseline was significantly improved from the first test period on LCIG treatment until month 24. In LCIG-non-naïve patients, there were no significant changes in mean OTS until month 36. The OTS correlated adequately with total UPDRS (rho = 0.59) and total PDQ-39 (0.59). Responsiveness measured as effect size was 0.696 and 0.536 for OTS and UPDRS respectively. The trends of the test scores were similar to the trends of clinical rating scores but dropout rate was high. Correlations between OTS and clinical rating scales were adequate indicating that the test battery contains important elements of the information of well-established scales. The responsiveness and reproducibility were better for OTS than for total UPDRS.
Ämnesord
- NATURVETENSKAP -- Data- och informationsvetenskap -- Systemvetenskap, informationssystem och informatik (hsv//swe)
- NATURAL SCIENCES -- Computer and Information Sciences -- Information Systems (hsv//eng)
- NATURVETENSKAP -- Data- och informationsvetenskap -- Datorteknik (hsv//swe)
- NATURAL SCIENCES -- Computer and Information Sciences -- Computer Engineering (hsv//eng)
- NATURVETENSKAP -- Data- och informationsvetenskap (hsv//swe)
- NATURAL SCIENCES -- Computer and Information Sciences (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Annan medicinteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Other Medical Engineering (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- home assessment
- levodopa infusion
- Parkinson's disease
- remote monitoring
- telemedicine
- FLOAT - Flexible Levodopa Optimizing Assistive Technology
- FLOAT - Flexibel levodopa-optimerings och individanpassningsteknik
- Informatik
- telemedicine.
- monitoring
- remote
- disease (PD)
- Parkinson's
- levodopa infusion
- Home assessment
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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