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Predicting unintend...
Predicting unintended effects of drugs based on off-target tissue effects
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Kim, D. (författare)
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Lee, J. (författare)
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- Lee, Sunjae (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, South Korea
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Park, J. (författare)
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Lee, D. (författare)
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(creator_code:org_t)
- Elsevier, 2016
- 2016
- Engelska.
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Ingår i: Biochemical and Biophysical Research Communications - BBRC. - : Elsevier. - 0006-291X .- 1090-2104. ; 469:3, s. 399-404
- Relaterad länk:
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https://doi.org/10.1...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Unintended effects of drugs can be caused by various mechanisms. Conventional analysis of unintended effects has focused on the target proteins of drugs. However, an interaction with off-target tissues of a drug might be one of the unintended effect-related mechanisms. We propose two processes to predict a drug’s unintended effects by off-target tissue effects: 1) identification of a drug’s off-target tissue and; 2) tissue protein - symptom relation identification (tissue protein - symptom matrix). Using this method, we predicted that 1,177 (10.7%) side-effects were related to off-target tissue effects in 11,041 known side-effects. Off-target tissues and unintended effects of successful repositioning drugs were also predicted. The effectiveness of relations of the proposed tissue protein - symptom matrix were evaluated by using the literature mining method. We predicted unintended effects of drugs as well as those effect-related off-target tissues. By using our prediction, we are able to reduce drug side-effects on off-target tissues and provide a chance to identify new indications of drugs of interest.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Nyckelord
- Unintended effect
- Off-target tissue effect
- Tissue protein-symptom matrix
- Side-effect prediction
- Drug repositioning
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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