Search: onr:"swepub:oai:DiVA.org:hh-48392" >
Germinal Center B C...
Germinal Center B Cells Are Essential for Collagen-Induced Arthritis
-
- Dahdah, Albert (author)
- Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
-
- Habir, Katrin (author)
- Karolinska Institutet
-
- Nandakumar, Kutty Selva, 1965- (author)
- Karolinska Institutet
-
show more...
-
- Saxena, Amit (author)
- Karolinska Institutet
-
- Xu, Bingze (author)
- Karolinska Institutet
-
- Holmdahl, Rikard (author)
- Karolinska Institutet
-
- Malin, Stephen (author)
- Karolinska Institutet
-
show less...
-
(creator_code:org_t)
- 2018-01-22
- 2018
- English.
-
In: Arthritis & Rheumatology. - Hoboken : John Wiley & Sons. - 2326-5191 .- 2326-5205. ; 70:2, s. 193-203
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- OBJECTIVE: Rheumatoid arthritis (RA) is considered to be a prototypical autoimmune disorder. Several mechanisms have been proposed for the known pathologic function of B cells in RA, including antigen presentation, cytokine secretion, and humoral immunity. The aim of this study was to address the function of B lymphocytes in experimental arthritis.METHODS: We mapped the adaptive immune response following collagen-induced arthritis (CIA). We subsequently monitored these responses and disease outcomes in genetically modified mouse strains that lack mature B cell or germinal center (GC) functionality in a B cell-intrinsic manner.RESULTS: Following primary immunization, the draining lymph nodes broadly reacted against type II collagen (CII) with the formation of GCs and T cell activation. Mice that lacked mature B cell function were fully protected against CIA and had a severely attenuated ability to mount isotype-switched humoral immune responses against CII. Almost identical results were observed in mice that were selectively deficient in GC responses. Importantly, GC-deficient mice were fully susceptible to collagen antibody-induced arthritis.CONCLUSION: We identified GC formation and anticollagen antibody production as the key pathogenic functions of B cells in CIA. The role of B cells in RA is likely to be more complex. However, targeting the GC reaction could allow for therapeutic interventions that are more refined than general B cell depletion.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database