Resorbable Scaffolds from Three Different Techniques : Electrospun Fabrics, Salt-Leaching Porous Films, and Smooth Flat Surfaces

• Nanofibrous scaffolds of poly[(L-lactide)-co-(1,5-dioxepan-2-one)] generated by electrospinning have been compared with porous films obtained by solvent cast/salt leaching and homogeneous films. A comparison between the fibrous materials and the homogeneous solvent-cast films revelead that the surface of the nanofibers was more hydrophobic and that the nanofibers were degraded more rapidly in the presence of proteinase. It was obvious that the strain-to-break was reduced by the nanofiber formation, it decreased from 370% to 130% independent of fiber diameter. These values were however considerably higher than the strain-to-break of the solvent-cast/salt leaching scaffold. In addition, the nanofibrous material accelerated the adhesion and growth of the mesenchymal stem cell compared to the smooth material.

Nyckelord

cell proliferation

degradation

electrospinning

structure/property

relations

tissue engineering

mechanical-properties

nanofiber scaffolds

fibers

cell

regeneration

membrane

adhesion

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