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Prevalence and Impl...
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Kochar, BharatiDivision of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA; Clinical Translational Epidemiology Unit, Mongan Institute, Boston, Massachusetts, USA; Harvard Medical School, Boston, Massachusetts, USA; Center for Aging and Serious Illness, Mongan Institute, Boston, Massachusetts, USA
(author)
Prevalence and Implications of Frailty in Older Adults With Incident Inflammatory Bowel Diseases : A Nationwide Cohort Study
- Article/chapterEnglish2022
Publisher, publication year, extent ...
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Elsevier,2022
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LIBRIS-ID:oai:DiVA.org:hj-56122
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https://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-56122URI
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https://doi.org/10.1016/j.cgh.2022.01.001DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:151644907URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-201720URI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Background and Aims: We aimed to compare the risk of frailty in older adults with incident inflammatory bowel disease (IBD) and matched non-IBD comparators and assess the association between frailty and future hospitalizations and mortality.Methods: In a cohort of patients with incident IBD ≥60 years of age from 2007 to 2016 in Sweden identified using nationwide registers, we defined frailty using Hospital Frailty Risk Score. We compared prevalence of frailty in patients with IBD with age, sex, place of residency– and calendar year–matched population comparators. In the IBD cohort, we used Cox proportional hazards modeling to examine the associations between frailty risk and hospitalizations or mortality.Results: We identified 10,590 patients with IBD, 52% female with a mean age of 71 years of age, matched to 103,398 population-based comparators. Among patients with IBD, 39% had no risk for frailty, 49% had low risk for frailty, and 12% had higher risk for frailty. Mean Hospital Frailty Risk Score was 1.9 in IBD and 0.9 in matched comparators (P < .01). Older adults with IBD at higher risk for frailty had a 20% greater risk for mortality at 3 years compared with those who were not frail. Compared with nonfrail older patients with IBD, patients at higher risk for frailty had increased mortality (hazard ratio [HR], 3.22, 95% confidence interval [CI], 2.86–3.61), all-cause hospitalization (HR, 2.42; 95% CI, 2.24–2.61), and IBD-related hospitalization (HR, 1.50; 95% CI, 1.35–1.66). These associations were not attenuated after adjusting for comorbidities.Conclusions: Frailty is more prevalent in older adults with IBD than in matched comparators. Among older patients with IBD, frailty is associated with increased risk for hospitalizations and mortality.
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Jylhävä, JuuliaKarolinska Institutet,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
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Söderling, JonasDivision of Palliative Care and Geriatric Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
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Ritchie, Christine S.Harvard Medical School, Boston, Massachusetts, USA; Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet Stockholm, Sweden; Center for Aging and Serious Illness, Mongan Institute, Boston, Massachusetts, USA
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Olsson, M.
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Hjortswang, H.
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Myrelid, Pär,1970-Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US,SWIBREG Study Group(Swepub:liu)parmy24
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Bengtsson, J.
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Strid, H.
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Andersson, M.
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Jäghult, S.
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Eberhardson, M.
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Nordenvall, C.
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Björk, J.
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Fagerberg, U. L.
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Rejler, MartinJönköping University,The Jönköping Academy for Improvement of Health and Welfare,Department of Medicine, Höglandssjukhuset Eksjö, Region Jönköping County Council, Jönköping, Sweden
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Grip, O.
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Karling, P.
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Halfvarson, J.
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Ludvigsson, J. F.Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Pediatrics, Örebro University Hospital, Örebro, Sweden; Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, Nottingham, United Kingdom; Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York.
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Khalili, H.Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts; Clinical Translational Epidemiology Unit, Mongan Institute, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts.
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Olén, O.Karolinska Institutet,Division of Palliative Care and Geriatric Medicine, Massachusetts General Hospital, Boston, Massachusetts; Department of Pediatric Gastroenterology and Nutrition, Sachs' Children and Youth Hospital, Stockholm, Sweden; Department of Clinical Science and Education, Karolinska Institutet, Stockholm, Sweden.
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Group, the SWIBREG Study
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Karolinska InstitutetDivision of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA; Clinical Translational Epidemiology Unit, Mongan Institute, Boston, Massachusetts, USA; Harvard Medical School, Boston, Massachusetts, USA; Center for Aging and Serious Illness, Mongan Institute, Boston, Massachusetts, USA
(creator_code:org_t)
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In:Clinical Gastroenterology and Hepatology: Elsevier20:10, s. 2358-23651542-35651542-7714
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Kochar, Bharati
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Jylhävä, Juulia
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Söderling, Jonas
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Ritchie, Christi ...
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Olsson, M.
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Hjortswang, H.
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Myrelid, Pär, 19 ...
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Bengtsson, J.
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Strid, H.
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Andersson, M.
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Jäghult, S.
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Eberhardson, M.
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Nordenvall, C.
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Björk, J.
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Fagerberg, U. L.
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Rejler, Martin
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Grip, O.
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Karling, P.
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Halfvarson, J.
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Ludvigsson, J. F ...
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Khalili, H.
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Olén, O.
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