Sökning: onr:"swepub:oai:DiVA.org:his-24392" > Multi-omics profili...
Fältnamn | Indikatorer | Metadata |
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000 | 07505naa a2200613 4500 | |
001 | oai:DiVA.org:his-24392 | |
003 | SwePub | |
008 | 240717s2024 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:umu-228011 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-243922 URI |
024 | 7 | a https://doi.org/10.1016/j.tranon.2024.1020592 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-2280112 URI |
040 | a (SwePub)hisd (SwePub)umu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Borgmästars, Emmyu Umeå universitet,Institutionen för diagnostik och intervention,Kirurgi4 aut0 (Swepub:umu)embo0061 |
245 | 1 0 | a Multi-omics profiling to identify early plasma biomarkers in pre-diagnostic pancreatic ductal adenocarcinoma :b a nested case-control study |
264 | 1 | b Elsevier,c 2024 |
338 | a electronic2 rdacarrier | |
500 | a CC BY 4.0Corresponding author at: University Hospital of Umeå, 901 85 Umeå, Sweden. E-mail address: emmy.borgmastars@umu.se (E. Borgmästars)The authors thank Hanna Nyström, and Daniel Öhlund at Umeå University for valuable assistance in data collection. We thank Xiaoshuang Feng at International Agency for Research of Cancer, Lyon, France for guidance in statistical analyses. The authors would also like to thank Swedish Metabolomics Centre, Umeå, Sweden (www.swedishmetabolomicscentre.se) and Biobanken Norr. Funding: This study was funded by Umeå University, the Swedish Research Council [2016-02990, 2019-01690], the Swedish Cancer Society [CAN 2016/643, 19 0273], Region Västerbotten [RV-583411, RV-549731, RV-583411, RV-841551, RV 967602], Finska Läkaresällskapet, Medicinska Understödsföreningen Liv och Hälsa, the Sjöberg Foundation, The JC Kempe Memorial Foundation Scholarship Fund, The Royal Swedish Academy of Sciences (PE Lindahl Foundation, LM2021-0010 and LM2023-0012), The Swedish Society of Medicine (SLS-960379), Cancerforskningsfonden i Norrland (LP 23-2337), Bengt Ihre foundation (SLS-960529 and SLS-986656), and Bengt Ihre Research Fellowship Grant. The sponsors had no role in the study design, collection, analysis and interpretation of data, writing of the report, or in the decision to submit the article for publication. | |
520 | a Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with poor survival. Novel biomarkers are urgently needed to improve the outcome through early detection. Here, we aimed to discover novel biomarkers for early PDAC detection using multi-omics profiling in pre-diagnostic plasma samples biobanked after routine health examinations.A nested case-control study within the Northern Sweden Health and Disease Study was designed. Pre-diagnostic plasma samples from 37 future PDAC patients collected within 2.3 years before diagnosis and 37 matched healthy controls were included. We analyzed metabolites using liquid chromatography mass spectrometry and gas chromatography mass spectrometry, microRNAs by HTG edgeseq, proteins by multiplex proximity extension assays, as well as three clinical biomarkers using milliplex technology. Supervised and unsupervised multi-omics integration were performed as well as univariate analyses for the different omics types and clinical biomarkers. Multiple hypothesis testing was corrected using Benjamini-Hochberg's method and a false discovery rate (FDR) below 0.1 was considered statistically significant.Carbohydrate antigen (CA) 19-9 was associated with PDAC risk (OR [95 % CI] = 3.09 [1.31–7.29], FDR = 0.03) and increased closer to PDAC diagnosis. Supervised multi-omics models resulted in poor discrimination between future PDAC cases and healthy controls with obtained accuracies between 0.429–0.500. No single metabolite, microRNA, or protein was differentially altered (FDR < 0.1) between future PDAC cases and healthy controls.CA 19-9 levels increase up to two years prior to PDAC diagnosis but extensive multi-omics analysis including metabolomics, microRNAomics and proteomics in this cohort did not identify novel early biomarkers for PDAC. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
650 | 7 | a NATURVETENSKAPx Biologix Bioinformatik och systembiologi0 (SwePub)106102 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Bioinformatics and Systems Biology0 (SwePub)106102 hsv//eng |
650 | 7 | a NATURVETENSKAPx Data- och informationsvetenskapx Bioinformatik0 (SwePub)102032 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Computer and Information Sciencesx Bioinformatics0 (SwePub)102032 hsv//eng |
653 | a Pancreatic neoplasms | |
653 | a miRNomics | |
653 | a Metabolomics | |
653 | a Proteomics | |
653 | a Risk | |
653 | a Bioinformatik | |
653 | a Bioinformatics | |
700 | 1 | a Ulfenborg, Benjamin,d 1985-u Högskolan i Skövde,Institutionen för biovetenskap,Forskningsmiljön Systembiologi,Translational Bioinformatics,School of Bioscience, Department of Biology and Bioinformatics, University of Skövde, Skövde, Sweden4 aut0 (Swepub:his)ulfb |
700 | 1 | a Johansson, Mattiasu Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France4 aut |
700 | 1 | a Jonsson, Päru Umeå universitet,Kemiska institutionen4 aut0 (Swepub:umu)parjon95 |
700 | 1 | a Billing, Ola,d 1981-u Umeå universitet,Institutionen för diagnostik och intervention,Kirurgi4 aut0 (Swepub:umu)olabig00 |
700 | 1 | a Franklin, Oskar,d 1985-u Umeå universitet,Institutionen för diagnostik och intervention,Kirurgi,Division of Surgical Oncology, Department of Surgery, University of Colorado School of Medicine, CO, Aurora, United States4 aut0 (Swepub:umu)osfr0002 |
700 | 1 | a Lundin, Christina,d 1970-u Umeå universitet,Institutionen för diagnostik och intervention,Kirurgi4 aut0 (Swepub:umu)chlu0008 |
700 | 1 | a Jacobson, Sarau Umeå universitet,Institutionen för diagnostik och intervention,Kirurgi4 aut0 (Swepub:umu)saja0030 |
700 | 1 | a Simm, Majau Umeå universitet,Institutionen för diagnostik och intervention,Obstetrik och gynekologi,Kirurgi4 aut0 (Swepub:umu)makr0062 |
700 | 1 | a Lubovac-Pilav, Zelminau Högskolan i Skövde,Institutionen för biovetenskap,Forskningsmiljön Systembiologi,Translational Bioinformatics,School of Bioscience, Department of Biology and Bioinformatics, University of Skövde, Skövde, Sweden4 aut0 (Swepub:his)lubz |
700 | 1 | a Sund, Malinu Umeå universitet,Institutionen för diagnostik och intervention,Kirurgi,Department of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland4 aut0 (Swepub:umu)masu0021 |
710 | 2 | a Umeå universitetb Institutionen för diagnostik och intervention4 org |
773 | 0 | t Translational Oncologyd : Elsevierg 48q 48x 1944-7124x 1936-5233 |
856 | 4 | u https://doi.org/10.1016/j.tranon.2024.102059y Fulltext |
856 | 4 | u https://his.diva-portal.org/smash/get/diva2:1884505/FULLTEXT02.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1885143/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-24392 |
856 | 4 8 | u https://doi.org/10.1016/j.tranon.2024.102059 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-228011 |
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